Umenzi womgubo we-CMS121 Inombolo ye-CAS: 1353224-53-9 Ubumsulwa obuyi-98.0% ubuncinci bezithako ezongezelelweyo
Iiparamitha zeMveliso
| Igama lemveliso | I-CMS121 |
| Elinye igama | I-CMS-121; 1,2-Benzenediol,4-[4-(cyclopentyloxy)-2-quinolinyl]-; 4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol(CMS121); I-ACC, i-AcetylCoenzymeACarboxylase, isifo, i-neuroprotective, i-inhibit, i-anti-inflammatory, i-mitochondrial, i-Alzheimer's, i-antioxidative, i-acetylation, i-Inhibitor, i-H3K9, i-Acetyl-CoACarboxylase, i-CMS121, i-dementia, i-ACC1, i-CMS-121 |
| Inombolo ye-CAS | 1353224-53-9 |
| Ifomula yemolekyuli | C20H19NO3 |
| Ubunzima be-molecular | 321.37 |
| Ubunyulu | 98.0% |
| Inkangeleko | Umgubo otyheli okhanyayo |
| Isicelo | Isongezelelo sokutya Izinto eziluhlaza |
Intshayelelo yemveliso
I-4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol yikhompawundi ekwabizwa ngokuba yi-CMS121. Ubunzima besakhiwo sekhompawundi bubonisa ukuba inokuba neempawu ezizodwa kunye nokusetyenziswa okunokwenzeka. Ukuqonda ukubaluleka kwayo, kunceda ukuchonga amaqela asebenzayo akhoyo kunye nokuhlalutya impembelelo yawo enokubakho. Ubukho beringi ye-quinoline bubonisa ukuba ikhompawundi inokuba isebenza ngokwebhayoloji. Iimolekyuli ezivela kwi-Quinoline zaziwa ngeempawu zazo ezahlukeneyo zebhayoloji, kubandakanya imisebenzi yokulwa neentsholongwane kunye nokulwa nokuvuvukala. Ukunamathela kweqela le-cyclopentyloxy kunokunceda ekunyibilikeni kwekhompawundi okanye kuphucule umsebenzi wayo webhayoloji ngeziphumo ze-steric. Kwizifundo kwiiseli ze-HT22, i-CMS-121 ibonakalise iziphumo ezibalulekileyo zokukhusela imithambo-luvo, ikhusela ngempumelelo ezi seli kwi-ischemia kunye nomonakalo we-oxidative. Ngaphezu koko, i-CMS-121 ineempawu ezibalulekileyo zokulwa nokuvuvukala, ebonisa amandla ayo okulawula iimpendulo zokuvuvukala. Ngokwenza njalo, i-CMS-121 inako ukunciphisa ukuvuvukala kwizicubu ezahlukeneyo kunye namalungu omzimba. I-CMS-121 inomsebenzi omkhulu wezonyango njengomthinteli we-acetyl-CoA carboxylase 1 (ACC1). Isiphumo sayo esinamandla sokuthintela kwi-ACC1 senza ukuba ibe yikhompawundi ethembisayo.
Uphawu
(1) Ubunyulu obuphezulu: I-CMS-121 inokufumana iimveliso ezinyulu obuphezulu ngeenkqubo zemveliso ezicociweyo. Ubunyulu obuphezulu buthetha ukufumaneka ngcono kwezinto eziphilayo kunye neempendulo ezimbalwa ezingalunganga.
(2) Ukhuseleko: Ukhuseleko oluphezulu, zimbalwa iziphumo ezibi.
(3) Uzinzo: I-CMS-121 izinzile kwaye ingayigcina iyasebenza phantsi kweemeko ezahlukeneyo kunye neemeko zokugcina.
Izicelo
I-CMS-121 sisithinteli se-quinolone esisuka kwi-quinolone kwaye sisebenza ngomlomo i-acetyl-CoA carboxylase 1 (ACC1) esineempawu ezithembisayo ze-pharmacological. Uphando olubanzi lwenziwe ukuphanda iingenelo ezinokubakho ze-CMS-121 kwiindawo ezahlukeneyo, kubandakanya ukhuseleko lwe-neurological, iziphumo zokulwa nokuvuvukala, umsebenzi we-antioxidant, kunye nempembelelo yayo kwiimpawu ezinxulumene nokwaluphala okunempilo.
