Umenzi womgubo weRiboside we-1,4-DihydronicotinaMide Inombolo ye-CAS:19132-12-8 Ubumsulwa obuyi-98% ubuncinane bezithako ezongezelelweyo
Iiparamitha zeMveliso
| Igama lemveliso | I-1,4-DihydronicotinaMide Riboside |
| Elinye igama | I-1,4-DIHYDRONICOTINAMIDE RIBOSIDE1-[(3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,4-dihydropyridine-3-carboxamideI-SCHEMBL188493711-[(3R,4S,5R)-3,4-DIHYDROXY-5-(HYDROXYMETHYL)OXOLAN-2-YL]-4H-PYRIDINE-3-CARBOXAMIDE |
| Inombolo ye-CAS | 19132-12-8 |
| Ifomula yemolekyuli | C11H16N2O5 |
| Ubunzima be-molecular | 256.26 |
| Ubunyulu | 98% |
| Inkangeleko | Umgubo omhlophe |
| Ukupakisha | 1kg/ibhegi; 25kg/igubu |
| Isicelo | Izinto zokutya ezongezelelweyo |
Intshayelelo yemveliso
I-1,4-dihydronicotinamide riboside, ekwaziwa ngokuba yi-NRH.Uhlobo oluncitshisiweyo lwe-NRH luhlobo oluphambili lwe-NAD+ olunceda ekuzaliseni amanqanaba ayo kwiseli.
Okokuqala nokubalulekileyo, kubalulekile ukuqonda indima ye-NAD+ emzimbeni. I-NAD+ yi-coenzyme ebandakanyeka kwiinkqubo ezininzi zeseli, kubandakanya imetabolism yamandla, ukulungiswa kwe-DNA, kunye nokubonakaliswa kwezakhi zofuzo. Njengoko sikhula, amanqanaba ethu e-NAD+ ayancipha, nto leyo ebandakanyekileyo kwinkqubo yokwaluphala kunye nezifo ezinxulumene nokuguga. Oku kukhokelele ekukhuleni komdla wokuchonga iimolekyuli ezinokunyusa amanqanaba e-NAD+ emzimbeni, kwaye i-1,4-dihydronicotinamide riboside yenye yeemolekyuli ezinjalo.
I-1,4-dihydronicotinamide riboside yi-NAD+ enamandla, kwaye uphando lubonise ukuba inokunyusa ngempumelelo amanqanaba e-NAD+ kwiiseli. Oku kukhokelele ekuqikeleleni ukuba ukongezwa kwe-1,4-dihydronicotinamide riboside kunokuba namandla okunyanga kwiimeko ezahlukeneyo zempilo, kubandakanya iingxaki zemetabolism, izifo ze-neurodegenerative, kunye nokwehla okunxulumene nokwaluphala.
Enyanisweni, kukho ubungqina obubonisa ukuba i-1,4-dihydronicotinamide riboside inokuba nefuthe elingcono kunemolekyuli yayo engumzali, i-nicotinamide riboside, xa inyusa amanqanaba e-NAD+. Oku kungenxa yokuba i-1,4-dihydronicotinamide riboside inciphisa amandla ngakumbi, oko kuthetha ukuba ingcono ekunikeleni ngee-elektroni kwindlela yokwenziwa kwe-NAD+. Ngenxa yoko, inamandla okuxhasa imveliso ye-NAD+ yeselula ngokufanelekileyo.
Ukongeza kwindima yayo kwi-NAD+ biosynthesis, i-1,4-dihydronicotinamide riboside ikwanazo neempawu ze-antioxidant. Uxinzelelo lwe-oxidative, olubangelwa kukungalingani phakathi kwee-free radicals kunye nee-antioxidants emzimbeni, luchaphazeleka kwizifo ezininzi, kubandakanya umhlaza, isifo sentliziyo, kunye neengxaki ze-neurodegenerative. Ngokususa ii-free radicals kunye nokunciphisa umonakalo we-oxidative, i-1,4-dihydronicotinamide riboside inokubonelela ngeenzuzo ezongezelelweyo zempilo ngaphaya kwendima yayo njengomanduleli we-NAD+.
Uphawu
(1) Ubunyulu obuphezulu: I-1,4-dihydronicotinamide riboside inokufumana iimveliso ezinyulu obuphezulu ngeenkqubo zokuvelisa ezicociweyo. Ubunyulu obuphezulu buthetha ukufumaneka ngcono kwezinto eziphilayo kunye neempendulo ezimbalwa ezingalunganga.
(2) Ukhuseleko: I-1,4-dihydronicotinamide riboside yimveliso yendalo eye yangqinwa ukuba ikhuselekile emzimbeni womntu.
(3) Uzinzo: I-1,4-dihydronicotinamide riboside inozinzo oluhle kwaye inokugcina umsebenzi wayo kunye nesiphumo phantsi kweemeko ezahlukeneyo kunye neemeko zokugcina.
Izicelo
I-1,4-Dihydronicotinamide yindlela encitshisiweyo ye-nicotinamide riboside. Inokubakho zombini kwiindlela ezi-oxidized kunye nezincitshisiweyo kwaye ingumlandeli we-NAD esandul' ukufunyanwa (i-nicotinamide adenine dinucleotide), efumaneka njengesongezelelo, kwaye i-NRH ingumlandeli we-NAD+ onamandla kwaye okhawulezayo kune-NR.
