O-304 Inombolo yeCAS:1261289-04-6 Yakha izihlunu kwaye unciphise amafutha.
Iiparamitha zeMveliso
| Igama lemveliso | O-304 |
| Elinye igama | I-4-Chloro-N-[2-[(4-chlorophenyl)methyl]-2,3-dihydro-3-oxo-1,2,4-thiadiazol-5-yl]benzamide |
| Inombolo ye-CAS | 1261289-04-6 |
| Ifomula yemolekyuli | C16H11Cl2N3O2S |
| Ubunzima be-molecular | 380.25 |
| Ubunyulu | 98% |
| Inkangeleko | Umgubo omhlophe ukuya komhlophe ongekho mhlophe |
| Ukupakisha | 1kg/ibhegi, 25kg/umphanda |
| Isicelo | Isongezelelo sokutya Izinto eziluhlaza |
Intshayelelo yemveliso
I-O-304 sisishukumisi se-AMPK esineemolekyuli ezincinci esiphucula umsebenzi we-AMPK ngokuthintela i-dephosphorylation ye-AMPK (pAMPK) ene-phosphorylated, ngaloo ndlela sonyusa amanqanaba e-pAMPK ngaphandle kokunciphisa ubuninzi be-adenosine triphosphate (ATP) ngaphakathi kweseli. Ineendlela ezininzi zokusebenza, kubandakanya ukuphucula imetabolism ye-glucose, ukunciphisa ukumelana ne-insulin, kunye nokukhusela inkqubo yentliziyo.
Uphawu
(1) Ubunyulu obuphezulu: I-O-304 iveliswa ngenkqubo yokuvelisa ecociweyo, nto leyo efezekisa ubunyulu obuphezulu bemveliso. Ubunyulu obuphezulu buthetha ukufumaneka ngcono kwezinto eziphilayo.
(2) Umsebenzi Webhayoloji:I-O-304 sisivuseleli se-AMPK (i-AMP-activator protein kinase) esisebenza ngomlomo. Siphucula umsebenzi we-AMPK ngokuthintela i-dephosphorylation ye-pAMPK.
Izicelo
1. Ukusebenza kwe-AMPK: I-O-304 yonyusa umsebenzi we-AMPK ngokuthintela inkqubo ye-dephosphorylation ye-AMPK (pAMPK) ene-phosphorylated, ngaloo ndlela ilawula ulungelelwaniso lwe-metabolism yamandla.
2. Ukuphucula imetabolism yeswekile: Kwizifundo zezilwanyana, idosi ye-100 mg/kg ye-O-304 incede ngokufanelekileyo ukugcina iswekile yegazi engazinzanga kunye namanqanaba e-insulin egazini, kunciphisa kakhulu umthwalo wemetabolism obangelwa kukutya okunamafutha amaninzi, kunye nokuthintela ukuguquguquka kweswekile egazini kunye nokunyuka okungaqhelekanga kwe-insulin okubangelwa kukungalingani kokutya.
3. Pukuthintela ukuthamba kwemithambo yegazi:I-O-304 inceda ukugcina uxinzelelo lwegazi lukwizinga elisempilweni, inciphisa uxinzelelo kwimithambo yegazi, kwaye inika ukhuseleko oluhlala ixesha elide noluthambileyo kwiinkqubo zentliziyo kunye nemithambo yegazi, ixhasa ukuzinza kweemvakalelo kunye namandla ahlala ixesha elide.
4.Ukukhuthaza ubutsha obuhlala ixesha elide:I-O-304 ijolise ngqo kwindlela yokubonisana ye-AMPK-mTOR, ilawula ngobuchule inkqubo ye-autophagy yeselula, ikhuthaza ukuqhekeka kweeproteni ezindala kunye nee-lipids ezingaqhelekanga, kwaye igcina indawo ecocekileyo nephilayo yeselula, ngaloo ndlela ilibazisa ukuguga kweseli.
