Umenzi womgubo weNefiracetam Inombolo yeCAS: 77191-36-7 Ubumsulwa obuyi-99% ubuncinane bezithako ezongezelelweyo
Ividiyo yeMveliso
Iiparamitha zeMveliso
| Igama lemveliso | I-Nefiracetam |
| Elinye igama | n-(2,6-dimethylphenyl)-2-oxo-1-pyrrolidineacetamide;NEFIRACETAM; i-2-oxo-1-pyrrolidinylaceticacid, i-2,6-dimethylanilide; dm9384; n-(2,6-dimethylphenyl)-2-oxo-1-pyrrolidineacetamid;DM-9384,(2-(2-Oxopyrrolidin-1-yl)-N-(2,6-dimethylphenyl)-acetamide); I-DMMPA |
| Inombolo ye-CAS | 77191-36-7 |
| Ifomula yemolekyuli | C14H18N2O2 |
| Ubunzima be-molecular | 246.3 |
| Ubunyulu | 99.0% |
| Inkangeleko | Umgubo omhlophe |
| Ukupakisha | 25 kg/umphanda |
| Isicelo | i-nootropic |
Intshayelelo yemveliso
I-Nefiracetam iyinxalenye yosapho lwe-piracetam, udidi lwamayeza aziwa ngeempawu zawo zokuphucula ingqondo. I-Nefiracetam yaqalwa ukwenziwa ekuqaleni kweminyaka yoo-1980 kwaye yakhawuleza yatsala ingqalelo ngenxa yendlela yayo yokwenza izinto eyahlukileyo kunye nokusetyenziswa kwayo okunokwenzeka konyango. Le khompawundi ye-racemic kucingelwa ukuba ichaphazela ii-neurotransmitters kunye nee-receptors ebuchosheni, ekugqibeleni ikhuthaza ubuchule bokuqonda obuphuculweyo. I-Nefiracetam ichaphazela kakhulu amanqanaba engqondo ye-acetylcholine, i-neurotransmitter ephambili enoxanduva lwenkumbulo, ukufunda, kunye nomsebenzi wokuqonda. Ngokuguqula ii-receptors ze-acetylcholine, i-nefiracetam ikhuthaza unxibelelwano olwandisiweyo phakathi kwee-neurons, ngaloo ndlela iphucula i-synaptic plasticity kwaye iphucula ukugcinwa kwememori. Ukongeza, i-nefiracetam isebenzisana nee-receptors ze-gamma-aminobutyric acid (GABA) ukunceda ukulinganisela imeko ye-neurotransmitter. Ngokuchaphazela kakuhle ii-neurotransmitters ezivuselelayo nezithintelayo, i-nefiracetam inceda ukugcina ukusebenza kobuchopho okufanelekileyo, ngaloo ndlela iphucula ukugxila, ingqalelo, kunye nokusebenza kwengqondo ngokubanzi.
Uphawu
(1) Ubunyulu obuphezulu: I-Nefiracetam inokufumana iimveliso ezinyulu obuphezulu ngokusebenzisa iinkqubo zokuvelisa ezicociweyo. Ubunyulu obuphezulu buthetha ukufumaneka ngcono kwezinto eziphilayo kunye neempendulo ezimbalwa ezingalunganga.
(2) Ukhuseleko: Ukhuseleko oluphezulu, zimbalwa iziphumo ezibi.
(3) Uzinzo: I-Nefiracetam izinzile kakuhle kwaye ingayigcina iyasebenza phantsi kweemeko ezahlukeneyo kunye neemeko zokugcina.
Izicelo
I-Nefiracetam sisithako esiphuma kwi-piracetam esingena manzi, esithathwa njengesithako esinoxanduva lokufunyanwa kweendlela ze-calcium emzimbeni kunye nokudluliselwa ngokungathanga ngqo kwezinto ezibangela ukukhupha imiqondiso njenge-agonist engaphelelanga yeendlela ze-calcium ion. Indawo yokubopha i-Glycine ye-NDMA receptor. Ngempembelelo yayo kwi-cortex yobuchopho, i-nefiracetam inokuphucula amandla okuqonda kwaye ithintele ukukhubazeka kokufunda kunye nokukhumbula. Ayinazo iimpawu ze-muscarinic receptor agonist okanye i-antagonist, kwaye ayithinteli umsebenzi we-acetylcholinease. Ke ngoko, iziphumo zayo zokulwa ne-amnestic kunye nokuphucula inkumbulo zifezekiswa ngokuphucula ukukhululwa kwe-acetylcholine kwi-cortex yobuchopho.
