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I-BAM15A Inombolo ye-CAS:210302-02-6 Yakha izihlunu kwaye unciphise amafutha. Umfanekiso oPhambili
  • I-BAM15A CAS No.:210302-02-6 Yakha izihlunu kwaye unciphise amafutha.
  • I-BAM15A CAS No.:210302-02-6 Yakha izihlunu kwaye unciphise amafutha.
  • I-BAM15A CAS No.:210302-02-6 Yakha izihlunu kwaye unciphise amafutha.
  • I-BAM15A CAS No.:210302-02-6 Yakha izihlunu kwaye unciphise amafutha.
  • I-BAM15A CAS No.:210302-02-6 Yakha izihlunu kwaye unciphise amafutha.

I-BAM15A CAS No.:210302-02-6 Yakha izihlunu kwaye unciphise amafutha.

Inkcazo emfutshane:

I-BAM15A yi-modulator yesizukulwana esitsha se-mitochondrial. Njenge-mitochondrial proton uncoupler egqwesileyo, ilawula ngobunono i-proton gradient kuyo yonke i-inner mitochondrial membrane, inyusa ukusebenza kakuhle kwe-metabolism yamandla omzimba kwaye ikhawulezise ukuqhekeka kwendalo kwamafutha, ngaphandle kokuchaphazela ubunzima bemisipha okanye ukutya okuqhelekileyo.

Izifundo zangaphambi kweklinikhi ziqinisekisile ukuba esi sithako sinceda ekuphuculeni ukudumba komzimba, siphucule uvakalelo lwe-insulin, sinciphise ukuqokelelwa kwamafutha esibindini kwaye sinciphise iimpendulo zokudumba komzimba. Sifumaneka ngomlomo ukuya kuthi ga kwi-67% kwaye sineempawu ezincinci kwaye sikhuselekile kakhulu. Ngokungafaniyo nezithako zemveli ezifanayo, asibangeli ubushushu bomzimba obungaqhelekanga okanye umonakalo weseli, nto leyo eyenza ukuba sibe sisixhobo esikumgangatho ophezulu sesondlo sokulawula ubunzima kunye nokulawula imetabolism.


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  • Inombolo ye-CAS ye-BAM15A:210302-02-6:Yakha izihlunu kwaye unciphise amafutha.

    • Iinkcukacha zeMveliso

    Iithegi zeMveliso

    Iiparamitha zeMveliso

    Igama lemveliso BAM15A
    Elinye igama I-N5,N6-Bis(2-Chlorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine
    Inombolo ye-CAS 210302-02-6
    Ifomula yemolekyuli C16H10Cl2N6O
    Ubunzima be-molecular 373.2
    Ubunyulu 98%
    Inkangeleko Umgubo omhlophe ukuya kotyheli okhanyayo
    Ukupakisha 1kg/ibhegi, 25kg/umphanda
    Isicelo Isongezelelo sokutya Izinto eziluhlaza

    Intshayelelo yemveliso

    I-BAM15A yi-modulator yesizukulwana esitsha se-mitochondrial. Njenge-mitochondrial proton uncoupler egqwesileyo, ilawula ngobunono i-proton gradient kuyo yonke i-inner mitochondrial membrane, inyusa ukusebenza kakuhle kwe-metabolism yamandla omzimba kwaye ikhawulezise ukuqhekeka kwendalo kwamafutha, ngaphandle kokuchaphazela ubunzima bemisipha okanye ukutya okuqhelekileyo.

    Izifundo zangaphambi kweklinikhi ziqinisekisile ukuba esi sithako sinceda ekuphuculeni ukudumba komzimba, siphucule uvakalelo lwe-insulin, sinciphise ukuqokelelwa kwamafutha esibindini kwaye sinciphise iimpendulo zokudumba komzimba. Sifumaneka ngomlomo ukuya kuthi ga kwi-67% kwaye sineempawu ezincinci kwaye sikhuselekile kakhulu. Ngokungafaniyo nezithako zemveli ezifanayo, asibangeli ubushushu bomzimba obungaqhelekanga okanye umonakalo weseli, nto leyo eyenza ukuba sibe sisixhobo esikumgangatho ophezulu sesondlo sokulawula ubunzima kunye nokulawula imetabolism.

    Uphawu

    (1) Ubunyulu obuphezulu: BAM15Ainokuvelisa iimveliso ezicocekileyo kakhulu ngenkqubo yemveliso ecociweyo. Ukucoceka okuphezulu kuthetha ukufumaneka ngcono kwezinto eziphilayo.

    (2) Indlela yokudibanisa esebenza kakuhle: Njengesithwali seproton ye-mitochondrial, iphazamisa i-proton gradient ye-membrane yangaphakathi ye-mitochondrial, ikhuthaza ukuguqulwa kwamandla e-oxidative ukusuka kwizondlo ukuya kumandla obushushu endaweni ye-ATP, nto leyo ephucula kakhulu ukusetyenziswa kwamandla.

    (3) Ukulahleka kwamafutha ngokukhuselekileyo kunye nokuphuculwa kwe-metabolism: Kwizilingo zezilwanyana, ukufumaneka kokutya ngomlomo kufikelele kwi-67%, kunciphisa amafutha emzimbeni ngaphezulu kwe-20% ngaphandle kokunciphisa ubunzima bemisipha, okuchaphazela ukutya okanye ubushushu bomzimba, ngelixa kuphucula uvakalelo lwe-insulin, ukunciphisa isibindi esinamafutha kunye nokuvuvukala.

    (4) Inzuzo ephantsi yetyhefu: Xa kuthelekiswa nee-agents zemveli zokukhulula, akukho mngcipheko wokuba nomkhuhlane ophezulu okanye ubuthi obuvela kwi-cytotoxicity. Akukho monakalo kwizitho zomzimba okanye iziphumo ebezingalindelekanga zemithambo-luvo.

    Izicelo

    1. Ukunciphisa amafutha kunye nokuphucula imetabolism: Ngokudibanisa i-mitochondrial, kunciphisa kakhulu amafutha omzimba (kwiimodeli zezilwanyana, amafutha omzimba ancipha ngaphezulu kwama-20%), ngaxeshanye kunciphisa iswekile egazini, ukumelana ne-insulin, kunye nokuqokelelwa kwamafutha esibindi, ngaphandle kokuchaphazela inkanuko yokutya okanye ubunzima bemisipha;

    2. Ukulwa nokwaluphala: Yonyusa ubunzima bemisipha (nge-8%) kunye namandla (nge-40%) kwizilwanyana ezindala, yehlisa amafutha kwaye ithintele ukudumba okungapheliyo, kwaye ilwe nokutyeba okubangelwa yi-myogenic.

    3. I-Anti-inflammatory: Inciphisa umngcipheko wokulimala kwe-acute kidney okubangelwa yi-sepsis (AKI), kwaye inciphisa iimpendulo zokudumba komzimba ngokuthintela ukuveliswa kwe-mitochondrial ROS kunye nokukhululwa kwe-mtDNA.

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