Umenzi weMitoquinone Bromide Inombolo yeCAS: 336184-91-9 Ubumsulwa obungama-25% ubuncinane. Kwizithako zezongezo
Iiparamitha zeMveliso
| Igama lemveliso | I-Mitoquinone Bromide |
| Elinye igama | i-mitoquinone bromide I-Mito-Q I-MitoQ i-mitoquinone i-mitoquinone cation (10-(4,5-Dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl)decyl)triphenylphosphonium bromide DMRUQISFVFDWGE-UHFFFAOYSA-M 10-(6'-ubiquinolyl)decyltriphenylphosphonium J-690299 [10-(4,5-Dimethoxy-2-methyl-3,6-dioxo-1,4-cyclohexadien-1-yl)decyl]triphenyl-phosphonium Bromide |
| Inombolo ye-CAS | 336184-91-9 |
| Ifomula yemolekyuli | C37H44O4I-BrP |
| Ubunzima be-molecular | 663.6 |
| Ubunyulu | 25% |
| Inkangeleko | Umgubo otyheli okanye otyheli okhanyayo |
| Ukupakisha | 1kg/ibhegi, 25kg/umphanda |
| Isicelo | Izinto eziluhlaza zeSongezo sokutya |
Intshayelelo yemveliso
I-Mitoquinone bromide yi-analog ye-Coenzyme Q10 ebonakaliswe ukuba inomsebenzi onamandla we-antioxidant. I-Mitoquinone, eyaziwa ngokuba yi-MitoQ, luhlobo olulodwa lwe-Coenzyme Q10 (CoQ10) olujolise kwaye luqokelele kwi-mitochondria, amandla eseli. Ngokungafaniyo nee-antioxidants eziqhelekileyo ezinokuba nobunzima bokungena kwi-membrane ye-mitochondrial, i-Mitoquinone yenzelwe ukufikelela ngempumelelo kule organelle ibalulekileyo apho ivelisa khona imiphumo yayo enamandla ye-antioxidant. I-Bromide yi-ion etshajiweyo kakubi enefomyula yekhemikhali i-Br⁻. Liyinxalenye ebalulekileyo kwiindlela ezahlukeneyo ze-chemical reactions, ngakumbi kwiindlela ze-SN2 reactions apho inokusebenza njenge-nucleophile okanye i-radical ionizing. I-Mitoquinone bromide ijoliswe kwi-mitochondria ngokuncamathisela kwe-covalent kwi-lipophilic triphenylphosphine cation. Ngenxa yamandla amakhulu e-mitochondrial membrane, i-cation iqokelelana ukuya kuthi ga kwi-1,000 ngaphezulu kwi-mitochondria kune-non-target antioxidants ezifana neCoenzyme Q okanye ii-analogues zayo, nto leyo evumela ukuba i-antioxidant moiety ithintele i-lipid peroxidation kwaye ikhusele i-mitochondria kumonakalo we-oxidative. Ngokuthintela ngokukhetha umonakalo we-mitochondrial oxidative, ithintela ukufa kweeseli. I-Mitoquinone bromide inokuba ngumlamli oluncedo wokusetyenziswa kwe-oksijini ye-mitochondrial.
Uphawu
(1) Ubunyulu obuphezulu: I-Mitoquinone bromide inokufumana iimveliso ezinyulu obuphezulu ngokusebenzisa iinkqubo zokucoca imveliso. Ubunyulu obuphezulu buthetha ukufumaneka ngcono kwezinto eziphilayo kunye neempendulo ezimbalwa ezingalunganga.
(2) Ukhuseleko: Ukhuseleko oluphezulu, zimbalwa iziphumo ezibi.
(3) Uzinzo: I-Mitoquinone bromide izinzile kwaye inokugcina umsebenzi wayo kunye nefuthe phantsi kweemeko ezahlukeneyo kunye neemeko zokugcina.
Izicelo
Kwimeko yokwaluphala, ukwehla komsebenzi we-mitochondrial kunye nokuqokelelana komonakalo we-oxidative zezona zinto zibalulekileyo kwinkqubo yokwaluphala. Iziphumo ze-antioxidant ezijoliswe kwi-mitoquinones zibenza babe ngabaviwa abanamandla bokungenelela okujoliswe ekukhuthazeni ukwaluphala okunempilo kunye nobomi obude. Ukongeza, iipropati zayo zokukhusela i-neurological zinokulibazisa ukwehla kwengqondo okunxulunyaniswa nobudala, zisinike indlela enokwenzeka yokugcina amandla okuqonda ngexesha lenkqubo yokwaluphala. I-Mitoquinone ikwatsale ingqalelo kumandla ayo e-antioxidant kwicandelo lokhathalelo lolusu. Ulusu luhlala luvezwa zizinto ezibangela uxinzelelo lokusingqongileyo kwaye lusengozini enkulu yokonakala kwe-oxidative. Ngokusebenzisa amandla e-quinones ye-mitochondrial, umbala wolutsha nokhanyayo unokufezekiswa.
