Umenzi womgubo weLemairamin (WGX-50) Inombolo yeCAS: 29946-61-0 Ubumsulwa obuyi-98.0% ubuncinane bezithako ezongezelelweyo
Ividiyo yeMveliso
Iiparamitha zeMveliso
| Igama lemveliso | I-Lemairamin |
| Elinye igama | I-2-Propenamide, i-N-[2-(3,4-dimethoxyphenyl)ethyl]-3-phenyl-, (2E)-; I-Lemairamin (WGX-50) |
| Inombolo ye-CAS | 29946-61-0 |
| Ifomula yemolekyuli | C19H21NO3 |
| Ubunzima be-molecular | 311.37 |
| Ubunyulu | 98.0% |
| Inkangeleko | Umgubo omhlophe ukuya komhlophe ongekho mhlophe |
| Isicelo | Isongezelelo sokutya Izinto eziluhlaza |
Intshayelelo yemveliso
I-Lemairamin okanye i-Wgx50 yikhompawundi yendalo ekhutshwe kwi-chili peppers ebonakalise iziphumo ezithembisayo ekuthinteleni isifo se-Alzheimer. Izifundo zifumanise ukuba inokuthintela i-apoptosis ye-neuronal ebangelwa yi-Aβ, inciphise ubuthi be-calcium ye-neuronal, kwaye inciphise ukuqokelelwa kwe-Aβ oligomers kwi-cortex yobuchopho. Ukongeza, i-wgx50 ibonakalisiwe ukuba iphucula ukusebenza kwengqondo kwiimpuku. Uphando lubonisa ukuba i-wgx50 inamandla okuthintela ukuhlanganiswa kweproteni-protein phakathi kweemolekyuli ze-amyloid. Ngokubanzi, i-wgx50 inamandla okuthintela isifo se-Alzheimer kwaye inokubonelela ngeendlela ezintsha zophuhliso lwamayeza ajolise kwi-Aβ oligomers. Ukongeza, i-WGX-50 ibonisa umsebenzi obalulekileyo wokulwa nokuvuvukala, okwenza ukuba ibe ngumviwa othembisayo wokunyanga izifo ezivuthayo. I-WGX-50 ifunyenwe ineempembelelo ezibalulekileyo eluswini, njengokunciphisa imibimbi kunye nokuphucula ukuthamba kolusu. Ukongeza kwiikhompawundi zendalo ezikhutshwe kwisityalo i-Zanthoxylum bungeanum, okwangoku kukho iikhompawundi ezininzi zokwenziwa ezisetyenziswa kwiindawo ezahlukeneyo kwaye zifanelekile ngakumbi kwimarike.
Uphawu
(1) Ubunyulu obuphezulu: I-Lemairamin inokufumana iimveliso ezinyulu obuphezulu ngokusebenzisa iinkqubo zendalo zokukhupha kunye nokucoca. Ubunyulu obuphezulu buthetha ukufumaneka ngcono kwezinto eziphilayo kunye neempendulo ezimbalwa ezingalunganga.
(2) Ukhuseleko: Ukhuseleko oluphezulu, zimbalwa iziphumo ezimbi, akukho ziphumo ezimbi zicacileyo nokuba zisetyenziswe ixesha elide.
(3) Uzinzo: I-Lemairamin izinzile kakuhle kwaye ingayigcina iyasebenza phantsi kweemeko ezahlukeneyo kunye neemeko zokugcina.
(4) Kulula ukufunxa: I-Lemairamin inokufunxwa ngokukhawuleza ngumzimba womntu ize isasazwe kwiithishu kunye namalungu ahlukeneyo.
Izicelo
I-Lemairamin yi-amide compound ekhutshwe kwixolo lesityalo se-Zanthoxylum bungeanum. Okwangoku isetyenziswa njengesongezelelo sokutya, ikwasebenza njenge-agonist ye-alpha7 nicotinic acetylcholine receptor (α7nAChR), enciphisa ukudumba kwe-neuroinflammation kwisifo se-Alzheimer, kwaye yenziwe ngokupheleleyo. I-Wgx50 ibonise iziphumo ezikhuthazayo kwizifundo zangaphambi kweklinikhi, kubandakanya ukuthintela i-apoptosis ye-neuronal ebangelwa yi-Aβ, ukunciphisa ubuthi be-calcium ye-neuronal, ukunciphisa ukuqokelelwa kwe-oligomers ze-Aβ kwi-cortex ye-cerebral, kunye nokuphucula ukusebenza kwengqondo kwiimpuku.
