1-Methylnicotinamide Chloride Inombolo yeCAS:1005-24-9
Iiparamitha zeMveliso
| Igama lemveliso | I-1-Methylnicotinamide chloride |
| Elinye igama | I-N-Methylnicotinamide chloride；I-NMN-Cl；I-1-MNA chloride；i-3-carbamoyl-1-methyl-pyridinium chloride |
| Inombolo ye-CAS | 1005-24-9 |
| Ifomula yemolekyuli | C7H9N2I-OCl |
| Ubunzima be-molecular | 172.61 |
| Ubunyulu | 98.5% |
| Inkangeleko | Umhlophe – omhlophe qhwa, oqinileyo ocwebezelayoumgubo |
| Ukupakisha | 1kg/ibhegi; 25kg/igubu |
| Isicelo | ci-hemicaleuvavanyomiiteriyali |
Intshayelelo yemveliso
I-1-Methylnicotinamide chloride yi-methylated derivative ye-nicotinamide, ebonakaliswa yisakhiwo setyuwa ye-quaternary ammonium esizinzileyo. Isebenza njengesixhobo esibalulekileyo ekufundeni imetabolism ye-nicotinamide. Ukunyibilika kwayo kakuhle emanzini kunye nokuzinza kweekhemikhali kwenza ukuba ifaneleke njengesixhobo sophando lwe-biochemical.
I-1-MNA yinto eyenzeka ngokwendalo emzimbeni womntu, esebenza njengemveliso eqhelekileyo ye-niacin metabolism. Njengenxalenye ephambili kule ndlela ye-metabolic, i-1-MNA icutshungulwa ngakumbi yi-aldehyde oxidase ukuvelisa ii-metabolites ezisezantsi ezifana ne-N-methyl-2-pyridone-5-carboxamide (2PY) kunye ne-N-methyl-4-pyridone-3-carboxamide (4PY), ekugqibeleni ezikhutshwa kwinkqubo yomchamo.
I-1-Methylnicotinamide chloride yi-methylated derivative ye-nicotinamide, ebonakaliswa yisakhiwo setyuwa ye-quaternary ammonium esizinzileyo. Isebenza njengesixhobo esibalulekileyo ekufundeni imetabolism ye-nicotinamide. Ukunyibilika kwayo kakuhle emanzini kunye nokuzinza kweekhemikhali kwenza ukuba ifaneleke njengesixhobo sophando lwe-biochemical.
I-1-MNA yinto eyenzeka ngokwendalo emzimbeni womntu, esebenza njengemveliso eqhelekileyo ye-niacin metabolism. Njengenxalenye ephambili kule ndlela ye-metabolic, i-1-MNA icutshungulwa ngakumbi yi-aldehyde oxidase ukuvelisa ii-metabolites ezisezantsi ezifana ne-N-methyl-2-pyridone-5-carboxamide (2PY) kunye ne-N-methyl-4-pyridone-3-carboxamide (4PY), ekugqibeleni ezikhutshwa kwinkqubo yomchamo.
Uphawu
(1) Ukunyibilika kwamanzi: Kunyibilika lula emanzini nakwizinyibilikisi zendalo ezicoliweyo.
(2) Uzinzo: Izinzile phantsi kobushushu begumbi kodwa ifuna ukugcinwa kwiindawo ezingangenisi manzi.
(3) Ukhuseleko: I-European Union yenze uvavanyo lwesayensi lwe-1-MNA njengesithako esitsha sokutya. Ngokwe-EU Regulation (EC) No 258/97, i-1-MNA ithathwa njengekhuselekileyo ukutyiwa, kunye nomlinganiselo ophezulu ocetyiswayo wokutya kwabantu abadala we-58 mg, ojolise kakhulu ekusetyenzisweni kwizongezo zokutya.
Izicelo
I-1-Methylnicotinamide chloride (efinyeziweyo njenge-MNC) yi-methylated derivative ye-nicotinamide. Ukufunyanwa kwe-1-MNA kungenziwa ngeendlela ezifana ne-high-performance liquid chromatography (HPLC) kunye ne-enzyme-linked immunosorbent assay (ELISA). Ibonisa amandla okusetyenziswa kumacandelo okutya kunye nemveliso yezempilo. Kwishishini lokutya, ingasebenza njenge-antioxidant ukulibazisa i-lipid oxidation kunye nokugcina umgangatho wokutya. Ngenxa yeempawu zayo zesakhiwo, ingasebenza njengesithako esisebenzayo ekutyeni okuqinisiweyo ngesondlo. Ngaphezu koko, i-1-MNA ibonisa imisebenzi ekulawuleni i-metabolic kunye nokuphucula imeko ye-physiological, iyinika ixabiso lophuhliso lokutya okusebenzayo kunye nezongezo zokutya ezineemfuno zempilo.
Uvavanyo lwe-EU lugqibe kwelokuba ukutya i-58 mg ye-1-MNA imihla ngemihla kwizongezo zokutya akunakwenzeka ukuba kukhokelele kwiziphumo ezibi zempilo ebantwini, kwaye oku kufakiwe ngokusesikweni kwikhathalogu yokutya entsha ye-EU.
Njengemolekyuli ebalulekileyo ye-bioactive kunye nomgangatho wesalathiso, i-1-methylnicotinamide chloride inamathuba amaninzi okusetyenziswa kuphando lwesayensi, uphuhliso lwamayeza, kunye nomzi-mveliso wezongezo zokutya. Uvavanyo lwayo lokhuseleko oluchazwe kakuhle kunye nemisebenzi eyahlukeneyo yebhayoloji luyibeka njengesifundo esibalulekileyo sophando kunye nenxalenye yezicelo ezahlukeneyo.
