Umenzi womgubo we-YDL223C (HBT1) Inombolo ye-CAS: 489408-02-8 Ubumsulwa obuyi-99% ubuncinane bezithako ezongezelelweyo
Ividiyo yeMveliso
Iiparamitha zeMveliso
| Igama lemveliso | HBT1 |
| Elinye igama | YDL223C |
| Inombolo ye-CAS | 489408-02-8 |
| Ifomula yemolekyuli | C16H17F3N4O2S |
| Ubunzima be-molecular | 386.40 |
| Ubunyulu | 99.0% |
| Inkangeleko | I-solid etyheli ekhanyayo |
| Ukupakisha | 1kg ngebhegi nganye 25kg ngedrama nganye |
| Isicelo | ii-nootropics |
Intshayelelo yemveliso
I-HBT1 ibopha kwi-ligand-binding domain ye-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPA-R) ngendlela exhomekeke kwi-glutamate. Oku kuthetha ukuba i-HBT1 yimolekyuli enokubopha kuphela kwindawo ethile kwiproteni ye-AMPA-R xa i-glutamate ikhona, kwaye oku kubopha kunceda ukulawula umsebenzi weproteni. Ii-receptor ze-AMPA zibonakaliswa kuyo yonke inkqubo ye-nervous ephakathi kwaye zidlala indima ebalulekileyo kunxibelelwano lwe-neuronal, ukucubungula izivamvo, ukufunda, inkumbulo, kunye ne-synaptic plasticity. Ii-receptor ze-AMPA zinegalelo elikhulu kwi-neurotransmission evuselelayo, zilawula ngokukhawuleza, ngokukhawuleza ukukhukulisa i-synapses ezininzi, kwaye zibandakanyeka kwiimpendulo zokuqala kwi-glutamate kwimimandla ye-synaptic. Ii-receptor ze-AMPA zihlala zivezwa kunye nee-receptor ze-NMDA kwi-synapses, kwaye xa zidibene zikhuthaza iinkqubo ze-synaptic plasticity ezibandakanyeka ekufundeni, kwimemori, kwi-excitotoxicity, nakwi-neuroprotection. I-neurotrophic factor (BDNF) efumaneka ebuchotsheni yinto edlala indima ebalulekileyo ekugcineni nasekukhuleni kwee-neurons kwaye inefuthe elinamandla nelininzi ekwandeni, ekuhlukaniseni, ekusindeni nasekufeni kweeseli ze-neuronal kunye nezingezizo ii-neuronal. , i-neurotransmitter modulator enegalelo kwi-neuronal plasticity ekufundeni nasekukhumbuleni. Ke ngoko, ibalulekile kwimpilo nakwimpilo-ntle yenkqubo ye-nervous.
Uphawu
(1) Ubunyulu obuphezulu: I-HBT1 inokufumana iimveliso ezinyulu obuphezulu ngokusebenzisa iinkqubo zokuvelisa ezicociweyo. Ubunyulu obuphezulu buthetha ukufumaneka ngcono kwezinto eziphilayo kunye neempendulo ezimbalwa ezingalunganga.
(2) Ukhuseleko: I-HBT1 ibonakalisiwe ukuba ikhuselekile emzimbeni womntu.
(3) Uzinzo: I-HBT1 izinzile kakuhle kwaye ingayigcina iyasebenza phantsi kweemeko ezahlukeneyo kunye neemeko zokugcina.
Izicelo
I-HBT1 sisithambisi esitsha se-AMPA receptor esine-agonism ephantsi, esikhuthaza ukuveliswa kwe-neurotrophic factor (BDNF) efunyenwe ebuchotsheni kwaye sineziphumo ezincinci ze-agonistic kwi-neurons eziphambili. I-HBT1 ibopha kwi-ligand-binding domain ye-AMPA-R ngendlela exhomekeke kwi-glutamate. Xa zidibene, zikhuthaza iinkqubo ze-synaptic plasticity ezibandakanyeka ekufundeni, kwimemori, ekuvuselelekeni, nakwi-neuroprotection. Ingaphucula amandla okuqonda kunye nenkumbulo yengqondo, kwaye iphucule amandla okufunda abantu. Ihlala yongezwa kukutya kwemihla ngemihla ngendlela yezongezo zokutya.
