YDL223C (HBT1) umenzi we-powder CAS No.: 489408-02-8 99% ubumsulwa min.zokongeza izithako
IiParameters zeMveliso
| Igama lemveliso | HBT1 |
| Elinye igama | YDL223C |
| Inombolo yeCAS. | 489408-02-8 |
| Ifomula yemolekyuli | I-C16H17F3N4O2S |
| Ubunzima bemolekyuli | 386.40 |
| Ubunyulu | 99.0% |
| Imbonakalo | Ukukhanya okuqinileyo okutyheli |
| Ukupakisha | 1kg kwingxowa nganye 25kg igubu ngalinye |
| Isicelo | nootropics |
Intshayelelo yemveliso
I-HBT1 ibophelela kwi-domain ye-ligand-binding ye-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPA-R) ngendlela exhomekeke kwi-glutamate.Oku kuthetha ukuba i-HBT1 yimolekyuli ekwazi ukubophelela kuphela kwiindawo ezithile kwiprotheyini ye-AMPA-R xa kukho i-glutamate, kwaye oku kubopha kunceda ukulawula umsebenzi weprotheni.Ama-receptors e-AMPA abonakaliswa kuyo yonke inkqubo ye-nervous central kwaye adlale indima ebalulekileyo kunxibelelwano lwe-neuronal, ukusetyenzwa kweenzwa, kunye nokufunda, imemori, kunye ne-synaptic plasticity.I-AMPA i-receptors inegalelo elikhulu kwi-neurotransmission evuselelayo, i-mediate ngokukhawuleza, i-desensitized excitation ye-synapses ezininzi, kwaye ibandakanyeka kwiimpendulo zangaphambili zemimandla ye-synaptic kwi-glutamate.I-AMPA i-receptors ihlala idityaniswa kunye ne-NMDA receptors kwii-synapses, kwaye kunye zikhuthaza iinkqubo zeplastiki ze-synaptic ezibandakanyeka ekufundeni, imemori, i-excitotoxicity, kunye ne-neuroprotection.
Uphawu
I-Brain-derived neurotrophic factor (BDNF) yi-neurotrophic factor edlala indima ebalulekileyo ekugcinweni nasekukhuliseni i-neurons, kwaye ineempembelelo ezinamandla kunye ezininzi ekwandeni, ukwahlula, ukusinda kunye nokufa kweeseli ze-neuronal kunye ne-non-neuronal, Izenzo njenge. imodyuli ye-neurotransmitter kwaye inegalelo kwiplastiki ye-neuronal yokufunda kunye nenkumbulo.Ngoko ke ibalulekile kwimpilo nakwintlalontle yenkqubo yemithambo-luvo.Ukunyuka kwe-BDNF kunokungqina ukuba luncedo kunyango kunye nokuthintela izifo ezininzi.
Usetyenziso
I-HBT1 yinoveli ye-AMPA receptor enhancer ene-agonism ephantsi xa kuthelekiswa ne-LY451395 kunye ne-OXP1, yenza ukuveliswa kwe-brain-derived neurotrophic factor (BDNF), kwaye ibonisa impembelelo encinci kwi-primary neurons Agitation.I-HBT1 ibophelela kwi-ligand-binding domain ye-AMPA-R ngendlela exhomekeke kwi-glutamate.Ngokudibeneyo, bakhuthaza iinkqubo zeplastiki ze-synaptic ezibandakanyekayo ekufundeni, kwimemori, e-excitability kunye ne-neuroprotection.Inokuphucula amandla okuqonda kunye nenkumbulo yengqondo, kwaye iphucule isakhono sokufunda sabantu.
