Umenzi womgubo we-N-Boc-O-Benzyl-D-serine Inombolo ye-CAS:47173-80-8 Ubumsulwa obuyi-98% ubuncinane kwi-Intermediates
Iiparamitha zeMveliso
| Igama lemveliso | I-N-Boc-O-Benzyl-D-serine |
| Elinye igama | i-N-Boc-O-benzyl-D-serine; I-Boc-O-benzyl-D-serine; I-O-Benzyl-N-(tert-butoxycarbonyl)-D-serine; I-Boc-(R)-2-amino-3-benzyloxypropionic acid; I-Boc-D-Ser(Bzl)-OH;Nat.-Boc-O-benzyl-D-serine; I-N-tert-butyloxycarbonyl-O-benzyl-D-serine; I-Nalpha-t-butoxycarbonyl-O-benzyl-D-serine; |
| Inombolo ye-CAS | 47173-80-8 |
| Ifomula yemolekyuli | C15H21NO5 |
| Ubunzima be-molecular | 295.33 |
| Ubunyulu | 98% |
| Ukupakisha | 1kg/ibhegi; 25kg/igubu |
| Isicelo | Abaphakathi |
Intshayelelo yemveliso
I-N-Boc-O-Benzyl-D-serine yikhompawundi efumene ingqwalasela enkulu kwicandelo le-organic chemistry kunye nophando lwezamayeza. Le khompawundi, eyaziwa ngokuba yi-Boc-D-serine, yi-derivative ye-amino acid D-serine kwaye isetyenziswa kakhulu ekuhlanganiseni amayeza ahlukeneyo kunye neemolekyuli ezisebenzayo. I-N-Boc-O-Benzyl-D-serine yi-crystalline powder emhlophe ukuya kwemhlophe enyibilikayo emanzini kwaye inyibilikayo kwizinyibilikisi ze-organic ezifana ne-methanol kunye ne-ethanol. Yi-derivative ye-D-serine, eyi-amino acid engeyiyo i-proteinogenic edlala indima ebalulekileyo kwinkqubo ye-nervous central njenge-co-agonist ye-N-methyl-D-aspartate (NMDA) receptor. Amaqela e-N-Boc (tert-butoxycarbonyl) kunye ne-O-Benzyl kwikhompawundi asebenza njengamaqela akhuselayo, avumela ukusetyenziswa kwe-amino acid ngokukhetha ngexesha lokwenziwa kweekhemikhali. I-N-Boc-O-Benzyl-D-serine isetyenziswa kakhulu njengebhloko yokwakha ekuhlanganisweni kweepeptides kunye neepeptidomimetics. Iipeptides ziitsheyini ezimfutshane zee-amino acids ezidlala indima eyahlukeneyo kwiinkqubo zebhayoloji kwaye zinomdla omkhulu ekufumaneni amayeza kunye nophuhliso. Ngokufaka i-N-Boc-O-Benzyl-D-serine kulandelelwano lweepeptide, iingcali zamachiza zinokuguqula iipropati kunye nemisebenzi yeepeptides ezivelayo, okwenza ukuba ibe sisixhobo esibalulekileyo kuyilo lweearhente ezintsha zamayeza. Ngaphezu koko, i-N-Boc-O-Benzyl-D-serine isetyenziswa ekulungiseleleni ii-pharmaceutical intermediates kunye nezithako ezisebenzayo zamayeza (ii-API). Ukusebenza kwayo okuguquguqukayo kunye nokuhambelana kwayo neempendulo ezahlukeneyo zamakhemikhali kwenza ukuba ibe yinxalenye efunwayo ekuhlanganisweni kweemolekyuli zendalo ezintsonkothileyo ezinesakhono sonyango.
Uphawu
(1) Ubunyulu obuphezulu: I-N-Boc-O-Benzyl-D-serine inokufumana iimveliso ezinyulu obuphezulu ngokusebenzisa iinkqubo zokuvelisa ezicociweyo. Ubunyulu obuphezulu buthetha ukufumaneka ngcono kwezinto eziphilayo kunye neempendulo ezimbalwa ezingalunganga.
(2) Ukhuseleko: Ukhuseleko oluphezulu, zimbalwa iziphumo ezibi.
(3) Uzinzo: I-N-Boc-O-Benzyl-D-serine izinzile kakuhle kwaye inokugcina umsebenzi wayo kunye nesiphumo phantsi kweemeko ezahlukeneyo kunye neemeko zokugcina.
Izicelo
Ukufakwa kwe-N-Boc-O-Benzyl-D-serine kwiimolekyuli zamayeza kubonakalisiwe ukuba kunika iipropati ezinqwenelekayo ze-pharmacokinetic kunye ne-pharmacodynamic. Iipeptidomimetics ezivela kwi-N-Boc-O-Benzyl-D-serine zibonakalise ukuzinza okuphuculweyo, ukufumaneka kwezinto eziphilayo, kunye nokucaciswa kwethagethi, nto leyo ebenza babe ngabaviwa abathembisayo kunyango lwezifo ezahlukeneyo, kubandakanya umhlaza, izifo ezosulelayo, kunye neengxaki zemithambo-luvo. Ngaphezu koko, ukukwazi ukutshintsha ngokukhethayo i-N-Boc-O-Benzyl-D-serine kuvumela ukulungiswa kakuhle kwabaviwa bamayeza, ukuphucula ukusebenza kwabo kunye neeprofayili zabo zokhuseleko.
