I-Mitoquinone mesylate CAS No: 845959-50-4 Ubumsulwa obuyi-98% ubuncinane. Kwintliziyo kunye nokukhusela iingqondo
Iiparamitha zeMveliso
| Igama lemveliso | I-Mitoquinone mesylate |
| Elinye igama | I-Mitoquinone methanesulfonate; iMitoQ; iMitoquinone (i-mesylate) |
| Inombolo ye-CAS | 845959-50-4 |
| Ifomula yemolekyuli | C38H47O7PS |
| Ubunzima be-molecular | 678.81 |
| Ubunyulu | 98.0% 50.0% |
| Inkangeleko | Ukusuka kumdaka okhanyayo ukuya kumdaka (ioyile) |
| Ukupakisha | 1 kg/ibhotile, 20-25kg/ibhareli |
| Isicelo | Ii-antioxidants zokuthintela umonakalo we-oxidative |
Intshayelelo yemveliso
I-Mitoquinone mesylate yi-derivative ye-coenzyme Q10 (CoQ10), ikhompawundi eyenzeka ngokwemvelo emzimbeni edlala indima ebalulekileyo ekuvelisweni kwamandla ngaphakathi kweeseli. Yinto enamandla nekhethayo yokususa ii-reactive oxygen species (ROS), okanye ii-free radicals, ezinokonakalisa izakhiwo zeeseli kwaye zinegalelo kwizifo ezahlukeneyo. Ngokuthomalalisa ezi molekyuli ziyingozi, i-mitoquinone mesylate inceda ukugcina impilo kunye nokusebenza kweeseli.
I-Mitoquinone mesylate ikhethekile kuba ijolise ngokukhethekileyo kwi-mitochondria, eyaziwa ngokuba yi-powerhouse yeseli. I-Mitochondria inoxanduva lokuvelisa i-adenosine triphosphate (ATP), umthombo oyintloko wamandla okusebenza kweseli. Nangona kunjalo, ngexesha lokuveliswa kwe-ATP, i-mitochondria ikwavelisa i-ROS njengemveliso ephumayo, enokukhokelela kuxinzelelo lwe-oxidative kunye nomonakalo. I-Mitoquinone mesylate iqokelelana kuphela kwi-mitochondria, inciphisa ngempumelelo amanqanaba e-ROS kwaye iwakhusele kuxinzelelo lwe-oxidative.
Uphawu
(1)Isenzo esijoliswe kwiMitochondria: I-Mitoquinone mesylate ijolise ngokukodwa kwaye iqokelelane kwi-mitochondria, eyindlu yamandla eeseli. Esi senzo sijoliswe kuyo siyivumela ukuba ilwe noxinzelelo lwe-oxidative kwaye ikhusele i-mitochondria ekonakaleni ngempumelelo.
(2)Iipropati ze-Antioxidant: Njenge-antioxidant, iMitoquinone mesylate inceda ekupheliseni ii-free radicals eziyingozi kunye neentlobo ze-oxygen (ROS) ezisebenza ngaphakathi kwi-mitochondria. Oku kunokunceda ekuthinteleni umonakalo we-oxidative kwizakhiwo zeseli kunye nokunciphisa ukudumba.
(3)Inkxaso yokuveliswa kwamandla: Ngokukhusela i-mitochondria, i-Mitoquinone mesylate inokuphucula ukuveliswa kwamandla ngaphakathi kweeseli. Oku kunokukhuthaza ukusebenza kweeseli ngokubanzi kwaye kunokuba neengenelo ezinokubakho kwiimeko ezinxulumene nokungasebenzi kakuhle kwe-mitochondrial.
(4)Iprofayili yokhuseleko: I-Mitoquinone mesylate ifundwe ngokubanzi ngenxa yokhuseleko lwayo kunye nokunyamezeleka kwayo. Ibonakalise iprofayili yokhuseleko elungileyo kwaye ineziphumo ebezingalindelekanga ezincinci kwizilingo zeklinikhi.
Izicelo
Ukusetyenziswa okunokwenzeka kweMitoquinone mesylate kugubungela iindawo ezininzi zophando. Kwi-neurology, ibonakalise ithemba ekunyangeni izifo ze-neurodegenerative ezinxulumene nokuguga ngokuphucula ukusebenza kwe-mitochondrial kunye nokunciphisa uxinzelelo lwe-oxidative. Ukongeza, uphando lubonisa amandla ayo njengonyango oluncedisayo kunyango lomhlaza, njengoko ijolise kwi-mitochondria yeeseli ze-tumor, iphazamisa ukuveliswa kwamandla azo kwaye ikhuthaza ukufa kweeseli. Ukongeza kwezi ndawo, iMitoquinone mesylate ikwabonisa amandla ekunyangeni ukudumba okungapheliyo kunye nezifo zentliziyo. Ngokuzinzisa umsebenzi we-mitochondrial kunye nokunciphisa uxinzelelo lwe-oxidative, iphucula impilo yeseli iyonke, ngaloo ndlela iphucula iziphumo.
