I-Agomelatine powder umenzi we-CAS No.: 138112-76-2 99% ubumsulwa min.zokongeza izithako
IiParameters zeMveliso
| Igama lemveliso | IAgomelatine |
| Elinye igama | N-[2-(7-Methoxy-1-naphthyl)ethyl]acetamide;N-[2-(7methoxynaphthalen-1-yl)ethyl]acetamide |
| Inombolo yeCAS. | 138112-76-2 |
| Ifomula yemolekyuli | C15H17NO2 |
| Ubunzima bemolekyuli | 243.3082 |
| Ubunyulu | 99.0% |
| Imbonakalo | Umgubo omhlophe |
| Ukupakisha | 1kg/ibhegi 25kg/igubu |
| Isicelo | Imveliso yezempilo imathiriyeli ekrwada |
Intshayelelo yemveliso
I-Agomelatine luhlobo olutsha lwe-antidepressant.Indlela yokusebenza kwayo iqhawuka kwinkqubo yemveli yokuhambisa imonoamine.Ivuselela i-melatonin receptors, i-MT1 kunye ne-MT2, kwaye ichasene ne-5-HT2C receptors.Inokuphucula umgangatho wokulala kwaye ibuyisele isigqi sebhayoloji ngelixa inesiphumo sokudakumba;phakathi kwabo, ngokuchasa i-5-HT2C i-receptor ye-membrane ye-postsynaptic, inokunyusa ukukhululwa kwe-DA kunye ne-NE kwi-cortex yangaphambili kwaye idlale indima echasayo.Xa i-MT agonism kunye ne-5-HT2C i-antagonism ye-receptor ikhona ngexesha elifanayo, umphumo oyingqayizivele we-synergistic unokuveliswa ukukhuthaza ukukhululwa kwe-DA eninzi kunye ne-NE kwindawo yengqondo ye-PFC, ukomeleza ngakumbi umphumo we-antidepressant.Ukongezelela, i-agomelatine inokukhuthaza ukukhululwa kwe-brain-derived neurotrophic factor kwi-PFC kwaye ivimbele ukukhululwa okubangelwa uxinzelelo lwe-glutamate kwingingqi yengqondo ye-amygdala.
Uphawu
(1) Ukulawulwa kabini: Akunakulawula kuphela ukukhululwa kwe-melatonin, kodwa nokulawula ukukhululwa kwe-5-hydroxytryptamine kunye ne-norepinephrine, ngaloo ndlela idlala indima ekulawuleni isimo sengqondo, ukulala, intlungu kunye nokunye.
(2) Ukuphuculwa kokulala: I-Agomelatine isenokuthi iphucule ukuphuthelwa ngaphandle kokubangela ukozela okanye isiqaqa.
(3) Ukuphucula umsebenzi wokuqonda: I-Agomelatine inokuphucula umsebenzi wokuqonda ngokuphucula i-neuroplasticity kwi-hippocampus.
(4) Ukhuseleko oluphezulu: Xa kuthelekiswa namanye amayeza okudakumba, iyeza lineziphumo ebezingalindelekanga ezingaphantsi xa kunyangwa ukudakumba, kwaye aliyi kuchaphazela umsebenzi wesondo kunye nobunzima bomzimba.
Usetyenziso
I-Agomelatine yeyeyeza lokuthomalalisa uxinezeleko ekwangumchasi we-melatonin.Iyanciphisa iimpawu zokudakumba ngokumodareyitha amanqanaba e-melatonin MT1 receptors (ukunciphisa imiqondiso ye-cortical alarm) kunye ne-MT2 receptors (kwi-circadian rhythms of sleep) kunye ne-serotonin.Ithathwa ebusuku ukulinganisa isigqi sendalo sokukhutshwa kwemelatonin, inokuphucula kakhulu umgangatho wokulala.
