Umenzi womgubo we-Oleoylethanolamide (OEA) Inombolo ye-CAS: 111-58-0 98%,85% ubumsulwa obuncinci bezithako ezongezelelweyo
Iiparamitha zeMveliso
| Igama lemveliso | I-Oleoyl ethanolamide |
| Elinye igama | i-N-oleoyl ethanolamine; I-N-(2-hydroxyethyl)-,(Z)-9-Octadecenamide |
| Inombolo ye-CAS | 111-58-0 |
| Ifomula yemolekyuli | C20H39NO2 |
| Ubunzima be-molecular | 325.53 |
| Ubunyulu | 98.0% ，85.0% |
| Inkangeleko | Umgubo omhlophe wekristale ocolekileyo |
| Ukupakisha | 1kg/ibhegi, 25kg/igubu |
| Isicelo | Ukuphelisa iintlungu, ukulwa nokudumba |
Intshayelelo yemveliso
I-Oleoylethanolamide yi-amide compound yesibini eyenziwe yi-lipophilic oleic acid kunye ne-hydrophilic ethanolamine. I-Oleoylethanolamide ikwayi-lipid molecule yendalo kwezinye izicubu zezilwanyana nezityalo. Ifumaneka kakhulu kwizicubu zezilwanyana nezityalo ezifana nomgubo wekoko, iisoya, kunye namandongomane, kodwa umxholo wayo uphantsi kakhulu. Kuphela xa imeko yangaphandle itshintsha okanye ukutya kukhuthazwa, izicubu zeseli zomzimba Kulapho ke kuphela apho kuya kuveliswa uninzi lwale nto.
Kwiqondo lobushushu begumbi, i-Oleoylethanolamide sisixhobo esimhlophe esinendawo yokunyibilika emalunga nama-50°C. Inyibilika lula kwizinyibilikisi ezinxilisayo ezifana ne-methanol kunye ne-ethanol, inyibilika lula kwizinyibilikisi ezingezizo ze-polar ezifana ne-n-hexane kunye ne-ether, kwaye ayinyibiliki emanzini. I-OEA yimolekyuli ye-amphiphilic esetyenziswa ngokwesiko njenge-surfactant kunye ne-detergent kwishishini leekhemikhali. Nangona kunjalo, uphando olongezelelweyo lufumanise ukuba i-OEA inokusebenza njengemolekyuli yokubonisa i-lipid kwi-gut-brain axis kwaye ibonise uthotho lwemisebenzi yebhayoloji emzimbeni, kubandakanya: ukulawula inkanuko, ukuphucula i-lipid metabolism, ukuphucula inkumbulo kunye nokuqonda kunye neminye imisebenzi. Phakathi kwazo, imisebenzi ye-Oleoylethanolamide yokulawula inkanuko kunye nokuphucula i-lipid metabolism iye yafumana ingqalelo enkulu.
I-Oleoylethanolamide inokulawula ukutya kunye ne-homeostasis yamandla ngokusebenzisa i-receptor-α evuselelweyo yi-peroxisome proliferator. Ukongeza, i-Oleoylethanolamide ibonisa eminye imisebenzi enxulumene nempilo, kubandakanya nokuguqula umsebenzi wokuguqula kwindlela yokubonisana ye-lysosomal-to-nuclear ehambelana nolawulo lobomi obude kunye nokukhusela imithambo-luvo elawula ukuziphatha okudakumbisayo. Uphando lukwacebisa ukuba i-Oleoylethanolamide inokuba nemiphumo yokukhusela imithambo-luvo. Kwiimodeli zezilwanyana, ifunyenwe inciphisa umonakalo ovela kwistroke kunye nokwenzakala kwengqondo okubuhlungu. Isiphumo sokulawula se-Oleoylethanolamide sibangelwa kukubopha kwayo kwi-PPARα, etshintsha nge-retinoid X receptor (RXR) kwaye iyisebenzise njenge-transcription factor enamandla ebandakanyeka kwi-homeostasis yamandla adibeneyo, i-lipid metabolism, i-autophagy, kunye nokuvuvukala.
Uphawu
(1) Ubunyulu obuphezulu: I-OEA inokufumana iimveliso ezinyulu obuphezulu ngokusebenzisa iinkqubo zemveliso zokucoca. Ubunyulu obuphezulu buthetha ukufumaneka ngcono kwezinto eziphilayo kunye neempendulo ezimbalwa ezingalunganga.
(2) Ukhuseleko: I-OEA ibonakalisiwe ukuba ikhuselekile emzimbeni womntu.
(3) Uzinzo: I-OEA inozinzo oluhle kwaye inokugcina umsebenzi wayo kunye nesiphumo phantsi kweemeko ezahlukeneyo kunye neemeko zokugcina.
(4) Kulula ukufunxa: I-OEA inokufunxwa ngokukhawuleza ngumzimba womntu ize isasazwe kwiithishu kunye namalungu ahlukeneyo.
Izicelo
I-Oleoylethanolamide yi-lipid yendalo ye-ethanolamide esetyenziswa njengocwangciso lokutya kunye nokulawula ubunzima bomzimba kwiintlobo ngeentlobo zezilwanyana ezinethambo lomqolo. Yi-metabolite ye-oleic acid eyenziwe emathunjini amancinci omntu. I-Oleylethanolamide (OEA) yimolekyuli elawula imetabolism ye-lipid kunye ne-homeostasis yamandla. Inamathela kwii-receptors ze-PPAR Alpha kwaye inceda ukulawula izinto ezine: indlala, amafutha omzimba, i-cholesterol kunye nobunzima. I-PPAR Alpha imele i-receptor esebenzayo ye-peroxide proliferator-activated alpha, kwaye i-lipid esebenzayo ye-bioactive amide oleoylethanolamide (OEA) ineempawu ezahlukeneyo ze-homeostatic, kubandakanya umsebenzi wokulwa nokuvuvukala, ukuguqulwa kwempendulo yomzimba, kunye nemiphumo ye-antioxidant.
