5-Amino-1-methylquinolinium chloride Inombolo yeCAS:42464-96-0 Ubumsulwa obuyi-98.0% ubuncinci | umenzi wezithako ezongezelelweyo
Iiparamitha zeMveliso
| Igama lemveliso | I-5-Amino-1-methylquinolinium chloride (5-amino-1MQ) |
| Elinye igama | I-5-amino-1MQI-5-Amino-1-mq chloride I-5-Amino-1-methylquinolinium chloride I-5-Amino-1-methylquinolin-1-ium chloride I-5-AMINO-1-METHYLQUINOLIN-1-IUM CHLOEIDE I-5-Amino-1-methyl-1-quinolinium chloride |
| Inombolo ye-CAS | 42464-96-0 |
| Ifomula yemolekyuli | C₁₀H₁₁ClN₂ |
| Ubunzima be-molecular | 194.6 |
| Ubunyulu | 98% |
| Inkangeleko | Umdaka oqinileyo ukuya kubomvu |
| Ukupakisha | 1kg/ibhegi, 25kg/umphanda |
| Isicelo | Isongezelelo sokutya Izinto eziluhlaza |
Intshayelelo yemveliso
I-5-Amino-1-methylquinolinium chloride yi-enzyme evezwa kakhulu ngexesha lokwaluphala kwemisipha yamathambo kwaye inxulunyaniswa nokulungiswa komonakalo wendlela ye-NAD+, umsebenzi we-sirtuin1 ongasebenzi kakuhle, kunye nokwanda kokukhula kweeseli ze-muscle stem. I-5-Amino-1-methylquinolinium chloride ikhuthaza ukwahluka kwe-myoblast kwi-vitro kwaye iphucula ukuhlanganiswa kunye nokuhlaziywa kweeseli ze-muscle stem kwiimpuku ezindala. I-5-Amino-1-methylquinolinium chloride ikwangumthinteli onamandla we-nicotinamide N-methyltransferase (NNMT), ebopha ngokukhetha kwiindawo ezihlala kwi-NNMT substrate binding. I-5-Amino-1-methylquinolinium chloride ikhuthaza ukwahluka kwe-myoblast kwi-vitro kwaye iphucula ukuhlanganiswa kunye nokuhlaziywa kweeseli ze-muscle stem kwiimpuku ezindala. Phakathi kwazo, i-cytosolic enzyme nicotinamide N-methyltransferase (NNMT) isandul' ukufunyanwa ukulawula amanqanaba e-nicotinamide precursors afunekayo kwi-NAD+ biosynthesis, kwaye ke ngoko idlala indima ebalulekileyo ekulawuleni indlela yokusindisa i-NAD+ kunye ne-metabolism yeseli.
I-5-Amino-1-Methylquinolinium Chloride isebenza ngaphakathi kwi-microbiome yakho ukunciphisa izicubu zamafutha kwaye ikuncede unciphise ubunzima. Xa iiseli zamafutha ezongezelelweyo ziqokelelana, umzimba wakho uvelisa i-enzyme eyaziwa ngokuba yi-NNMT (nicotinamide N-methyltransferase). Okukhona i-NNMT ininzi, kokukhona umzimba wakho unyusa ukudumba kwaye ugcina amafutha. I-5-Amino-1-Methylquinolinium Chloride ithintela i-NNMT, ivumela umzimba wakho ukuba wehlise ubunzima obugqithisileyo.
Uphawu
(1) Ubunyulu obuphezulu: I-5-Amino-1-methylquinolinium chloride inokufumana iimveliso ezinyulu obuphezulu ngeenkqubo zemveliso ezicociweyo. Ubunyulu obuphezulu buthetha ukufumaneka ngcono kwezinto eziphilayo.
(2) Ukujolisa: I-5-Amino-1-methylquinolinium chloride ijolisa ngokukodwa kwi-enzyme ye-NNMT kwaye inokuthintela ngempumelelo umsebenzi wayo, ngaloo ndlela ichaphazela indlela ye-metabolic ye-nicotinamide.
(3) Uzinzo: I-5-Amino-1-methylquinolinium chloride inozinzo oluhle kwaye inokugcina umsebenzi wayo kunye nesiphumo phantsi kweemeko ezahlukeneyo kunye neemeko zokugcina.
(4) Amathuba ophuhliso: Ngenxa yeempawu ezahlukeneyo ze-5-Amino-1-methylquinolinium chloride, uphuhliso lwayo luye lwafumana ingqalelo ebanzi kwaye luneziphumo zophando olubanzi kunye nokusetyenziswa.
Izicelo
I-5-Amino-1-methylquinolinium chloride sisithinteli se-nicotinamide N-methyltransferase (NNMT) esikhuthaza ukwahluka kwe-myoblast. I-5-Amino-1-methylquinolinium chloride ingasetyenziswa njengesongezelelo ukunceda ukunciphisa ubunzima kunye namafutha kunye nokuphucula amafutha esibindi.
