5-Amino-1-methylquinolinium iodide（NNMTi） Inombolo yeCAS:42464-96-0 Ubumsulwa obuyi-98.0% ubuncinci | umenzi wezithako ezongezelelweyo
Iiparamitha zeMveliso
| Igama lemveliso | I-5-Amino-1-methylquinolinium iodide（NNMTi） |
| Elinye igama | I-NNMTiI-5-AMINO-1-METHYLQUINOLIN-1-IUM IODAYIDE i-5-amino-1-methylquinolinium iodide I-5-Amino-1-methylquinolin-1-iumiodide i-1-methylquinolin-1-ium-5-amine; iodide I-5-Amino-1-methyl-1-quinolinium Iodide iodide ye-5-Amino-1-mq |
| Inombolo ye-CAS | 42464-96-0 |
| Ifomula yemolekyuli | C10H11IN2 |
| Ubunzima be-molecular | 286.11 |
| Ubunyulu | 98.0% |
| Inkangeleko | Umdaka oqinileyo ukuya kubomvu |
| Ukupakisha | 1kg/ibhegi, 25kg/umphanda |
| Isicelo | Isongezelelo sokutya Izinto eziluhlaza |
Intshayelelo yemveliso
I-enzyme ye-cytosolic nicotinamide N-methyltransferase (NNMT) ifunyenwe kutshanje ukulawula amanqanaba e-nicotinamide precursors afunekayo kwi-NAD+ biosynthesis kwaye ke ngoko idlala indima ebalulekileyo ekulawuleni indlela yokusindisa i-NAD+ kunye ne-metabolism yeselula. I-NNMT ibonakaliswa kwimisipha yamathambo, kwaye ukubonakaliswa kwayo kuyanda kancinci kancinci ngokuguga kwezicubu zemisipha. Okubalulekileyo, i-NNMT yinxalenye ephambili ye-sarcopenic gene expression signature, kwaye ukubonakaliswa kwayo kakhulu kunokukhokelela ekwehleni okukhulu kwamanqanaba e-NAD+ kunye nokwehla kobunzima bemisipha, amandla, kunye nomsebenzi ohamba nokuguga. Unyango lweempuku ezindala nge-molecule encinci i-NNMT inhibitor (NNMTTi) luphucule ukwanda, ukuhlanganiswa, kunye namandla okuvuselela ama-muSC, ngaloo ndlela kuphucule ukusebenza kwemisipha yamathambo. Iziphumo ezifanayo zifunyenwe kwi-vitro kusetyenziswa iiseli ze-C2C12, ezifana kakhulu ne-muSC, apho unyango lwe-NNMTi lukhuthaze ukwahluka kwe-myoblast kwaye luxhasa utshintsho lwe-metabolic kwi-metabolites zeseli ezinxulumene nendlela yokusindisa i-NAD +.
I-NNMT yi-enzyme evezwa kakhulu ngexesha lokwaluphala kwemisipha yamathambo kwaye inxulunyaniswa nomonakalo kwindlela ye-NAD+, umsebenzi we-sirtuin1 ongasebenzi kakuhle, kunye nokwanda kokukhula kweeseli ze-muscle stem. I-NNMT yi-enzyme ye-metabolic evuselela i-methylation ye-nicotinamide (NAM) isebenzisa i-universal methyl donor S-adenosylmethionine (SAM), edibanisa imeko ye-metabolic yeseli kunye nokulinganisela kwe-methylation kunye namanqanaba e-NAD+ angaphakathi kweseli. I-NNMT ibonakaliswa kakhulu kwizicubu zesibindi kunye ne-adipose, kunye nakwiimeko ze-pathological ezibonakaliswa kukwanda kweemfuno ze-metabolic, njengezifo ezithile zesibindi esinamafutha kunye nesifo seswekile. I-NNMT ibandakanyeka kwiinkqubo ezahlukeneyo zokwahlulahlula, kubandakanya ukuguquka kweseli ye-stem yomntu esandul' ukuzalwa ukuya kokuvuthwa, i-myogenesis, kunye notshintsho lwe-epithelial kunye ne-neuromesenchymal kwiintlobo ngeentlobo zomhlaza. Ukubonakaliswa kwe-NNMT kulawulwa ngendlela ethile yezicubu kunye nomxholo endaweni yendlela yokulawula eqhelekileyo.
Uphawu
(1) Ubunyulu obuphezulu: I-NNMTi inokufumana iimveliso ezinyulu obuphezulu ngeenkqubo zemveliso ezicociweyo. Ubunyulu obuphezulu buthetha ukufumaneka ngcono kwezinto eziphilayo.
(2) Ukujolisa: I-NNMTTi ijolisa ngokukodwa kwi-enzyme ye-NNMT kwaye inokuthintela ngempumelelo umsebenzi wayo, ngaloo ndlela ichaphazela indlela ye-metabolic ye-nicotinamide.
(3) Uzinzo: I-NNMTi izinzile kakuhle kwaye inokugcina umsebenzi wayo kunye nesiphumo phantsi kweemeko ezahlukeneyo kunye neemeko zokugcina.
(4) Amathuba ophuhliso: Ngenxa yeempawu ezahlukeneyo ze-NNMTi, uphuhliso lwayo luye lwafumana ingqalelo ebanzi kwaye luneziphumo zophando olubanzi kunye nezicelo.
Izicelo
I-NNMTi (CAS 42464-96-0) sisithinteli se-nicotinamide N-methyltransferase (NNMT), isithinteli esinamandla (IC50=1.2 μM) se-nicotinamide N-methyltransferase (NNMT) esikhuthaza ukwahluka kwe-myoblast. I-NNMTi ibopha ngokukhetha kwiindawo ezibopha i-substrate ze-NNMT. I-NNMTi ikhuthaza ukwahluka kwe-myoblast kwi-vitro kwaye iphucula ukuhlanganiswa kweeseli ze-muscle stem kunye nokuvuselelwa kwiimpuku ezindala. I-NNMT yi-enzyme ye-cytosolic biotransformation esisiseko ekhuthaza i-N-methylation ye-xenobiotics engapheliyo neyangaphandle. Xa kuthelekiswa nokutshintshwa kokutya okunamafutha kuphela, unyango lwe-NNMTi oludityaniswe nokutshintshwa kokutya okunamafutha anamafutha lukhawulezise ukuphuculwa kokulahleka kwamafutha omzimba, ukwanda kobunzima bomzimba wonke ukuya kumlinganiselo wobunzima bomzimba, ukunciphisa ubunzima bezicubu ezimhlophe ze-epididymal yesibindi, ukunciphisa ukubekwa kwamafutha esibindi, kunye nokuphucula i-steatosis yesibindi. Ukongeza, i-NNMTi inokunyusa amandla kwaye ikhuthaze amandla okuvuselela izihlunu ezindala, ezinokuba luncedo kunyango lwe-sarcopenia.
