Umenzi womgubo we-7,8-Dihydroxyflavone (7,8-DHF) Inombolo ye-CAS: 38183-03-8 Ubumsulwa obuyi-98.0% ubuncinci bezithako ezongezelelweyo
Ividiyo yeMveliso
Iiparamitha zeMveliso
| Igama lemveliso | I-7,8-Dihydroxyflavone |
| Elinye igama | I-7,8-DIHYDROXYFLAVONE; i-7,8-dihydroxy-2-phenyl-4-benzopyrone; I-DIHYDROXYFLAVONE, 7,8-(RG); i-hydrate ye-7,8-Dihydroxyflavone; I-7,8-dihydroxy-2-phenyl-1-benzopyran-4-enye |
| Inombolo ye-CAS | 38183-03-8 |
| Ifomula yemolekyuli | C15H10O4 |
| Ubunzima be-molecular | 254.24 |
| Ubunyulu | 98.0% |
| Inkangeleko | Umgubo otyheli |
| Isicelo | Isongezelelo sokutya Izinto eziluhlaza |
Intshayelelo yemveliso
I-7,8-Dihydroxyflavone, eyaziwa ngokuba yi-7,8-DHF, yi-flavonoid yendalo efumaneka kwiintlobo ngeentlobo zezityalo, kuquka i-Tridacna tridacna. Eyaziwa ngeempawu zayo zokulwa ne-antioxidant kunye ne-neurotrophic, enye yezona zinto zinomdla kwi-7,8-dihydroxyflavone kukuba inamandla okuxhasa impilo yengqondo kunye nokuphucula ukusebenza kwengqondo. Uphando lubonisa ukuba le khompawundi isebenza njenge-neurotrophin enamandla, ivuselela ukukhula kunye nokusinda kwee-neurons engqondweni. Izifundo kwizilwanyana zaselabhoratri zibonise ukuba i-7,8-DHF iphucula kakhulu imemori kunye nobuchule bokufunda. Ngokukhuthaza ukwakheka konxibelelwano olutsha lwe-synaptic kunye nokuphucula unxibelelwano phakathi kweeseli zengqondo, le khompawundi ithembisa ukuvula amandla ethu okuqonda. Ukongeza, i-7,8-dihydroxyflavone isebenzisana nee-receptors ze-serotonin zengqondo, ezibandakanyeka kulawulo lweemvakalelo. Ngokuguqula ezi receptors, inokukwazi ukunciphisa iimpawu zokuxhalaba kunye nokudakumba.
Uphawu
(1) Ubunyulu obuphezulu: I-7,8-Dihydroxyflavone inokufumana iimveliso ezinyulu obuphezulu ngokusebenzisa ukutsalwa kwendalo kunye nenkqubo yokwenziwa kwezinto ezincinci. Ubunyulu obuphezulu buthetha ukufumaneka ngcono kwezinto eziphilayo kunye neempendulo ezimbalwa ezimbi.
(2) Ukhuseleko: I-7,8-Dihydroxyflavone yimveliso yendalo eye yangqinwa ukuba ikhuselekile ebantwini. Ngaphakathi koluhlu lwedosi, ayinatyhefu okanye iziphumo ebezingalindelekanga.
(3) Uzinzo: I-7,8-Dihydroxyflavone inozinzo oluhle kwaye ingayigcina iyasebenza phantsi kweemeko ezahlukeneyo zokusingqongileyo kunye nokugcinwa kwayo.
(4) Kulula ukufunxa: I-7,8-Dihydroxyflavone inokufunxwa ngokukhawuleza ngumzimba womntu, ingene kwi-blood circulation nge-intestinal tract, ize isasazwe kwiithishu kunye namalungu ahlukeneyo.
Izicelo
I-7, 8-DHF, njenge-activator ye-molecule encinci esebenzayo ye-TrkB receptor, inokudlala indima yokukhusela ii-neuron, ukuvuselelwa kwee-neuron, ukulawulwa kwe-synaptic plasticity, njl. ngokulinganisa ukubopha okuthile kwe-BDNF kwi-TrkB kunye nokusebenzisa iindlela zesignali ezisezantsi, ukuze kuphuculwe kakhulu iimpawu zokufunda ngokweemvakalelo kunye nokwehla kwememori yendawo, ukwehla kwamandla okuqonda, ukwehla kokusebenza kwemisipha kunye nezinye iimpawu zesifo se-nervous system ezifana nesifo se-Alzheimer okanye iimodeli zezilwanyana ezigugayo, Kwaye kuncitshiswe iimpawu ezinxulumene nezifo zengqondo kunye nezilwanyana ezityebileyo. Okwangoku, ukuza kuthi ga ngoku, akukho ziphumo zibalulekileyo zetyhefu ze-7,8-DHF ezifunyenweyo kwizilwanyana ezivavanyiweyo. I-7,8-DHF inamandla amakhulu kunye nexabiso ekuthinteleni nasekunyangeni imiba enxulumene ne-BDNF/TrkB.
