Umenzi womgubo we-RU58841 Inombolo ye-CAS: 154992-24-2 Ubumsulwa obuyi-99.0% ubuncinci bezithako ezongezelelweyo
Iiparamitha zeMveliso
| Igama lemveliso | 4-[3-(4-Hydroxybutyl)-4,4-dimethyl-2,5-dioxo-1-imidazolidinyl]-2-(trifluoromethyl)benzonitrile |
| Elinye igama | RU58841 |
| Inombolo ye-CAS | 154992-24-2 |
| Ifomula yemolekyuli | C17H18F3N3O3 |
| Ubunzima be-molecular | 369.34 |
| Ubunyulu | 99.0% |
| Inkangeleko | umgubo omhlophe |
| Ukupakisha | 1kg/ibhegi |
| Isicelo | Khulisa iinwele |
Intshayelelo yemveliso
I-RU58841 (ekwaziwa ngokuba yi-RU-58841) yi-compound, i-RU58841 ikhuphisana ne-dihydrotestosterone ukugcina amanqanaba e-DHT ngaphakathi koluhlu oluqhelekileyo, ngaloo ndlela ilawula umjikelo wokukhula kweenwele. Ivuselela ukuguqulwa kwee-follicles zeenwele ezintsha zibe zii-follicles zeenwele ze-anagen ngokungena kwisigaba se-anagen. Ukuvumela ii-follicles ezonakeleyo ixesha lokubuyela kwisigaba sokukhula esiqhelekileyo kunceda iiseli ukuba zibuyele kwisimo sazo sokukhula. Ikwanyusa ukuhamba kwegazi kwii-follicles ezonakeleyo kwaye izincede ziphinde zikhule. Kwelinye icala, i-RU58841 (RU-58841) isebenza ngokubopha kwii-receptors ze-androgen kwii-follicles zeenwele. Ngoko ke ii-androgens azinalo ithuba lokubopha nokuqalisa i-chain reaction ye-androgenetic alopecia kwaye ziqalise inkqubo ebizwa ngokuba yi-miniaturization. Kuye kwabonakala ukuba iyawuphazamisa lo myalezo wokulahleka kweenwele ukuze ukukhula kweenwele okuqhelekileyo kuqhubeke.
Uphawu
(1) Ingathintela ukulahleka kweenwele: I-RU58841 sisithinteli sehomoni esikhethekileyo, esinokuthintela ukudibana kweeseli ze-androgen kunye nee-follicle zeenwele zentloko, ngaloo ndlela kunciphisa umngcipheko wokulahleka kweenwele.
(2) Ukufunxa kakuhle: I-RU58841 inobunzima obuncinci be-molecular, isakhiwo esilula, kwaye kulula ukuyifunxa. Ingangena ngokukhawuleza emzimbeni ize isebenze ngexesha elifutshane.
(3) Ukukhetha okuphezulu kune-androgen: I-RU58841 inokuthintela ngokukhethekileyo isenzo se-androgen ngaphandle kokuchaphazela ezinye iihomoni.
(4) Ubude bexesha lokusebenza: I-RU58841 inobomi obude besiqingatha emzimbeni, inokuthintela ngokuqhubekayo isiphumo se-androgen, kwaye ixesha lokusebenza linokuba lide njengeeyure ezingama-48.
(5) Ubunyulu obuphezulu: Ngokusebenzisa inkqubo yokukhupha izinto ngokwendalo kunye nokuvelisa izinto ezincinci, uphuhliso lwe-RU58841 lunokufumana iimveliso ezicocekileyo kakhulu.
Izicelo
Kuphando nakwizilingo zeklinikhi, i-RU58841 ibonakalisiwe ukuba inyusa izinga lokuphindaphindeka kweeseli kwiiseli ze-stromal, inyusa ukwanda kweeseli kwiiseli zeengcambu zangaphandle kwaye inyusa ububanzi beenwele kunye noxinano lweenwele, ngoko ke i-RU58841 liyeza lophando lokunyanga i-androgenetic alopecia. Umgaqo osebenzayo oyintloko kukuthintela indibaniselwano ye-DHT kunye ne-AR yeefollicle zeenwele, ezihlala zisetyenziselwa ukunyanga iingxaki zokulahleka kweenwele kunye nokulahleka kweenwele.
