I-Oleoylethanolamide (OEA) umenzi we-powder CAS No.: 111-58-0 98%,85% ubumsulwa min. zokongeza izithako
Iiparamitha zeMveliso
| Igama lemveliso | Oleoyl ethanolamide |
| Elinye igama | N-oleoyl ethanolamine; N-(2-hydroxyethyl)-,(Z)-9-Octadecenamide |
| Inombolo yeCAS. | 111-58-0 |
| Ifomula yemolekyuli | C20H39NO2 |
| Ubunzima bemolekyuli | 325.53 |
| Ubunyulu | 98.0% , 85.0% |
| Imbonakalo | Umgubo ococekileyo wekristale |
| Ukupakisha | 1kg / ibhegi, 25kg / igubu |
| Isicelo | Ukunciphisa iintlungu, ukuchasana nokuvuvukala |
Intshayelelo yemveliso
I-Oleoylethanolamide yinto yesibini ye-amide ehlanganiswe ne-lipophilic oleic acid kunye ne-hydrophilic ethanolamine. I-Oleoylethanolamide ikwayindalo ye-lipid molekyuli kwezinye izilwanyana kunye nezityalo. Ifumaneka ngokubanzi kwizicubu zezilwanyana kunye nezityalo ezifana ne-cocoa powder, iimbotyi zesoya, kunye namantongomane, kodwa umxholo wayo uphantsi kakhulu. Kuphela xa imeko yangaphandle itshintsha okanye ukutya kukhuthazwa, izicubu zeeseli zomzimba Kuphela ke kuya kuveliswa ngaphezulu kwale nto.
Kwiqondo lobushushu begumbi, iOleoylethanolamide yinto eqinileyo emhlophe enendawo yokunyibilika emalunga ne-50°C. Inyibilika ngokulula kwizinyibilikisi ezinxilisayo ezifana ne-methanol kunye ne-ethanol, ngokulula ngakumbi ukunyibilika kwizinyibilikisi ezingekho kwi-polar ezifana ne-n-hexane kunye ne-ether, kwaye ayinyibiliki emanzini. I-OEA yiamphiphilic molekyuli ngokwesiko esetyenziswa njenge-surfactant kunye nesicoci kwishishini lemichiza. Nangona kunjalo, uphando olongezelelweyo lufumene ukuba i-OEA inokusebenza njengemolekyuli yokubonisa i-lipid kwi-axis yengqondo ye-gut-brain kwaye ibonise uluhlu lwemisebenzi yezinto eziphilayo emzimbeni, kubandakanywa: ukulawula ukutya, ukuphucula i-lipid metabolism, ukuphucula imemori kunye nokuqonda kunye neminye imisebenzi. Phakathi kwabo, imisebenzi ye-Oleoylethanolamide yokulawula ukutya kunye nokuphucula i-lipid metabolism ifumene ingqalelo enkulu.
I-Oleoylethanolamide inokulawula ukutya kunye ne-homeostasis yamandla ngokuvula i-peroxisome proliferator-activated receptor-α. Ukongeza, i-Oleoylethanolamide ibonisa ezinye izinto ezinxulumene nempilo, kubandakanywa ukumodareyitha umsebenzi wokuguqula kwindlela yokubonisa i-lysosomal-to-nuclear ehambelana nokulawulwa kwexesha elide kunye nokukhusela imithambo-luvo elawula ukuziphatha okudakumba. Uphando lukwabonisa ukuba i-Oleoylethanolamide ingaba nemiphumo ye-neuroprotective. Kwiimodeli zezilwanyana, kufunyenwe ukunciphisa umonakalo kwi-stroke kunye nokulimala kwengqondo. Umphumo wokulawula we-Oleoylethanolamide unxulunyaniswa nokubophelela kwayo kwi-PPARα, eyancipha nge-retinoid X receptor (RXR) kwaye isebenze njengento enamandla yokubhala ebandakanyekayo kwi-homeostasis yamandla edibeneyo, i-lipid metabolism, i-autophagy, kunye nokuvuvukala. ekujoliswe kuko.
Uphawu
(1) Ukucoceka okuphezulu: I-OEA inokufumana iimveliso ezicocekileyo ngokucokisa iinkqubo zokuvelisa. Ukucoceka okuphezulu kuthetha ukuba ngcono kwe-bioavailability kunye neempendulo ezimbalwa ezimbi.
(2) Ukhuseleko: I-OEA ingqineke ikhuselekile kumzimba womntu.
(3) Uzinzo: I-OEA inozinzo oluhle kwaye inokugcina umsebenzi wayo kunye nesiphumo phantsi kweemeko ezahlukeneyo kunye neemeko zokugcina.
(4) Kulula ukufunxa: I-OEA inokufunxwa ngokukhawuleza ngumzimba womntu kwaye isasazwe kwizicubu kunye namalungu ahlukeneyo.
Usetyenziso
I-Oleoylethanolamide yi-lipid ye-ethanolamide yendalo esetyenziswa njengesicwangciso sokutya kunye nokulawula ubunzima bomzimba kwiindidi zeentlobo ze-vertebrate. Yimetabolite ye-oleic acid eyenziwe kwithumbu elincinci lomntu. I-Oleylethanolamide (OEA) yi-molecule elawula i-lipid metabolism kunye ne-homeostasis yamandla. Inamathela kwi-PPAR Alpha receptors kwaye inceda ukulawula izinto ezine: indlala, amafutha omzimba, i-cholesterol kunye nobunzima. I-PPAR Alpha imele i-peroxide proliferator-activated receptor alpha, kunye ne-bioactive lipid amide oleoylethanolamide (OEA) ineendlela ezahlukeneyo ze-homeostatic, ezibandakanya umsebenzi wokuchasana nokuvuvukala, ukuguqulwa kwe-immune response, kunye ne-antioxidant effects.
