I-CMS121 umenzi we-powder CAS No.: 1353224-53-9 98.0% ubumsulwa min. zokongeza izithako
Iiparamitha zeMveliso
| Igama lemveliso | I-CMS121 |
| Elinye igama | CMS-121; 1,2-Benzenediol,4-[4-(cyclopentyloxy)-2-quinolinyl]-; 4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol(CMS121); I-ACC, i-AcetylCoenzymeACarboxylase, isifo, i-neuroprotective, inhibit, anti-inflammatory, mitochondrial, i-Alzheimer's, i-antioxidative, i-acetylation, i-Inhibitor, i-H3K9, i-Acetyl-CoACarboxylase, i-CMS121, i-dementia, i-ACC1, i-CMS-121 |
| Inombolo yeCAS. | 1353224-53-9 |
| Ifomula yemolekyuli | C20H19NO3 |
| Ubunzima bemolekyuli | 321.37 |
| Ubunyulu | 98.0% |
| Imbonakalo | Umgubo otyheli okhanyayo |
| Isicelo | I-Dietary Supplement Raw Material |
Intshayelelo yemveliso
I-4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol yikhompawundi ekwabizwa ngokuba yiCMS121. Ukuntsonkotha kolwakhiwo lwekhompawundi kubonisa ukuba inokuba neepropati ezizodwa kunye nokusetyenziswa okunokwenzeka. Ukuqonda ukubaluleka kwayo, kunceda ukuchonga amaqela asebenzayo akhoyo kwaye ahlalutye impembelelo yawo enokubakho. Ubukho beringi yequinoline bucebisa ukuba ikhompawundi inokusebenza ngokwebhayoloji. Iimolekyuli eziphuma kwi-Quinoline ziyaziwa ngeempawu zazo ezahlukeneyo zebhayoloji, kubandakanya imisebenzi yokulwa ne-antibacterial kunye ne-anti-inflammatory. I-Attachment yeqela le-cyclopentyloxy inokufaka isandla kwi-solubility ye-compound okanye ukuphucula umsebenzi wayo webhayoloji ngemiphumo ye-steric. Kwizifundo kwiiseli ze-HT22, i-CMS-121 ibonise imiphumo ebalulekileyo ye-neuroprotective, ikhusela ngokufanelekileyo ezi seli kwi-ischemia kunye nomonakalo we-oxidative. Ngapha koko, i-CMS-121 ineempawu ezichasene nokudumba, ezibonisa amandla ayo okulungelelanisa iimpendulo ezivuthayo. Ngokwenza njalo, i-CMS-121 inamandla okunciphisa ukuvuvukala kwizicubu ezahlukeneyo kunye namalungu. I-CMS-121 inomsebenzi onamandla we-pharmacological njenge-inhibitor ye-acetyl-CoA carboxylase 1 (ACC1). Impembelelo yayo enamandla yokuthintela kwi-ACC1 iyenza ibe yikhompawundi ethembisayo.
Uphawu
(1) Ukucoceka okuphezulu: I-CMS-121 inokufumana iimveliso ezihlambulukileyo ngokusebenzisa iinkqubo zokuvelisa eziphuculweyo. Ukucoceka okuphezulu kuthetha ukuba ngcono kwe-bioavailability kunye neempendulo ezimbalwa ezimbi.
(2) Ukhuseleko: Ukhuseleko oluphezulu, zimbalwa izenzo ezibi.
(3) Ukuzinza: I-CMS-121 inozinzo oluhle kwaye inokugcina umsebenzi wayo kunye nesiphumo phantsi kweemeko ezahlukeneyo kunye neemeko zokugcina.
Usetyenziso
I-CMS-121 yi-quinolone derivative kunye ne-acetyl-CoA esebenzayo yomlomo i-acetyl-CoA carboxylase 1 (ACC1) inhibitor eneempawu ezithembisayo ze-pharmacological. Uphando olubanzi luye lwenziwa ukuphanda iingenelo ezinokuthi zenzeke kwi-CMS-121 kwiindawo ezahlukeneyo, kubandakanywa neuroprotection, i-anti-inflammatory effects, umsebenzi we-antioxidant, kunye nefuthe lawo kumakishi ahambelana nokuguga okunempilo.
