Umenzi womgubo we-Agomelatine Inombolo ye-CAS: 138112-76-2 Ubumsulwa obuyi-99% ubuncinane bezithako ezongezelelweyo
Ividiyo yeMveliso
Iiparamitha zeMveliso
| Igama lemveliso | I-Agomelatine |
| Elinye igama | I-N-[2-(7-Methoxy-1-naphthyl)ethyl]acetamide;N-[2-(7methoxynaphthalen-1-yl)ethyl]acetamide |
| Inombolo ye-CAS | 138112-76-2 |
| Ifomula yemolekyuli | C15H17NO2 |
| Ubunzima be-molecular | 243.3082 |
| Ubunyulu | 99.0% |
| Inkangeleko | Umgubo omhlophe |
| Ukupakisha | 1kg/ibhegi 25kg/igubu |
| Isicelo | Izinto eziluhlaza zemveliso yezempilo |
Intshayelelo yemveliso
I-Agomelatine yaqaliswa okokuqala eYurophu ngo-2009 kwaye ngoku ivunyiwe ukuba isetyenziswe kumazwe angaphezu kwama-70. Ngokungafaniyo nemithi yokunciphisa uxinzelelo yendabuko, i-agomelatine isebenza ngokujolisa kwi-melatonin kunye nee-serotonin receptors engqondweni. Ngokusebenza njenge-agonist kwi-melatonin receptors, i-agomelatine inceda ukulungelelanisa iipatheni zokulala eziphazamisekileyo ezidla ngokunxulunyaniswa nokudakumba. Le ndlela ayincedi nje kuphela ukuphucula umgangatho wokulala kodwa ikwanceda ukubuyisela i-circadian rhythms yendalo. Ukongeza, i-agomelatine isebenza njengomchasi kwii-receptor ezithile ze-serotonin (ii-receptors ze-5-HT2C). Le ntshukumo ingaqhelekanga kabini iphucula ngokungathanga ngqo ukufumaneka kwe-serotonin engqondweni, i-neurotransmitter enoxanduva lokulawula imood. Ngokulawula amanqanaba e-serotonin, i-agomelatine ingasebenza njenge-antidepressant esebenzayo, ikhulula iimpawu ezinje ngosizi, ukuphelelwa ngumdla, iimvakalelo zokuba netyala okanye ukungabi naxabiso. Ukongeza, i-agomelatine inokubonelela ngezinye izibonelelo. Uphando lubonisa ukuba inokunceda ukuphucula umsebenzi wokuqonda Uphando lubonisa amandla ayo okuphucula inkumbulo, ingqalelo, kunye nomsebenzi wokulawula, okwenza kube yindawo enomdla yophando lwexesha elizayo.
Uphawu
(1) Ubunyulu obuphezulu: I-Agomelatine inokufumana iimveliso ezinyulu obuphezulu ngokusebenzisa iinkqubo zokucoca imveliso. Ubunyulu obuphezulu buthetha ukufumaneka ngcono kwezinto eziphilayo kunye neempendulo ezimbalwa ezingalunganga.
(2) Ukhuseleko: Ukhuseleko oluphezulu, zimbalwa iziphumo ezibi.
(3) Uzinzo: I-Agomelatine izinzile kakuhle kwaye ingayigcina iyasebenza phantsi kweemeko ezahlukeneyo kunye neemeko zokugcina.
Izicelo
I-Agomelatine sisithinteli-ngxaki soxinzelelo kunye ne-melatonin antagonist. Inciphisa iimpawu zokudakumba ngokulawula ii-receptors ze-melatonin MT1 (inciphisa imiqondiso ye-cortical alarm) kunye nee-receptors ze-MT2 (isigqi sokulala se-circadian) kunye namanqanaba e-serotonin. Ithathwa ebusuku, ixelisa isigqi sendalo sokukhululwa kwe-melatonin kwaye inokuphucula kakhulu umgangatho wokulala. Indlela esebenza ngayo iphula inkqubo yesiqhelo yokudlulisela i-monoamine. Ivuselela ii-receptors ze-melatonin MT1 kunye ne-MT2 kwaye ichasene nee-receptors ze-5-HT2C. Iphucula umgangatho wokulala, ibuyisela isigqi sebhayoloji, kwaye inesiphumo sokudakumba; phakathi kwazo, ngokuchasa ii-receptors ze-5-HT2C kwi-membrane ye-postsynaptic, inokunyusa ukukhululwa kwe-DA kunye ne-NE kwi-prefrontal cortex, isebenzise isiphumo sokudakumba. Xa i-MT agonism kunye ne-5-HT2C receptor zidibene, isiphumo esikhethekileyo sokusebenzisana sinokuveliswa, sikhuthaze ukukhululwa kwe-DA kunye ne-NE engaphezulu kwindawo yengqondo ye-PFC, siqinise ngakumbi isiphumo sokudakumba. Ukongeza, i-agomelatine inokukhuthaza ukukhululwa kwe-neurotrophic factor efumaneka ebuchotsheni kwi-PFC kwaye ithintele ukukhululwa kwe-glutamate okubangelwa luxinzelelo kwindawo yengqondo ye-amygdala.
