Inombolo ye-CAS ye-SLU-PP-332: 303760-60-3
Iiparamitha zeMveliso
| Igama lemveliso | I-SLU-PP-332 |
| Elinye igama | I-SLU-PP-332； (E)-4-Hydroxy-N′(Naphthalen-2-Ylmethylene)Benzohydrazide；4-Hydroxybenzoic acid 2-(2-naphthalenylmethylene)hydrazide； |
| Inombolo ye-CAS | 303760-60-3 |
| Ifomula yemolekyuli | C18H14N2O2 |
| Ubunzima be-molecular | 290.32 |
| Ubunyulu | 98% |
| Inkangeleko | Umgubo omhlophe okanye omhlophe qhwa |
| Ukupakisha | 1kg/ibhegi, 25kg/umphanda |
| Isicelo | Isongezelelo sokutya Izinto eziluhlaza |
Intshayelelo yemveliso
I-SLU-PP-332 yi-compound entsha encinci ye-molecule esebenza njenge-agonist ye-perifollicle estrogen receptor (ERR), ejolise kakhulu kwi-ERRα, ERRβ, kunye ne-ERRγ, enefuthe elinamandla kakhulu lokusebenza kwi-ERRα (EC₅₀=98 nM). Le compound ivuselela indlela yokubonisa i-ERR ngokulinganisa iindlela zokulawula i-metabolic zokuzilolonga, ngaloo ndlela ilawula i-metabolism yamandla, umsebenzi we-mitochondrial, kunye nokunyamezela kwemisipha.
Uphawu
(1) Indlela yokusebenza: yenza kusebenze i-ERRα/β/γ, yonyusa i-fatty acid oxidation (FAO) kunye ne-mitochondrial respiration related genes, ikhuthaza ukuqhekeka kwamafutha ukuze kubonelelwe ngamandla, inciphise ukuqokelelwa kwamafutha, iphucule ukusebenza kwe-mitochondrial muscle muscle, iphucule amandla e-oxidative kunye nokunyamezela, okufana nefuthe loqeqesho lwe-aerobic.
(2) Ukusebenza kwe-Bio: a) Iziphumo zemodeli yezilwanyana: Iimpuku ezityebileyo: emva kweentsuku ezingama-28 zonyango, ubunzima bomzimba behle nge-12%, kwaye amafutha esibindi, i-cholesterol, kunye ne-triglycerides zehlisiwe kakhulu; iimpuku eziqhelekileyo: ixesha lokusebenza lenyuke nge-70%, umgama wenyuka nge-45%, ngaphandle kokuchaphazela ukutya okanye ukuhamba ngokuzithandela. b) Ukhuseleko: akukho miphumo mibi ebonwe kwizifundo zangaphambi kweklinikhi.
(3) Iimpawu zomzimba nezekhemikhali: ezimhlophe ukuya kumhlophe eziqinileyo, ezinyibilikayo kwi-DMSO (75 mg/mL) kunye ne-ethanol, ezinganyibilikiyo emanzini; kufuneka zigcinwe ebumnyameni.
Izicelo
I-SLU-PP-332 ifezekisa ukulahleka kwamafutha kunye nokulawulwa kweglucose egazini ngokukhuthaza ukunyibilika kwamafutha kunye nokuphucula uvakalelo lwe-insulin; iphucula isifo sesibindi esinamafutha esingenatywala (i-NAFLD), inciphisa umxholo wamafutha esibindi; inika inkxaso yemetabolism kubantu abangakwaziyo ukuzilolonga, ukugcina ubunzima bemisipha kunye nokusebenza; inciphisa ukulahleka kwemisipha ngexesha lenkqubo yokulahleka kwamafutha; kwaye inamathuba abanzi kwiindawo zokulahleka kwamafutha, ukuphucula ukunyamezela, kunye nokuphucula imetabolism.
