RU58841 umenzi we-powder CAS No.: 154992-24-2 99.0% ubumsulwa min. zokongeza izithako
Iiparamitha zeMveliso
| Igama lemveliso | 4--[3-(4-Hydroxybutyl)-4,4-dimethyl-2,5-dioxo-1-imidazolidinyl]-2-(trifluoromethyl)benzonitrile |
| Elinye igama | RU58841 |
| Inombolo yeCAS. | 154992-24-2 |
| Ifomula yemolekyuli | I-C17H18F3N3O3 |
| Ubunzima bemolekyuli | 369.34 |
| Ubunyulu | 99.0% |
| Imbonakalo | umgubo omhlophe |
| Ukupakisha | 1kg/ibhegi |
| Isicelo | Khulisa iinwele |
Intshayelelo yemveliso
I-RU58841 (eyaziwa nangokuthi i-RU-58841) i-compound, i-RU58841 ikhuphisana ne-dihydrotestosterone ukugcina amanqanaba e-DHT ngaphakathi kwinqanaba eliqhelekileyo, ngaloo ndlela ilawula umjikelezo wokukhula kweenwele. Ivuselela ukuguqulwa kweenwele ezitsha zeenwele kwi-anagen follicles ngokungena kwisigaba se-anagen. Ukuvumela iifollicles ezonakalisiweyo ixesha lokutshintshela kwisigaba sokukhula esiqhelekileyo kunceda iiseli ukuba zibuyele. Kwakhona kwandisa ukuhamba kwegazi kwiifollicles ezonakalisiweyo kwaye zibancede bahlaziye. Ngakolunye uhlangothi, i-RU58841 (RU-58841) isebenza ngokubophelela kwi-androgen receptors kwiifollicle zeenwele. Ke i-androgens ayinalo ithuba lokubopha kwaye iqale i-chain reaction ye-androgenetic alopecia kwaye iqale inkqubo ebizwa ngokuba yi-miniaturization. Kuye kwaboniswa ukuphazamisa ekuhlaleni lo myalezo wokulahleka kweenwele ukwenzela ukuba ukukhula kweenwele eziqhelekileyo kuqhubeke.
Uphawu
(1) Inokuthintela ukulahleka kweenwele: I-RU58841 yi-hormone inhibitor ekhethekileyo, enokuthintela ukudibanisa i-androgen kunye neeseli ze-scalp hair follicle, ngaloo ndlela inciphisa umngcipheko wokulahleka kweenwele.
(2) Ukufunxa kakuhle: I-RU58841 inobunzima obuncinane be-molecular, isakhiwo esilula, kwaye kulula ukuyifumana. Inokungena ngokukhawuleza emzimbeni kwaye isebenze ngexesha elifutshane.
(3) Ukukhetha okuphezulu kwi-androgen: I-RU58841 inokuthintela ngokukhetha isenzo se-androgen ngaphandle kokuchaphazela amanye amahomoni.
(4) Ixesha elide lesenzo: I-RU58841 inobomi obude emzimbeni, inokunqanda ngokuqhubekayo umphumo we-androgen, kwaye ixesha elisebenzayo linokuba lide njengeeyure ze-48.
(5) Ukucoceka okuphezulu: Ngokukhutshwa kwendalo kunye nenkqubo yokuvelisa kakuhle, ukuphuhliswa kwe-RU58841 kunokufumana iimveliso ezicocekileyo.
Usetyenziso
Kuphando kunye nezilingo zeklinikhi, i-RU58841 ibonakaliswe ukwandisa izinga lokuphindaphinda kweeseli kwiiseli ze-stromal, ukwandisa ukwanda kweeseli kwiiseli zangaphandle zeengcambu kunye nokwandisa ububanzi beenwele kunye nobuninzi beenwele, ngoko i-RU58841 iyiyeza lophando lonyango lwe-androgenetic alopecia. Umgaqo oyintloko wokusebenza kukuthintela ukudibanisa kwe-DHT kunye ne-AR ye-follicles yeenwele, ehlala isetyenziselwa ukuphatha ukulahleka kweenwele kunye neengxaki zokulahleka kweenwele.
