I-Agomelatine powder umenzi we-CAS No.: 138112-76-2 99% ubumsulwa min. zokongeza izithako
Ividiyo yeMveliso
Iiparamitha zeMveliso
| Igama lemveliso | IAgomelatine |
| Elinye igama | N-[2-(7-Methoxy-1-naphthyl)ethyl]acetamide;N-[2-(7methoxynaphthalen-1-yl)ethyl]acetamide |
| Inombolo yeCAS. | 138112-76-2 |
| Ifomula yemolekyuli | C15H17NO2 |
| Ubunzima bemolekyuli | 243.3082 |
| Ubunyulu | 99.0% |
| Imbonakalo | Umgubo omhlophe |
| Ukupakisha | 1kg/ibhegi 25kg/igubu |
| Isicelo | Imveliso yezempilo imathiriyeli ekrwada |
Intshayelelo yemveliso
I-Agomelatine yasungulwa okokuqala eYurophu ngo-2009 kwaye ngoku ivunyiwe ukuba isetyenziswe kumazwe angaphezu kwama-70. Ngokungafaniyo ne-antidepressants yendabuko, i-agomelatine isebenza ngokujolisa i-melatonin kunye ne-serotonin receptors kwingqondo. Ngokusebenza njenge-agonist kwi-melatonin receptors, i-agomelatine inceda ukulungisa iipatheni eziphazamisekileyo zokulala zihlala zinxulunyaniswa nokudakumba. Lo matshini awuncedi nje ukuphucula umgangatho wokulala kodwa ukwanceda ukubuyisela izingqisho zendalo ze-circadian. Ukongezelela, i-agomelatine yenza njengomchasi kwi-receptors ethile ye-serotonin (i-5-HT2C receptors). Esi senzo sintlu-mbini sikhethekileyo sonyusa ngokungangqalanga ukufumaneka kwe-serotonin engqondweni, i-neurotransmitter enoxanduva lokulawula imo. Ngokulawula amanqanaba e-serotonin, i-agomelatine inokusebenza njenge-antidepressant esebenzayo, ukukhulula iimpawu ezinjengosizi, ukulahlekelwa ngumdla, ukuziva unetyala okanye ukungabi naxabiso. Ukongeza, i-agomelatine inokubonelela ngezinye izibonelelo. Uphando lucebisa ukuba lunokunceda ukuphucula umsebenzi wokuqonda Uphando lubonisa amandla alo okuphucula inkumbulo, ingqalelo, kunye nomsebenzi wesigqeba, oko kuyenza ibe yindawo enomdla yophando lwexesha elizayo.
Uphawu
(1) Ukucoceka okuphezulu: I-Agomelatine inokufumana iimveliso ezicocekileyo ngokucokisa iinkqubo zokuvelisa. Ukucoceka okuphezulu kuthetha ukuba ngcono kwe-bioavailability kunye neempendulo ezimbalwa ezimbi.
(2) Ukhuseleko: Ukhuseleko oluphezulu, zimbalwa izenzo ezibi.
(3) Ukuzinza: I-Agomelatine inozinzo oluhle kwaye inokugcina umsebenzi wayo kunye nesiphumo phantsi kweemeko ezahlukeneyo kunye neemeko zokugcina.
Usetyenziso
I-Agomelatine yi-antidepressant kunye ne-antagonist ye-melatonin. Iyanciphisa iimpawu zokudakumba ngokulawula i-melatonin MT1 receptors (inciphisa iimpawu ze-cortical alarm) kunye ne-MT2 receptors (i-circadian sleep rhythm) kunye namanqanaba e-serotonin. Ithathwa ebusuku, ilinganisa isingqisho sendalo sokukhutshwa kwemelatonin kwaye inokuphucula kakhulu umgangatho wokulala. Indlela yokusebenza kwayo iqhawuka kwinkqubo yemveli yokuhambisa imonoamine. Ivula i-melatonin receptors MT1 kunye ne-MT2 kwaye ichasene ne-5-HT2C receptors. Iphucula umgangatho wokulala, ibuyisela isigqi sebhayoloji, kwaye inesiphumo sokudakumba; phakathi kwabo, ngokuchasa i-5-HT2C i-receptors kwi-membrane ye-postsynaptic, inokunyusa ukukhululwa kwe-DA kunye ne-NE kwi-cortex yangaphambili, eyenza i-antidepressant effect. Xa i-MT agonism kunye ne-5-HT2C i-antagonism ye-receptor antagonism idibene, isiphumo esiyingqayizivele se-synergistic sinokuveliswa, ukukhuthaza ukukhululwa kwe-DA eninzi kunye ne-NE kwindawo yengqondo ye-PFC, ukomeleza ngakumbi umphumo we-antidepressant. Ukongezelela, i-agomelatine inokukhuthaza ukukhululwa kwe-brain-derived neurotrophic factor kwi-PFC kwaye ivimbele ukukhutshwa koxinzelelo lwe-glutamate kwindawo yengqondo ye-amygdala.
