I-5-amino-1-methylquinolinium iodide ye-CAS No.: 42464-96-0 98.0% ubumsulwa min. | ukongeza izithako umenzi
IiParameters zeMveliso
| Igama lemveliso | I-5-amino-1-methylquinolinium iodide |
| Elinye igama | NNMTi5-Amino-1-mq iodide I-5-amino-1-methylquinolinium iodide I-5-AMINO-1-METHYLQUINOLIN-1-IUM IODIDE I-5-Amino-1-methylquinolin-1-iumiodide I-1-methylquinolin-1-ium-5-amine;iodide I-5-Amino-1-methyl-1-quinolinium Iodide |
| Inombolo yeCAS. | 42464-96-0 |
| Ifomula yemolekyuli | C10H11IN2 |
| Ubunzima bemolekyuli | 286.11 |
| Ubunyulu | 98% |
| Imbonakalo | Umdaka ukuya kubomvu omdaka oqinileyo |
| Ukupakisha | 1kg/bag, 25kg/barrel |
| Isicelo | I-Dietary Supplement Raw Material |
Intshayelelo yemveliso
I-NNMTi yi-enzyme egxininiswe kakhulu ngexesha lokuguga kwemisipha kwaye inxulunyaniswa nokulungiswa komonakalo wendlela ye-NAD +, umsebenzi we-sirtuin1 we-dysregulated, kunye nokwanda kwe-muscle stem cell senescence. I-NNMTi ikhuthaza ukuhlukana kwe-myoblast kwi-vitro kwaye iphucula ukudibanisa kunye nokuhlaziywa kweeseli ze-muscle stem kwiigundane ezikhulileyo. I-NNMTi ikwayi-inhibitor enamandla ye-nicotinamide N-methyltransferase (NNMT) (IC50=1.2 μM), ibophelela ngokukhethekileyo kwiintsalela zesayithi ezibophelelayo kwi-substrate ye-NNMT. I-NNMTi ikhuthaza ukuhlukana kwe-myoblast kwi-vitro kwaye iphucula ukudibanisa kunye nokuhlaziywa kweeseli ze-muscle stem kwiigundane ezikhulileyo. Phakathi kwazo, i-enzyme ye-cytosolic i-nicotinamide N-methyltransferase (NNMT) isanda kufunyaniswa ukulawula amanqanaba e-nicotinamide precursors efunekayo kwi-NAD + biosynthesis, kwaye ke idlala indima ebalulekileyo ekulawuleni indlela ye-NAD + yokusindisa kunye nemetabolism yeselula.
Uphawu
(1) Ukucoceka okuphezulu: I-NNMTi inokufumana iimveliso ezicocekileyo ngokusebenzisa iinkqubo zokuvelisa eziphuculweyo. Ukucoceka okuphezulu kuthetha ukuba ngcono kwe-bioavailability.
(2) Ukujoliswa: I-NNMti ijolise ngokukodwa kwi-enzyme ye-NNMT kwaye inokuthintela ngokufanelekileyo umsebenzi wayo, ngaloo ndlela ichaphazela indlela ye-metabolic ye-nicotinamide.
(3) Uzinzo: I-NNMTi inozinzo oluhle kwaye inokugcina umsebenzi wayo kunye nesiphumo phantsi kweemeko ezahlukeneyo kunye neemeko zokugcina.
(4) Amathuba ophuhliso: Ngenxa yeempawu ezahlukeneyo zeNNMT, uphuhliso lwayo lufumene ingqwalasela ebanzi kwaye lunophando olubanzi kunye nethemba lokusetyenziswa.
Usetyenziso
I-NNMTi yi-nicotinamide N-methyltransferase (NNMT) inhibitor ekhuthaza ukuhlukana kwe-myoblast. I-NNMTi inokusetyenziswa njengesongezelelo ekuncedeni ukunciphisa ubunzima kunye namafutha kunye nokuphucula amafutha esibindi.
