I-7,8-Dihydroxyflavone (7,8-DHF) yi-flavonoid yendalo ebonisa ithemba kwiindawo ezahlukeneyo zempilo. Ukuba unomdla kwizongezo zendalo okanye izithako zokutya ezinokuxhasa impilo yengqondo, isimo sengqondo, kunye nokuphila kakuhle, i-7,8-DHF inokuba yinto efanelekileyo ukuyihlola. I-7,8-Dihydroxyflavone Powder ebonelelwa yiSuzhou Myland inenombolo ye-CAS engu-38183-03-8 kunye nobunyulu obufikelela kwi-98%. Le mveliso iye yalawulwa ngokungqongqo komgangatho kwaye ihambelana nemigangatho yamazwe ngamazwe, iqinisekisa ukusebenza kakuhle kunye nokhuseleko lwemveliso. , efanelekileyo kuphando lwesayensi, uphuhliso lwamayeza, ukuveliswa kwemveliso yokhathalelo lwempilo kunye nezinye iindawo, ikunika ukhetho oluthembekileyo.
I-7,8-Dihydroxyflavone (7,8-DHF)yi-flavonoid compound engaqhelekanga eyenzeka ngokwendalo. Ifunyenwe kwi-Astragalus pumila, Primula grandifolia kunye ne-Hubei crabapple. Ivele njenge-nootropic compound ethembisayo. Ibonakalise uluhlu lweziphumo ze-neuropharmacological kwizifundo zangaphambi kweklinikhi,
Iiflavonoids ziluhlu lweekhompawundi zepolyphenolic ezifumaneka kwiintlobo ngeentlobo zeziqhamo, imifuno, kunye nezinye izityalo. Kwiminyaka yakutshanje, zifumene ingqwalasela enkulu ngenxa yeempawu zazo zokulwa ne-antioxidant, ukulwa nokuvuvukala, kunye nokukhusela imithambo-luvo.
Ezi khompawundi zibonakalisiwe zineziphumo eziluncedo engqondweni, kubandakanya ukuphucula ukusebenza kwengqondo kunye nokuthintela izifo eziwohlokayo kwimithambo-luvo. I-7,8-DHF yenye yezona khompawundi ze-polyphenolic zibalaseleyo ezifumana ingqwalasela eyandayo njenge-nootropic. Ifundwe ngeziphumo zayo ezinokubakho kwimood, imemori, ukufunda, ixhala, kunye neminye imisebenzi yengqondo.
Iziphumo ze-neurological ze-7,8-DHF kucingelwa ukuba zibangelwa kukusebenzisana kwayo nee-receptors ezithile. Kufunyaniswe ukuba yi-TrkA, i-receptor ebandakanyeka kwi-nerve growth factor signaling kwaye ibalulekile ekusindeni kwe-neuronal kunye ne-plasticity.
I-7,8-DHF isebenza ngokulawula ukubonakaliswa kwee-receptors ezahlukeneyo, kuquka ii-subunits ze-glutamate receptor kunye ne-BDNF. Ikwachaphazela ukwakheka kwe-synapse, imetabolism yamandla, kunye nokukhululwa kwe-acetylcholine kwiindawo ezithile zobuchopho.
Ukongeza, i-osteoporosis yaziwa ngokuba "ngumbulali othuleyo" womzimba womntu, isongela kakhulu impilo yabantu abakwiminyaka ephakathi kunye nabantu abadala, ingakumbi abafazi abasele beyekile ukuya exesheni. Phantsi kweemeko eziqhelekileyo zomzimba, ukuhlaziywa kwamathambo kukwimeko elungeleleneyo; kodwa xa kukho ukungalingani phakathi kokwakheka kwamathambo okubangelwa yi-osteoblast kunye nokufunxwa kwamathambo okubangelwa yi-osteoclast, kwaye ubungakanani bamathambo abunayo ayanelanga ukongeza ubunzima bamathambo obufunxiweyo, ubunzima bamathambo buya kuncipha. , isakhiwo sezicubu zamathambo siyatshatyalaliswa, nto leyo ebangela i-osteoporosis.
I-7,8-Dihydroxyflavone (7,8-DHF) yi-flavonoid efumaneka kwizityalo enokulinganisa umsebenzi we-brain-derived neurotrophic factor (BDNF), ikhuthaze i-dimerization ye-TrkB receptors kwaye isebenze iimolekyuli zayo zesignali ezisezantsi. Izifundo zibonise ukuba i-BDNF inokukhuthaza ukwahluka kwe-osteoblast kunye nokufuduka kwayo kwaye ikhawulezise ukuphiliswa kwamathambo.
I-7,8-DHF inokukhuthaza ukwanda kunye nokwahluka kwee-osteoblast ngokusebenzisana ne-TrkB kunye nokusebenzisa indlela yokubonisa ye-Wnt/β-catenin, kwaye inokuthintela ukuveliswa kwee-osteoclasts ngokunciphisa i-transcription factor c-fos; ukongeza, i-7,8-DHF inokuphucula i-osteoporosis phenotype kwiigundane ezifakwe kwi-ovariectomized.
Ulwakhiwo lweekhemikhali kunye neempawu ze-7,8-dihydroxyflavone
Iqulethe amaqela amabini e-hydroxyl kwiringi ye-benzene kunye neqela elinye le-hydroxyl kwiringi ye-pyrrolone. Makhe sijonge ngokusondeleyo ulwakhiwo lweekhemikhali lwe-7,8-dihydroxyflavone:
Ifomula yemolekyuli ye-7,8-DHF yi-C15H10O5, ebonisa ukuba inee-athomu zekhabhoni ezili-15, ii-athomu ze-hydrogen ezili-10, kunye nee-athomu ze-oksijini ezi-5.
I-7,8-Dihydroxyflavone yikristale etyheli eqinileyo enobunzima bemolekyuli obuyi-286.24 g/mol. Inyibilika kancinci emanzini ngenxa yamaqela amaninzi e-hydroxyl anokudibanisa i-hydrogen kwiimolekyuli zamanzi.
7,8-DHF indlela yokusebenza: Ulawulo lwe-BDNF kunye nokusebenza kwe-Trkb receptor
Ngokuphathelele indlela yokusebenza, i-7,8-DHF yaziwa ngokukhuthaza ukuveliswa kwe-BDNF (i-neurotrophic factor efumaneka ebuchotsheni) ngokubophelela nakwi-receptor yayo i-TrkB. Ngaphandle kokusebenzisa ubuchwepheshe kakhulu, oku kukhokelela kuthotho lwemisebenzi yeselula eluncedo ekugcineni ukusebenza kakuhle kwe-neuronal kunye nokukhuthaza i-neurogenesis.
Makhe sijonge ngokusondeleyo indlela ephambili yokusebenza ye-7,8-DHF ngezantsi.
I-Brain-derived neurotrophic factor (BDNF) kunye nendima yayo kwi-neuroplasticity
Ngokufumanisa ukuba ukubonakaliswa kwe-neurotrophic factor (BDNF) efunyenwe ebuchotsheni kunciphisa kwizifo ze-neurodegenerative, ingakumbi isifo sika-Alzheimer (AD), ukubaluleka kwaso ekugcineni nasekuphuculeni impilo yengqondo kuya kubonakala ngakumbi.
I-BDNF ibalulekile kwimisebenzi eyahlukeneyo ye-neuronal njengoko ikhuthaza ukudluliselwa kwe-synaptic, i-synaptogenesis, kunye ne-synaptic plasticity ngokusebenzisa i-signaling kunye ne-TrkB receptors. Oku kwenza indlela ye-BDNF-TrkB signaling ibe yindawo ethembisayo yophuhliso lweendlela zonyango ezijolise ekulweni nezifo ze-neurodegenerative.
Izifundo zakutshanje zihlolisise iingenelo ezinokubakho zemolekyuli encinci i-TrkB agonist 7,8-dihydroxyflavone (7,8-DHF) ekunciphiseni iziphumo zokuqala zesifo esinxulumene ne-AD. Kuphononongo lwemodeli yegundane ye-5xFAD ye-AD, iimpuku zanyangwa nge-7,8-DHF kangangeenyanga ezimbini ukususela kwinyanga enye ubudala.
Iziphumo zolu phando zibonisa amandla okunyanga e-7,8-DHF ekujongeni utshintsho lwe-neurochemical olunxulumene ne-AD kunye neempawu ze-pathological. Okuphawulekayo kukuba, unyango lwe-7,8-DHF lubangele ukwehla kokubekwa kwe-cortical Aβ plaque, uphawu oluphambili lwe-AD.
Ngaphezu koko, ikhusela ii-neurons ze-cortical ekunciphiseni ubunzima be-dendritic arbor, inceda ukugcina ulwakhiwo lwe-neuronal iyonke. Nangona kunjalo, ayizange ichaphazele kakhulu uxinano lomqolo we-dendritic.
Ngokutsho kuka-Aytan, uNurgul nabanye, olu nyango lukwabonise nemiphumo yokukhusela imithambo-luvo kwi-hippocampus, luthintela amanqanaba aphezulu eekhompawundi ezine-choline kwaye lunciphisa ukulahleka kwe-glutamate.
Indlela yokubonisana ye-receptor ye-Tropomyosin receptor kinase B (Trkb)
Ngowama-2010, iqela likaNjingalwazi uYe Keqiang weYunivesithi yase-Emory labika okokuqala kwiProceedings of the National Academy of Sciences (PNAS) ukuba i-7,8-DHF ingasetyenziswa njenge-molecule encinci ethile ye-tropomyosin receptor kinase B (TrkB), enokulinganisa umsebenzi we-brain-derived neurotrophic factor (BDNF) ovuselela iindlela zokubonisana ezisezantsi kwe-TrkB, ezifana ne-MAPK/ERK, PI3K/Akt kunye ne-PKC. Ngaphezu koko, izifundo ezilandelayo zifumanise ukuba i-7,8-DHF inokunciphisa ukutyeba okubangelwa kukutya okunamafutha amaninzi kwiimpuku zabasetyhini ngokusebenzisa i-skeletal muscle TrkB, nto leyo ebonisa umahluko omkhulu ngokwesini.
I-neurotrophic factor (BDNF) efumaneka ebuchotsheni inokukhuthaza ukwahluka kwe-osteoblast, ukufuduka kunye nokuphiliswa kwamathambo. I-BDNF lilungu losapho lwe-neurotrophic factor kwaye ilawula iinkqubo ezahlukeneyo zebhayoloji ngokuyintloko ngokubophelela kwi-transmembrane receptor tyrosine kinase B (TrkB). Nangona kunjalo, isignali ye-TrkB ebangelwe yi-BDNF yayidlula kwimizuzu eli-10 kwaye yafikelela kwincopho kwimizuzu engama-60. Nangona kunjalo, i-BDNF inobomi obufutshane obufutshane kwaye ayinakunqumla lula umqobo wegazi-ingqondo.
I-7,8-dihydroxyflavone (7,8-DHF) yi-flavonoid ephuma kwizityalo ekwaziyo ukoyisa imida engentla ye-BDNF kwaye ichongiwe njenge-mimetic esebenzayo ye-BDNF kwaye ngoku isetyenziswa kwiinkqubo ezahlukeneyo ze-biochemical kunye neeseli. Kwaqinisekiswa ukuba inokubangela i-TrkB dimerization kwaye isebenze iimolekyuli zayo zokubonisa ezisezantsi.
I-receptor ye-tropomyosin receptor kinase B (TrkB) idlala indima ebalulekileyo ekulawuleni iziphumo ze-BDNF kwii-neurons. Njenge-receptor ye-transmembrane tyrosine kinase, i-TrkB yi-receptor ephambili ye-BDNF kwaye iqala uluhlu lweziganeko zokubonisa ngaphakathi kweseli xa zibotshelelwa kwizinto ze-neurotrophic.
I-BDNF isebenzisa i-TrkB ukuze iqalise iindlela ezininzi eziphambili zangaphakathi kweseli, kuquka i-phosphatidylinositol 3-kinase (PI3K)-Akt, i-mitogen-activated protein kinase (MAPK)-extracellular signal-regulated kinase (ERK), kunye ne-phospholipase Cγ (PLCγ)-protein kinase C (PKC). Ngayinye kwezi ndlela inegalelo kwinkalo eyahlukileyo yomsebenzi we-neuronal kunye nokuphila kakuhle.
Indlela ye-PI3K-Akt ibalulekile ekukhuthazeni ukusinda kwe-neuronal kunye nokuthintela i-apoptosis. I-BDNF-TrkB signaling ivuselela le ndlela ukuze inyuse ukusinda kweseli ngokuthintela izinto ezibangela i-apoptotic kunye nokuvuselela izinto ezichasene ne-apoptotic, ngaloo ndlela iqinisekisa ukugcinwa kwee-neurons eziphilileyo.
Kwelinye icala, indlela ye-MAPK-ERK idlala indima ebalulekileyo ekuhlukaniseni nasekukhuleni kwe-neuronal. Umqondiso we-BDNF-TrkB ukhuthaza ukusebenza kwendlela ye-MAPK-ERK, nto leyo exhasa ukuvuthwa kunye nokwahlukana kwe-neuronal kunye nokuhlanganiswa kwayo kwiinethiwekhi ze-neuronal ezikhoyo.
Indlela ye-PLCγ-PKC ibalulekile ekulawuleni i-synaptic plasticity, inkqubo esisiseko yokufunda kunye nenkumbulo. I-BDNF-TrkB signaling ilawula umsebenzi wale ndlela, ekugqibeleni ikhokelele kutshintsho kumandla e-synaptic kunye noqhagamshelwano.
Olu hlengahlengiso lukhuthaza uhlengahlengiso kunye nokuhlelwa kwakhona kweesekethe ze-neural ukuphendula kumava amatsha kunye nezinto ezikhuthaza okusingqongileyo.
Iipropati zokukhusela i-neuroprotective
Uphando lubonisa ukuba le flavonoid ikhusela ii-neurons kwi-oxidative stress kunye ne-apoptosis (ukufa kweeseli okucwangcisiweyo). Uxinzelelo lwe-oxidative luyinto ebalulekileyo kwizifo ze-neurodegenerative ezifana nesifo sika-Alzheimer kunye nesifo sikaParkinson. Ngokususa ii-free radicals kunye nokunciphisa umonakalo we-oxidative, i-7,8-DHF inokunceda ukukhusela ukuqina kwe-neuron kunye nokusebenza kwayo.
Kwizifundo zezilwanyana, i-7,8-DHF ibonakalisiwe ukuba iphucula ukusebenza kwengqondo kunye nenkumbulo. Umzekelo, kwiimodeli zesifo sika-Alzheimer, i-7,8-DHF ibonakalisiwe ukuba iphucula i-synaptic plasticity, ebaluleke kakhulu ekufundeni nasekukhumbuleni. Indlela yokusebenza
Isiphumo sokuchasana nokuvuvukala
Ukongeza kwiipropati zayo zokukhusela imithambo-luvo, i-7,8-dihydroxyflavone ikwanazo neziphumo zokulwa nokuvuvukala. Ukudumba okungapheliyo luphawu oluqhelekileyo lwezifo ezininzi, kuquka nezifo eziwohlokayo kwimithambo-luvo. Ngokuguqula iindlela zokudumba, i-7,8-DHF inokunceda ukunciphisa ukudumba kwemithambo-luvo, okuhlala kunxulunyaniswa nokuwohloka kwengqondo.
Iipropati ze-Antioxidant: Ukususa i-ROS kunye ne-lipid peroxidation
I-7,8-DHF ineempawu ze-antioxidant njengoko kubonakaliswa kukukwazi kwayo ukususa ii-reactive oxygen species (ROS) kunye nokunciphisa i-lipid peroxidation. Ezi ziphumo zinegalelo kwimiphumo yayo yokukhusela i-neurological ngokunciphisa umonakalo kunye nokungasebenzi kakuhle kwe-neuronal okubangelwa luxinzelelo lwe-oxidative.
Izifundo zibonise ukuba i-7,8-DHF ithintela ukuveliswa kwee-cytokines ezibangela ukuvuvukala kwaye inciphisa ukusebenza kwe-microglia, iiseli zomzimba kwinkqubo yemithambo-luvo ephakathi. Esi siphumo sokulwa nokuvuvukala asigcini nje ngokukhusela ii-neurons kodwa sikwadala imeko-bume efanelekileyo yokusebenza kwengqondo.
Ngenxa yemiphumo yayo emihle kwimpilo yengqondo, i-7,8-dihydroxyflavone inokusetyenziswa kwiindawo ezahlukeneyo zempilo kunye namayeza. Ezinye zezona zinto zidumileyo ziquka:
Ukuhlanganiswa kwememori kunye nokugcinwa kwayo
I-7,8-DHF ifunyenwe iphucula ukuhlanganiswa kwememori kunye nokubuyiswa kwayo kwimisebenzi eyahlukeneyo yokufunda kunye nememori exhomekeke kwi-hippocampal kwiimodeli zeempuku. Ezi ziphumo zibonisa ukuba i-7,8-DHF isenokuba yi-nootropic ethembisayo yokuphucula ukusebenza kwememori kubantu abasempilweni kunye nabo bane-memory impairment.
I-synaptic plasticity: amandla okuhlala ixesha elide kunye nokudakumba
Njengoko bekutshiwo ngaphambili, i-7,8-DHF ibonakalisiwe ukuba iguqula i-synaptic plasticity ngokunyusa i-LTP kunye nokunciphisa i-LTD kwi-hippocampus. Ezi ziphumo kucingelwa ukuba zibangelwa kukukwazi kwayo ukwenza ii-receptors ze-TrkB zisebenze kwaye emva koko ziphucule indlela yokubonisa i-BDNF.
Olu hlengahlengiso lwe-synaptic plasticity lunegalelo ekuphuculweni komsebenzi wokuqonda obonwa emva kokulawulwa kwe-7,8-DHF.
Ukuphuculwa kwengqondo
Njengoko bekutshiwo ngaphambili, i-7,8-DHF ibonisa amandla okuphucula ukusebenza kwengqondo kunye nenkumbulo. Oku kuyenza ibe yeyona nto ifanelekileyo kwizongezo ezijolise ekuphuculeni ukusebenza kwengqondo, ingakumbi kubantu abadala okanye abantu abanengxaki yokuphazamiseka kwengqondo.
Ukufunxa, Ukusasazwa, iMetabolism, kunye nokuKhupha (ADME): I-7,8-DHF ibonisa iipropati ezilungileyo ze-pharmacokinetic, kubandakanya ukufunxa ngokukhawuleza, ukusasazwa ngokubanzi, kunye nokungena kakuhle kwengqondo. Isetyenziswa kakhulu sisibindi, uninzi lwekhompawundi lukhutshwa kwindle kwaye inani elincinci likhutshwa kumchamo.
Ukungena komqobo wegazi nobuchopho kunye nokungena kwezicubu zobuchopho. Enye yeempawu eziphambili ze 7,8-DHFkukukwazi kwayo ukunqumla umqobo wegazi-ubuchopho (i-BBB) ize ingene kwizicubu zobuchopho, nto leyo ibalulekileyo ekusebenzeni kwayo njenge-nootropic.
Iprofayili yoKhuseleko lwangaphambi kweklinikhi - Izifundo zobuTyhefu obubukhali nobungapheliyo: Izifundo zokhuseleko lwangaphambi kweklinikhi zibonise ukuba i-7,8-DHF ineprofayili yokhuseleko elungileyo, ngaphandle kwemiphumo emibi ebalulekileyo ebonwe kwizifundo zobuTyhefu obubukhali nobungapheliyo kwiimpuku. Nangona kunjalo, uvavanyo olongezelelweyo lokhuseleko, kubandakanya nezifundo kwizilwanyana eziphezulu kunye nabantu, luyafuneka ukuze kuqinisekiswe ukhuseleko lwayo ekusetyenzisweni kweklinikhi.
Nangona izifundo zangaphambi konyango zibonise ukuba i-7,8-DHF ineprofayili yokhuseleko efanelekileyo, iziphumo ebezingalindelekanga ezinokubakho kubantu azikaziwa kangako. Njengakweyiphi na i-compound entsha, kufuneka kuqatshelwe kwaye iziphumo ezimbi ezinokubakho zijongwe xa kuvavanywa ukusetyenziswa kwayo ebantwini.
Ngokuxhomekeke kwindlela esebenza ngayo i-7,8-DHF kunye neziphumo zayo kwii-receptors ze-TrkB, ezinye iziphumo ebezingalindelekanga ezinokunxulunyaniswa ne-7,8-DHF zingabandakanya:
Intloko ebuhlungu: Ukusebenza kwe-BDNF kunye ne-TrkB receptor kulawula umsebenzi we-neuronal kunye nokuvuseleleka; ukunikwa kwe-7,8-DHF kunokubangela iintloko ezibuhlungu kwabanye abantu.
Ukungalali: Ukwanda komsebenzi we-neuronal kunye nokuqina kwe-synaptic kunokuchaphazela iipatheni zokulala, okunokubangela ukungalali okanye ukuphazamiseka kokulala.
Iingxaki zesisu: Njengeekhompawundi ezininzi ezisebenzayo kwi-bioactive, i-7,8-DHF inokubangela iziphumo ebezingalindelekanga zesisu, ezifana nokucaphuka, ukuhlanza, okanye urhudo kwabanye abantu.
Kubalulekile ukuqaphela ukuba ezi ziphumo ebezingalindelekanga kufuneka zifundwe ngakumbi kwiimvavanyo zeklinikhi. Ngenxa yokuba ikwazi ukuguqula i-BDNF signaling kunye nokusebenza kwe-TrkB receptor, kufuneka kuqatshelwe xa kuhlanganiswa i-7,8-DHF kunye nezinye iziyobisi ezijolise kwezi ndlela okanye ezineendlela ezifanayo zokusebenza.
Njengekhompawundi ebalulekileyo, i-7,8-Dihydroxyflavone itsale ingqalelo enkulu ngenxa yemisebenzi yayo eyahlukileyo yebhayoloji. Kubaphandi bezenzululwazi kunye namashishini, kubalulekile ukufumana i-7,8-Dihydroxyflavone Powder ekumgangatho ophezulu. I-7,8-Dihydroxyflavone Powder ebonelelwa yiSuzhou Myland inenombolo ye-CAS engu-38183-03-8 kunye nobunyulu obufikelela kwi-98%. Imveliso ilawulwa ngokungqongqo komgangatho kwaye ihambelana nemigangatho yamazwe ngamazwe, iqinisekisa ukusebenza kakuhle kunye nokhuseleko lwemveliso. , ifanelekile kuphando lwesayensi, uphuhliso lwamayeza, ukuveliswa kwemveliso yokhathalelo lwempilo kunye nezinye iinkalo, ikunika ukhetho oluthembekileyo.
Ukuqinisekisa umgangatho
Siyazi ukuba umgangatho weemveliso zethu uchaphazela ngokuthe ngqo uphando lwabathengi bethu kunye neziphumo zesicelo. Ke ngoko, iSuzhou Myland ilandela ngokungqongqo imigangatho ye-GMP (iGood Manufacturing Practice) kunye ne-ISO ngexesha lenkqubo yemveliso ukuqinisekisa uzinzo kunye nokuhambelana kwebhetshi nganye yeemveliso. Ukongeza, iqela lethu le-R&D liyaqhubeka nokwenza izinto ezintsha zobuchwepheshe kwaye lizama ukuphucula umgangatho wemveliso kunye nokusebenza kwayo rhoqo.
Inkonzo eyenzelwe
I-Suzhou Myland ayiboneleli nje kuphela ngeemveliso ezikumgangatho ophezulu, kodwa ikwanika ingqalelo kwiimfuno zabathengi. Sineqela lenkxaso yobugcisa elinobuchule elinokubonelela abathengi ngeengcebiso zokusetyenziswa kwemveliso kunye nesikhokelo sobugcisa ukunceda abathengi bafumane iziphumo ezingcono kuphando kunye nokusetyenziswa kwayo. Nokuba kukuvavanya okuncinci okanye ukuvelisa okukhulu, sinokubonelela ngezisombululo eziguquguqukayo ukuhlangabezana neemfuno zabathengi abahlukeneyo.
Indlela yokufumana i-7,8-Dihydroxyflavone Powder
Ukuba ujonge i-7,8-Dihydroxyflavone Powder ekumgangatho ophezulu, iSuzhou Myland yeyona ifanelekileyo kuwe. Ungaqhagamshelana nathi ngale ndlela:
Iwebhusayithi esemthethweni: Ndwendwela iwebhusayithi esemthethweni yeSuzhou Myland ukuze ufunde okungakumbi ngolwazi lwemveliso kunye nenkxaso yobugcisa.
Ukubonisana kwi-intanethi: Nxibelelana ngokuthe ngqo neqela lethu lenkonzo yabathengi ngokusebenzisa umsebenzi wokubonisana kwi-intanethi obonelelwa yiwebhusayithi ukuze ufumane ulwazi lwemveliso kunye neekowuteshini ozifunayo.
Umnxeba: Fowunela inombolo yethu yoqhagamshelwano ukuze unxibelelane nabasebenzi abangoochwephesha bokuthengisa kwaye ufumane ulwazi oluneenkcukacha ngemveliso kunye neengcebiso zokuthenga.
Uphando nge-imeyile: Ungasicela ulwazi ngemveliso nge-imeyile, kwaye siya kukuphendula ngokukhawuleza.
Ukuququmbela
Njengekhompawundi ebalulekileyo enemisebenzi eyahlukeneyo yebhayoloji, i-7,8-Dihydroxyflavone iya isiba yinxalenye ebalulekileyo kuphando lwesayensi kunye nokusetyenziswa kwemizi-mveliso. I-7,8-Dihydroxyflavone Powder ecocekileyo kakhulu enikezelwa yiSuzhou Myland iya kubonelela ngenkxaso enamandla kuphando lwakho kunye nophuhliso lwemveliso ngomgangatho wayo ogqwesileyo kunye nenkonzo ethembekileyo. Silangazelela ukusebenza nawe ukuze sihlolisise ezinye iindlela zokusetyenziswa kwe-7,8-Dihydroxyflavone.
Q: Yintoni i-7,8-dihydroxyflavone?
I-A:7,8-Dihydroxyflavone yi-flavonoid yendalo eyaziwa ngokuba neempawu zayo zokukhusela imithambo-luvo kwaye ifundwa ngemiphumo yayo ekusebenzeni kwengqondo kunye nokuphucula imood.
Q: Zeziphi iingenelo ezinokubakho ze-7,8-dihydroxyflavone?
A: Uphando lubonisa ukuba i-7,8-dihydroxyflavone inokunceda ukuphucula inkumbulo, ukunciphisa ixhala, kunye nokuthintela izifo eziwohlokayo kwimithambo-luvo. Iimpawu zayo ze-antioxidant zinokukhuthaza impilo iyonke ngokulwa noxinzelelo lwe-oxidative.
Q: Ingakanani i-bioavailability ye-7,8-DHF?
A: Ukufumaneka kwe-7,8-dihydroxyflavone (7,8-DHF) kwizifundo zezilwanyana malunga ne-5% (kwiimpuku) ngenxa yokunyibilika kwayo okungekuhle kunye nemetabolism ekhawulezayo. Nangona ifumaneka kancinci, i-7,8-DHF isenokuthi idlule kumqobo wegazi-ubuchopho kwaye ichaphazele ingqondo. Kufuneka uphando olongezelelekileyo ukuze kuchongwe ukufumaneka kwayo ebantwini kunye neendlela zokuyiphucula.
Q: Ikwenza uzive njani i-7,8-DHF?
A: Njenge-nootropic, i-7,8-dihydroxyflavone (7,8-DHF) inefuthe elihle ekusebenzeni kwengqondo nakwimo yengqondo. Abantu bafumana inkumbulo engcono, ukugxila okuphezulu, kunye nezakhono zokufunda eziphuculweyo.
Isikhanyeli: Eli nqaku lenzelwe ulwazi oluqhelekileyo kuphela kwaye akufuneki lithathwe njengengcebiso yezonyango. Olunye ulwazi lweposi yebhlog luvela kwi-Intanethi kwaye alungobungcali. Le webhusayithi inoxanduva lokuhlela, ukufomatha kunye nokuhlela amanqaku kuphela. Injongo yokudlulisa ulwazi oluthe kratya ayithethi ukuba uyavumelana nezimvo zayo okanye uqinisekisa ubunyani bomxholo wayo. Soloko uqhagamshelana neengcali zezempilo ngaphambi kokusebenzisa naziphi na izongezo okanye ukwenza utshintsho kwindlela yakho yokhathalelo lwempilo.
Ixesha leposi: Oktobha-14-2024
