I-7,8-Dihydroxyflavone (7,8-DHF) yi-flavonoid eyenzeka ngokwemvelo ebonisa isithembiso kwiindawo ezahlukeneyo zempilo. Ukuba unomdla kwizongezo zendalo okanye izithako zokutya ezinokuxhasa impilo yengqondo, isimo sengqondo, kunye nokuphila kakuhle, i-7,8-DHF inokufaneleka ukuhlola. I-7,8-Dihydroxyflavone Powder enikezwe nguSuzhou Myland inenombolo ye-CAS ye-38183-03-8 kunye nokuhlambuluka ukuya kwi-98%. Imveliso iphantsi kolawulo olungqongqo lwekhwalithi kwaye ihambelana nemigangatho yamazwe ngamazwe, iqinisekisa ukusebenza kakuhle kunye nokhuseleko lwemveliso. , ilungele uphando lwezenzululwazi, ukuphuhliswa kweziyobisi, ukuveliswa kwemveliso yokhathalelo lwempilo kunye nezinye iinkalo, ukubonelela ngokukhetha okuthembekileyo.
7,8-Dihydroxyflavone (7,8-DHF)yinkompawundi yeflavonoid enqabileyo ngokwendalo eyenzeka ngokwendalo. Ifunyenwe kwi-Astragalus pumila, i-Primula grandifolia kunye ne-Hubei crabapple. kuye kwavela njengento ethembisayo ye-nootropic. Ibonise uluhlu lweziphumo ze-neuropharmacological kwizifundo zangaphambili,
I-Flavonoids yiklasi yeekhompawundi ze-polyphenolic ezifumaneka kwiintlobo ngeentlobo zeziqhamo, imifuno, kunye neminye imithombo yezityalo. Kwiminyaka yakutshanje, baye bafumana ingqalelo enkulu ngenxa ye-antioxidant, anti-inflammatory, kunye ne-neuroprotective properties.
Ezi khompawundi zibonakaliswe ukuba zineziphumo eziluncedo kwingqondo, kubandakanya nokuphucula ukusebenza kwengqondo kunye nokuthintela izifo ze-neurodeergenerative. I-7,8-DHF yenye yezona zinto zibalaseleyo ze-polyphenolic compounds ezifumana ingqalelo ekhulayo njenge-nootropic. Ifundwe ngeziphumo zayo ezinokubakho kwimeko, inkumbulo, ukufunda, ukuxhalaba, kunye neminye imisebenzi yokuqonda.
Imiphumo ye-neurological ye-7,8-DHF icingelwa ukuba idibene ngokubambisana kwayo kunye ne-receptors ethile. Kufunyenwe ukuba yi-TrkA, i-receptor ebandakanyekayo kwi-nerve factor factor signaling kwaye ibalulekile kwi-neuronal survival and plasticity.
I-7,8-DHF yenza ngokulawula ukubonakaliswa kwee-receptors ezahlukeneyo, kuquka i-glutamate receptor subunits kunye ne-BDNF. Ikwachaphazela ukubunjwa kwe-synapse, i-metabolism yamandla, kunye nokukhululwa kwe-acetylcholine kwiindawo ezithile zengqondo.
Ukongeza, i-osteoporosis yaziwa ngokuba "ngumbulali othuleyo" womzimba womntu, esongela kakhulu impilo yabantu abaneminyaka ephakathi kunye nabasele bekhulile, ngakumbi abafazi be-postmenopausal. Ngaphantsi kweemeko eziqhelekileyo ze-physiological, ukulungiswa kwamathambo kukwimeko elinganayo; kodwa xa kukho ukungalingani phakathi kwe-osteoblast-mediated bone formation kunye ne-osteoclast-mediated bone resorption, kwaye inani lethambo elibunjiweyo alinakwanela ukuncedisa ithambo elifunliweyo, ubunzima bamathambo buya kuncipha. , i-microstructure yezicubu zethambo iyatshatyalaliswa, ibangela i-osteoporosis.
I-7,8-Dihydroxyflavone (i-7,8-DHF) i-flavonoid ephuma kwisityalo ekwazi ukulinganisa umsebenzi wengqondo ephuma kwi-neurotrophic factor (BDNF), ibangele i-dimerization ye-TrkB receptors kwaye isebenze i-athomu yayo yomqondiso ezantsi. Izifundo zibonise ukuba i-BDNF inokukhuthaza ukuhlukana kwe-osteoblast kunye nokufuduka kunye nokukhawulezisa ukuphulukiswa kwe-fracture.
I-7,8-DHF inokukhuthaza ukwanda kunye nokuhlukana kwe-osteoblasts ngokusebenzisana ne-TrkB kunye nokuvula indlela yokubonisa i-Wnt / β-catenin, kwaye inokuthintela ukuveliswa kwe-osteoclasts ngokunciphisa i-transcription factor c-fos; ukongeza, i-7, i-8-DHF inokuphucula i-osteoporosis phenotype kwiigundane ze-ovariectomized.
Ubume beMichiza kunye neempawu ze-7,8-dihydroxyflavone
Iqulethe amaqela amabini e-hydroxyl kwiringi ye-benzene kunye neqela elinye le-hydroxyl kwiringi ye-pyrrolone. Makhe sijonge ngakumbi kubume bekhemikhali ye-7,8-dihydroxyflavone:
I-molecular formula ye-7,8-DHF yi-C15H10O5, ebonisa ukuba iqukethe i-athomu ye-carbon ye-15, i-athomu ye-hydrogen eyi-10 kunye ne-athomu ye-oksijini ye-5.
I-7,8-Dihydroxyflavone i-crystalline ephuzi eqinile kunye nobunzima be-molecular 286.24 g / mol. Inyibilika kancinane emanzini ngenxa yamaqela amaninzi e-hydroxyl anokudibanisa i-hydrogen kwiimolekyuli zamanzi.
7,8-DHF Indlela yokusebenza: Ukulawulwa kwe-BDNF kunye nokusebenza kwe-Trkb receptor
Ngokwendlela yokusebenza, i-7,8-DHF iyaziwa ngokukhuthaza ukuveliswa kwe-BDNF (i-brain-derived neurotrophic factor) ngokuzibophelela kunye nokuvula i-receptor yayo ye-TrkB. Ngaphandle kokufumana ubuchwephesha kakhulu, oku kukhokelela kwi-cascade yemisebenzi yeselula eluncedo ekugcineni umsebenzi ofanelekileyo we-neuronal kunye nokukhuthaza i-neurogenesis.
Makhe sijonge ngakumbi kwi-7,8-DHF eyona ndlela yokwenza ngezantsi.
I-brain-derived neurotrophic factor (BDNF) kunye nendima yayo kwi-neuroplasticity
Ngokufumanisa ukuba i-brain-derived neurotrophic factor (BDNF) ibonakaliso iyancitshiswa kwizifo ze-neurodeergenerative, ngakumbi isifo se-Alzheimer's (AD), ukubaluleka kwayo ekugcineni kunye nokuphucula impilo yengqondo kuya kubonakala ngokucacileyo. .
I-BDNF ibaluleke kakhulu kwimisebenzi eyahlukeneyo ye-neuronal njengoko ikhuthaza ukuhanjiswa kwe-synaptic, i-synaptogenesis, kunye ne-synaptic plasticity ngokusebenzisa izibonakaliso kunye ne-TrkB receptors. Oku kwenza ukuba i-BDNF-TrkB ibonise indlela yomqondiso ekujoliswe kuyo ekujoliswe kuyo ekuphuhliseni ukungenelela kwonyango olujoliswe ukulwa nezifo ze-neurodeergenerative.
Uphononongo lwakutsha nje luye lwaphonononga kwiingenelo ezinokubakho ze-molecule encinci ye-TrkB agonist 7,8-dihydroxyflavone (7,8-DHF) ekunciphiseni iziphumo zokuqala ze-pathology enxulumene ne-AD. Kuphononongo lwe-5xFAD imodeli ye-mouse ye-AD, iigundane zaphathwa nge-7,8-DHF kwiinyanga ezimbini ziqala kwinyanga enye ubudala.
Iziphumo zolu phando zityhila amandla onyango e-7,8-DHF ekujonganeni nokuguqulwa kwe-neurochemical enxulumene ne-AD kunye namanqaku e-pathological markers. Ngokucacileyo, unyango lwe-7,8-DHF lubangele ukuthotywa kwe-cortical Aβ plaque, uphawu oluphambili lwe-AD.
Ngapha koko, ikhusela i-cortical neurons ekunciphiseni ubunzima be-dendritic arbor, inceda ukugcina ubume be-neuronal ngokubanzi. Nangona kunjalo, ayizange ichaphazele kakhulu i-dendritic spine density.
Ngokutsho kwe-Aytan, i-Nurgul kunye nabanye, unyango luye lwabonisa iziphumo ze-neuroprotective kwi-hippocampus, ukukhusela amanqanaba aphezulu e-choline-containing compounds kunye nokunciphisa ilahleko ye-glutamate.
I-Tropomyosin receptor kinase B (Trkb) indlela yokubonisa i-receptor
Kwi-2010, iqela likaNjingalwazi uYe Keqiang weYunivesithi yase-Emory libike okokuqala kwiiNkqubo zeSizwe zeSayensi zeSayensi (PNAS) ukuba i-7,8-DHF ingasetyenziselwa njenge-molecule encinci ye-agonist ye-tropomyosin receptor kinase B ( I-TrkB), enokuthi ifanise Umsebenzi we-brain-derived neurotrophic factor (BDNF) iqhubekisela phambili i-signing pathways ezantsi kwe-TrkB, njenge-MAPK / ERK, PI3K / Akt kunye ne-PKC. Ngaphezu koko, uphando olulandelayo lufumene ukuba i-7,8-DHF inokunciphisa ukutya okunamafutha aphezulu-okubangelwa ukutyeba kakhulu kwiigundane zabasetyhini ngokuvula i-skeletal muscle ye-TrkB, ebonisa ukungafani okukhulu kwesini.
I-brain-derived neurotrophic factor (BDNF) inokukhuthaza ukuhlukana kwe-osteoblast, ukufuduka kunye nokuphulukiswa kwe-fracture. I-BDNF ilungu lentsapho ye-neurotrophic factor kwaye ilawula iindidi zeenkqubo ze-biological ikakhulu ngokuzibophelela kwi-transmembrane receptor tyrosine kinase B (TrkB). Nangona kunjalo, i-BDNF-induced TrkB isignali yayidlula kwi-10 min kwaye iphakamileyo kwi-60 min. Nangona kunjalo, i-BDNF inobomi obufutshane obufutshane kwaye ayikwazi ukuwela ngokulula umqobo wegazi-ubuchopho.
I-7,8-dihydroxyflavone (7,8-DHF) yi-flavonoid ephuma kwisityalo ekwazi ukunqoba le mida engentla ye-BDNF kwaye ichongiwe njenge-BDNF mimetic esebenzayo kwaye ngoku isetyenziswa kwiinkqubo ezahlukeneyo ze-biochemical kunye neselula Kwaqinisekiswa ukuba inokwenza i-TrkB idimerization kwaye isebenze iimolekyuli zayo zokubonisa ezantsi.
I-tropomyosin receptor kinase B (TrkB) i-receptor idlala indima ebalulekileyo ekulungelelaniseni imiphumo ye-BDNF kwi-neurons. Njenge-transmembrane tyrosine kinase receptor, i-TrkB yi-receptor yokuqala ye-BDNF kwaye iqalisa i-cascade yeziganeko ze-intracellular signaling xa zibophelela kwizinto ze-neurotrophic.
I-BDNF yenza i-TrkB iqalise iindlela ezininzi eziphambili ze-intracellular, kubandakanywa i-phosphatidylinositol 3-kinase (PI3K) -Akt, i-protein kinase (MAPK) -extracellular signal-regulated kinase (ERK), kunye ne-phospholipase Cγ (PLCγ) -protein kinase ( PKC) indlela. Nganye yale ndlela inegalelo kwinkalo eyahlukileyo yomsebenzi we-neuronal kunye nokuphila kakuhle.
Indlela ye-PI3K-Akt ibalulekile ekukhuthazeni ukusinda kwe-neuronal kunye nokuthintela i-apoptosis. Ukubonakaliswa kwe-BDNF-TrkB kusebenze le ndlela yokwandisa ukusinda kweeseli ngokuthintela izinto ze-pro-apoptotic kunye nokuvuselela izinto ezichasene ne-apoptotic, ngaloo ndlela iqinisekisa ukugcinwa kwe-neurons enempilo.
Ngakolunye uhlangothi, indlela ye-MAPK-ERK idlala indima ebalulekileyo ekuhlukeni kwe-neuronal kunye nokwanda. Isibonakaliso se-BDNF-TrkB sikhuthaza ukusebenza kwendlela ye-MAPK-ERK, leyo ixhasa ukuvuthwa kwe-neuronal kunye nokwahlula kunye nokudibanisa kwabo kwiinethiwekhi ze-neuronal ezikhoyo.
Indlela ye-PLCγ-PKC ibalulekile ekulawuleni iplastiki ye-synaptic, inkqubo esisiseko yokufunda kunye nenkumbulo. I-BDNF-TrkB yokubonisa imodareyitha umsebenzi wale ndlela, ekugqibeleni ikhokelela ekutshintsheni amandla e-synaptic kunye nokudibanisa.
Olu hlengahlengiso lukhuthaza uhlengahlengiso kunye nohlengahlengiso lweesekethe ze-neural ekuphenduleni amava amatsha kunye nokuvuselela kokusingqongileyo.
Iimpawu ze-neuroprotective
Uphando lubonisa ukuba le flavonoid ikhusela i-neurons kuxinzelelo lwe-oxidative kunye ne-apoptosis (ukufa kweeseli ezicwangcisiweyo). Uxinzelelo lwe-oxidative luyinto ebalulekileyo kwizifo ze-neurodeergenerative ezifana ne-Alzheimer kunye nesifo sika-Parkinson. Ngokukhupha i-radicals yamahhala kunye nokunciphisa umonakalo we-oxidative, i-7,8-DHF inokunceda ukukhusela ingqibelelo ye-neuronal kunye nomsebenzi.
Kwizifundo zezilwanyana, i-7,8-DHF ibonakaliswe ukuphucula umsebenzi wokuqonda kunye nememori. Ngokomzekelo, kwiimodeli zesifo se-Alzheimer, i-7,8-DHF ibonakaliswe ukwandisa iplastiki ye-synaptic, ebaluleke kakhulu ekufundeni nasekukhumbuleni. Indlela yokwenza
I-Anti-inflammatory effect
Ukongeza kwiipropati zayo ze-neuroprotective, i-7,8-dihydroxyflavone nayo ineempembelelo ezichasayo. Ukuvuvukala okungapheliyo yinto eqhelekileyo yezifo ezininzi, kuquka izifo ze-neurodeergenerative. Ngokumodareyitha iindlela zokuvuvukala, i-7,8-DHF inokunceda ukunciphisa i-neuroinflammation, ehlala ihambelana nokuncipha kwengqondo.
Iimpawu ze-Antioxidant: I-ROS yokucoca kunye ne-lipid peroxidation
I-7,8-DHF inezakhiwo ze-antioxidant njengoko ibonakaliswe ngokukwazi ukukhupha iintlobo ze-oksijeni ezisebenzayo (ROS) kunye nokunciphisa i-lipid peroxidation. Ezi ziphumo zinegalelo kwiimpembelelo zayo ze-neuroprotective ngokunciphisa umonakalo we-neuronal we-oxidative kunye nokungasebenzi kakuhle.
Ucwaningo luye lwabonisa ukuba i-7,8-DHF inqanda ukuveliswa kwe-cytokines e-pro-inflammatory kunye nokunciphisa ukusebenza kwe-microglia, iiseli ze-immune kwinkqubo ye-nervous central. Esi siphumo sokuchasana nokudumba asikhuseli nje kuphela i-neurons kodwa sikwadala indawo efanelekileyo yokusebenza kwengqondo.
Ngenxa yeziphumo zayo eziluncedo kwimpilo yengqondo, i-7,8-dihydroxyflavone inezicelo ezinokubakho kwiindawo ezahlukeneyo zempilo kunye neyeza. Ezinye zezona zicelo zidumileyo ziquka:
Ukuqinisa inkumbulo kunye nokufunyanwa kwakhona
I-7,8-DHF ifunyenwe ukuphucula ukuhlanganiswa kwememori kunye nokufunyanwa kwiintlobo ezahlukeneyo zokufunda ezixhomekeke kwi-hippocampal kunye nemisebenzi yememori kwiimodeli ze-rodent. Ezi ziphumo zibonisa ukuba i-7,8-DHF ingaba yi-nootropic ethembisayo yokuphucula umsebenzi wememori kubantu ababini abaphilileyo kunye nabanokukhubazeka kwememori.
Iplastiki ye-Synaptic: amandla exesha elide kunye nokudakumba
Njengoko kukhankanyiwe ngaphambili, i-7,8-DHF iboniswe ukulungelelanisa iplastiki ye-synaptic ngokukhuthaza i-LTP kunye nokunciphisa i-LTD kwi-hippocampus. Ezi ziphumo zicingelwa ukuba zilungelelaniswe ngokukwazi kwayo ukwenza i-TrkB i-receptors isebenze kwaye emva koko iphucule indlela yokubonisa i-BDNF.
Oku kumodareyithwa kweplastiki ye-synaptic igalelo ekuphuculeni umsebenzi wokuqonda oqatshelwe emva kolawulo lwe-7,8-DHF.
Ukuphuculwa kwengqondo
Njengoko bekutshiwo ngaphambili, i-7,8-DHF ibonisa amandla okuphucula umsebenzi wokuqonda kunye nenkumbulo. Oku kuyenza ibe ngumgqatswa wezongezelelo ezijolise ekuphuculeni ukusebenza kwengqondo, ngakumbi kubantu abalupheleyo okanye abantu abanokuncipha kwengqondo.
I-Absorption, Distribution, Metabolism, and Excretion (ADME): I-7,8-DHF ibonisa iimpawu ezifanelekileyo ze-pharmacokinetic, kubandakanywa ukuxutywa ngokukhawuleza, ukusabalalisa ngokubanzi, kunye nokungena kwengqondo okusebenzayo. Ngokuyinhloko i-metabolized yisibindi, kunye neninzi yekhompawundi ekhutshwe kwi-feces kunye nexabiso elincinci elikhutshwe kumchamo.
Umqobo wegazi-ubuchopho obungangeni kunye nokungena kwezicubu zobuchopho. Enye yeempawu eziphambili ze 7,8-DHFkukukwazi ukuwela isithintelo segazi-ingqondo (BBB) kunye nokungena kwizicubu zobuchopho, ezibaluleke kakhulu ekusebenzeni kwayo njenge-nootropic.
Iprofayili yoKhuseleko lwe-Preclinical - Izifundo ze-Toxicity e-Acute and Chronic Toxicity: Izifundo zokhuseleko lwangaphambili zibonise ukuba i-7,8-DHF ineprofayili ekhuselekileyo yokhuseleko, ngaphandle kwemiphumo emibi ebalulekileyo ebonwa kwizifundo ezinobungozi kunye nezingapheliyo kwiigundane. Nangona kunjalo, uvavanyo olongezelelweyo lokhuseleko, kubandakanywa nezifundo kwizilwanyana eziphezulu kunye nezifundo zabantu, ziyafuneka ukuze kuqinisekiswe ukhuseleko lwayo ukusetyenziswa kweklinikhi.
Nangona uphando lwangaphambili lubonise ukuba i-7,8-DHF ineprofayili yokhuseleko olufanelekileyo, iziphumo ezinokuthi zibekho kwizifundo zabantu zihlala zingaziwa. Njengayo nayiphi na i-compound yenoveli, kufuneka kulumke kwaye kujongwe iziphumo ezingalunganga xa kuvavanywa ukusetyenziswa kwayo ebantwini.
Ngokuxhomekeke kwindlela ye-7,8-DHF yokusebenza kunye nemiphumo kwi-TrkB receptors, ezinye iziphumo ezinokuthi zidibanise ne-7,8-DHF zingabandakanya:
Intloko: I-BDNF kunye ne-TrkB i-receptor activation ilawula umsebenzi we-neuronal kunye no-excitability; Ukulawulwa kwe-7,8-DHF kunokubangela intloko ebuhlungu kwabanye abantu.
I-Insomnia: Ukwanda komsebenzi we-neuronal kunye ne-synaptic plasticity kunokuchaphazela iipatheni zokulala, ezinokukhokelela ekuphutheni okanye ukuphazamiseka kokulala.
Iingxaki zesisu: Njengezinye iikhompawundi ezininzi zebioactive, i-7,8-DHF inokubangela iziphumo ebezingalindelekanga zesisu, njengesicaphucaphu, ukugabha, okanye isifo sorhudo kwabanye abantu.
Kubalulekile ukuqaphela ukuba ezi ziphumo bezingalindelekanga kufuneka zifundwe ngakumbi kulingo lwezonyango. Ngenxa yokukwazi ukulungelelanisa ukubonakaliswa kwe-BDNF kunye ne-TrkB receptor activation, ukulumkisa kufuneka kusetyenziswe kwakhona xa kudibanisa i-7,8-DHF kunye nezinye iziyobisi ezijolise kule ndlela okanye zineendlela ezifanayo zokwenza.
Njengekhompawundi ebalulekileyo, i-7,8-Dihydroxyflavone iye yatsala ingqalelo enkulu ngenxa yemisebenzi yayo ekhethekileyo yezinto eziphilayo. Kubaphandi benzululwazi kunye namashishini, kubalulekile ukufumana umgangatho ophezulu we-7,8-Dihydroxyflavone Powder. I-7,8-Dihydroxyflavone Powder enikezwe nguSuzhou Myland inenombolo ye-CAS ye-38183-03-8 kunye nokuhlambuluka ukuya kwi-98%. Imveliso iphantsi kolawulo olungqongqo lwekhwalithi kwaye ihambelana nemigangatho yamazwe ngamazwe, iqinisekisa ukusebenza kakuhle kunye nokhuseleko lwemveliso. , ilungele uphando lwezenzululwazi, ukuphuhliswa kweziyobisi, ukuveliswa kwemveliso yokhathalelo lwempilo kunye nezinye iinkalo, ukubonelela ngokukhetha okuthembekileyo.
Ukuqinisekisa umgangatho
Siyazi ukuba umgangatho weemveliso zethu uchaphazela ngqo uphando lwabathengi bethu kunye neziphumo zezicelo. Ke ngoko, i-Suzhou Myland ilandela ngokungqongqo i-GMP (Uqheliselo oluLungileyo lweMveliso) kunye nemigangatho yesatifikethi se-ISO ngexesha lenkqubo yokuvelisa ukuqinisekisa ukuzinza kunye nokuhambelana kwebhetshi nganye yeemveliso. Ukongeza, iqela lethu le-R&D liyaqhubeka nokwenza izinto ezintsha zobuchwepheshe kwaye lizama ukuqhubeka nokuphucula umgangatho wemveliso kunye nokusebenza.
Inkonzo eyenzelwe
I-Suzhou Myland ayinikezeli kuphela iimveliso ezikumgangatho ophezulu, kodwa inika ingqalelo kwiimfuno zabathengi. Sineqela lenkxaso yezobugcisa elinokubonelela abathengi ngeengcebiso zokusetyenziswa kwemveliso kunye nesikhokelo sobugcisa ukunceda abathengi bafezekise iziphumo ezingcono kuphando kunye nesicelo. Ingaba uvavanyo oluncinci okanye imveliso enkulu, sinokunika izisombululo eziguquguqukayo ukuhlangabezana neemfuno zabathengi abahlukeneyo.
Indlela yokufumana i-7,8-Dihydroxyflavone Powder
Ukuba ukhangela umgangatho ophezulu we-7,8-Dihydroxyflavone Powder, iSuzhou Myland lukhetho lwakho olufanelekileyo. Ungaqhagamshelana nathi nge:
Iwebhusayithi esemthethweni: Ndwendwela iwebhusayithi esemthethweni yeSuzhou Myland ukufunda ngakumbi malunga nolwazi lwemveliso kunye nenkxaso yobugcisa.
Uthethwano lwe-Intanethi: Nxibelelana ngokuthe ngqo neqela lethu lenkonzo yabathengi ngokusebenzisa umsebenzi wokubonisana kwi-intanethi obonelelwe yiwebhusayithi ukufumana ulwazi lwemveliso kunye neekowuteshini ozifunayo.
Ukufowunela umnxeba: Fowunela inombolo yethu yoqhagamshelwano ukuze unxibelelane nabasebenzi abaziingcali zorhwebo kwaye ufumane ulwazi oluneenkcukacha ngemveliso kunye neengcebiso zokuthenga.
Umbuzo nge-imeyile: Unokuphinda usibuze ngolwazi lwemveliso nge-imeyile, kwaye siya kukuphendula ngokukhawuleza.
Ukuququmbela
Njengomxube obalulekileyo kunye noluhlu olubanzi lwemisebenzi yezinto eziphilayo, i-7,8-Dihydroxyflavone ngokuthe ngcembe ibe yinto ebalulekileyo kuphando lwezesayensi kunye nezicelo zoshishino. Ucoceko oluphezulu lwe-7,8-Dihydroxyflavone Powder olunikezelwe nguSuzhou Myland luya kunika inkxaso eqinile kuphando lwakho kunye nophuhliso lwemveliso kunye nomgangatho obalaseleyo kunye nenkonzo ethembekileyo. Sijonge phambili ekusebenzeni nawe ukuze sijonge ngakumbi izicelo ezinokwenzeka ze-7,8-Dihydroxyflavone.
Q:Yintoni i-7,8-dihydroxyflavone?
A: 7,8-Dihydroxyflavone yi-flavonoid eyenzeka ngokwemvelo eyaziwa ngokuba yi-neuroprotective properties kwaye iphononongwa ngemiphumo yayo ekusebenzeni kwengqondo kunye nokuphucula isimo sengqondo.
Q:Ziziphi iingenelo ezinokubakho ze-7,8-dihydroxyflavone?
A: Uphando lubonisa ukuba i-7,8-dihydroxyflavone inokunceda ukuphucula imemori, ukunciphisa ixhala, kunye nokukhusela izifo ze-neurodeergenerative. Iimpawu zayo ze-antioxidant zinokukhuthaza impilo yonke ngokulwa noxinzelelo lwe-oxidative.
Q:Yintoni i-bioavailability ye-7,8-DHF?
A: I-bioavailability ye-7,8-dihydroxyflavone (7,8-DHF) kwizifundo zezilwanyana malunga ne-5% (kwiimpuku) ngenxa yokunganyibiliki kwayo kunye nokukhawuleza kwemetabolism. Nangona i-bioavailability yayo iphantsi, i-7,8-DHF isenokuwela umqobo wegazi-ingqondo kwaye ichaphazele ingqondo. Uphando olongezelelweyo luyafuneka ukumisela ukubakho kwayo ebantwini kunye nokuphonononga iindlela zokuyiphucula.
Umbuzo: Ingaba i-7,8-DHF ikwenza uzive njani?
A: Njenge-nootropic, i-7,8-dihydroxyflavone (7,8-DHF) ineempembelelo ezintle ekusebenzeni kwengqondo kunye nomoya. Abantu ngabanye bafumana inkumbulo engcono, ukugxila okuphezulu, kunye nezakhono zokufunda eziphuculweyo.
Ukuziphendulela: Eli nqaku lelolwazi ngokubanzi kuphela kwaye akufanele lithathwe njengeliphi na icebiso lonyango. Olunye ulwazi lweposti yebhlog luvela kwi-Intanethi kwaye alunamsebenzi. Le webhusayithi inoxanduva kuphela lokuhlela, ukufomatha kunye nokuhlela amanqaku. Injongo yokudlulisa ulwazi olongezelelekileyo ayithethi ukuba uyavumelana neembono zayo okanye uqinisekise ubunyani bomxholo wayo. Soloko udibana nengcali yezempilo ngaphambi kokuba usebenzise naziphi na izongezo okanye wenze utshintsho kwirejimeni yokhathalelo lwempilo.
Ixesha lokuposa: Oct-14-2024
