Yintoni i-NAD+ kwaye kutheni uyidinga kwimpilo yakho?

Kwihlabathi elikhula rhoqo lempilo nokuphila kakuhle, i-NAD+ iye yaba ligama elidumileyo, itsala ingqalelo yoososayensi kunye nabathandi bezempilo ngokufanayo. Kodwa yintoni kanye kanye i-NAD+? Kutheni ibaluleke kangaka kwimpilo yakho? Masifunde ngakumbi ngolwazi olufanelekileyo ngezantsi!

Yintoni i-NAD+?

Igama lesayensi le-NAD yi-nicotinamide adenine dinucleotide. I-NAD+ ikhona kwiseli nganye yomzimba wethu. Yi-metabolite ephambili kunye ne-coenzyme kwiindlela ezahlukeneyo ze-metabolic. Ilawula kwaye ithatha inxaxheba kwiinkqubo ezahlukeneyo zebhayoloji. Ii-enzymes ezingaphezu kwama-300 zixhomekeke kwi-NAD+ ukuze isebenze.

I-NAD+sisifinyezo sesiNgesi seNicotinamide adenine dinucleotide. Igama layo elipheleleyo ngesiTshayina yi-nicotinamide adenine dinucleotide, okanye iCoenzyme I ngamafutshane. Njenge-coenzyme edlulisela ii-hydrogen ions, i-NAD+ idlala indima kwiinkalo ezininzi zemetabolism yomntu, kubandakanya i-glycolysis, i-Gluconeogenesis, umjikelo we-tricarboxylic acid, njl. Ezinye izifundo zibonise ukuba ukuncipha kwe-NAD+ kunxulumene nobudala, kwaye iindlela zomzimba ezilawulwa yi-NAD+ zinxulumene nokwaluphala, izifo zemetabolism, i-neuropathy kunye nomhlaza, kubandakanya ukulawula i-homeostasis yeseli, ii-sirtuins ezaziwa ngokuba yi-"longevity genes", ukulungisa i-DNA, iiproteni zosapho lwe-PARP ezinxulumene ne-necroptosis kunye ne-CD38 enceda ekudluliseleni i-calcium.

I-NAD+ isebenza njengebhasi yokuthutha, ithwala ii-electron ukusuka kwimolekyuli yeseli ukuya kwenye. Kunye ne-NADH, ithatha inxaxheba kwiimpendulo ezahlukeneyo ze-metabolic ngokusebenzisa i-electron exchange evelisa i-adenosine triphosphate (ATP), imolekyuli "yamandla" yomzimba.

Ngamafutshane, i-NAD+ ibalulekile ekugcineni impilo yomzimba kunye nokulinganisela. I-Metabolism, i-redox, ukugcinwa kunye nokulungiswa kwe-DNA, uzinzo lwezakhi zofuzo, ukulawulwa kwe-epigenetic, njl. zonke zifuna inxaxheba ye-NAD+.

Ngoko ke, imizimba yethu ifuna kakhulu i-NAD+. I-NAD+ iyaqhubeka idityaniswa, iqhekeka kwaye iphinda isetyenziswe kwiiseli ukugcina amanqanaba e-NAD+ eseli azinzileyo.

I-NAD+ yinxalenye ebalulekileyo yomsebenzi weseli kwaye ibandakanyeka ekunikezelweni kwamandla kunye nokulungiswa kwe-DNA, zombini ezi zinto zinxulumene kakhulu nokwaluphala okunempilo.

1) Isasazeke kakhulu kuzo zonke iiseli zomzimba womntu kwaye ithatha inxaxheba kumawaka eempendulo ze-biocatalytic. Ingakhuthaza imetabolism yeswekile, amafutha kunye nee-amino acids, kwaye ithathe inxaxheba ekuhlanganisweni kwamandla. Yi-coenzyme ebalulekileyo efunekayo emzimbeni womntu.

2) I-NAD+ yeyona substrate kuphela yee-enzymes ezisebenzisa i-coI (eyona substrate kuphela ye-enzyme yokulungisa i-DNA i-PARP, eyona substrate kuphela yeproteni yexesha elide i-Sirtuins, kwaye yeyona substrate kuphela ye-cyclic ADP ribose synthase CD38/157).

Nangona kunjalo, njengoko iminyaka ikhula, inqanaba le-NAD+ emzimbeni liyehla ngokukhawuleza. Liza kuncipha ngama-50% rhoqo emva kweminyaka engama-20. Phantse kwiminyaka engama-40 ubudala, umxholo we-NAD+ emzimbeni womntu yi-25% kuphela yoko bekukuko ebantwaneni.

Ukuba iiseli zomntu azinayo i-NAD+, ukungasebenzi kakuhle kwe-mitochondrial kuyancitshiswa, amandla okulungisa umonakalo we-DNA ayancitshiswa, kwaye usapho lweproteni yejini ende iSirtuin nalo alusebenzi, njl. Ezi zinto zimbi zinokukhokelela kwi-apoptosis, izifo zomntu, ukwaluphala kwanokufa.

Indima ye-NAD+ kwiMpilo yakho iyonke

Ukuthintela ukwaluphala

I-NAD+ igcina unxibelelwano lweekhemikhali phakathi kwe-nucleus kunye ne-mitochondria, kwaye unxibelelwano olubuthathaka luyimbangela ebalulekileyo yokwaluphala kweeseli.

I-NAD+ inokususa inani elikhulayo leekhowudi ze-DNA ezingalunganga ngexesha lokusetyenziswa kweeseli, igcine ukubonakaliswa okuqhelekileyo kweejini, igcine ukusebenza okuqhelekileyo kweeseli, kwaye inciphise ukuguga kweeseli zabantu.

Ukulungisa umonakalo we-DNA

I-NAD+ sisixhobo esibalulekileyo kwi-enzyme yokulungisa i-DNA i-PARP, enefuthe elikhulu ekulungisweni kwe-DNA, ukubonakaliswa kwezakhi zofuzo, uphuhliso lweeseli, ukusinda kweeseli, ukwakhiwa kwakhona kwee-chromosome, kunye nokuzinza kwezakhi zofuzo.

Yenza iproteni ehlala ixesha elide isebenze

IiSirtuin zihlala zibizwa ngokuba lusapho lweeproteni zobomi obude kwaye zidlala indima ebalulekileyo ekulawuleni imisebenzi yeeseli, njengokuvuvukala, ukukhula kweeseli, isigqi se-circadian, imetabolism yamandla, umsebenzi we-neuronal, kunye nokumelana noxinzelelo, kwaye i-NAD+ yi-enzyme ebalulekileyo yokwenziwa kweeproteni zobomi obude.

Ivuselela zonke iiproteni ezisi-7 ezihlala ixesha elide emzimbeni womntu, idlala indima ebalulekileyo ekuchaseni uxinzelelo lweeseli, imetabolism yamandla, ithintele utshintsho lweeseli, i-apoptosis kunye nokwaluphala.

Nika amandla

Ikhuthaza ukuveliswa kwamandla angaphezu kwama-95% afunekayo kwimisebenzi yobomi. I-Mitochondria kwiiseli zabantu zizityalo zamandla zeeseli. I-NAD+ yi-coenzyme ebalulekileyo kwi-mitochondria ukuvelisa imolekyuli yamandla i-ATP, iguqula izondlo zibe ngamandla afunekayo emzimbeni womntu.

Khuthaza ukuvuselelwa kwemithambo yegazi kwaye ugcine ukuqina kwemithambo yegazi

Imithambo yegazi zizinto ezibalulekileyo kwimisebenzi yobomi. Njengoko sikhula, imithambo yegazi ilahlekelwa bukuguquguquka kwayo kancinci kancinci ize ibe nzima, ibe nkulu, ibe mxinwa, nto leyo ebangela "i-arteriosclerosis."

I-NAD+ inokunyusa umsebenzi we-elastin kwimithambo yegazi, ngaloo ndlela igcina ukuthamba kwemithambo yegazi kunye nokugcina impilo yemithambo yegazi.

Khuthaza imetabolism

I-Metabolism yindibaniselwano yeempendulo ezahlukeneyo zeekhemikhali emzimbeni. Umzimba uya kuqhubeka nokutshintshiselana ngezinto kunye namandla. Xa olu tshintshiselwano luyeka, ubomi bomzimba buya kuphela.

UNjingalwazi uAnthony kunye neqela lakhe lophando kwiYunivesithi yaseCalifornia, eMelika, bafumanise ukuba i-NAD+ inokuphucula ngempumelelo ukucotha kwemetabolism yeeseli enxulumene nokwaluphala, ngaloo ndlela iphucula impilo yabantu kwaye yandise ubomi babo.

Khusela impilo yentliziyo

Intliziyo yeyona nto ibalulekileyo ebantwini, kwaye inqanaba le-NAD+ emzimbeni lidlala indima ebalulekileyo ekugcineni ukusebenza kwentliziyo ngokuqhelekileyo.

Ukuncipha kwe-NAD+ kusenokunxulunyaniswa nesifo sentliziyo, kwaye inani elikhulu lezifundo ezisisiseko liqinisekisile isiphumo sokongeza i-NAD+ kwizifo zentliziyo.

Ukuthintela izifo zentliziyo kunye nezifo zemithambo yegazi

Izifundo zibonise ukuba phantse zonke iintlobo ezisixhenxe ze-sirtuins (SIRT1-SIRT7) zinxulumene nokwenzeka kwesifo sentliziyo. Ii-Sirtuins zithathwa njengezona zinto zibalulekileyo zonyango lwezifo zentliziyo, ngakumbi i-SIRT1.

I-NAD+ yeyona nto iphambili kwiSirtuins. Ukongezwa kwe-NAD+ ngexesha elifanelekileyo emzimbeni womntu kunokuvuselela ngokupheleleyo umsebenzi we-Sirtuins nganye, ngaloo ndlela kukhusela impilo yentliziyo kunye nokuthintela izifo zentliziyo.

Khuthaza ukukhula kweenwele

Eyona nto ibangela ukulahleka kweenwele kukulahlekelwa bubomi beeseli zomama weenwele, kwaye ukulahleka kobomi beeseli zomama weenwele kungenxa yokuba inqanaba le-NAD+ emzimbeni womntu liyehla. Iiseli zomama weenwele azinayo i-ATP eyaneleyo yokwenza ukwenziwa kweeproteni zeenwele, ngaloo ndlela zilahlekelwa bubomi bazo kwaye zikhokelele ekulahlekelweni bubomi beeenwele.

Ngoko ke, ukongeza i-NAD+ kunokuqinisa umjikelo we-asidi kwaye kuvelise i-ATP, ukuze iiseli zoomama beenwele zibe namandla aneleyo okuvelisa iproteni yeenwele, ngaloo ndlela ziphucula ukulahleka kweenwele.

Apho ungathenga khona i-Beta-NAD+ Supplement ngokukhuselekileyo kwi-Intanethi

I-Suzhou Myland Pharm & Nutrition Inc. ngumvelisi obhalisiweyo kwi-FDA obonelela ngomgubo we-NAD+ Supplement okumgangatho ophezulu nococekileyo.

Apha eSuzhou Myland Pharm sizibophelele ekuboneleleni ngeemveliso ezikumgangatho ophezulu ngamaxabiso angcono. Umgubo wethu we-NAD+ Supplement uvavanywa ngokungqongqo ubumsulwa kunye namandla, ukuqinisekisa ukuba ufumana isongezelelo esikumgangatho ophezulu onokusithemba. Nokuba ufuna ukuxhasa impilo yeseli, ukukhulisa amajoni akho omzimba okanye ukuphucula impilo iyonke, umgubo wethu we-NAD+ Supplement lukhetho olufanelekileyo.

Ngamava angama-30 eminyaka kwaye eqhutywa bubuchwepheshe obuphezulu kunye namaqhinga ophando nophuhliso aphucukileyo, iSuzhou Myland Pharm iphuhlise uluhlu lweemveliso ezikhuphisanayo kwaye yaba yinkampani yeenkonzo zokongeza izinto ezintsha zesayensi yobomi, ukwenziwa kwezinto ngokwezifiso kunye neenkonzo zokuvelisa.

Ukongeza, iSuzhou Myland Pharm ikwangumvelisi obhalisiweyo yi-FDA. Izixhobo zeR&D zenkampani, izixhobo zemveliso, kunye nezixhobo zokuhlalutya zizinto zanamhlanje kwaye zisebenza ngeendlela ezininzi, kwaye zinokuvelisa iikhemikhali ukusuka kwi-milligrams ukuya kwiitoni ngobukhulu, kwaye zihambelana nemigangatho ye-ISO 9001 kunye neenkcukacha zemveliso ze-GMP.