Yintoni i-NAD + kwaye kutheni uyifuna ngeMpilo yakho?

Kwilizwe elihlala likhula lezempilo kunye nokuba sempilweni, i-NAD+ iye yaba yi-buzzword, itsala umdla wezazinzulu kunye nabathandi bezempilo ngokufanayo. Kodwa yintoni kanye kanye i-NAD+? Kutheni le nto ibaluleke kangaka kwimpilo yakho? Masifunde ngakumbi malunga nolwazi olufanelekileyo olungezantsi!

Yintoni i-NAD+?

Igama lenzululwazi le-NAD yi-nicotinamide adenine dinucleotide. I-NAD + ikhona kuzo zonke iiseli zomzimba wethu. Yimetabolite ephambili kunye ne-coenzyme kwiindlela ezahlukeneyo zemetabolism. Ilamla kwaye ithathe inxaxheba kwiinkqubo ezahlukeneyo zebhayoloji. Ngaphezulu kwe-300 ye-enzymes ixhomekeke kwi-NAD + Ukusebenza.

NAD+sisishunqulelo sesiNgesi sikaNicotinamide adenine dinucleotide. Igama layo elipheleleyo ngesiTshayina yi-nicotinamide adenine dinucleotide, okanye iCoenzyme I ngokufutshane. Njenge-coenzyme ehambisa i-hydrogen ions, i-NAD + idlala indima kwiinkalo ezininzi ze-metabolism yabantu, kuquka i-glycolysis, i-Gluconeogenesis, i-tricarboxylic acid cycle, njl njl. Ezinye izifundo zibonise ukuba ukuchithwa kwe-NAD + kuhambelana nobudala, kunye neendlela ze-physiological mediated. nge-NAD + inxulumene nokuguga, izifo ze-metabolic, i-neuropathy kunye nomhlaza, kubandakanywa nokulawula i-homeostasis ye-cell, i-sirtuins eyaziwa ngokuba yi-"longevity genes", ukulungisa i-DNA, iiprotheni zentsapho ze-PARPs ezinxulumene ne-necroptosis kunye ne-CD38 encedisa ukubonakaliswa kwe-calcium.

I-NAD+ isebenza njengebhasi ehambayo, ethwala ii-electron ukusuka kwi-molecule yeeseli ukuya kwenye. Ikunye nomlingani wayo wemolekyuli i-NADH, ithatha inxaxheba kwiinguqu ezahlukeneyo zemetabolism ngokutshintshiselana kwe-electron evelisa i-adenosine triphosphate (ATP), imolekyuli "yamandla" yomzimba.

Ngamafutshane, i-NAD + ibalulekile ekugcineni impilo yomzimba kunye nokulinganisela. I-Metabolism, i-redox, ukugcinwa kwe-DNA kunye nokulungiswa, ukuzinza kwe-gene, ukulawulwa kwe-epigenetic, njl. zonke zifuna ukuthatha inxaxheba kwe-NAD +.

Ke ngoko, umzimba wethu unemfuno ephezulu ye-NAD +. I-NAD+ iyadityaniswa ngokuqhubekayo, yaphulwa kwaye iphinda isetyenziswe kwiiseli ukuze kugcinwe amanqanaba e-NAD+ eselula.

I-NAD + yinxalenye ebalulekileyo yomsebenzi weselula kwaye ibandakanyeka kunikezelo lwamandla kunye nokulungiswa kwe-DNA, zombini ezi zinto zihambelana ngokusondeleyo nokuguga okunempilo.

1) Isasazwa ngokubanzi kuzo zonke iiseli zomzimba womntu kwaye ithatha inxaxheba kumawaka eempendulo ze-biocatalytic. Inokukhuthaza i-metabolism yeswekile, i-fat kunye ne-amino acids, kwaye ithatha inxaxheba kwi-synthesis yamandla. Yi-coenzyme ebalulekileyo eyimfuneko kumzimba womntu.

I-2) I-NAD + iyona kuphela i-substrate ye-coI-consuming enzymes (i-substrate kuphela ye-DNA yokulungisa i-enzyme ye-PARP, i-substrate kuphela ye-protein ye-longevity i-Sirtuins, kunye ne-substrate kuphela ye-cyclic ADP ribose synthase CD38/157).

Nangona kunjalo, njengoko iminyaka ikhula, inqanaba le-NAD + emzimbeni liyancipha ngokukhawuleza. Iza kuhla nge-50% rhoqo kwiminyaka engama-20. Phantse kwiminyaka engama-40 ubudala, umxholo we-NAD + emzimbeni womntu yi-25% kuphela yento ebiyiyo ebantwaneni.

Ukuba iiseli zomntu azinayo i-NAD +, ukungasebenzi kwe-mitochondrial kuncitshisiwe, amandla okulungisa umonakalo we-DNA ayancitshiswa, kwaye ubomi obude beprotheyini yentsapho yaseSirtuin nayo ingasebenzi, njl.

Indima ye-NAD+ kwiMpilo yakho iyonke

Ukuchasa ukuguga

I-NAD + igcina unxibelelwano lweekhemikhali phakathi kwe-nucleus kunye ne-mitochondria, kwaye unxibelelwano olubuthathaka luyimbangela ebalulekileyo yokuguga kwamaselula.

I-NAD+ inokususa inani elandayo leekhowudi ze-DNA ezingalunganga ngexesha le-cell metabolism, igcine ukubonakaliswa okuqhelekileyo kwemfuza, igcine ukusebenza okuqhelekileyo kweeseli, kwaye icothise ukuguga kweeseli zomntu.

Lungisa umonakalo weDNA

I-NAD + i-substrate ebalulekileyo ye-DNA yokulungisa i-enzyme ye-PARP, enempembelelo ebalulekileyo ekulungisweni kwe-DNA, ukubonakaliswa kofuzo, ukuphuhliswa kweeseli, ukusinda kweeseli, ukwakhiwa kwakhona kwe-chromosome, kunye nokuzinza kwemfuza.

Sebenzisa iprotheni yokuphila ixesha elide

IiSirtuins zihlala zibizwa ngokuba lusapho lweprotheyini yokuphila ixesha elide kwaye zidlala indima ebalulekileyo yolawulo kwimisebenzi yeeseli, njengokudumba, ukukhula kweeseli, isigqi esijikelezayo, i-metabolism yamandla, umsebenzi we-neuronal, kunye nokumelana noxinzelelo, kwaye i-NAD + yi-enzyme ebalulekileyo yokwenziwa kweeproteni zobomi obude. .

Yenza kusebenze zonke iiprotheyini ezi-7 zobomi obude emzimbeni womntu, zidlala indima ebalulekileyo ekuxhathiseni uxinzelelo lweselula, i-metabolism yamandla, ukuthintela ukuguquka kweeseli, i-apoptosis kunye nokuguga.

Nika amandla

Ibangela ukuveliswa kwamandla angaphezu kwama-95% afunekayo kwimisebenzi yobomi. I-Mitochondria kwiiseli zomntu zizityalo zamandla kwiiseli. I-NAD + yi-coenzyme ebalulekileyo kwi-mitochondria ukuvelisa i-molecule yamandla i-ATP, iguqula izondlo zibe amandla afunwa ngumzimba womntu.

Ukukhuthaza ukuvuselelwa kwemithambo yegazi kunye nokugcina ukunwebeka kwemithambo yegazi

Imithambo yegazi zizicubu eziyimfuneko kwimisebenzi yobomi. Njengoko sikhula, imithwalo yegazi ngokuthe ngcembe ilahlekelwa ukuguquguquka kwayo kwaye ibe nzima, iyancipha, kwaye iyancipha, ibangela "i-arteriosclerosis."

I-NAD + inokonyusa umsebenzi we-elastin kwimithambo yegazi, ngaloo ndlela igcina ukuqina kwemithambo yegazi kunye nokugcina impilo yemithambo yegazi.

Ukukhuthaza imetabolism

I-Metabolism sisimbuku seentshukumo ezahlukeneyo zeekhemikhali emzimbeni. Umzimba uya kuqhubeka nokutshintshisa izinto kunye namandla. Xa olu tshintshiselwano luyekile, ubomi bomzimba buya kuphela.

UNjingalwazi Anthony kunye neqela lakhe lophando kwiYunivesithi yaseCalifornia, eU.SA, bafumanisa ukuba i-NAD+ inokuphucula ngokufanelekileyo ukucotha kwemetabolism yeeseli ezinxulumene nokuguga, ngaloo ndlela iphucula impilo yabantu kunye nokwandisa ubomi.

Khusela impilo yentliziyo

Intliziyo lelona lungu libalulekileyo ebantwini, kwaye inqanaba leNAD + emzimbeni lidlala indima ebalulekileyo ekugcineni ukusebenza kwentliziyo okuqhelekileyo.

Ukwehliswa kwe-NAD + kunokunxulumana ne-pathogenesis yezifo ezininzi zentliziyo, kwaye inani elikhulu lezifundo ezisisiseko nazo ziqinisekisile isiphumo sokongeza i-NAD + kwizifo zentliziyo.

Ukuthintela izifo ze-cardiovascular and cerebrovascular

Uphononongo lubonise ukuba phantse zonke ii-subtypes ezisixhenxe ze-sirtuins (SIRT1-SIRT7) zihambelana nokuvela kwesifo senhliziyo. I-Sirtuins ithathwa njengeenjongo ze-agonistic kunyango lwezifo ze-cardiovascular, ngakumbi i-SIRT1.

I-NAD+ kuphela kwe-substrate ye-Sirtuins. Ukongezwa kwangexesha kwe-NAD + emzimbeni womntu kunokuwenza usebenze ngokupheleleyo uhlobo ngalunye lwe-Sirtuins, ngaloo ndlela lukhusela impilo yentliziyo kunye nokuthintela izifo zentliziyo.

Ukukhuthaza ukukhula kweenwele

Esona sizathu siphambili sokulahleka kweenwele kukulahleka kweenwele zikamama weseli, kwaye ukulahleka kobunzima bomzimba kamama kungenxa yokuba inqanaba leNAD + emzimbeni womntu liyehla. Iiseli zikamama weenwele azinayo i-ATP eyaneleyo yokwenza iprotein synthesis yeenwele, ngaloo ndlela zilahlekelwa ngamandla kwaye zikhokelela ekulahlekeni kweenwele.

Ke ngoko, ukongeza i-NAD + kunokomeleza umjikelo we-asidi kwaye kuvelise i-ATP, ukuze iiseli zikamama weenwele zibe namandla okwaneleyo okuvelisa iprotein yeenwele, ngaloo ndlela kuphuculwe ukulahleka kweenwele.

Apho unokuyithenga khona iBeta-NAD+ Yongeza ngokuKhuselekileyo kwi-Intanethi

I-Suzhou Myland Pharm & Nutrition Inc. ngumvelisi obhalisiweyo we-FDA obonelela ngekhwalithi ephezulu kunye nokucoceka okuphezulu kwe-NAD + Supplement powder.

ESuzhou Myland Pharm sizimisele ukubonelela ngezona mveliso zikumgangatho ophezulu ngamaxabiso angcono. Ipowder yethu ye-NAD + eyoNgezelelweyo ivavanywa ngokungqongqo ukuba icocekile kwaye inamandla, iqinisekisa ukuba ufumana isongezelelo esikumgangatho ophezulu onokumthemba. Nokuba ufuna ukuxhasa impilo yeselula, yongeza amajoni akho omzimba okanye uphucule impilo yonke, i-NAD + yethu yoLwaphulelo lomgubo lolona khetho lufanelekileyo.

Ineminyaka engama-30 yamava kwaye iqhutywa bubuchwepheshe obuphezulu kunye nezicwangciso ze-R&D eziphuculwe kakhulu, iSuzhou Myland Pharm iphuhlise uluhlu lweemveliso ezikhuphisanayo kwaye ibe sisongezelelo sesayensi yobomi, ukudibanisa isiko kunye nenkampani yeenkonzo zokuvelisa.

Ukongeza, iSuzhou Myland Pharm ikwangumvelisi obhalisiweyo we-FDA. Izixhobo ze-R&D zenkampani, izixhobo zemveliso, kunye nezixhobo zohlalutyo zezanamhlanje kwaye zinemisebenzi emininzi, kwaye zinokuvelisa iikhemikhali ukusuka kwimilligrams ukuya kwiitoni kwisikali, kwaye zithobela imigangatho ye-ISO 9001 kunye neenkcukacha zemveliso ye-GMP.