Yintoni i-7,8-Dihydroxyflavone kwaye kutheni kufuneka ukhathalele?

I-7,8-Dihydroxyflavone (7,8-DHF)yi-flavonoid yendalo, ikhompawundi ye-polyphenolic efumaneka kwiintlobo ngeentlobo zezityalo. Ii-Flavonoids zaziwa ngeempawu zazo ze-antioxidant kwaye zidlala indima ebalulekileyo kwiinkqubo zokuzikhusela kwizityalo. I-7,8-Dihydroxyflavone ifumaneka ngakumbi kwizityalo ezifana neGodmania aesculifolia kunye neTridax procumbens.

I-7,8-Dihydroxyflavone yahlukile kwezinye ii-flavonoids kubuchule bayo bokulinganisa umsebenzi we-neurotrophic factor (BDNF) efunyenwe ebuchotsheni. I-BDNF yiproteni exhasa ukusinda, uphuhliso, kunye nokusebenza kwee-neurons engqondweni. Idlala indima ebalulekileyo kwi-neuroplasticity, amandla engqondo okuzihlela ngokutsha ngokwenza unxibelelwano olutsha lwee-neural. Le propati ye-7,8-DHF ivula iindlela ezininzi zophando, ngakumbi kwicandelo le-neuroscience.

Indlela yokusebenza

Indlela ephambili esebenzisa ngayo i-7,8-Dihydroxyflavone kukusebenza kwe-TrkB (tropomyosin receptor kinase B) receptor. I-TrkB yi-receptor ene-affinity ephezulu ye-BDNF. Xa i-7,8-Dihydroxyflavone ibopha kwi-TrkB, ibangela uthotho lweendlela zokubonisana ngaphakathi kweseli ezikhuthaza ukusinda, ukukhula, kunye nokwahlukana kwe-neuronal.

Izifundo zangaphambi kweklinikhi zibonise ukuba i-7,8-dihydroxyflavone inokulinganisa i-BDNF (i-neurotrophic factor efumaneka ebuchotsheni) kwaye yonyuse ukubonakaliswa kwayo kunye namanqanaba kwi-hippocampus. Kwiimodeli zezilwanyana, inamandla okunyanga izifo ezininzi ze-neurological okanye iingxaki, ezizezi: i-stroke, ukudakumba, kunye nesifo sikaParkinson. Kwizifundo ezimbini ezahlukeneyo, i-7,8-dihydroxyflavone ibonakalise ukufumaneka okubonakalayo komlomo kwaye ifunyenwe iwela umqobo wegazi lobuchopho (BBB). Kuba isebenza kwindlela yokubonisa i-nitric oxide kunye ne-activated TrkB receptor (tropomyosin receptor kinase B)

I-neurotrophic factor BDNF ikakhulu idlulisela imiqondiso ngokubophelela kwii-receptors ezithile, ngaloo ndlela ichaphazela iinkqubo ze-physiological ze-neurons. Ngelixa i-7,8-DHF inokulinganisa isiphumo se-neurotrophic factor BDNF, eyona nto iphambili ikwindlela yayo yokusebenzisana ne-BDNF receptor. Izifundo zibonise ukuba i-7,8-DHF inokubopha kwi-BDNF receptor TrkB kwaye isebenze iindlela zokuhambisa imiyalezo ezisezantsi.

Ngokukodwa, xa i-7,8-DHF ibopha kwi-TrkB, ibangela uthotho lweziganeko zokudluliselwa kwesignali ngaphakathi kweseli. Oku kuquka ukusebenza kwee-protein kinases ezifana neendlela ze-PI3K/Akt kunye ne-MAPK/ERK. Ukusebenza kwezi ndlela kubalulekile ekukhuthazeni ukusinda kwe-neuronal, ukukhula, kunye ne-synaptic plasticity. Ngokulinganisa ukusebenza kwezi ndlela yi-BDNF, i-7,8-DHF inceda ukuphucula ukuziqhelanisa kwe-neuronal kunye nokuxhathisa uxinzelelo lwangaphandle.

I-7,8-DHF ikwalawula ukubonakaliswa kwezakhi zofuzo ngaphakathi kwee-neurons. Ingachaphazela ukuguqulelwa kwezakhi zofuzo ezinxulumene nophuhliso lwe-neuro, ukukhuselwa kwe-neuro kunye nokwakheka kwe-synapse, ngaloo ndlela ilinganisa iziphumo ze-BDNF kwinqanaba leemolekyuli. Olu hlengahlengiso lokubonakaliswa kwezakhi zofuzo luxhasa ngakumbi indima ye-7,8-DHF ekukhuthazeni impilo ye-neurological.

I-7,8-Dihydroxyflavone (7,8-DHF) yi-flavonoid ye-monophenolic eneziphumo ezininzi. Isebenza njenge-agonist ye-neurotrophic tyrosine kinase receptor TrkB (Kd=320nM) kwaye ikhusela ii-neurons eziveza i-TrkB kwi-apoptosis. I-Brain-derived neurotrophic factor (BDNF) yiproteni eneziphumo ze-neurotrophic ezibalulekileyo ekwakhiweni kwengqondo, ekufundeni nasekukhumbuleni.

• Ukhuseleko lwe-Neuro: I-7,8-DHF ikhusela i-neuroprotective kwiimodeli zezilwanyana zesifo sikaParkinson, ixhasa ukufunda ngokweemvakalelo kwiimpuku kwaye ibuyisela ukungabikho kwememori kwiimodeli zegundane zesifo sika-Alzheimer, kwaye inokuphucula ukusebenza kwemisipha kunye nokwandisa ixesha lokusinda kwe-huntingtin kwiimodeli zezilwanyana ezinesifo. I-BDNF inokuphucula i-neuroplasticity kunye nokusinda kwe-neuron, incede ingqondo ivelise unxibelelwano olutsha lwe-neural, ilungise iiseli zengqondo ezingasebenzi kakuhle, kwaye ikhusele iiseli zengqondo ezisempilweni. Ibalulekile ekwakhiweni kwengqondo, ekufundeni nasekukhumbuleni, kwaye inokukhusela ingqondo ekuphazamisekeni kwengqondo okunxulumene nobudala. Ukuncipha kwezakhono zengqondo kunye nokukhusela kwizifo ze-neurodegenerative ezifana nesifo sika-Alzheimer kunye nesifo sikaParkinson.

• Ilawula ukusinda kwee-neuronal: I-7,8-DHF inokubopha kwi-TrkB kwaye isebenze iindlela zokuhambisa imiyalezo ezisezantsi, ezifana neendlela ze-PI3K/Akt kunye ne-MAPK/ERK. Ukusebenza kwezi ndlela kubalulekile ekukhuthazeni ukusinda kwee-neuronal, ukukhula kunye ne-synaptic plasticity. Kubalulekile. I-BDNF ikwayinto ye-neurotrophic enokwenza iindlela zokuhambisa imiyalezo ezingaphakathi kweseli zisebenze ngokubophelela kwii-receptor ze-TrkB kwaye ikhuthaze ukusinda nokukhula kwee-neurons.

• Ukukhuthaza i-synaptic plasticity: I-7,8-DHF inokukhuthaza ukwakheka nokuqiniswa kwee-synapses ngokusebenzisa ii-TrkB receptors, ngaloo ndlela iphucula ukusebenza kakuhle kokudluliselwa kwe-synapses. I-BDNF ikwacingelwa ukuba ikhuthaza ukwakheka nokuqiniswa kwee-synapses, ngaloo ndlela inyusa ukusebenza kakuhle kokudluliselwa kwe-synapses kwaye ngaloo ndlela iphucula ubuchule bokufunda nokukhumbula.

• Imiphumo ekufundeni nakwimemori: I-7,8-DHF inokuphucula ubuchule bokufunda nokukhumbula kwiimpuku, nto leyo enokunxulunyaniswa nemiphumo yayo ekusindeni kwe-neuronal kunye ne-synaptic plasticity. I-BDNF ikwadlala indima ebalulekileyo kwiinkqubo zokufunda kunye nememori ngokukhuthaza ukusinda kwee-neurons kunye nokwakhiwa kwee-synapses, ngaloo ndlela iphucula ubuchule bokufunda kunye nememori.

• Iguqula imood: I-7,8-DHF ineempembelelo zokuguqula imood, ezinokunxulunyaniswa neziphumo zayo ekusindeni kwe-neuronal kunye ne-synaptic plasticity. I-BDNF ikwacingelwa ukuba idlala indima ekulawuleni imood ngokulawula ukusinda kwee-neurons kunye nokwakheka kwee-synapses, ngaloo ndlela ichaphazela ukubonakaliswa kweemvakalelo.

Ngamafutshane, i-7,8-DHF kunye ne-BDNF zineendlela ezifanayo zokusebenza ekukhuseleni imithambo-luvo, zilawula ukusinda kwe-neuronal, zikhuthaza i-synaptic plasticity, zichaphazela ukufunda kunye nenkumbulo, kwaye zilawula iimvakalelo.

I-Suzhou Myland Pharm & Nutrition Inc. ngumvelisi obhalisiweyo kwi-FDA obonelela nge-7,8-Dihydroxyflavone ekumgangatho ophezulu necocekileyo.

Apha eSuzhou Myland Pharm sizibophelele ekuboneleleni ngeemveliso ezikumgangatho ophezulu ngamaxabiso angcono. I-7,8-Dihydroxyflavone yethu ivavanywe ngokungqongqo ukuba icocekile kwaye inamandla kangakanani, iqinisekisa ukuba ufumana isongezelelo esisemgangathweni onokusithemba. Nokuba ufuna ukuxhasa impilo yeseli, ukukhulisa amajoni akho omzimba okanye ukuphucula impilo iyonke, i-7,8-Dihydroxyflavone yethu lukhetho olufanelekileyo.

Ngamava angama-30 eminyaka kwaye eqhutywa bubuchwepheshe obuphezulu kunye namaqhinga ophando nophuhliso aphucukileyo, iSuzhou Myland Pharm iphuhlise uluhlu lweemveliso ezikhuphisanayo kwaye yaba yinkampani yeenkonzo zokongeza izinto ezintsha zesayensi yobomi, ukwenziwa kwezinto ngokwezifiso kunye neenkonzo zokuvelisa.

Ukongeza, iSuzhou Myland Pharm ikwangumvelisi obhalisiweyo yi-FDA. Izixhobo zeR&D zenkampani, izixhobo zemveliso, kunye nezixhobo zokuhlalutya zizinto zanamhlanje kwaye zisebenza ngeendlela ezininzi, kwaye zinokuvelisa iikhemikhali ukusuka kwi-milligrams ukuya kwiitoni ngobukhulu, kwaye zihambelana nemigangatho ye-ISO 9001 kunye neenkcukacha zemveliso ze-GMP.