Yintoni i-7,8-Dihydroxyflavone kwaye Kutheni kufuneka Ukhathalele?

7,8-Dihydroxyflavone (7,8-DHF)yi-flavonoid eyenzeka ngokwemvelo, ikhompawundi ye-polyphenolic efumaneka kwiintlobo ngeentlobo zezityalo. I-Flavonoids iyaziwa ngokuba yi-antioxidant kwaye idlala indima ebalulekileyo kwiindlela zokukhusela izityalo. I-7,8-Dihydroxyflavone ifumaneka ngokukodwa kwizityalo ezifana ne-Godmania aesculifolia kunye ne-Tridax procumbens.

I-7,8-Dihydroxyflavone ihluke kwezinye i-flavonoids ngokukwazi ukulinganisa umsebenzi we-brain-derived neurotrophic factor (BDNF). I-BDNF yiprotheyini exhasa ukuphila, uphuhliso, kunye nomsebenzi we-neurons kwingqondo. Idlala indima ephambili kwi-neuroplasticity, ukukwazi kwengqondo ukuzilungisa kwakhona ngokwenza unxibelelwano lwe-neural olutsha. Le propati ye-7,8-DHF ivula iindlela ezininzi zophando, ngakumbi kwinkalo ye-neuroscience.

Indlela yokwenza

Indlela ephambili apho i-7,8-Dihydroxyflavone ikhupha iziphumo zayo kukusebenza kwe-TrkB (tropomyosin receptor kinase B) receptor. I-TrkB i-high-affinity receptor ye-BDNF. Xa i-7,8-Dihydroxyflavone ibophelela kwi-TrkB, ibangela uluhlu lweendlela zokubonisa i-intracellular ezikhuthaza ukusinda kwe-neuronal, ukukhula, kunye nokwahlula.

Izifundo zangaphambili zibonise ukuba i-7,8-dihydroxyflavone inokulinganisa i-BDNF (i-brain-derived neurotrophic factor) kwaye yandise ukubonakaliswa kwayo kunye namanqanaba kwi-hippocampus. Kwiimodeli zezilwanyana, inamandla onyango kwizifo ezininzi ze-neurological okanye ukuphazamiseka, okubizwa ngokuba sistroke, ukudakumba, kunye nesifo sikaParkinson. Kwizifundo ezimbini ezahlukeneyo, i-7,8-dihydroxyflavone ibonise i-bioavailability ebalulekileyo yomlomo kwaye yafunyanwa ukuwela umqobo we-brain-blood barrier (BBB). Ngenxa yokuba isebenza kwindlela yokubonisa i-nitric oxide kunye ne-TrkB receptor esebenzayo (i-tropomyosin receptor kinase B)

I-neurotrophic factor BDNF ikakhulu idlulisela imiqondiso ngokubophelela kwi-receptors ethile, ngaloo ndlela ichaphazela iinkqubo ze-physiological of neurons. Ngelixa i-7,8-DHF inokufanisa umphumo we-neurotrophic factor BDNF, eyona nto iphambili kukusebenzisana kwayo kunye ne-BDNF receptor. Uphononongo lubonise ukuba i-7,8-DHF inokubophelela kwi-BDNF receptor TrkB kwaye isebenze iindlela zokubonisa ezisezantsi.

Ngokukodwa, xa i-7,8-DHF ibophelela kwi-TrkB, ibangela uchungechunge lweziganeko ze-intracellular transduction transduction. Oku kubandakanya ukusebenza kweprotein kinases njenge-PI3K / Akt kunye ne-MAPK / ERK iindlela. Ukusebenza kwezi ndlela kubalulekile ekukhuthazeni ukusinda kwe-neuronal, ukukhula, kunye ne-synaptic plasticity. Ngokufanisa ukusebenza kwezi ndlela nge-BDNF, i-7,8-DHF inceda ukuphucula ukulungelelaniswa kwe-neuronal kunye nokuchasana noxinzelelo lwangaphandle.

I-7,8-DHF iphinda ilawule i-gene expression ngaphakathi kwe-neurons. Inokuchaphazela ukubhaliswa kweegenes ezinxulumene ne-neurodevelopment, neuroprotection kunye nokwakheka kwe-synapse, ngaloo ndlela ilinganisa imiphumo ye-BDNF kwinqanaba le-molecular. Oku kumodareyithwa kokuchazwa kofuzo kuxhasa ngakumbi indima ye-7,8-DHF ekukhuthazeni impilo yemithambo-luvo.

I-7,8-Dihydroxyflavone (7,8-DHF) i-flavonoid ye-monophenolic enemiphumo emininzi. Isebenza njenge-agonist ye-neurotrophic tyrosine kinase receptor TrkB (Kd = 320nM) kwaye ikhusela i-TrkB-ebonisa i-neurons kwi-apoptosis. I-brain-derived neurotrophic factor (BDNF) yiprotheni eneziphumo ze-neurotrophic eziyimfuneko ekubunjweni kwengqondo, ukufunda kunye nememori.

• I-Neuroprotection: I-7,8-DHF yi-neuroprotective kwiimodeli zezilwanyana ze-Parkinson's disease, ixhasa ukufunda ngokweemvakalelo kwiimpuku kwaye ibuyisela umva ukusilela kwememori kwiimodeli zempuku zesifo se-Alzheimer's, kwaye inokuphucula ukusebenza kweemoto kunye nokwandisa ixesha lokusinda lokuzingela i-huntingtin yezilwanyana ezigulayo. I-BDNF inokuphucula i-neuroplasticity kunye ne-neuron survival, inceda ingqondo ivelise uxhulumaniso olutsha lwe-neural, ukulungisa iiseli zengqondo ezisilelayo, kunye nokukhusela iiseli zengqondo eziphilileyo. Ibalulekile ekwenziweni kobuchopho, ukufunda kunye nenkumbulo, kwaye inokukhusela ingqondo kukuphazamiseka kwengqondo okunxulumene nobudala. Yehla kwizakhono zokuqonda kunye nokukhusela kwizifo ze-neurodeergenerative ezifana nesifo se-Alzheimer kunye nesifo sika-Parkinson.

• Ukulawula ukusinda kwe-neuronal: I-7,8-DHF inokubophelela kwi-TrkB kwaye isebenze iindlela zokubonisa ezantsi, njenge-PI3K/Akt kunye ne-MAPK/ERK iindlela. Ukusebenza kwezi ndlela kubalulekile ekukhuthazeni ukusinda kwe-neuronal, ukukhula kunye neplastiki ye-synaptic. kubalulekile. I-BDNF nayo i-neurotrophic factor enokuthi isebenze i-intracellular signaling pathways ngokuzibophelela kwi-TrkB receptors kunye nokukhuthaza ukusinda kunye nokukhula kwee-neurons.

• Ukukhuthaza iplastiki ye-synaptic: I-7,8-DHF inokukhuthaza ukubunjwa kunye nokomelezwa kwe-synapses ngokuvula i-TrkB receptors, ngaloo ndlela iphucula ukuhanjiswa kwe-synaptic. I-BDNF ikwacingelwa ukuba ikhuthaze ukuqulunqwa kunye nokomelezwa kwe-synapses, ngaloo ndlela ikhulisa ukusebenza kakuhle kokuhanjiswa kwe-synaptic kwaye ngaloo ndlela iphucula amandla okufunda kunye nokukhumbula.

• Iimpembelelo ekufundeni nakwinkumbulo: I-7,8-DHF inokuphucula izakhono zokufunda kunye nenkumbulo kwiimpuku, ezinokunxulumana neziphumo zayo kubomi be-neuronal kunye ne-synaptic plasticity. I-BDNF nayo idlala indima ebalulekileyo kwiinkqubo zokufunda kunye nememori ngokukhuthaza ukusinda kwee-neurons kunye nokwakhiwa kwee-synapses, ngaloo ndlela kuphuculwe izakhono zokufunda kunye nememori.

• Imodareyitha imo: I-7,8-DHF ineempembelelo zokumodareyitha imo, ezinokunxulunyaniswa neziphumo zayo kwi-neuronal survival kunye ne-synaptic plasticity. I-BDNF iphinda icinge ukuba idlala indima ekulawuleni imvakalelo ngokulawula ukusinda kwe-neurons kunye nokwakhiwa kwe-synapses, ngaloo ndlela ichaphazela ukubonakaliswa kweemvakalelo.

Isishwankathelo, i-7,8-DHF kunye ne-BDNF zineendlela ezifanayo zokwenza kwi-neuroprotection, ukulawula ukusinda kwe-neuronal, ukukhuthaza iplastiki ye-synaptic, echaphazela ukufunda kunye nememori, kunye nokulawula iimvakalelo.

I-Suzhou Myland Pharm & Nutrition Inc. ngumvelisi obhalisiweyo we-FDA obonelela ngekhwalithi ephezulu kunye nococeko oluphezulu lwe-7,8-Dihydroxyflavone.

ESuzhou Myland Pharm sizimisele ukubonelela ngezona mveliso zikumgangatho ophezulu ngamaxabiso angcono. I-7,8-Dihydroxyflavone yethu ivavanywa ngokungqongqo ukucoceka kunye namandla, ukuqinisekisa ukuba ufumana isongezelelo somgangatho ophezulu onokuthembela kuwo. Nokuba ufuna ukuxhasa impilo yeselula, ukomeleza amajoni akho omzimba okanye ukomeleza impilo yonke, i-7,8-Dihydroxyflavone yethu lolona khetho lufanelekileyo.

Ineminyaka engama-30 yamava kwaye iqhutywa bubuchwepheshe obuphezulu kunye nezicwangciso ze-R&D eziphuculwe kakhulu, iSuzhou Myland Pharm iphuhlise uluhlu lweemveliso ezikhuphisanayo kwaye ibe sisongezelelo sesayensi yobomi, ukudibanisa isiko kunye nenkampani yeenkonzo zokuvelisa.

Ukongeza, iSuzhou Myland Pharm ikwangumvelisi obhalisiweyo we-FDA. Izixhobo ze-R&D zenkampani, izixhobo zemveliso, kunye nezixhobo zohlalutyo zezanamhlanje kwaye zinemisebenzi emininzi, kwaye zinokuvelisa iikhemikhali ukusuka kwimilligrams ukuya kwiitoni kwisikali, kwaye zithobela imigangatho ye-ISO 9001 kunye neenkcukacha zemveliso ye-GMP.