Yintoni ekufuneka uyazi malunga ne-palmitoylethanolamide (PEA)?

I-Palmitoylethanolamide (PEA) yi-amide ye-fatty acid yendalo eyenzekileyo etsalele ingqalelo kwiingenelo zayo zempilo. Le khompawundi ifumaneka kwiithishu ezahlukeneyo emzimbeni wonke, kwaye uphando lubonisa ukuba i-palmitamideethanol (PEA) inokunciphisa ukudumba, inciphise iintlungu, kwaye inokukhuthaza impilo yamathumbu kunye nokulibazisa ukuguga. Inokuba neengenelo ezahlukeneyo zempilo. Oku kulandelayo kuza kuhlola iingenelo zempilo ze-palmitoylethanolamide (PEA), indlela esebenza ngayo emzimbeni womntu, kunye nendlela yokufumana i-palmitoylethanolamide (PEA) ekumgangatho ophezulu.

Yintoni i-palmitoylethanolamide (i-PEA)?

I-Palmitoylethanolamide (i-PEA) yikhemikhali efana ne-endocannabinoid eyenzeka ngokwendalo eyaziwa ngeempawu zayo ezingapheliyo zokuthomalalisa iintlungu kunye nokulwa nokuvuvukala. Ukongeza ekubeni yenziwe ngumzimba, i-PEA ifumaneka kwiintlobo ngeentlobo zokutya eziquka: itshizi, amaqanda, inyama, ubisi, amandongomane, i-soy lecithin.

Ubusazi? Xa umzimba udibana nezinto ezibangela uxinzelelo, ezinje ngokwenzakala okanye ukudumba, amanqanaba e-PEA ayahlengahlengisa ukugcina i-homeostasis yeseli.

I-palmitoylethanolamide iwuchaphazela njani umzimba womntu?

Izazinzulu azikayiqondi ngokupheleleyo indlela esebenza ngayo i-palmitoylethanolamide. Nangona kunjalo, sihambe umgama omde, ngenxa kaNjingalwazi uRita Levi-Montalcini, owathi ngo-1992-1996 wacacisa indlela esebenza ngayo i-palmitoylethanolamide. Ukususela ngoko, uye waqhubeka nokufunda ngemiphumo ye-palmitoylethanolamide kwiintlungu ze-neuropathic kunye ne-allergies.

I-Palmitoylethanolamide inokuzisa iingenelo ezine ezibalulekileyo zempilo ebantwini:

●Nciphisa ukuvuvukala.

●Nciphisa ukusebenza kweeseli zemast (i-allergy).

●Qinisa umsebenzi wenkqubo ye-hemp endalo.

●Vuselela ii-receptors ezithile emzimbeni.

I-PEA iyisebenzisa njani imiphumo yayo yokulwa nokuvuvukala kunye neyokuthomalalisa iintlungu?

Iingenelo zempilo zePEA ziquka iziphumo kwiiseli zomzimba ezilawula ukudumba, ingakumbi engqondweni. IPEA inokunceda ukunciphisa imveliso yezinto ezibangela ukudumba. Nangona kunjalo, iPEA isebenza kakhulu kwii-receptors kwiiseli, ezilawula iinkalo ezahlukeneyo zomsebenzi weseli. Ezi receptors zibizwa ngokuba zii-PPAR. IPEA kunye nezinye izinto ezinceda ekusebenzeni kwe-PPAR zinokunciphisa iintlungu kwaye zinokwandisa imetabolism ngokutshisa amafutha, ukunciphisa i-triglycerides kwi-serum, ukwandisa i-cholesterol ye-HDL kwi-serum, ukuphucula ulawulo lweswekile egazini, kunye nokunceda ukunciphisa umzimba.

Iingenelo zePalmitoylethanolamide

Ngenxa yeziphumo zayo zokuthomalalisa iintlungu kunye nokulwa nokuvuvukala, uphando lubonisa ukuba i-PEA inokunceda kwiimeko ezahlukeneyo ezinxulumene nentlungu, ezifana ne-fibromyalgia, i-sciatica, kunye ne-osteoarthritis.

1. Nciphisa iintlungu kunye nempendulo yokudumba

Iintlungu ezingapheliyo yingxaki enkulu echaphazela izigulane kwihlabathi liphela, kwaye njengoko uluntu lukhula, le ngxaki iya kuba nkulu ngakumbi nangakumbi. Omnye wemisebenzi ye-palmitoylethanolamide kukuba inokunceda ekunciphiseni iintlungu kunye nokudumba. I-palmitoylethanolamide isebenzisana nee-receptors ze-CB1 kunye ne-CB2, eziyinxalenye ebalulekileyo yenkqubo ye-hemp endogenous. Le nkqubo inoxanduva lokugcina i-homeostasis okanye ibhalansi emzimbeni.

Xa kwenzeka ingozi okanye ukusabela kokudumba, umzimba ukhupha iikhompawundi zehemp ezingaphakathi ukunceda ukulawula impendulo yomzimba. I-palmitoylethanolamide inokunceda ukonyusa amanqanaba ehemp engaphakathi emzimbeni, ngaloo ndlela ithomalalisa iintlungu kunye nokudumba.

Ukongeza, i-palmitoylethanolamide inokunciphisa ukukhutshwa kweekhemikhali zokudumba kwaye inciphise iimpendulo zokudumba zemithambo-luvo ngokubanzi. Ezi ziphumo zenza i-palmitoylethanolamide ibe sisixhobo esinokunceda ukulawula iintlungu kunye neempendulo zokudumba. Izifundo zibonisa ukuba i-palmitoylethanolamide inokuba luncedo nakwintlungu ye-sciatica kunye ne-carpal tunnel syndrome.

2. I-Fibromyalgia

Izifundo ezininzi zibonisa ukuba i-PEA inokunceda ekunciphiseni iimpawu ze-fibromyalgia, isifo semithambo-luvo esingapheliyo esibangela iintlungu ezisasazekayo. Xa isetyenziswa njengesincedisi kunyango lwendabuko, ukuginywa kwe-PEA kunciphisa ubukhali bentlungu kwaye kuphucula umgangatho wobomi ngokuhamba kwexesha. Ngokutsho kolunye uphando, ukuthatha i-PEA iinyanga ezintathu kunciphisa kakhulu iintlungu kubantu abane-fibromyalgia.

3. Intlungu yomqolo

Uphando lokuqala lubonisa ukuba i-PEA iyasebenza na kwiintlungu zomqolo. Uphononongo lokujonga luka-2017 lubonise ukuba i-PEA inciphise ngakumbi ukuqina kwentlungu kwizigulana ezine-syndrome yotyando lomqolo olungasebenzi kakuhle.

Abantu abaphethwe yi-sciatica, intlungu eqala ezantsi emqolo ukuya ezantsi komnye okanye kumlenze womibini, banokufumana isiqabu emva kokuthatha i-PEA. Uvavanyo olucwangcisiweyo, olungaboni kabini, olulawulwa yi-placebo luhlolisise iziphumo ze-PEA yedosi ephezulu nephantsi xa kuthelekiswa ne-placebo. Intlungu incitshiswe ngaphezulu kwama-50% kwiqela ledosi ephezulu. Nangona i-PEA yedosi ephantsi ingazange ifumane isiqabu esifanayo sentlungu njengedosi ephezulu, zombini iidosi bezisebenza ngcono kakhulu kune-placebo.

4. I-Osteoarthritis

I-PEA inokuba luncedo kubantu abane-osteoarthritis, isifo esibonakaliswa kukonakala kwe-cartilage kunye nethambo lamalungu. Abathathi-nxaxheba kolunye uphando abafumene i-PEA bafumene uphuculo olukhulu kumanqaku eWestern Ontario kunye neMcMaster Universities Osteoarthritis Index (WOMAC) xa kuthelekiswa neqela le-placebo. I-WOMAC yimibuzo eyenzelwe ukuvavanya imeko kunye neempawu (umz., iintlungu, ukuqina, ukusebenza komzimba) kwizigulana ezine-osteoarthritis yamadolo kunye ne-hip.

Olunye uphando olubandakanya izigulana ezineentlungu ze-temporomandibular arthritic (TMJ) ezinxulumene ne-osteoarthritis lubonise ukuba ukongezwa kwe-PEA kuphucule kakhulu ubukhali bentlungu emva kweentsuku ezili-14 xa kuthelekiswa ne-ibuprofen. Iqela elinikwe i-PEA iintsuku ezili-14 libonise ukuphucuka okukhulu ekuvulekeni komlomo okuphezulu (umlinganiselo wokunciphisa iintlungu) kuneqela le-ibuprofen.

5. Intlungu ye-neuropathic

Izifundo zamatyala okuqala kunye novavanyo lwezilwanyana zibonisa ukuba i-PEA inokunceda kwiintlungu ze-neuropathic (ezibangelwa kukonakala kwemithambo-luvo ethwala imiyalezo phakathi kwengqondo kunye nomgogodla), ingakumbi kubantu abane-carpal tunnel syndrome, i-diabetes neuropathy, i-chemotherapy Abantu abane-peripheral neuropathy, iintlungu ezingapheliyo ze-pelvic, kunye neentlungu ezinxulumene ne-stroke kunye ne-multiple sclerosis. Kufuneka uvavanyo olongezelelweyo lweklinikhi ukuze kuchongwe ukusebenza kwe-PEA ekusombululeni iintlungu ze-neuropathic.

6. Ukwaluphala Okusempilweni

Ukulibazisa inkqubo yokwaluphala yinjongo ebalulekileyo elandelwa zizazinzulu ezininzi kwihlabathi liphela. I-Palmitoylethanolamide ithathwa njengesongezelelo sokulwa nokwaluphala esinokunceda ukukhusela iiseli kumonakalo we-oxidative, nto leyo ebangela ukwaluphala.

Xa iiseli zivezwa kwimisebenzi emininzi ye-free radicals, ii-oxidative reactions zinokwenzeka, nto leyo ekhokelela ekufeni kweeseli ngaphambi kwexesha. Ukutya ukutya okungenampilo, ukutshaya, kunye nezinye izinto ezibangela ukungcola komoya kwandisa umonakalo we-oxidative. I-Palmitoylethanolamide inokuthintela lo monakalo ngokususa ii-free radicals kunye nokunciphisa impendulo yokuvuvukala emzimbeni.

Ukongeza, i-palmitoylethanolamide ethanol ibonakalisiwe ukuba inokukhuthaza ukuveliswa kwe-collagen kunye nezinye iiproteni ezibalulekileyo zesikhumba. Ke ngoko, inokunciphisa ukubonakala kwemibimbi kunye nemigca emincinci, isebenze njengesikhuseli ngaphakathi kwiiseli.

I-Suzhou Myland Pharm & Nutrition Inc. ngumvelisi obhalisiweyo kwi-FDA obonelela ngomgubo wePalmitoylethanolamide (PEA) okumgangatho ophezulu nococekileyo.

Apha eSuzhou Myland Pharm sizibophelele ekuboneleleni ngeemveliso ezikumgangatho ophezulu ngamaxabiso angcono. Umgubo wethu wePalmitoylethanolamide (PEA) uvavanywa ngokungqongqo ubumsulwa kunye namandla, ukuqinisekisa ukuba ufumana isongezelelo esisemgangathweni onokusithemba. Nokuba ufuna ukuxhasa impilo yeseli, ukukhulisa amajoni akho omzimba, okanye ukuphucula impilo iyonke, umgubo wethu wePalmitoylethanolamide (PEA) lolona khetho lufanelekileyo.

Ngamava angama-30 eminyaka kwaye eqhutywa bubuchwepheshe obuphezulu kunye namaqhinga ophando nophuhliso aphucukileyo, iSuzhou Myland Pharm iphuhlise uluhlu lweemveliso ezikhuphisanayo kwaye yaba yinkampani yeenkonzo zokongeza izinto ezintsha zesayensi yobomi, ukwenziwa kwezinto ngokwezifiso kunye neenkonzo zokuvelisa.

Ukongeza, iSuzhou Myland Pharm ikwangumvelisi obhalisiweyo yi-FDA. Izixhobo zeR&D zenkampani, izixhobo zemveliso, kunye nezixhobo zokuhlalutya zizinto zanamhlanje kwaye zisebenza ngeendlela ezininzi, kwaye zinokuvelisa iikhemikhali ukusuka kwi-milligrams ukuya kwiitoni ngobukhulu, kwaye zihambelana nemigangatho ye-ISO 9001 kunye neenkcukacha zemveliso ze-GMP.