Yintoni ekufuneka uyazi malunga nepalmitoylethanolamide (PEA)?

I-Palmitoylethanolamide (PEA) yindalo ye-amide enamafutha e-asidi eye yatsala ingqalelo kwiinzuzo zayo zempilo. Le khompawundi ifumaneka kwizicubu ezahlukeneyo kuwo wonke umzimba, kwaye uphando lucebisa ukuba i-palmitamideethanol (PEA) inokuphelisa ukudumba, inciphise iintlungu, kwaye inokukhuthaza impilo yamathumbu kunye nokulibazisa ukuguga. Isenokuba neenzuzo ezahlukeneyo zempilo. Umxholo olandelayo uya kuphonononga inzuzo yezempilo ye-palmitoylethanolamide (PEA), indlela esebenza ngayo emzimbeni womntu, kunye nendlela yokufumana umgangatho ophezulu we-palmitoylethanolamide (PEA).

Yintoni i-palmitoylethanolamide (PEA)?

Palmitoylethanolamide (PEA) yinto eyenzeka ngokwemvelo efana ne-endocannabinoid eyaziwa ngokuba yi-analgesic engapheliyo kunye ne-anti-inflammatory properties. Ukongeza ekudityanisweni ngumzimba, i-PEA ifumaneka kwiindidi zokutya ezibandakanya: itshizi, iqanda leqanda, inyama, ubisi, amandongomane, i-soy lecithin.

ubusazi? Xa umzimba udibana noxinzelelo, njengokulimala okanye ukuvuvukala, amanqanaba e-PEA ahlengahlengisa ukugcina i-homeostasis yeselula.

I-palmitoylethanolamide iwuchaphazela njani umzimba womntu?

Iingcali zenzululwazi azikaqondi ngokupheleleyo indlela yokwenza i-palmitoylethanolamide. Nangona kunjalo, siye sahamba ngokude, sibonga kuNjingalwazi uRita Levi-Montalcini, owathi ngo-1992-1996 wachaza indlela yokusebenza ngokubanzi ye-palmitoylethanolamide. Ukususela ngoko, uye waqhubeka efunda iziphumo zepalmitoylethanolamide kwiintlungu ze-neuropathic kunye ne-allergies.

I-Palmitoylethanolamide inokuzisa izibonelelo ezine zezempilo ebantwini:

● Ukuphelisa ukukrala.

● Nciphisa ukusebenza kweeseli zemast (aleji).

●Qinisa umsebenzi we-endogenous hemp system.

●Vuselela izamkeli ezithile emzimbeni.

I-PEA izisebenzisa njani iziphumo zayo zokuchasa ukudumba kunye ne-analgesic?

Izibonelelo zezempilo ze-PEA ziquka iziphumo kwiiseli zomzimba ezilawula ukuvuvukala, ngakumbi kwingqondo. I-PEA inokunceda ukunciphisa ukuveliswa kwezinto ezivuthayo. Nangona kunjalo, i-PEA isebenza ikakhulu kwii-receptors kwiiseli, ezilawula imiba eyahlukeneyo yokusebenza kweeseli. Ezi zamkeli zibizwa ngokuba zii-PPAR. I-PEA kunye nezinye iikhompawundi ezinceda ukwenza i-PPAR isebenze inokunciphisa intlungu kwaye inokunyusa i-metabolism ngokutshisa amafutha, i-serum triglycerides ephantsi, ukwandisa i-serum HDL i-cholesterol, ukuphucula ukulawula iswekile yegazi, kunye nokunceda ukunciphisa umzimba.

Palmitoylethanolamide Benefits

Ngenxa yemiphumo ye-analgesic kunye ne-anti-inflammatory, uphando lubonisa ukuba i-PEA inokunceda ngeendlela ezahlukeneyo ezinxulumene neentlungu, ezifana ne-fibromyalgia, i-sciatica, kunye ne-osteoarthritis.

1. Ukuphelisa intlungu kunye nempendulo yokuvuvukala

Intlungu engapheliyo yingxaki enzima ephazamisa izigulane emhlabeni jikelele, kwaye njengoko abantu beminyaka yobudala, le ngxaki iya kuba yinto ebaluleke kakhulu. Omnye wemisebenzi yepalmitoylethanolamide kukuba inokunceda ukukhulula iintlungu kunye nokudumba. i-palmitoylethanolamide isebenzisana ne-CB1 kunye ne-CB2 receptors, eziyinxalenye ebalulekileyo yenkqubo ye-hemp engapheliyo. Le nkqubo inoxanduva lokugcina i-homeostasis okanye ibhalansi emzimbeni.

Xa ukwenzakala okanye impendulo yokuvuvukala isenzeka, umzimba ukhupha iikhompawundi ze-hemp ezingapheliyo ukunceda ukulawula impendulo yomzimba. I-palmitoylethanolamide inokunceda ukonyusa amanqanaba e-hemp engapheliyo emzimbeni, ngaloo ndlela ithomalalisa iintlungu kunye nokudumba.

Ukongeza, i-palmitoylethanolamide inokunciphisa ukukhutshwa kweekhemikhali ezivuthayo kunye nokunciphisa iimpendulo ezivuthayo ze-neurological. Ezi ziphumo zenza i-palmitoylethanolamide ibe sisixhobo esinokunceda ukulawula intlungu kunye neempendulo ezivuthayo. Uphononongo lubonisa ukuba i-palmitoylethanolamide inokusebenza kwintlungu ye-sciatica kunye ne-carpal tunnel syndrome.

2. IFibromyalgia

Izifundo ezininzi zibonisa ukuba i-PEA inokunceda ukunciphisa iimpawu ze-fibromyalgia, isifo esingapheliyo se-neurological esibangela intlungu ebanzi. Xa isetyenziswe njengenxalenye yonyango lwendabuko, ukungeniswa kwe-PEA kunciphisa ubunzima beentlungu kunye nokuphucula umgangatho wobomi ngokuhamba kwexesha. Ngokutsho kwesinye isifundo, ukuthatha i-PEA kwiinyanga ezintathu kunciphisa kakhulu intlungu kubantu abane-fibromyalgia.

3. Iintlungu zomqolo

Uphando lwangaphambili lubonisa ukusebenza kakuhle kwe-PEA kwiintlungu zangasemva. Uphononongo lokuqwalasela lwe-2017 lubonise ukuba i-PEA iphinde yanciphisa ubunzima beentlungu kwizigulane ezine-syndrome yokuhlinzwa emva kokusilela.

Abantu abahluphekayo kwi-sciatica, intlungu ephuma kwi-back back down enye okanye yomibini imilenze, banokufumana ukukhululeka emva kokuthatha i-PEA. Ulingo olungenamkhethe, oluyimfama oluphindwe kabini, olulawulwa yi-placebo lufunde iziphumo zedosi ephezulu kunye nephantsi ye-PEA ngokuchasene ne-placebo. Intlungu yancitshiswa ngaphezu kwe-50% kwiqela le-dose ephezulu. Nangona idosi ephantsi ye-PEA ayizange ifezekise iqondo elifanayo lokukhululeka kweentlungu njengedosi ephezulu, zombini iidosi zazisebenza kakhulu kune-placebo.

4. I-Osteoarthritis

I-PEA inokuba luncedo kubantu abane-osteoarthritis, isifo esibonakala ngokuwohloka kwe-cartilage edibeneyo kunye nethambo. Abathathi-nxaxheba kuphononongo olunye abafumana i-PEA bafumana uphuculo olubalulekileyo kwi-Western Ontario kunye neMcMaster Universities Osteoarthritis Index (WOMAC) amanqaku xa kuthelekiswa neqela le-placebo. I-WOMAC yi-questionnaire eyenzelwe ukuvavanya imeko kunye neempawu (umzekelo, intlungu, ukuqina, ukusebenza komzimba) kwizigulane ezinedolo kunye ne-hip osteoarthritis.

Olunye uphando olubandakanya izigulane ezineentlungu ze-temporomandibular arthritic (TMJ) ezinxulumene ne-osteoarthritis zibonise ukuba ukuxhaswa kwe-PEA kwaphucula kakhulu intlungu emva kweentsuku ze-14 xa kuthelekiswa ne-ibuprofen. Iqela elinikwe i-PEA kwiintsuku ze-14 libonise ukuphucuka okukhulu kakhulu ekuvuleni umlomo ophezulu (umlinganiselo wokunciphisa intlungu) kuneqela le-ibuprofen.

5. Intlungu ye-neuropathic

Izifundo zangaphambili kunye novavanyo lwezilwanyana zibonisa ukuba i-PEA inokunceda ngeentlungu ze-neuropathic (ezibangelwa ngumonakalo kwimithambo-luvo ethwala imiyalezo phakathi kwengqondo kunye nentambo yomgogodla), ngakumbi kubantu abane-carpal tunnel syndrome, isifo seswekile, i-chemotherapy Abantu abane-peripheral neuropathy, engapheliyo. iintlungu ze-pelvic, kunye neentlungu ezinxulumene ne-stroke kunye ne-multiple sclerosis. Iimvavanyo ezongezelelweyo zeklinikhi ziyafuneka ukufumanisa ukusebenza kwe-PEA ekucombululeni intlungu ye-neuropathic.

6. Ukuguga okunempilo

Ukulibazisa inkqubo yokwaluphala lusukelo oluluncedo oluphunyezwa zizazinzulu ezininzi ehlabathini lonke. I-Palmitoylethanolamide ithathwa njengesongezelelo esichasene nokuguga esinokunceda ukukhusela iiseli kumonakalo we-oxidative, eyona nto ibangela ukuguga.

Xa iiseli zisesichengeni sokusebenza ngokugqithisileyo kweradical yasimahla, iimpendulo ze-oxidative zinokwenzeka, ezikhokelela ekufeni kweseli kwangaphambi kwexesha. Ukungena kokutya okungenampilo, ukutshaya, kunye nokunye ukuvezwa kokusingqongileyo okunjengokungcola komoya nako kwandisa umonakalo oxidative.Palmitoylethanolamide inokuthintela lo monakalo ngokususa i-radicals yamahhala kunye nokunciphisa impendulo yokuvuvukala ngokubanzi emzimbeni.

Ukongeza, i-palmitoylethanolamide ethanol ibonakaliswe ukuba inokukhuthaza ukuveliswa kwe-collagen kunye nezinye iiproteni zolusu ezibalulekileyo. Ngoko ke, inokunciphisa ukubonakala kwemibimbi kunye nemigca emihle, esebenza njengomkhuseli ngaphakathi kweeseli.

I-Suzhou Myland Pharm & Nutrition Inc. ngumvelisi obhalisiwe we-FDA obonelela ngekhwalithi ephezulu kunye nococeko oluphezulu lwePalmitoylethanolamide (PEA) powder.

ESuzhou Myland Pharm sizimisele ukubonelela ngezona mveliso zikumgangatho ophezulu ngamaxabiso angcono. Umgubo wethu wePalmitoylethanolamide (PEA) uvavanywa ngokungqongqo ubunyulu kunye namandla, ukuqinisekisa ukuba ufumana isongezelelo esikumgangatho ophezulu onokuthembela kuwo. Nokuba ufuna ukuxhasa impilo yeselula, ukonyusa amajoni akho omzimba, okanye ukomeleza impilo yonke, iPalmitoylethanolamide (PEA) powder yethu lolona khetho lugqibeleleyo.

Ineminyaka engama-30 yamava kwaye iqhutywa bubuchwepheshe obuphezulu kunye nezicwangciso ze-R&D eziphuculwe kakhulu, iSuzhou Myland Pharm iphuhlise uluhlu lweemveliso ezikhuphisanayo kwaye ibe sisongezelelo sesayensi yobomi, ukudibanisa isiko kunye nenkampani yeenkonzo zokuvelisa.

Ukongeza, iSuzhou Myland Pharm ikwangumvelisi obhalisiweyo we-FDA. Izixhobo ze-R&D zenkampani, izixhobo zemveliso, kunye nezixhobo zohlalutyo zezanamhlanje kwaye zinemisebenzi emininzi, kwaye zinokuvelisa iikhemikhali ukusuka kwimilligrams ukuya kwiitoni kwisikali, kwaye zithobela imigangatho ye-ISO 9001 kunye neenkcukacha zemveliso ye-GMP.