Yintoni ekufuneka uyazi malunga ne-nicotinamide adenine dinucleotide (NAD+)?

I-NAD+ ikwabizwa ngokuba yi-coenzyme, kwaye igama layo elipheleleyo yi-nicotinamide adenine dinucleotide. Yi-coenzyme ebalulekileyo kumjikelo we-tricarboxylic acid. Ikhuthaza imetabolism yeswekile, amafutha, kunye nee-amino acids, ithatha inxaxheba ekuhlanganisweni kwamandla, kwaye ithatha inxaxheba kumawaka eempendulo kwiseli nganye. Inani elikhulu ledatha yovavanyo lubonisa ukuba i-NAD+ ibandakanyeka kakhulu kwimisebenzi eyahlukeneyo ye-physiological esisiseko kwi-organism, ngaloo ndlela ingenelela kwimisebenzi ephambili yeseli efana nemetabolism yamandla, ukulungiswa kwe-DNA, ukuguqulwa kwezakhi zofuzo, ukudumba, i-biological rhythms, kunye nokumelana noxinzelelo.

Ngokophando olufanelekileyo, inqanaba le-NAD+ emzimbeni womntu liya kwehla xa umntu ekhula. Ukwehla kwamanqanaba e-NAD+ kunokukhokelela ekuwohlokeni kwemithambo-luvo, ukulahleka kombono, ukutyeba kakhulu, ukwehla kokusebenza kwentliziyo kunye nokunye ukwehla kokusebenza. Ke ngoko, indlela yokunyusa inqanaba le-NAD+ emzimbeni womntu ibisoloko ingumbuzo. Umxholo wophando oshushu kuluntu lwezonyango.

Kutheni i-NAD+ incipha?

Kuba, njengoko sikhula, umonakalo we-DNA uyanda. Ngexesha lenkqubo yokulungisa i-DNA, imfuno ye-PARP1 iyanda, umsebenzi we-SIRT ulinganiselwe, ukusetyenziswa kwe-NAD+ kuyanda, kwaye ubungakanani be-NAD+ ngokwemvelo buyancipha.

Ukuba sincedisa ngokwaneleyoI-NAD+, siza kufumanisa ukuba imisebenzi emininzi yomzimba iqala ukubuyisela ubutsha.

Iiseli ziqulethe i-NAD+. Ngaba kusafuneka siphinde siyifake?

Umzimba wethu wenziwe ngeeseli ezimalunga ne-37 trillion. Iiseli kufuneka zenze "umsebenzi" omninzi okanye ii-cell reactions ukuze zihlale zisebenza. Iseli nganye kwiiseli zakho ezingama-37 trillion ixhomekeke kwi-NAD+ ukuze yenze umsebenzi wayo oqhubekayo.

Njengoko uluntu lwehlabathi lukhula, izifo ezinxulumene nokwaluphala ezifana nesifo sika-Alzheimer, isifo sentliziyo, iingxaki zamalungu, ubuthongo kunye neengxaki zentliziyo ziye zaba zizifo ezibalulekileyo ezisongela impilo yoluntu.

Ngoko ke, ukusukela oko i-NAD yafunyanwa zizazinzulu zaseMelika, i-NAD ingene ebomini babantu, kwaye i-NAD+ kunye nezongezo zayo zibonise amathuba amakhulu okusetyenziswa ekuthinteleni izifo ezinxulumene nokwaluphala.

① I-NAD+ isebenza njenge-coenzyme kwi-mitochondria ukukhuthaza ulungelelwaniso lwe-metabolic. I-NAD+ idlala indima esebenzayo kakhulu kwiinkqubo ze-metabolic ezifana ne-glycolysis, umjikelo we-TCA (owaziwa ngokuba yi-Krebs cycle okanye umjikelo we-citric acid) kunye nochungechunge lothutho lwe-electron. Yindlela iiseli ezifumana ngayo amandla. Ukwaluphala kunye nokutya okuneekhalori eziphezulu kunciphisa amanqanaba e-NAD+ emzimbeni.

Izifundo zibonise ukuba kwiimpuku ezindala, ukuthatha izongezo ze-NAD+ kunciphisa ukutyeba okunxulumene nokutya okanye nokukhula kunye nokuphucula amandla okuzilolonga. Ukongeza, izifundo zide zaguqula iziphumo zesifo seswekile kwiimpuku ezibhinqileyo, zibonisa amaqhinga amatsha okulwa nezifo ze-metabolic ezifana nokutyeba kakhulu.

I-NAD+ ibopha kwii-enzymes kwaye idlulise ii-electron phakathi kwee-molecules. Ii-electron zisisiseko samandla eseli. I-NAD+ isebenza kwiiseli njengokuphinda itshaje ibhetri. Xa ii-electron zigqityiwe, ibhetri iyafa. Kwiiseli, i-NAD+ inokukhuthaza ukudluliselwa kwee-electron kwaye inike amandla kwiiseli. Ngale ndlela, i-NAD+ inokunciphisa okanye yonyuse umsebenzi wee-enzyme, ikhuthaze ukubonakaliswa kwezakhi zofuzo kunye nokuhanjiswa kweseli.

② I-NAD+ inceda ukulawula umonakalo we-DNA

Njengoko izinto eziphilayo zikhula, izinto ezimbi ezingqongileyo ezifana nemitha, ungcoliseko, kunye nokuphindaphinda kwe-DNA okungachanekanga zingonakalisa i-DNA. Le yenye yeengcamango zokwaluphala. Phantse zonke iiseli ziqulathe "umatshini weemolekyuli" wokulungisa lo monakalo.

Olu lungiso lufuna i-NAD+ kunye namandla, ngoko ke umonakalo omkhulu we-DNA udla izixhobo ezixabisekileyo zeseli. Umsebenzi we-PARP, iprotheyini ebalulekileyo yokulungisa i-DNA, uxhomekeke kwi-NAD+. Ukwaluphala okuqhelekileyo kubangela ukuba umonakalo we-DNA uqokelele emzimbeni, i-RARP iyanda, kwaye ngenxa yoko amanqanaba e-NAD+ ayancipha. Umonakalo we-Mitochondrial DNA nangaliphi na inyathelo uya kuyenza mandundu le nciphiso.

③ NAD+ichaphazela umsebenzi we-gene ende ye-Sirtuins kwaye ithintela ukuguga

Iijini ezisandula ukufunyanwa ze-sirtuins ezihlala ixesha elide, ezaziwa ngokuba "ngabagcini bejini," zidlala indima ebalulekileyo ekugcineni impilo yeseli. Ii-Sirtuins zintsapho yee-enzymes ezibandakanyekayo ekuphenduleni uxinzelelo lweseli kunye nokulungisa umonakalo. Zikwabandakanyeka ekukhutshweni kwe-insulin, inkqubo yokwaluphala, kunye neemeko zempilo ezinxulumene nokwaluphala ezifana nezifo ze-neurodegenerative kunye nesifo seswekile.

I-NAD+ yifutha enceda ii-sirtuins zigcine ukuthembeka kwe-genome kwaye zikhuthaze ukulungiswa kwe-DNA. Kanye njengokuba imoto ingenakuphila ngaphandle kwefutha, ii-Sirtuins zifuna i-NAD+ ukuze isebenze. Iziphumo ezivela kwizifundo zezilwanyana zibonisa ukuba ukonyuka kwamanqanaba e-NAD+ emzimbeni kuyenza isebenze iiproteni ze-sirtuin kwaye kwandisa ubomi kwimvubelo nakwiimpuku.

④ Umsebenzi wentliziyo

Ukunyusa amanqanaba e-NAD+ kukhusela intliziyo kwaye kuphucula ukusebenza kwentliziyo. Uxinzelelo lwegazi oluphezulu lunokubangela ukwandiswa kwentliziyo kunye nokuvaleka kwemithambo yegazi, okunokukhokelela kwistroke. Emva kokugcwalisa amanqanaba e-NAD+ entliziyweni ngokusebenzisa izongezo ze-NAD+, umonakalo entliziyweni obangelwa kukuphinda kuphume igazi uyathintelwa. Ezinye izifundo zibonise ukuba izongezo ze-NAD+ zikwakhusela iimpuku ekukhuleni kwentliziyo okungaqhelekanga.

⑤ Ukonakala kwemithambo-luvo

Kwiimpuku ezinesifo sika-Alzheimer, ukonyusa amanqanaba e-NAD+ kuphucula ukusebenza kwengqondo ngokunciphisa ukuqokelelana kweeproteni eziphazamisa unxibelelwano lobuchopho. Ukunyusa amanqanaba e-NAD+ kukwakhusela iiseli zobuchopho ekubeni zife xa kungekho gazi laneleyo eliya ebuchotsheni. I-NAD+ ibonakala inesithembiso esitsha sokukhusela ukuwohloka kwemithambo-luvo nokuphucula inkumbulo.

⑥ Inkqubo yomzimba yokuzikhusela

Njengoko sikhula, amajoni ethu omzimba ayawohloka kwaye sisengozini enkulu yokugula. Uphando lwakutshanje lubonisa ukuba amanqanaba e-NAD+ adlala indima ebalulekileyo ekulawuleni iimpendulo zomzimba kunye nokudumba kunye nokusinda kweeseli ngexesha lokwaluphala. Olu phononongo lubonisa amandla okunyanga e-NAD+ kwingxaki yokungasebenzi kakuhle komzimba.

Ubudlelwane phakathi kwendima ye-NAD+ kunye nokwaluphala

Ii-coenzymes zithatha inxaxheba kwi-metabolism yezinto ezibalulekileyo ezifana neswekile, amafutha, kunye neproteni emzimbeni womntu, kwaye zidlala indima ebalulekileyo ekulawuleni i-metabolism yezinto zomzimba kunye namandla kunye nokugcina imisebenzi eqhelekileyo yomzimba. I-NAD yeyona coenzyme ibalulekileyo emzimbeni womntu, ekwabizwa ngokuba yi-coenzyme I. Ithatha inxaxheba kumawaka eempendulo ze-redox enzyme emzimbeni womntu. Yinto eyimfuneko kwi-metabolism yeseli nganye. Inemisebenzi emininzi, imisebenzi ephambili yile:

1. Khuthaza ukuveliswa kwamandla endalo

I-NAD+ ivelisa i-ATP ngokuphefumla kweeseli, yongeza ngokuthe ngqo amandla eeseli kwaye iphucula ukusebenza kweeseli;

2. Ukulungisa iijini

I-NAD+ yeyona nto iphambili kwi-enzyme yokulungisa i-DNA i-PARP. Olu hlobo lwe-enzyme luthatha inxaxheba ekulungisweni kwe-DNA, lunceda ekulungiseni i-DNA kunye neeseli ezonakeleyo, lunciphisa amathuba okuguquka kweeseli, kwaye luthintele ukwenzeka komhlaza;

3. Sebenzisa zonke iiproteni ezihlala ixesha elide

I-NAD+ ingenza zonke iiproteni ezisi-7 zobomi obude zisebenze, ngoko ke i-NAD+ inempembelelo ebaluleke ngakumbi ekulweni nokwaluphala kunye nokwandisa ubomi;

4. Yomeleza inkqubo yomzimba yokuzikhusela

I-NAD+ yomeleza inkqubo yomzimba yokuzikhusela kwaye iphucula ukhuseleko lweseli ngokuchaphazela ngokukhethekileyo ukusinda kunye nokusebenza kweeseli ze-T ezilawulayo.

5. Khuthaza ukukhula kweenwele

Eyona nto ibangela ukulahleka kweenwele kukulahlekelwa bubomi beeseli zomama weenwele, kwaye ukulahleka kobomi beeseli zomama weenwele kungenxa yokuba inqanaba le-NAD+ emzimbeni womntu liyehla. Iiseli zomama weenwele azinayo i-ATP eyaneleyo yokwenza ukwenziwa kweeproteni zeenwele, ngaloo ndlela zilahlekelwa bubomi bazo kwaye zikhokelele ekulahlekelweni bubomi beeenwele.

6. Ukulawula ubunzima, ukukhuthaza imetabolism

Ngowama-2017, uNjingalwazi uDavid Sinclair weHarvard Medical School kunye neqela elivela kwiAustralian Medical College benze uvavanyo lokuthelekisa kwiimpuku zamabhinqa ezityebileyo ezenza umthambo kwi-treadmill kangangeeveki ezili-9 kwaye zithatha i-NMN yonke imihla kangangeentsuku ezili-18. Olu phononongo lufumanise ukuba i-NMN ichaphazela imetabolism yamafutha esibindi. Kwaye isiphumo sokwenziwa kwezinto ngokucacileyo sikhulu kunesomthambo.

Okuphawulekayo kukuba, ukwaluphala kuhamba nokwehla okuqhubekekayo kwamanqanaba e-NAD+ kwizicwili nakwiiseli kwiintlobo ngeentlobo zezinto eziphilayo, kuquka iimpuku kunye nabantu. Ukwehla kwamanqanaba e-NAD+ kunxulunyaniswa nezifo ezininzi ezinxulumene nokwaluphala, kuquka ukwehla kwengqondo, umhlaza, isifo se-metabolic, i-sarcopenia, kunye nobuthathaka.

Ndingayongeza njani i-NAD+ yonke imihla?

Akukho kunikezelwa okungapheliyo kwe-NAD+ emizimbeni yethu. Umxholo kunye nomsebenzi we-NAD+ emzimbeni womntu uya kuncipha njengoko iminyaka ikhula, kwaye uya kuncipha ngokukhawuleza emva kweminyaka engama-30, nto leyo ekhokelela ekugugeni kweeseli, ukuphelelwa ngamandla okuhlaziya.

Ngaphezu koko, ukuncitshiswa kwe-NAD+ kuya kubangela uthotho lweengxaki zempilo, ngoko ke ukuba i-NAD+ ayinakufumaneka kwakhona ngexesha, iziphumo zingacingelwa.

1. Isongezelelo esisuka ekutyeni

Ukutya okufana nekhaphetshu, ibroccoli, iavokhado, isteak, amakhowa, kunye ne-edamame kuqulethe izinto ezizandulela i-NAD+, ezinokuguqulwa zibe yi-NAD* esebenzayo emzimbeni emva kokufunxwa.

2. Nciphisa ukutya kunye neekhalori

Ukuncitshiswa kweekhalori okuphakathi kunokuvula iindlela zokuvavanya amandla ngaphakathi kweeseli kwaye kunyuse ngokungathanga ngqo amanqanaba e-NAD*. Kodwa qiniseka ukuba utya ukutya okunesondlo ukuze uhlangabezane neemfuno zesondlo somzimba wakho.

3. Hlala usebenza kwaye uzilolonge

Ukuzilolonga okuphakathi kwe-aerobic njengokubaleka nokudada kunokunyusa amanqanaba e-NAD+ ngaphakathi kweeseli, kuncede ekwandiseni ukunikezelwa kweoksijini emzimbeni kwaye kuphucule imetabolism yamandla.

4. Landela imikhwa yokulala esempilweni

Ngexesha lokulala, umzimba womntu wenza iinkqubo ezininzi ezibalulekileyo ze-metabolic kunye nokulungisa, kubandakanya ukwenziwa kwe-NAD*. Ukulala ngokwaneleyo kunceda ukugcina amanqanaba aqhelekileyo e-NAD

5. Yongeza izinto ezisandula ukwenziwa ze-NAD+

I-Nicotinic acid (NA) kunye ne-nicotinamide (NAM) zombini zizinto ezandulela i-NAD+. Zingadityaniswa kwaye ziguqulwe zibe yi-NAD emzimbeni womntu, ngaloo ndlela zandisa umxholo wayo. Nangona kunjalo, ngenxa yokunqongophala kwendlela yokwenza izinto kunye nee-enzymes ezithintela izinga, i-bioavailability iphantsi.

6 Yongeza ngokuthe ngqo i-NAD+

Ukongezwa kwe-NAD+ ngaphandle kunokubuyisela ngokukhawuleza amanqanaba e-NAD+ emzimbeni, okuvumela amalungu abalulekileyo afana nentliziyo nengqondo ukuba afumane ukongezwa kwe-NAD+ okusebenzayo ngakumbi.

I-Suzhou Myland Pharm & Nutrition Inc. ngumvelisi obhalisiweyo kwi-FDA obonelela nge-NAD+ supplement powder ekumgangatho ophezulu necocekileyo.

Apha eSuzhou Myland Pharm sizibophelele ekuboneleleni ngeemveliso ezikumgangatho ophezulu ngamaxabiso angcono. Iipowder zethu ze-NAD+ supplement zivavanywa ngokungqongqo ukuze zibonakale zicocekile kwaye zinamandla, okuqinisekisa ukuba ufumana isongezelelo esisemgangathweni onokusithemba. Nokuba ufuna ukuxhasa impilo yeseli, ukukhulisa amajoni akho omzimba okanye ukuphucula impilo iyonke, ipowder yethu ye-NAD+ supplement yeyona ifanelekileyo.

Ngamava angama-30 eminyaka kwaye eqhutywa bubuchwepheshe obuphezulu kunye namaqhinga ophando nophuhliso aphucukileyo, iSuzhou Myland Pharm iphuhlise uluhlu lweemveliso ezikhuphisanayo kwaye yaba yinkampani yeenkonzo zokongeza izinto ezintsha zesayensi yobomi, ukwenziwa kwezinto ngokwezifiso kunye neenkonzo zokuvelisa.

Ukongeza, iSuzhou Myland Pharm ikwangumvelisi obhalisiweyo yi-FDA. Izixhobo zeR&D zenkampani, izixhobo zemveliso, kunye nezixhobo zokuhlalutya zizinto zanamhlanje kwaye zisebenza ngeendlela ezininzi, kwaye zinokuvelisa iikhemikhali ukusuka kwi-milligrams ukuya kwiitoni ngobukhulu, kwaye zihambelana nemigangatho ye-ISO 9001 kunye neenkcukacha zemveliso ze-GMP.