I-7,8-Dihydroxyflavone yikhemikhali yendalo efumaneka kwizityalo efumene ingqalelo enkulu ngenxa yeenzuzo zayo ekusebenzeni kwengqondo nakwimemori. Le khemikhali ye-flavone ikwiqela leekhemikhali ezibizwa ngokuba zii-flavonoids, ezaziwa ngeempawu zazo zokulwa ne-antioxidant kunye nokulwa nokuvuvukala. Uphando lubonise ukuba i-7,8-dihydroxyflavone inokuba nemiphumo emihle emininzi engqondweni.
I-7,8-Dihydroxyflavone yikhompawundi enamandla neguquguqukayo eyinxalenye yosapho lwe-flavonoid. Ii-Flavonoids ziikhompawundi zendalo ezisasazwa kakhulu kwizityalo kwaye zidlala indima ebalulekileyo kwiinkqubo ezahlukeneyo zebhayoloji. Enye yeempawu eziphawulekayo ze-7,8-dihydroxyflavone kukukwazi kwayo ukusebenzisana nokulawula iiproteni kunye nee-enzymes emzimbeni, nto leyo evuse umdla omkhulu kuluntu lwezenzululwazi.
Uphando lubonise ukuba i-compound engu-7,8-dihydroxyflavone ineengenelo zempilo, ineempawu ze-antioxidant, anti-inflammatory kunye ne-neuroprotective. Phakathi kwazo, umsebenzi onamandla we-antioxidant we-7,8-dihydroxyflavone uvumela ukuba ikwazi ukukhupha ii-free radicals eziyingozi emzimbeni kwaye ithintele uxinzelelo lwe-oxidative ekubangeleni umonakalo weeseli kunye nezifo ezahlukeneyo. Uphando olwenziweyo ukuza kuthi ga ngoku kwi-7,8-dihydroxyflavones luyakhuthaza, kodwa uphando oluthe kratya luyadingeka ukufumanisa ukusebenza kakuhle kunye nokhuseleko lwe-7,8-dihydroxyflavones zokusetyenziswa ebantwini. Nangona kunjalo, le compound ye-flavonoid inesithembiso esikhulu njengesongezelelo sokutya okanye umviwa wamayeza kwixesha elizayo.
I-7,8-Dihydroxyflavone yikhompawundi yendalo, ekwaziwa ngokuba yi-7,8-DHF, eye yafumana ingqwalasela eninzi kwiminyaka yakutshanje ngenxa yeenzuzo zayo kwimpilo yabantu.
Le khompawundi yendalo iyinxalenye yosapho lwe-flavonoid kwaye ifumaneka kwiintlobo ngeentlobo zezityalo, kuquka ingcambu yeScutellaria baicalensis.
1. Ukuphucula ukusebenza kwengqondo
Uphando lubonisa ukuba le khompawundi isebenza njenge-agonist ye-TrkB, oko kuthetha ukuba ivuselela ii-receptor ze-TrkB ebuchotsheni. Ezi receptors zinoxanduva lokukhuthaza ukukhula nokusinda kwee-neurons, kunye nokuphucula i-synaptic plasticity -- amandla engqondo okuzivumelanisa nokutshintsha. Ngokuvuselela ii-receptor ze-TrkB, i-7,8-dihydroxyflavone ibonakalisiwe ukuba iphucula inkumbulo kunye nokuqonda. Oku kuyenza ibe sisixhobo esinokwenzeka sonyango lokunyanga izifo ze-neurodegenerative ezifana nesifo se-Alzheimer's.
2. Isiphumo sokudakumba
Ngokusebenzisa ii-receptor ze-TrkB, le khompawundi ikhuthaza ukukhula kwee-neurons ezintsha kwi-hippocampus, indawo yengqondo ebandakanyekayo ekulawuleni imood. Izifundo zemodeli yezilwanyana zibonise ukuba i-7,8-dihydroxyflavone inokunciphisa iimpawu zokudakumba kwaye yonyuse ukumelana noxinzelelo. Ezi ziphumo zibonisa ukuba le khompawundi ingasetyenziswa njengendlela yendalo endaweni ye-antidepressants yendabuko.
3. Iimpawu zokulwa nokuvuvukala kunye nomthamo we-antioxidant
I-7,8-Dihydroxyflavone yi-antioxidant enamandla enceda ukukhusela iiseli kwi-oxidative stress ebangelwa yi-free radicals. Olu khuselo lunciphisa umngcipheko wezifo ezingapheliyo kwaye lucothisa inkqubo yokwaluphala.
Ukudumba kobuchopho kunokunceda ekuphuhlisweni nasekuqhubekeni kwezifo ezahlukeneyo ze-neurological, kuquka isifo sikaParkinson kunye ne-multiple sclerosis. Uphando lubonisa ukuba i-7,8-DHF ineempawu zokulwa nokudumba ezinceda ekunciphiseni ukudumba engqondweni kwaye zithintele ukuwohloka kwemithambo-luvo. Ngokuthintela ukuveliswa kwee-molecules ezibangela ukudumba, le compound inokuba namandla okunciphisa iimpawu kwaye icothise ukuqhubekeka kwezi zifo zibuthathaka.
4. Inamandla okunyanga iingxaki zokuxhalaba
Izifundo zezilwanyana zibonise ukuba le khemikhali inokunciphisa ukuziphatha okufana nokuxhalaba ngokusebenzisa ii-receptors ze-TrkB kwi-amygdala, indawo yengqondo ebandakanyeka kwiimpendulo zoloyiko kunye nokuxhalaba. Ngokulawula umsebenzi wezi receptors, ii-7,8-dihydroxyflavones zinokubonelela ngendlela yendalo nesebenzayo yokulawula ukuxhalaba ngaphandle kwemiphumo emibi enxulunyaniswa namayeza emveli okulwa nokuxhalaba.
Ngaphambi kokuba sijonge imithombo yokutya, masiqonde ukuba yintoni kanye kanye i-7,8-dihydroxyflavone. Yi-flavonoid yendalo ekwiqela le-flavonoids. Ii-Flavonoids ziikhompawundi ezisekwe kwizityalo ezaziwa ngeempawu zazo ze-antioxidant, ezinceda ekukhuseleni iiseli kwi-free radicals eziyingozi.
Ngoku, makhe sihlolisise ukutya okuqulethe i-7,8-dihydroxyflavone eninzi:
1. Iziqhamo zeCitrus
Enye yezona mithombo zibalaseleyo ze-7,8-dihydroxyflavones ziziqhamo ze-citrus ezifana nee-orenji, iilamuni, iigrapefruit kunye neelayimu. Ezi ziqhamo azityebanga nje kuphela kwi-vitamin C, kodwa zikwaqulathe iintlobo ngeentlobo ze-flavonoids, kuquka ne-7,8-dihydroxyflavone.
2. Amaqunube
Amaqunube afana neeblueberries, amaqunube, amaqunube, kunye namaqunube amnyama aziwa ngokuba nomxholo ophezulu we-antioxidant. Ezi ziqhamo zimnandi zikwangumthombo omkhulu we-7,8-dihydroxyflavone, nto leyo ekunika iingenelo zempilo eziphindwe kabini.
3. Itshokholethi emnyama
Iindaba ezimnandi kubathandi betshokholethi! Itshokholethi emnyama, ingakumbi leyo inomxholo ophezulu wekhokho, inezixa eziphezulu ze-7,8-dihydroxyflavonoids. Nangona kunjalo, khetha iintlobo ezineswekile encinci ukuze ufumane iingenelo ezipheleleyo.
4. Iti eluhlaza
Ukongeza ekubeni sisiselo esidumileyo, iti eluhlaza ikwatyebile kwiiflavonoids, kuquka i-7,8-dihydroxyflavone. Ukutya iti eluhlaza rhoqo kunokunceda ukwandisa ukutya kwakho ii-antioxidant kunye nokuxhasa impilo iyonke.
5. Isoya
Ukuba ujonge umthombo wesityalo we-7,8-dihydroxyflavone, isoya lukhetho oluhle. Ayipheleli nje ekubeni ineproteni eninzi, kodwa ikwanazo nee-flavonoids ezahlukeneyo ezinegalelo kwizakhiwo zazo eziluncedo.
6. Imifuno eluhlaza enamagqabi
Imifuno efana nekale, ispinatshi, kunye nebroccoli ayigcini nje ngokuba neekhalori eziphantsi, kodwa ikwatyebile kwii-antioxidants. Le mifuno iluhlaza ingumthombo obalaseleyo we-7,8-dihydroxyflavone, kunye nezinye izondlo ezibalulekileyo.
7. Iwayini ebomvu
Hayi bo! Ukusela iwayini ebomvu ngokulinganiselayo kuqulethe uhlobo lwe-flavonoid ebizwa ngokuba yi-resveratrol, equka i-7,8-dihydroxyflavone. Kukholelwa ukuba le khompawundi inegalelo kwizibonelelo zentliziyo ezinxulunyaniswa nokusetyenziswa kwewayini ebomvu ngokulinganiselayo.
Ukufaka ezi zinto zokutya ekutyeni kwakho kunokukunika iingenelo ezininzi ezinxulumene ne-7,8-dihydroxyflavone.
I-7,8-Dihydroxyflavone, eyaziwa ngokuba yi-DHF okanye i-baicalein, yi-flavonoid yendalo efumaneka kwiintlobo ngeentlobo zezityalo, kuquka ingcambu yeScutellaria baicalensis. Le khompawundi ifumene ingqwalasela eninzi kwiminyaka yakutshanje ngenxa yeenzuzo zayo zempilo kunye neempawu zonyango. Nangona kunjalo, xa kujongwa ukhuseleko lwayo nayiphi na into, kubalulekile ukuphonononga ubungqina besayensi obukhoyo. Ngoko ke, ngaba i-7,8-dihydroxyflavone ikhuselekile?
Ngokuphathelele ukhuseleko lwayo, uphando olulinganiselweyo luye lwenziwa malunga nokusetyenziswa ngokuthe ngqo kwe-7,8-dihydroxyflavone ebantwini. Ke ngoko, ukwenza iingxelo eziqinisekileyo malunga nokhuseleko lwayo kunzima. Nangona kunjalo, izifundo zezilwanyana zibonelele ngolwazi oluxabisekileyo malunga nokuba ingaba yingozi kangakanani na. Iimodeli ezahlukeneyo zezilwanyana azizange zibike ziphumo zibalulekileyo emva kokusetyenziswa kwe-DHF, nokuba ziphezulu kangakanani na. Oku kuthetha ukuba i-7,8-dihydroxyflavone inokunyamezelana kakuhle, ubuncinci ngaphakathi kwemilinganiselo efundweyo.
Nangona kunjalo, kufuneka kuqatshelwe xa kufikwa kwizigqibo ngokusekelwe kwizifundo zezilwanyana kuphela. Iziphumo zezinto zingahluka kakhulu phakathi kweentlobo, ngoko ke, kufuneka kuqatshelwe xa kujongwa iziphumo ebantwini. Ngaphezu koko, ukungabikho kwezifundo ezipheleleyo zabantu ezinde kuye kwathintela uvavanyo olucacileyo lokhuseleko lwazo.
I-7,8-Dihydroxyflavone (7,8-DHF) yi-flavonoid yendalo efumene ingqwalasela eninzi ngenxa yeenzuzo zayo zempilo, nangona kunjalo, kubaluleke kakhulu ukwazi idosi ecetyiswayo kunye neengcebiso xa usebenzisa i-7,8-DHF ebalulekileyo.
Kubalulekile ukubonisana nogqirha xa kufikwa kumthamo we-7,8-DHF, njengoko umthamo ofanelekileyo unokwahluka ngokusekelwe kwizinto ezininzi ezifana nobudala, ubunzima kunye neemeko ezithile zonyango. Uphononongo lwangoku lubonisa uluhlu lweendlela zokuthatha umthamo, ngesiqhelo i-20 ukuya kwi-60 mg ngosuku. Nangona kunjalo, kufuneka kuqatshelwe ukuba ezi ngcebiso azimiselwanga kwaye zinokutshintsha njengoko kuqokelelwa ubungqina besayensi.
Xa uthenga izongezo zokutya ze-7,8-DHF, kubalulekile ukukhetha umenzi othembekileyo nothembekileyo ukuqinisekisa ukhuseleko nokusebenza kakuhle kwemveliso. Ukufunda uphononongo lwabathengi kunye nokujonga uvavanyo lwelebhu yomntu wesithathu kunokunceda ekuqinisekiseni ukuthembeka kwemveliso. Kubaluleke kakhulu ukulandela iingcebiso zengcali yakho yezempilo. Baya kukwazi ukubonelela ngesikhokelo sobuqu ngokusekelwe kwimbali yakho yezonyango kunye neemeko zempilo zangoku. Kucetyiswa rhoqo ukuba uqale ngedosi ephantsi esebenzayo kwaye kancinci kancinci wonyuse njengoko kufuneka phantsi kweliso lengcali yezempilo.
Ngaphambi kokuba ufake i-7,8-DHF kucwangciso lwakho lwemihla ngemihla, kubalulekile ukuba uqaphele naziphi na iziphumo ebezingalindelekanga okanye ukusebenzisana namayeza. Nangona i-7,8-DHF idla ngokunyamezelwa kakuhle, abanye abantu banokufumana ubunzima obuncinci besisu okanye iimpembelelo ze-allergy. Kwakhona, qiniseka ukuba wazisa ingcali yakho yezempilo ngayo nayiphi na imithi okanye izongezo ozisebenzisayo ngoku ukuze uphephe naluphi na unxibelelwano olunokubakho. Khumbula ukuba ukuthatha naziphi na izongezo kufuneka kuhlale kuphantsi kolawulo lwengcali yezempilo ukuze kuphuculwe impilo yakho.
Q: Kuthatha ixesha elingakanani ukuba i-7,8-dihydroxyflavone okanye isebenze?
A: Isantya esisebenzisa ngaso i-7,8-dihydroxyflavone (7,8-DHF) sinokuhluka ngokuxhomekeke kwizinto ezahlukeneyo. Kwizifundo zesayensi, i-7,8-DHF ibonakalise ukuba ineziphumo ezahlukeneyo, ezinje ngokukhuthaza ukukhululwa kwezinto ze-neurotrophic kunye nokukhuselwa kwe-neuroprotection. Ixesha elithathayo ukuba ezi ziphumo zibonakale linokususela kwiiyure ukuya kwiintsuku okanye nangaphezulu, kuxhomekeke kwindlela ethile yokusebenza kunye nenjongo yekhompawundi.
Isikhanyeli: Eli nqaku lenzelwe ulwazi kuphela kwaye akufuneki lithathwe njengengcebiso yezonyango. Soloko unxibelelana neengcali zezempilo ngaphambi kokusebenzisa naziphi na izongezo okanye ukutshintsha inkqubo yakho yezempilo.
Ixesha lokuthumela: Julayi-04-2023
