I-7,8-Dihydroxyflavone yinto eyenzeka ngokwemvelo efunyenwe kwizityalo eziye zafumana ingqalelo ebalulekileyo kwiinzuzo zayo ezinokuthi zisebenze kwingqondo kunye nememori. Le khompawundi ye-flavone yeyodidi lweekhemikhali ezibizwa ngokuba yi-flavonoids, ezaziwa ngokuba ne-antioxidant kunye ne-anti-inflammatory properties. Uphando lubonise ukuba i-7,8-dihydroxyflavone inokuba neziphumo ezininzi ezintle kwingqondo.
I-7,8-Dihydroxyflavone yikhompawundi enamandla kwaye eguquguqukayo yentsapho ye-flavonoid. I-Flavonoids zikhompawundi zendalo ezisasazwa ngokubanzi kwizityalo kwaye zidlala indima ebalulekileyo kwiinkqubo ezahlukeneyo zebhayoloji. Enye yeempawu eziphawulekayo ze-7,8-dihydroxyflavone kukukwazi ukusebenzisana kunye nokulawula iiprotheni kunye ne-enzymes emzimbeni, oye wavusa umdla omkhulu kuluntu lwezenzululwazi.
Uphando lubonise ukuba i-compound 7,8-dihydroxyflavone ineenzuzo zempilo ezinokubakho, ezine-antioxidant, anti-inflammatory kunye ne-neuroprotective properties. Phakathi kwabo, umsebenzi oqinileyo we-antioxidant we-7,8-dihydroxyflavone wenza ukuba ikhuphe i-radicals eyingozi emzimbeni kwaye ithintele uxinzelelo lwe-oxidative ekubangeleni umonakalo weseli kunye nezifo ezahlukeneyo. Uphando olwenziweyo ngoku kwi-7,8-dihydroxyflavones luyakhuthaza, kodwa uphando olongezelelweyo lufunekayo ukuze kuqinisekiswe ukusebenza kunye nokhuseleko lwe-7,8-dihydroxyflavones ukuze isetyenziswe kubantu. Nangona kunjalo, le ngqungquthela ye-flavonoid ibambe isithembiso esikhulu njengesongezelelo sokutya okanye umviwa weziyobisi kwixesha elizayo.
I-7,8-Dihydroxyflavone yikhompawundi yendalo, ekwabizwa ngokuba yi-7,8-DHF, efumene ingqwalasela enkulu kwiminyaka yakutshanje ngenxa yeenzuzo zayo ezinokubakho kwimpilo yabantu.
Le khompawundi yenzeka ngokwendalo yeyosapho lweflavonoid kwaye ifumaneka kwiintlobo ngeentlobo zezityalo, kuquka ingcambu ye Scutellaria baikalensis.
1. Ukuphucula ukusebenza kwengqondo
Uphando lubonisa ukuba le khompawundi isebenza njenge-agonist ye-TrkB, oku kuthetha ukuba ivuselela i-TrkB receptors kwingqondo. La ma-receptors anoxanduva lokukhuthaza ukukhula kunye nokuphila kwee-neurons, kunye nokuphucula iplastiki ye-synaptic - amandla obuchopho ukulungelelanisa nokutshintsha. Ngokuvuselela i-TrkB receptors, i-7,8-dihydroxyflavone iboniswe ukuphucula imemori kunye nokuqonda. Oku kuyenza ibe yiarhente yonyango enokubakho ukunyanga izifo ze-neurodeergenerative ezifana nesifo sika-Alzheimer.
2. Isiphumo sokuthomalalisa uxinzelelo
Ngokuvula ii-receptors ze-TrkB, ikhompawundi ikhuthaza ukukhula kwee-neuron ezintsha kwi-hippocampus, indawo yobuchopho ebandakanyeka kulawulo lwemood. Uphononongo lwemodeli yezilwanyana lubonise ukuba i-7,8-dihydroxyflavone inokunciphisa iimpawu zokudakumba kwaye yandise ukumelana noxinzelelo. Ezi ziphumo zibonisa ukuba le khompawundi inokusetyenziswa njengenye indlela yendalo kunyango lokudakumba.
3. Iimpawu ezichasayo kunye nomthamo we-antioxidant
I-7,8-Dihydroxyflavone i-antioxidant enamandla enceda ukukhusela iiseli kuxinzelelo lwe-oxidative olubangelwa yi-radicals yamahhala. Olu khuselo lunciphisa umngcipheko wesifo esingapheliyo kwaye lunciphisa inkqubo yokuguga.
Ukudumba kwengqondo kunokufaka isandla ekuphuhliseni nasekuqhubeleni phambili kwezifo ezahlukahlukeneyo zemithambo-luvo, kuquka nesifo sikaParkinson kunye ne-multiple sclerosis. Uphando lubonisa ukuba i-7,8-DHF inezixhobo ezichasayo ezinceda ukunciphisa ukuvuvukala kwingqondo kunye nokukhusela i-neurodegeneration. Ngokuthintela ukuveliswa kweemolekyuli ze-pro-inflammatory, i-compound inokuba namandla okunciphisa iimpawu kunye nokunciphisa ukuqhubela phambili kwezi zifo eziphazamisayo.
4. Unamandla okuNyanga iziphazamiso zokuxhalaba
Izifundo zezilwanyana zibonise ukuba ikhompawundi inokunciphisa isimilo esifana nexhala ngokuvula i-TrkB receptors kwi-amygdala, indawo yengqondo ebandakanyeka kuloyiko kunye neempendulo zoxinzelelo. Ngokumodareyitha umsebenzi wala ma-receptors, i-7,8-dihydroxyflavones inokubonelela ngendlela engokwemvelo kunye nesebenzayo yokulawula ukuxhalaba ngaphandle kwemiphumo emibi ehambelana neyeza zendabuko ezichasene nokukhathazeka.
Phambi kokuphonononga kwimithombo yokutya, masiqonde ukuba yintoni kanye kanye i-7,8-dihydroxyflavone. Yiflavonoid eyenzeka ngokwemvelo eyeyeklasi ye-flavonoids. I-Flavonoids zikhompawundi ezisekelwe kwizityalo ezaziwa ngeempawu zazo ze-antioxidant, ezinceda ukukhusela iiseli kwii-radicals zamahhala eziyingozi.
Ngoku, makhe siphonononge okunye ukutya okuqulethe izixa eziphezulu ze-7,8-dihydroxyflavone:
1. Iziqhamo zeCitrus
Omnye wemithombo engcono kakhulu ye-7,8-dihydroxyflavones ziziqhamo ze-citrus ezifana ne-orenji, iilamuni, i-grapefruit kunye ne-limes. Ezi ziqhamo azityebi kuphela kwi-vitamin C, kodwa ziqulethe iindidi ze-flavonoids, kuquka i-7,8-dihydroxyflavone.
2. Amaqunube
Amaqunube afana namaqunube, amaqunube, amaqunube, kunye namaqunube amnyama ayaziwa ngokuba nomxholo wawo wokulwa ne-antioxidant. Ezi ziqhamo ezimnandi zikwangumthombo omkhulu we-7,8-dihydroxyflavone, ekunika uncedo oluphindwe kabini lwezempilo.
3. Itshokholethi emnyama
Iindaba ezimnandi kubathandi betshokolethi! Itshokolethi emnyama, ngakumbi enye enomxholo ophezulu we-cocoa, iqulethe ixabiso eliphezulu le-7,8-dihydroxyflavonoids. Nangona kunjalo, khetha iindidi ezinomlinganiselo omncinci weswekile eyongezelelweyo ukuze ufumane inzuzo epheleleyo.
4. Iti eluhlaza
Ukongeza ekubeni sisiselo esithandwayo, iti eluhlaza nayo ityebile kwi-flavonoids, kuquka i-7,8-dihydroxyflavone. Ukusetyenziswa rhoqo kweti eluhlaza kunokunceda ukwandisa i-antioxidant yakho kunye nokuxhasa impilo yonke.
5. Isoya
Ukuba ujonge umthombo wesityalo we-7,8-dihydroxyflavone, isoyi lukhetho olukhulu. Akunjalo kuphela iprotheni ephezulu, kodwa iqulethe i-flavonoids eyahlukeneyo enegalelo kwiipropati zabo ezincedo.
6. Imifuno enamagqabi aluhlaza
Imifuno efana ne-kale, isipinashi, kunye ne-broccoli azikho kuphela iikhalori eziphantsi, kodwa zicebile kwi-antioxidants. Ezi zityalo eziluhlaza zingumthombo obalaseleyo we-7,8-dihydroxyflavone, kunye nezinye izondlo ezibalulekileyo.
7. Iwayini ebomvu
Masinwabe! Ukusela iwayini ebomvu ngokuphakathi kuqulethe uhlobo lweflavonoid ebizwa ngokuba yi-resveratrol, equka i-7,8-dihydroxyflavone. Le khompawundi kucingelwa ukuba inegalelo kwiinzuzo zentliziyo ezinxulumene nokuselwa kwewayini ebomvu ephakathi.
Ukudibanisa oku kutya kwisidlo sakho kunokukunika intaphane yeenzuzo ezinxulumene ne-7,8-dihydroxyflavone.
I-7,8-Dihydroxyflavone, eyaziwa ngokuba yi-DHF okanye i-baicalein, yi-flavonoid yendalo efumaneka kwizityalo ezahlukeneyo, kuquka ingcambu ye-Scutellaria baicalensis. Le khompawundi ifumene ingqwalasela eninzi kwiminyaka yakutshanje ngenxa yeenzuzo zayo zempilo ezinokubakho kunye neempawu zonyango. Nangona kunjalo, xa kuqwalaselwa ukhuseleko kuyo nayiphi na into, kubalulekile ukuhlola ubungqina obukhoyo benzululwazi. Ke, ngaba i-7,8-dihydroxyflavone ikhuselekile?
Ngokuphathelele ukhuseleko lwayo, uphando olulinganiselwe luye lwenziwa ngokusetyenziswa ngokuthe ngqo komntu kwe-7,8-dihydroxyflavone. Ke ngoko, ukwenza ingxelo eqinisekileyo malunga nokhuseleko lwayo kulucelomngeni. Nangona kunjalo, izifundo zezilwanyana zibonelele ngengqiqo ebalulekileyo kwityhefu enokubakho. Iimodeli ezahlukeneyo zezilwanyana ziye zaxela ukuba akukho ziphumo bezingalindelekanga zibalulekileyo emva kolawulo lwe-DHF, nakwidosi ephezulu. Oku kuphakamisa ukuba i-7,8-dihydroxyflavone inokunyamezela kakuhle, ubuncinane ngaphakathi kweeparamitha ezifundiweyo.
Nangona kunjalo, kufuneka kulumke xa kusenziwa izigqibo ezisekelwe kuphela kwizifundo zezilwanyana. Iimpembelelo zezinto ezinokuthi zihluke kakhulu phakathi kweentlobo, ngoko ke, kufuneka kulumke xa ukhupha iziphumo ebantwini. Ngaphezu koko, ukungabikho kophando olubanzi lwabantu lwexesha elide luthintele uvavanyo olucacileyo lokhuseleko lwayo.
I-7,8-Dihydroxyflavone (7,8-DHF) yi-flavonoid eyenzeka ngokwemvelo efumene ingqalelo eninzi kwiinzuzo zayo zempilo, nangona kunjalo, kubaluleke kakhulu ukwazi idosi ecetyiswayo kunye neengcebiso xa usebenzisa i-7,8-DHF. kubalulekile.
Kubalulekile ukubonisana nochwepheshe bezempilo xa kuziwa kumthamo we-7,8-DHF, njengoko idosi efanelekileyo inokwahluka ngokusekelwe kwizinto ezininzi ezifana nobudala, ubunzima kunye neemeko ezithile zonyango. Uphononongo lwangoku lucebisa uluhlu lweenketho zedosi, ngokuqhelekileyo i-20 ukuya kwi-60 mg ngosuku. Nangona kunjalo, kufuneka kuqatshelwe ukuba ezi ngcebiso azibekwanga kwilitye kwaye zingatshintsha njengoko ubungqina obuninzi besayensi buqokelelwa.
Xa kuthengwa izongezo zokutya ze-7,8-DHF, kubalulekile ukukhetha umenzi othembekileyo nothembekileyo ukuqinisekisa ukhuseleko kunye nokusebenza kakuhle kwemveliso. Ukufunda uphononongo lwabathengi kunye nokujonga iimvavanyo zelebhu yomntu wesithathu nako kunokunceda ukumisela ukuthembeka kwemveliso. Kubaluleke kakhulu ukulandela iingcebiso zengcali yakho yezempilo. Baya kuba nakho ukubonelela ngesikhokelo somntu ngokusekwe kwimbali yakho yonyango kunye neemeko zempilo zangoku. Kuhlala kucetyiswa ukuba kuqalwe ngedosi esebenzayo esezantsi kwaye ngokuthe chu ngokunyuka njengoko kufuneka phantsi kweliso lengcali yezempilo.
Ngaphambi kokuba udibanise i-7,8-DHF kwirejimeni yakho yemihla ngemihla, kubalulekile ukuba uqaphele naziphi na iziphumo ebezingalindelekanga okanye ukusebenzisana kweziyobisi. Nangona ngokuqhelekileyo i-7,8-DHF inyamezeleka kakuhle, abanye abantu basenokufumana unxunguphalo olungephi lwesisu okanye ukungakwaleli. Kwakhona, qiniseka ukuba wazisa uchwepheshe wakho wezempilo ngawo nawaphi na amayeza okanye izongezo ozithathayo ngoku ukuthintela nakuphi na ukusebenzisana okunokwenzeka. Khumbula ukuba ukuthatha naziphi na izongezo kufuneka zihlale ziphantsi kolawulo lwengcali yokhathalelo lwempilo ukuze wenze impilo yakho ibe ngcono.
Q: Kuthatha ixesha elingakanani ukuba i-7,8-dihydroxyflavoneor isebenze?
A: Isantya apho i-7,8-dihydroxyflavone (7,8-DHF) iqala ukusebenza inokwahluka ngokuxhomekeke kwizinto ezininzi. Kwizifundo zesayensi, i-7,8-DHF ibonise ukuba ineempembelelo ezahlukeneyo, ezifana nokukhuthaza ukukhutshwa kwe-neurotrophic factor and neuroprotection. Ixesha elithathayo ukuba ezi ziphumo zibonakalise zinokusuka kwiiyure ukuya kwiintsuku okanye nangaphezulu, kuxhomekeke kwindlela ethile yokwenza kunye nokujoliswe kuyo kwikhompawundi.
Ukuziphendulela: Eli nqaku lenzelwe iinjongo zolwazi kuphela kwaye akufanele lithathwe njengengcebiso yezonyango. Soloko udibana nengcali yezempilo phambi kokuba usebenzise naziphi na izongezo okanye utshintshe irejimeni yokhathalelo lwempilo yakho.
Ixesha lokuposa: Jul-04-2023
