Njengoko sikhula, ukugcina impilo yethu iyonke kuya kuba yinto ebalulekileyo ngakumbi. Uphando olunxulumene nalo lubonisa ukuba i-nicotinamide riboside, uhlobo lwevithamini B3, inokulwa nokwaluphala kweeseli kwaye ikhuthaze ukwaluphala okunempilo. I-Nicotinamide Riboside Ukongeza ekuvuseleleni iiseli zokwaluphala, i-nicotinamide riboside ikwabonisa ithemba ekuphuculeni impilo iyonke kunye nobomi obude. Izifundo zezilwanyana zibonisa ukuba izongezo ze-NR zinokwandisa ubomi kwaye ziphucule impilo kwiimeko ezahlukeneyo ezinxulumene nokwaluphala, kubandakanya ukutyeba kakhulu, isifo sentliziyo, kunye nezifo ze-neurodegenerative.
Ukwaluphala yinkqubo yendalo eyenzeka kuzo zonke izinto eziphilayo. Njengabantu, imizimba neengqondo zethu zitshintsha kakhulu njengoko sikhula.
Utshintsho olucacileyo lolo lwesikhumba, olunemibimbi, amabala okuguga, njl.njl. abonakala. Ukongeza, izihlunu ziba buthathaka, amathambo alahlekelwa bubunzima, amalungu ayaqina, kwaye ukuhamba komntu ngamnye kuyathintelwa.
Enye into ebalulekileyo yokwaluphala kukwanda komngcipheko wezifo ezingapheliyo ezifana nesifo sentliziyo, isifo seswekile, kunye neentlobo ezithile zomhlaza. Ukongeza, ukuwohloka kwengqondo yenye ingxaki eqhelekileyo. Ukulahlekelwa yinkumbulo, ubunzima bokugxila, kunye nokuncipha kobuchule bengqondo kunokuchaphazela ubomi bethu bemihla ngemihla.
Abantu abadala abaninzi baziva benesizungu, bedandathekile, okanye bexhalabile, ingakumbi ukuba bajongene neengxaki zempilo okanye balahlekelwe ngumntu abamthandayo. Kule meko, kubalulekile ukufuna inkxaso yeemvakalelo kusapho, kubahlobo, kwanakwiingcali.
Nangona singenakuyimisa inkqubo yokwaluphala, kukho iindlela esinokuyicothisa ngazo size sigcine inkangeleko yobutsha ixesha elide. Izongezo zokulwa nokwaluphala zezinye iindlela ezilungileyo.
I-NAD+ yi-coenzyme ebalulekileyo efumaneka kuzo zonke iiseli eziphilayo. Umsebenzi wayo ophambili kukukhuthaza imetabolism yeseli ngokuncedisa ukudluliselwa kwee-electron kwiinkqubo ezininzi zebhayoloji ezifana nokuveliswa kwamandla. Nangona kunjalo, njengoko sikhula, amanqanaba e-NAD+ emizimbeni yethu ayancipha ngokwendalo. Ezinye izifundo zibonisa ukuba ukwehla kwamanqanaba e-NAD+ kunokuba yinto enegalelo kwinkqubo yokwaluphala.
Enye yezona zinto zibalulekileyo kuphando lwe-NAD+ kukufunyanwa kwemolekyuli yokuqala ye-NAD+ ebizwa ngokuba yi-nicotinamide riboside (NR). I-NR luhlobo lwe-vitamin B3 eguqulwa ibe yi-NAD+ ngaphakathi kweeseli zethu. Izifundo ezininzi zezilwanyana zibonise iziphumo ezithembisayo, zibonisa ukuba ukongezwa kwe-NR kunokunyusa amanqanaba e-NAD+ kwaye kunokubuyisela umva ukuhla okunxulumene nobudala.
Izifo ezininzi ezinxulumene nokwaluphala, ezifana nezifo ze-neurodegenerative kunye nokungasebenzi kakuhle kwe-metabolic, zinxulunyaniswa nokusebenza kakubi kwe-mitochondrial. I-Mitochondria ziindawo ezinamandla zeeseli zethu, ezinoxanduva lokuvelisa amandla. I-NAD+ idlala indima ebalulekileyo ekugcineni ukusebenza kakuhle kwe-mitochondrial. Ngokukhusela impilo ye-mitochondrial, i-NAD+ inako ukunciphisa umngcipheko wezifo ezinxulumene nokwaluphala kunye nokwandisa ubomi.
Ukongeza, i-NAD+ ibandakanyeka kumsebenzi we-sirtuins, usapho lweeproteni ezinxulumene nokuphila ixesha elide. Ii-Sirtuins zilawula iinkqubo ezahlukeneyo zebhayoloji, kubandakanya ukulungiswa kwe-DNA, iimpendulo zoxinzelelo lweeseli, kunye nokudumba. I-NAD+ ibalulekile kumsebenzi we-Sirtuin, isebenza njenge-coenzyme evuselela umsebenzi wayo we-enzyme. Ngokongeza i-NAD+ kunye nokuphucula umsebenzi we-Sirtuin, sinokukwazi ukulibazisa ukuguga kunye nokukhuthaza impilo kunye nokuphila ixesha elide.
Izifundo ezininzi zibonise ukuba ukongezwa kwe-NAD+ kunemiphumo emihle kwiimodeli zezilwanyana. Umzekelo, olunye uphando kwiimpuku lubonise ukuba ukongezwa kwe-NR kuphucula ukusebenza kwezihlunu kunye nokunyamezela. Ezinye izifundo zibonise ukuba ukongezwa kwe-NR kunokuphucula ukusebenza kwe-metabolic kwiimpuku ezindala, okwenza kufane nokweempuku eziselula. Ezi ziphumo zibonisa ukuba ukongezwa kwe-NAD+ kunokuba nemiphumo efanayo ebantwini, nangona kufuneka uphando olongezelelweyo.
I-riboside yeNicotinamide(ekwaziwa ngokuba yi-niagen) lolunye uhlobo lwe-niacin (ekwaziwa ngokuba yi-vitamin B3) kwaye ifumaneka ngokwendalo ngobuninzi obuncinci kubisi nakwezinye ukutya. Ingaguqulwa ibeI-NAD+ ngaphakathi kweeseli. Njengesandulela, i-NR ifunxwa lula kwaye ithuthwe iye kwiiseli, apho iguqulwa ibe yi-NAD+ ngothotho lwee-enzyme reactions.
Izifundo zokongezwa kwe-NR kwizifundo zezilwanyana nezabantu zibonise iziphumo ezithembisayo. Kwiimpuku, ukongezwa kwe-NR kufunyenwe kunyusa amanqanaba e-NAD+ kwiithishu ezahlukeneyo kwaye kuphucula ukusebenza kwe-metabolic kunye ne-mitochondrial.
I-NAD+ ibandakanyeka kwiinkqubo ezahlukeneyo zeseli eziyehla ngokukhula, kubandakanya ukulungiswa kwe-DNA, ukuveliswa kwamandla, kunye nokulawulwa kokubonakaliswa kwezakhi zofuzo. Kucingelwa ukuba ukuzalisa amanqanaba e-NAD+ nge-NR kunokubuyisela ukusebenza kweseli, ngaloo ndlela kuphuculwe impilo kwaye kwandiswe ubomi.
Ukongeza, kuphando lwamadoda atyebileyo natyebileyo, ukongezwa kwe-NR kwandisa amanqanaba e-NAD+, ngaloo ndlela kuphucula uvakalelo lwe-insulin kunye nomsebenzi we-mitochondrial. Ezi ziphumo zibonisa ukuba ukongezwa kwe-NR kunokuba nezicelo ezinokubakho ekulweni nezifo ze-metabolic ezifana nesifo seswekile sohlobo lwesibini kunye nokutyeba kakhulu.
1. Imithombo yokutya yendalo ye-nicotinamide riboside
Omnye umthombo onokubakho we-NR ziimveliso zobisi. Ezinye izifundo zibonise ukuba iimveliso zobisi ziqulathe ubuninzi be-NR, ingakumbi ubisi oluqiniswe yi-NR. Nangona kunjalo, umxholo we-NR kwezi mveliso uphantsi kwaye ukufumana ubuninzi obaneleyo ngokutya kuphela kunokuba nzima.
Ukongeza kwimithombo yokutya, izongezo ze-NR ziyafumaneka kwifomu ye-capsule okanye yomgubo. Ezi zongezo zihlala zifumaneka kwimithombo yendalo efana ne-yeast okanye i-bacterial fermentation. I-NR ephuma kwi-yeast ithathwa njengomthombo othembekileyo nozinzileyo kuba inokuveliswa ngobuninzi ngaphandle kokuxhomekeka kwimithombo yezilwanyana. I-NR eveliswa yi-bacteria lolunye ukhetho, oluhlala lufumaneka kwiintlobo ezithile zebhaktheriya ezivelisa i-NR ngokwendalo.
2. Yongeza i-nicotinamide riboside
Umthombo oqhelekileyo nothembekileyo we-nicotinamide riboside kukusebenzisa izongezo zokutya. Izongezo ze-NR zibonelela ngendlela elula nesebenzayo yokuqinisekisa ukusetyenziswa ngokugqibeleleyo kwale khompawundi ibalulekileyo. Xa ukhetha isongezo se-NR esilungileyo, kubalulekile ukuqwalasela ezi zinto zilandelayo:
a) Uqinisekiso loMgangatho: Khangela izongezo ezenziwe ziinkampani ezidumileyo kwaye unamathele kwimigangatho engqongqo yolawulo lomgangatho. Oku kuya kuqinisekisa ukuba ufumana imveliso esemgangathweni ophezulu engenangcoliseko okanye izinto ezingcolisayo.
b) Ukufumaneka kwe-bioavailability: Izongezo ze-NR zisebenzisa iinkqubo zokuhambisa eziphambili ezifana ne-encapsulation okanye iteknoloji ye-liposome ukuphucula ukufumaneka kwe-NR ukuze ikwazi ukufunxwa ngcono kwaye isetyenziswe ngumzimba. Khetha olu hlobo lwezongezo ukuze ufumane iingenelo ezininzi kwi-NR.
c) Ubumsulwa: Qinisekisa ukuba isongezelelo se-NR osikhethileyo sicocekile kwaye asinazo izongezo ezingafunekiyo, izizalisi okanye izithinteli. Ukufunda iilebheli nokuqonda izithako kunokukunceda wenze isigqibo esinolwazi.
1. Ukuphucula imveliso yamandla eeseli
I-NR idlala indima ebalulekileyo ekuvelisweni kwemolekyuli ebalulekileyo i-nicotinamide adenine dinucleotide (NAD+). I-NAD+ ibandakanyeka kwiinkqubo ezahlukeneyo zeseli, kuquka imetabolism yamandla. Njengoko sikhula, amanqanaba e-NAD+ emizimbeni yethu ayancipha, nto leyo ebangela ukwehla kwemveliso yamandla. Ngokukhuthaza ukwenziwa kwe-NAD+, i-NR inceda ukuvuselela iiseli kwaye yenze kube lula ukuvelisa amandla ngokufanelekileyo. La mandla eseli aphuculweyo andisa amandla, aphucula ukusebenza komzimba, kwaye anciphise ukudinwa.
2. Ukulungiswa kwe-DNA kunye nokulwa nokwaluphala
Ukwehla kwamanqanaba e-NAD+ kunxulunyaniswa nokwaluphala kunye nezifo ezinxulumene nokwaluphala. I-NR inokunyusa amanqanaba e-NAD+ emzimbeni, nto leyo eyenza ukuba ibe yiarhente yokulwa nokwaluphala. I-NAD+ ibandakanyeka kwiinkqubo zokulungisa i-DNA, iqinisekisa ukuthembeka kwezinto zethu zemfuza. Ngokukhuthaza ukulungiswa kwe-DNA, i-NR inokunceda ukuthintela umonakalo we-DNA onxulumene nokwaluphala kwaye ixhase ukwaluphala okunempilo. Ukongeza, indima ye-NR ekusebenziseni i-sirtuins, udidi lweeproteni ezaziwa ngokulawula impilo yeseli kunye nobomi bayo, iphucula ngakumbi amandla ayo okulwa nokwaluphala.
3. Impilo yentliziyo nemithambo yegazi
Ukugcina inkqubo yentliziyo esempilweni kubalulekile kwimpilo iyonke. I-Nicotinamide riboside ibonakalise iziphumo ezithembisayo kwimpilo yentliziyo. Ixhasa ukusebenza kweeseli ze-endothelial zemithambo yegazi, ikhuthaza ukuhamba kwegazi kwaye inciphisa ukudumba. I-NR ikwaphucula ukusebenza kwe-mitochondrial kwiiseli zentliziyo, ithintela uxinzelelo lwe-oxidative kwaye iphucula ukuveliswa kwamandla. Ezi ziphumo zinokunceda ukunciphisa umngcipheko wezifo zentliziyo ezifana ne-atherosclerosis kunye nokusilela kwentliziyo.
4. Ukhuseleko lwe-neuroprotection kunye nomsebenzi wokuqonda
I-NR ibonakalisiwe ukuba ineempawu zokukhusela imithambo-luvo, nto leyo eyenza ukuba ibe ngumhlobo onokuba luncedo ekugcineni impilo yengqondo. Inokuba nefuthe elihle ekusebenzeni kwe-neuronal kwaye ikhusele ekuwohlokeni kwengqondo okunxulumene nobudala. Ngokunyusa amanqanaba e-NAD+, i-NR ixhasa ukusebenza kwe-mitochondrial kwiiseli zobuchopho, iphucula ukuveliswa kwamandla kwaye ikhuthaza ukulungiswa kweeseli. Ukuphucula ukusebenza kwe-mitochondrial kunokuphucula izakhono zokuqonda ezifana nenkumbulo, ukugxila, kunye nokucaca kwengqondo iyonke.
5. Ulawulo lobunzima kunye nempilo yeMetabolic
Ukugcina ubunzima obusempilweni kunye nokulinganisela kwe-metabolism kubalulekile kwimpilo yethu iyonke. I-NR inxulunyaniswe nemiphumo emihle kwi-metabolism, nto leyo eyenza ukuba ibe luncedo ekulawuleni ubunzima. I-NR isebenzisa iproteni ebizwa ngokuba yi-Sirtuin 1 (SIRT1), elawula iinkqubo ze-metabolism ezifana ne-glucose metabolism kunye nokugcinwa kwamafutha. Ngokusebenzisa i-SIRT1, i-NR inokunceda ekunciphiseni ubunzima kwaye iphucule impilo ye-metabolism, ngaloo ndlela inciphisa umngcipheko wezifo ezifana nokutyeba kakhulu kunye nesifo seswekile sohlobo lwesibini.
Q: Yintoni iNicotinamide Riboside (NR)?
A: I-Nicotinamide Riboside (NR) sisandulela seNicotinamide Adenine Dinucleotide (NAD+), i-coenzyme edlala indima ebalulekileyo kwiinkqubo ezahlukeneyo zebhayoloji, kubandakanya ukuveliswa kwamandla kunye nokulawulwa kwemisebenzi ye-metabolic kunye neyeselula.
Q: Ngaba iNicotinamide Riboside (NR) inokunceda imetabolism?
A: Ewe, iNicotinamide Riboside (NR) ifunyenwe inceda imetabolism. Ngokunyusa amanqanaba e-NAD+, i-NR inokuvula ii-enzymes ezithile ezibandakanyeka kwimetabolism, ezifana nee-sirtuins. Oku kusebenza kunokuphucula ukusebenza kakuhle kwemetabolism, kuphucule uvakalelo lwe-insulin, kwaye kuxhase ulawulo lobunzima obusempilweni.
Isikhanyeli: Eli nqaku lenzelwe ulwazi oluqhelekileyo kuphela kwaye akufuneki lithathwe njengengcebiso yezonyango. Olunye ulwazi lweposi yebhlog luvela kwi-Intanethi kwaye alungobungcali. Le webhusayithi inoxanduva lokuhlela, ukufomatha kunye nokuhlela amanqaku kuphela. Injongo yokudlulisa ulwazi oluthe kratya ayithethi ukuba uyavumelana nezimvo zayo okanye uqinisekisa ubunyani bomxholo wayo. Soloko uqhagamshelana neengcali zezempilo ngaphambi kokusebenzisa naziphi na izongezo okanye ukwenza utshintsho kwindlela yakho yokhathalelo lwempilo.
Ixesha lokuthumela: Novemba-13-2023
