Njengoko sikhula, ukugcina impilo yethu iyonke kubaluleke kakhulu. Uphando oluyeleleneyo lubonisa ukuba i-nicotinamide riboside, uhlobo lwevithamin B3, inokulwa nokuguga kweselula kwaye ikhuthaze ukwaluphala okunempilo. INicotinamide Riboside Ukongeza ekuvuseleleni iiseli ezigugayo, i-nicotinamide riboside ikwabonisa isithembiso ekuphuculeni impilo kunye nobomi obude. Izifundo zezilwanyana zibonisa ukuba izongezelelo ze-NR zinokwandisa ubomi kunye nokuphucula impilo kwiimeko ezahlukeneyo ezinxulumene nobudala, kubandakanya ukutyeba, isifo sentliziyo, kunye nezifo ze-neurodeergenerative.
Ukwaluphala yinkqubo yendalo eyenziwa kuzo zonke izinto eziphilayo. Njengabantu, imizimba neengqondo zethu ziba notshintsho oluninzi njengoko sikhula.
Olona tshintsho lucacileyo lulo lwesikhumba, kunye nemibimbi, amabala obudala, njl. Ukongezelela, izihlunu ziba buthathaka, amathambo aphelelwa ngamandla, amalungu aqina, yaye ukuhamba komntu kulinganiselwe.
Enye inkalo ebalulekileyo yokuguga kukwandisa ingozi yezifo ezingapheliyo ezifana nesifo senhliziyo, isifo seswekile, kunye neentlobo ezithile zomhlaza. Ukongezelela, ukuncipha kwengqondo yenye ingxaki eqhelekileyo. Ukulahlekelwa yinkumbulo, ubunzima bokugxila, kunye nokunciphisa amandla engqondo kunokuchaphazela ubomi bethu bemihla ngemihla.
Abantu abaninzi abasele bekhulile nabo baziva bengamalolo, bedandathekile okanye benexhala, ingakumbi xa bekhathazwa yimpilo okanye bafelwe ngumntu abamthandayo. Kule meko, kubalulekile ukufuna inkxaso ngokweemvakalelo kusapho, abahlobo, kwanakwiingcali.
Nangona singenako ukuyiyeka inkqubo yokwaluphala, kukho iindlela esinokuyithothisa ngayo kwaye sigcine inkangeleko yobutsha ixesha elide. Izongezo zokulwa nokuguga yenye inketho elungileyo.
I-NAD + yi-coenzyme ebalulekileyo efumaneka kuzo zonke iiseli eziphilayo. Umsebenzi wayo ophambili kukukhuthaza i-metabolism yeselula ngokuncedisa ukuhanjiswa kwe-electron kwiinkqubo ezininzi zebhayoloji ezifana nokuveliswa kwamandla. Nangona kunjalo, njengoko sikhula, amanqanaba e-NAD + emizimbeni yethu aye ehla ngokwendalo. Olunye uphando lucebisa ukuba ukwehla kwamanqanaba e-NAD + kunokuba negalelo kwinkqubo yokuguga.
Enye yezona nkqubela zibalulekileyo kuphando lwe-NAD+ kukufunyanwa kwe-NAD+ yemolekyuli yangaphambili ebizwa ngokuba yi-nicotinamide riboside (NR). I-NR luhlobo lwevithamini B3 eguqulwa ibe yiNAD + ngaphakathi kweeseli zethu. Izifundo ezininzi zezilwanyana zibonise iziphumo ezithembisayo, ezicebisa ukuba ukuxhaswa kwe-NR kunokunyusa amanqanaba e-NAD + kunye nokubuyisela umva ukwehla okunxulumene nobudala.
Izifo ezininzi ezinxulumene nobudala, ezifana nezifo ze-neurodeergenerative kunye nokungasebenzi kakuhle kwe-metabolic, zidityaniswa nokungasebenzi kakuhle kwe-mitochondrial. I-Mitochondria zizixhobo zamandla kwiiseli zethu, ezinoxanduva lokuvelisa amandla. I-NAD+ idlala indima ebalulekileyo ekugcineni umsebenzi ofanelekileyo we-mitochondrial. Ngokukhusela impilo ye-mitochondrial, i-NAD + inamandla okunciphisa umngcipheko wezifo ezinxulumene neminyaka kunye nokwandisa ubomi.
Ukongeza, i-NAD + ibandakanyeka kumsebenzi we-sirtuins, usapho lweeprotheyini ezinxulumene nobomi obude. I-Sirtuins ilawula iinkqubo ezahlukeneyo zebhayoloji, kubandakanywa ukulungiswa kwe-DNA, iimpendulo zoxinzelelo lweselula, kunye nokuvuvukala. I-NAD+ ibalulekile kumsebenzi we-Sirtuin, isebenza njenge-coenzyme eyenza umsebenzi wayo we-enzymatic. Ngokuncedisa i-NAD + kunye nokuphucula umsebenzi we-Sirtuin, sinokukwazi ukulibazisa ukuguga kunye nokukhuthaza impilo kunye nokuphila ixesha elide.
Izifundo ezininzi zibonise ukuba ukuxhaswa kwe-NAD + kunemiphumo emihle kwiimodeli zezilwanyana. Ngokomzekelo, uphando oluthile kwiigundane lubonise ukuba ukuncedisa nge-NR kuphuculwe ukusebenza kwemisipha kunye nokunyamezela. Olunye uphononongo lubonise ukuba ukuxhaswa kwe-NR kunokuphucula ukusebenza kwemetabolism kwiimpuku ezikhulileyo, kuyenza ifane naleyo yeempuku ezincinci. Ezi ziphumo zibonisa ukuba ukuxhaswa kwe-NAD + kunokuba nemiphumo efanayo ebantwini, nangona uphando olongezelelweyo luyafuneka.
Nicotinamide riboside(ekwaziwa njenge-niagen) lolunye uhlobo lwe-niacin (ekwabizwa ngokuba yi-vitamin B3) kwaye ifumaneka ngokwendalo ngezixa ezincinci kubisi nokunye ukutya. Inokuguqulwa ibeNAD+ ngaphakathi kweeseli. Njengomanduleli, i-NR ifunxwa ngokulula kwaye ithuthelwe kwiiseli, apho iguqulwa ibe yi-NAD+ ngothotho lweempendulo ze-enzymatic.
Izifundo zokuncedisa i-NR kuzo zombini izilwanyana kunye nezifundo zabantu zibonise iziphumo ezithembisayo. Kwiimpuku, ukongezwa kwe-NR kwafunyanwa ukonyusa amanqanaba e-NAD + kwizicubu ezahlukeneyo kunye nokuphucula imetabolism kunye nomsebenzi we-mitochondrial.
I-NAD + ibandakanyeka kwiinkqubo ezahlukeneyo zeselula eziyehlayo ngobudala, kubandakanywa ukulungiswa kwe-DNA, ukuveliswa kwamandla, kunye nokulawulwa kwe-gene expression. Kucingelwa ukuba ukuzalisa kwakhona amanqanaba e-NAD+ nge-NR kunokubuyisela ukusebenza kweselula, ngaloo ndlela kuphuculwe impilo kunye nokwandisa ubomi.
Ukongeza, kuphononongo lwamadoda atyebileyo natyebe kakhulu, ukongezelelwa kwe-NR konyusa amanqanaba e-NAD+, ngaloo ndlela kuphuculwa ubuntununtunu be-insulin kunye nokusebenza kwe-mitochondrial. Ezi ziphumo zibonisa ukuba ukuxhaswa kwe-NR kunokuba nezicelo ezinokubakho ekujonganeni nezifo ze-metabolic ezifana nohlobo lwe-2 yeswekile kunye nokukhuluphala.
1. Imithombo yokutya yendalo ye-nicotinamide riboside
Omnye umthombo onokubakho we-NR ziimveliso zobisi. Olunye uphononongo lubonise ukuba iimveliso zobisi ziqulethe umkhondo we-NR, ngakumbi ubisi oluqiniswe nge-NR. Nangona kunjalo, umxholo we-NR kwezi mveliso uphantsi kwaye ukufumana imali eyaneleyo ngokutya kuphela kunokuba ngumngeni.
Ukongeza kwimithombo yokutya, izongezo ze-NR zifumaneka kwi-capsule okanye ifom ye powder. Ezi zongezo zihlala ziphuma kwimithombo yendalo efana negwele okanye ukuvutshelwa kwebhaktheriya. I-NR ephuma kwigwele ngokuqhelekileyo ithathwa njengomthombo othembekileyo nozinzileyo kuba inokuveliswa ngobuninzi ngaphandle kokuxhomekeka kwimithombo yezilwanyana. I-NR eveliswe ngebhakteria yenye inketho, efumaneka rhoqo kwiintlobo ezithile zebhaktheriya ezivelisa i-NR ngokwendalo.
2. Yongeza i-nicotinamide riboside
Owona mthombo uxhaphakileyo nothembekileyo we-nicotinamide riboside kukutya izongezo zokutya. Izongezelelo ze-NR zibonelela ngendlela efanelekileyo nesebenzayo yokuqinisekisa ukuthathwa ngokufanelekileyo kwale khompawundi ibalulekileyo. Xa ukhetha esona songezo se-NR, kubalulekile ukuqwalasela ezi zinto zilandelayo:
a) Uqinisekiso loMgangatho: Khangela izongezelelo ezenziwe ziinkampani ezithembekileyo kwaye ubambelele kwimigangatho engqongqo yolawulo lomgangatho. Oku kuya kuqinisekisa ukuba ufumana imveliso ekumgangatho ophezulu engenabumdaka okanye ungcoliseko.
b) I-Bioavailability: I-NR izongezelelo zisebenzisa iinkqubo zokuhambisa eziphambili ezifana ne-encapsulation okanye iteknoloji ye-liposome ukunyusa i-bioavailability ye-NR ukwenzela ukuba ikwazi ukufunxa ngcono kwaye isetyenziswe ngumzimba. Khetha olu hlobo lwezongezelelo ukwandisa izibonelelo ozifumanayo kwi-NR.
c) Ubunyulu: Qinisekisa ukuba isongezelelo se-NR osikhethayo sicocekile kwaye asiqulathanga izongezo ezingeyomfuneko, izihluzi okanye izithinteli. Ukufunda iilebhile kunye nokuqonda izithako kunokukunceda wenze isigqibo esinolwazi.
1. Ukuphucula imveliso yamandla eselula
I-NR idlala indima ebalulekileyo ekuvelisweni kwemolekyuli ebalulekileyo i-nicotinamide adenine dinucleotide (NAD+). I-NAD + ibandakanyeka kwiinkqubo ezahlukeneyo zeselula, kubandakanya i-metabolism yamandla. Njengoko sikhula, amanqanaba e-NAD+ emizimbeni yethu ayancipha, okukhokelela ekunciphiseni ukuveliswa kwamandla. Ngokukhuthaza ukuhlanganiswa kwe-NAD +, i-NR inceda ukuvuselela iiseli kunye nokwenza ukuveliswa kwamandla okusebenzayo. La mandla ongeziweyo eselula anyusa amandla, aphucula ukusebenza komzimba, kwaye anciphisa ukudinwa.
2. Ukuchasa ukuguga kunye nokulungiswa kwe-DNA
Ukwehla kwamanqanaba e-NAD + kunxulunyaniswa nokuguga kunye nezifo ezinxulumene neminyaka. I-NR inokunyusa amanqanaba e-NAD + emzimbeni, iyenze ibe yinto enokuchasana nokuguga. I-NAD + ibandakanyeka kwiindlela zokulungisa i-DNA, iqinisekisa ukuthembeka kwezinto zethu zemfuza. Ngokukhuthaza ukulungiswa kwe-DNA, i-NR inokunceda ukukhusela umonakalo we-DNA onxulumene neminyaka kunye nokuxhasa ukuguga okunempilo. Ukongeza, indima ye-NR ekwenzeni i-sirtuins isebenze, iklasi yeeprotheyini ezaziwa ngokulawula impilo yeselula kunye nexesha lokuphila, iphakamisa ngakumbi amandla ayo okuchasa ukuguga.
3. Impilo yentliziyo
Ukugcina inkqubo ye-cardiovascular system esempilweni kubalulekile kwimpilo iyonke. INicotinamide riboside ibonise iziphumo ezithembisayo kwimpilo yentliziyo. Ixhasa umsebenzi weeseli ze-vascular endothelial, ikhuthaza ukuhamba kwegazi kunye nokunciphisa ukuvuvukala. I-NR iphinda iphucule umsebenzi we-mitochondrial kwiiseli zentliziyo, ukuthintela uxinzelelo lwe-oxidative kunye nokwandisa ukuveliswa kwamandla. Ezi ziphumo zinokunceda ukunciphisa umngcipheko wezifo zentliziyo ezifana ne-atherosclerosis kunye nokungaphumeleli kwentliziyo.
4. I-neuroprotection kunye nomsebenzi wokuqonda
I-NR ibonakaliswe ukuba ineepropathi ze-neuroprotective, okwenza kube ngumhlobo onokuthi ugcine impilo yengqondo. Inokuba nefuthe elihle kumsebenzi we-neuronal kwaye ikhusele ekunciphiseni kwengqondo enxulumene neminyaka. Ngokunyusa amanqanaba e-NAD +, i-NR ixhasa umsebenzi we-mitochondrial kwiiseli zengqondo, iphucula imveliso yamandla kwaye ikhuthaza ukulungiswa kweselula. Ukuphucula umsebenzi we-mitochondrial kunokuphucula izakhono zokuqonda ezifana nememori, ukugxila, kunye nokucaca kwengqondo yonke.
5. Ulawulo lobunzima kunye neMpilo yeMetabolic
Ukugcina ubunzima obunempilo kunye nokulungelelana kwe-metabolic kubalulekile kwimpilo yethu iyonke. I-NR idibaniswe nemiphumo enenzuzo kwi-metabolism, eyenza ibe yinto enokuba luncedo ekulawuleni ubunzima. I-NR yenza iprotheni ebizwa ngokuba yi-Sirtuin 1 (SIRT1), elawula iinkqubo ze-metabolic ezifana ne-glucose metabolism kunye nokugcinwa kwamafutha. Ngokuvula i-SIRT1, i-NR inokunceda ukunciphisa umzimba kunye nokuphucula impilo ye-metabolic, ngaloo ndlela inciphisa umngcipheko wezifo ezinjengokutyeba kakhulu kunye nohlobo lwe-2 yeswekile.
Umbuzo: Yintoni iNicotinamide Riboside (NR)?
A: INicotinamide Riboside (NR) isandulela seNicotinamide Adenine Dinucleotide (NAD +), i-coenzyme edlala indima ebalulekileyo kwiinkqubo ezahlukeneyo zebhayoloji, kubandakanywa ukuveliswa kwamandla kunye nokulawulwa kwe-metabolic kunye nemisebenzi yeselula.
Umbuzo: Ngaba iNicotinamide Riboside (NR) inokunceda imetabolism?
A: Ewe, iNicotinamide Riboside (NR) ifunyenwe inceda imetabolism. Ngokunyusa amanqanaba e-NAD +, i-NR inokusebenzisa ii-enzymes ezithile ezibandakanyekayo kwi-metabolism, njenge-sirtuins. Oku kusebenze kunokuphucula ukusebenza kakuhle kwe-metabolic, ukuphucula ubuntununtunu be-insulin, kunye nokuxhasa ulawulo lobunzima obunempilo.
Ukuziphendulela: Eli nqaku lelolwazi ngokubanzi kuphela kwaye akufanele lithathwe njengeliphi na icebiso lonyango. Olunye ulwazi lweposti yebhlog luvela kwi-Intanethi kwaye alunamsebenzi. Le webhusayithi inoxanduva kuphela lokuhlela, ukufomatha kunye nokuhlela amanqaku. Injongo yokudlulisa ulwazi olongezelelekileyo ayithethi ukuba uyavumelana neembono zayo okanye uqinisekise ubunyani bomxholo wayo. Soloko udibana nengcali yezempilo ngaphambi kokuba usebenzise naziphi na izongezo okanye wenze utshintsho kwirejimeni yokhathalelo lwempilo.
Ixesha lokuposa: Nov-13-2023
