Ukwaluphala yinkqubo ethi yonke into ephilayo ihambe kuyo. Abantu abanakukuthintela ukuguga, kodwa banokuthatha amanyathelo okunciphisa inkqubo yokuguga kunye nokuvela kwezifo ezinxulumene neminyaka. Enye ikhompawundi ifumene ingqalelo eninzi-nicotinamide riboside, ekwabizwa ngokuba yi-NR. Njengomanduleli we-NAD+, i-nicotinamide riboside kucingelwa ukuba inefuthe elimangalisayo lokuchasa ukwaluphala.Ngokonyusa amanqanaba e-NAD+, i-nicotinamide riboside iphucula umsebenzi we-sirtuin, iphucula ukusebenza kwe-mitochondrial, kwaye ivule iindlela ezahlukeneyo zeselula ezibandakanyeka kwinkqubo yokulwa nokuguga.
INicotinamide riboside (NR) luhlobo lwevithamin B3, ekwaziwa njenge nicotinic acid okanye nicotinic acid. Yinto eyenzeka ngokwemvelo efumaneka kwimilinganiselo emincinci ekutyeni okuthile, okufana nobisi, igwele, kunye nemifuno ethile.
I-NR yi-precursor ye-nicotinamide adenine dinucleotide (NAD +), i-coenzyme ekhoyo kuzo zonke iiseli eziphilayo. I-NAD+ idlala indima ebalulekileyo kwiinkqubo ezahlukeneyo zebhayoloji, kubandakanya ukuveliswa kwamandla, ukulungiswa kweDNA, kunye nolawulo lwemetabolism yeselula. Njengoko sikhula, amanqanaba ethu e-NAD+ athande ukuncipha, nto leyo inokuchaphazela le misebenzi ibalulekileyo. Izongezelelo ze-NR ziye zacetywa njengendlela yokunyusa amanqanaba e-NAD+ kunye nokucothisa inkqubo yokuguga.
Enye yeenzuzo ezinkulu zokuxhaswa kwe-NR kukukwazi ukunyusa umsebenzi we-mitochondrial. I-Mitochondria zizindlu zamandla zeseli, ezinoxanduva lokuvelisa amandla amaninzi eseli ngendlela ye-adenosine triphosphate (ATP). I-NR ibonakaliswe ukukhuthaza imveliso ye-ATP ngokunyusa amanqanaba e-NAD +, ngaloo ndlela ikhuthaza ukuveliswa kwamandla okusebenzayo kunye nemetabolism yeselula. Oku kwanda kwimveliso yamandla kunokunceda iintlobo ezahlukeneyo zezicubu kunye namalungu, kubandakanya ingqondo, intliziyo kunye nezihlunu.
●Yandisa amandla eselula
INicotinamide riboside idlala indima ebalulekileyo ekunikeni amandla kwindlu yamandla yeseli, i-mitochondria. Le khompawundi yi-precursor ye-nicotinamide adenine dinucleotide (NAD +), i-coenzyme ebalulekileyo ebandakanyeka kwiinkqubo ezininzi zeselula, ngakumbi i-metabolism yamandla. Uphando lubonisa ukuba ukongeza nge-NR kunokunyusa amanqanaba e-NAD + kunye nokukhuthaza ukuphefumla okusebenzayo kweselula kunye nokuveliswa kwamandla.
Amanqanaba e-NAD+ athanda ukwehla njengoko sikhula, nto leyo ekhokelela ekusebenzeni okubuthathaka kwe-mitochondrial kunye namanqanaba asezantsi amandla. Nangona kunjalo, ngokuncedisa i-nicotinamide riboside, kunokwenzeka ukuhlehlisa oku kwehla kunye nokubuyisela amanqanaba olutsha lwamandla. I-NR ikwafunyaniswe ukuba yonyusa unyamezelo lomzimba kunye nokuphucula ukusebenza kwezemidlalo, iyenza ibe yinto enomtsalane kwiimbaleki nakubantu abafuna impilo entle.
●Ukuphucula ukulungiswa kweeseli kunye nokuchasana nokuguga
Omnye umba onomdla we-nicotinamide riboside kukukwazi kwayo ukukhuthaza ukulungiswa kwe-DNA kunye nokuchasana nomonakalo onxulumene nobudala. I-NAD + yinxalenye ebalulekileyo kwinkqubo yokulungisa i-DNA. Ngokuncedisa i-NR ukunyusa amanqanaba e-NAD+, sinokuphucula amandla eseli ukulungisa i-DNA, ngaloo ndlela sikhusela ngokufanelekileyo ekwaluphaleni.
Ukongezelela, i-NR iye yabandakanyeka kulawulo lweendlela eziphambili zokuphila ixesha elide, ezifana ne-sirtuins, edlala indima ebalulekileyo ekugcineni umsebenzi weselula onempilo. Ezi genes zexesha elide zinceda ukwandisa iindlela zokukhusela iiseli kuxinzelelo kunye nokukhuthaza ubomi obude. Ngokuvula i-sirtuins, i-nicotinamide riboside inokunceda ukulibazisa izifo ezinxulumene neminyaka kwaye inokwandisa impilo yethu.
●Thintela izifo ze-neurodeergenerative
Izifo ze-neurodeergenerative ezifana ne-Alzheimer kunye ne-Parkinson ziya zixhaphaka kuluntu lwethu. Uphando lucebisa ukuba i-nicotinamide riboside inokuba nesithembiso ekuthinteleni ezi zifo zibuthathaka. Uphononongo lufumene ukuba ulawulo lwe-NR luphucula umsebenzi we-mitochondrial, lunciphisa uxinzelelo lwe-oxidative, kunye nokuphucula i-neuroplasticity, yonke into enegalelo kwingqondo ephilileyo.
Ukongeza, ukongezwa kwe-NR kudityaniswe nomsebenzi wokuqonda ophuculweyo, ukugcinwa kwememori, kunye nokuphuculwa kokugxila kunye nexesha lokujonga. Ngelixa uphando olongezelelweyo lufuneka, ezi ziphumo zandulelayo zibonisa ukuba i-nicotinamide riboside inokubonakalisa ukuba sisenzo sothintelo okanye inkxaso yabantu abasemngciphekweni we-neurodegeneration.
●Yandisa uvakalelo lwe-insulin
Izifundo ezininzi zibonise ukuba i-NR inamandla okuphucula impilo yonke ye-metabolic. Kuye kwaboniswa ukuphucula ukuvakalelwa kwe-insulin, eyona nto ibalulekileyo ekugcineni amanqanaba eeshukela egazi kunye nokuthintela ukuphuhliswa kohlobo lwe-2 yeswekile. Izifundo ziye zafumanisa ukuba ukuxhaswa kwe-NR kunokuphucula i-lipid metabolism, ngaloo ndlela kuncitshiswe i-cholesterol ejikelezayo kunye namanqanaba e-triglyceride. Ezi ziphumo zibaluleke kakhulu kubantu abaneengxaki ze-metabolic okanye abo batyebe kakhulu okanye batyebe kakhulu.
●Inomthamo we-antioxidant
Ukongeza, i-NR ibonakaliswe ukonyusa ukhuseleko lweselula ngokuchasene noxinzelelo lwe-oxidative. Uxinzelelo lwe-oxidative lwenzeka xa kukho ukungalingani phakathi kokuveliswa kweentlobo ze-oksijini esebenzayo (ROS) kunye nokukwazi komzimba ukuzinciphisa nge-antioxidants. Amanqanaba aphezulu oxinzelelo lwe-oxidative anokonakalisa iiseli kwaye abe negalelo ekuqhubekeni kwezifo ezahlukeneyo, kubandakanya umhlaza, isifo sentliziyo, kunye nezifo ze-neurodeergenerative. Izifundo ziye zafumanisa ukuba ukuncedisa i-NR kunokuphucula amandla e-antioxidant yeeseli kunye nokunciphisa impembelelo yoxinzelelo lwe-oxidative emzimbeni.
Uphando lubonisa ukuba i-nicotinamide riboside inamandla okucotha ukuguga ngokunyusa amanqanaba e-nicotinamide adenine dinucleotide (NAD+) molekyuli. I-NAD + yimolekyuli ephambili edlala indima ephambili kwimetabolism yeselula.
Amanqanaba e-NAD + ngokwendalo aye ehla njengoko sikhula. Oku kuncipha kuthathwa njengonobangela omkhulu wenkqubo yokwaluphala. Ngokunyusa amanqanaba e-NAD +, i-nicotinamide riboside inokunceda ukuphelisa oku kwehla kwaye icothise iziphumo zokuguga.
I-NAD + ibandakanyeka kwiinkqubo ezininzi ezibalulekileyo zeselula, kubandakanya ukuveliswa kwamandla, ukulungiswa kwe-DNA, kunye nokubonakaliswa kofuzo. Ngokunyusa amanqanaba e-NAD +, i-nicotinamide riboside inokubanakho ukomeleza ezi nkqubo kwaye iphucule ukusebenza kweselula ngokubanzi.
Izifundo ezininzi zibonise iziphumo ezithembisayo kwizilwanyana kunye neeseli zabantu. Kolunye uphononongo, abaphandi bafumanise ukuba i-nicotinamide riboside supplementation yonyusa amanqanaba e-NAD+ kwizicubu zezihlunu, ngaloo ndlela iphucula ukusebenza kwe-mitochondrial kunye nokusebenza komthambo kwiimpuku.
Olunye uphononongo lufumanise ukuba i-nicotinamide riboside supplementation iphucule ubuntununtunu be-insulin kunye nokunyamezela i-glucose kwi-obese, iimpuku ze-prediabetic. Oku kuphakamisa ukuba i-nicotinamide riboside inokuba nezibonelelo ezinokubakho kwimpilo ye-metabolic.
Kuphononongo olunye oluncinci lwabantu abadala abaphakathi kunye nabadala, ukongezwa kwe-nicotinamide riboside konyusa amanqanaba e-NAD + kunye nokuphucula uxinzelelo lwegazi kunye nokuqina kwe-arterial, iimpawu ezimbini ezibalulekileyo zempilo yentliziyo.
Kolunye uphononongo, abaphandi bafumanise ukuba isongezelelo se-nicotinamide riboside siphucule ukusebenza kwezihlunu kunye nokuthintela ukulahleka kwemisipha kubantu abadala. Oku kuphakamisa ukuba i-nicotinamide riboside inokuba neenzuzo ezinokubakho ngokuchasene nokuhla kwezihlunu ezinxulumene neminyaka.
Kuyafaneleka ukuba uqaphele ukuba ukuguga yinkqubo enzima ephenjelelwa zizinto ezininzi, kubandakanywa i-genetics, indlela yokuphila kunye nokusingqongileyo. INicotinamide riboside kufuneka ijongwe njengesongezelelo esinokunceda ukucotha ukuguga kunye nokuxhasa ukwaluphala okunempilo kunembumbulu yomlingo.
AbaliqelaNAD+ ii-precursors ziye zachongwa, kubandakanywa i-nicotinamide riboside (NR), i-nicotinamide mononucleotide (NMN), kunye ne-nicotinic acid (NA). Ezi zandulela ziguqulwa zibe yi-NAD + kube kanye ngaphakathi kwiseli.
Phakathi kwaba bandulelayo, i-nicotinamide riboside ifumene ingqwalasela ebanzi ngenxa yokuzinza kwayo, i-bioavailability, kunye nokukwazi ukunyusa ngokufanelekileyo amanqanaba e-NAD +. I-NR yindlela yendalo ye-vitamin B3 kwaye ifumaneka kwiimali ezilandelwayo kubisi kunye nokunye ukutya. Kubonisiwe ukuba iphucula i-NAD + synthesis kwaye ivuselele umsebenzi we-sirtuins, iqela leeproteni ezinxulumene nobomi obude.
Enye yeenzuzo ze-nicotinamide riboside kukukwazi ukugqitha kumanyathelo aphakathi afunekayo kwi-NAD+ synthesis. Inokuguqulwa ngokuthe ngqo kwi-NAD + ngaphandle kwesidingo se-enzymes eyongezelelweyo. Ngokwahlukileyo, ezinye izandulela ezifana ne-nicotinamide mononucleotide zifuna amanyathelo ongezelelweyo e-enzymatic abandakanya i-nicotinamide phosphoribosyltransferase (NAMPT) ukuba iguqulelwe kwi-NAD +.
Izifundo ezininzi ziye zathelekisa ukusebenza kwe-nicotinamide riboside kwezinye ii-NAD+ zangaphambili, kwaye i-NR ihlala iphuma phezulu. Kuphononongo lwangaphambili kwiimpuku ezigugayo, ukuxhaswa kwe-nicotinamide riboside kwafunyanwa ukonyusa amanqanaba e-NAD +, ukuphucula ukusebenza kwe-mitochondrial, kunye nokuphucula ukusebenza kwezihlunu.
Uphononongo olungahleliwe, oluyimfama oluphindwe kabini, olulawulwa yi-placebo kubantu abadala abanempilo lubonise iziphumo ezithembisayo. Amanqanaba e-NAD+ anyuswe kakhulu kubathathi-nxaxheba abathatha i-nicotinamide riboside xa kuthelekiswa neqela le-placebo. Ukongezelela, baye bachaza ukuphuculwa komsebenzi wokuqonda kunye nokunciphisa ukukhathala okuzimeleyo.
Ngelixa abanye abanduleli be-NAD+, njenge-nicotinamide mononucleotide kunye ne-niacin, babonise iziphumo ezilungileyo kumanqanaba e-NAD+ kwezinye izifundo, abakabonisi inqanaba elifanayo lokusebenza njenge-nicotinamide riboside.
Kubalulekile ukuqaphela ukuba nangona i-nicotinamide riboside ibonakala isebenza ngakumbi kumanqanaba e-NAD +, iimpendulo zomntu ngamnye zinokwahluka. Abanye abantu banokufumanisa ukuba ezinye izandulela, ezifana ne-nicotinamide mononucleotide okanye i-niacin, zifaneleke ngakumbi kwiimfuno zabo ezithile.
I-Nicotinamide riboside izongezo ziyafumaneka kwithebhulethi, i-capsule, kunye neefom zomgubo. Ukufumana idosi efanelekileyo ye-NR kuxhomekeke kakhulu kwizinto ezahlukeneyo, kuquka iminyaka, impilo, kunye neziphumo ezifunwayo. Ke ngoko, kusoloko kububulumko ukubonisana nochwepheshe bezempilo ngaphambi kokuba uqalise nayiphi na irejimeni entsha yokongeza, njengoko banokubonelela ngeengcebiso ezenzelwe wena ngokusekwe kwiimfuno zakho ezithile.
Kwaye, ngokuthandwa kwe-NR kunyuka kunye nenani lemveliso elingena kwintengiso, kubalulekile ukukhetha umthombo othembekileyo nothembekileyo. Nazi ezinye izinto eziphambili ekufuneka uziqwalasele xa ukhetha isongezelelo se-NR:
1. Ubunyulu kunye noMgangatho: Khangela iimveliso ezivavanywe ngumntu wesithathu kwaye ziqinisekisiwe ukuqinisekisa ukuba ziyahlangabezana nemigangatho engqongqo yomgangatho. Jonga izongezo ezingenazo izihluzi, izongezo eziyingozi, kunye nezingcoliso ezinokubakho.
2. IiNdlela zokuSebenza: Khetha izongezo ezenziwe kwizibonelelo ezibhalisiweyo ze-FDA kwaye ulandele izikhokelo ze-Good Manufacturing Practice (GMP). Oku kuqinisekisa ukuhambelana kwemveliso, ukhuseleko kunye nokusebenza kakuhle.
4. Isidima kunye noPhononongo lwabathengi: Jonga uphononongo lwabathengi kunye nemilinganiselo ukuze ufumane ingqiqo ekusebenzeni kwesongezelelo kunye nokwaneliseka ngokubanzi kwabathengi.
Umbuzo: Isebenza njani iNicotinamide Riboside (NR)?
A: INicotinamide Riboside (NR) isebenza ngokunyusa amanqanaba e-NAD + emzimbeni. I-NAD + ibandakanyeka kwimveliso yamandla eselula, ukulungiswa kwe-DNA, kunye nokugcina impilo kunye nokusebenza kwe-mitochondria.
Umbuzo: Ziziphi iziphumo ezinokuthi zichase ukuguga kweNicotinamide Riboside (NR)?
A: I-Nicotinamide Riboside (NR) ibonise iziphumo ezithembisayo zokuguga ngendima yayo ekukhuliseni amanqanaba e-NAD +. Ukonyuka kwamanqanaba e-NAD + kunokuphucula ukusebenza kwe-mitochondrial, ukuphucula imveliso yamandla eselula, kunye nokukhuthaza ukulungiswa kwe-DNA, konke oku kunokuba negalelo ekulweni ukuhla okunxulumene neminyaka kunye nokuphucula impilo yonke.
Ukuziphendulela: Eli nqaku lelolwazi ngokubanzi kuphela kwaye akufanele lithathwe njengeliphi na icebiso lonyango. Olunye ulwazi lweposti yebhlog luvela kwi-Intanethi kwaye alunamsebenzi. Le webhusayithi inoxanduva kuphela lokuhlela, ukufomatha kunye nokuhlela amanqaku. Injongo yokudlulisa ulwazi olongezelelekileyo ayithethi ukuba uyavumelana neembono zayo okanye uqinisekise ubunyani bomxholo wayo. Soloko udibana nengcali yezempilo ngaphambi kokuba usebenzise naziphi na izongezo okanye wenze utshintsho kwirejimeni yokhathalelo lwempilo.
Ixesha lokuposa: Nov-10-2023
