I-NAD+ (iBeta-Nicotinamide Adenine Dinucleotide) yi-coenzyme efumaneka kuzo zonke iiseli eziphilayo kwaye ibalulekile kwiinkqubo ezahlukeneyo zebhayoloji, kubandakanya ukuveliswa kwamandla kunye nokulungiswa kwe-DNA. Njengoko sikhula, amanqanaba ethu e-NAD+ ayancipha, nto leyo ekhokelela kwiingxaki ezahlukeneyo zempilo. Ukulwa nale ngxaki, abantu abaninzi baphendukela kwizongezo ze-NAD+ ngendlela yomgubo. Nangona kunjalo, ngezinketho ezininzi ezikhoyo, ukumisela ukuba yeyiphi i-NAD+ powder efanelekileyo kuwe kunokuba nzima. Ukukhetha i-NAD+ powder efanelekileyo kufuna ukuqwalaselwa ngononophelo ubumsulwa, ukufumaneka kwezinto eziphilayo, umthamo, ukucaca, kunye nempendulo yabathengi. Ngokubeka ezi zinto phambili, ungenza isigqibo esinolwazi kwaye ukhethe i-NAD+ powder esemgangathweni ophezulu exhasa impilo yakho kunye nokuphila kakuhle.
I-NAD yenzeka ngokwendalo kwiiseli zethu,Nangona kunjalo, ikakhulu kwi-cytoplasm yazo kunye ne-mitochondria, amanqanaba endalo e-NAD ayancipha njengoko sikhula (enyanisweni rhoqo emva kweminyaka engama-20), okubangela iziphumo eziqhelekileyo zokwaluphala, Ezifana nokwehla kwamanqanaba amandla kunye nokwanda kwentlungu kunye nobuhlungu. Ngaphezu koko, ukwehla okunxulumene nokwaluphala kwi-NAD kunxulunyaniswa nezinye izifo ezinxulumene nokwaluphala, ezifana nomhlaza, ukwehla kwengqondo, kunye nobuthathaka.
I-NAD+ ayisiyo i-hormone, yi-coenzyme. I-NAD+ inokuphucula amandla e-DNA okuzilungisa, yandise ubomi bayo ngokuguqula ukwehla kwe-mitochondria, kwaye ikhusele i-DNA kunye nomonakalo we-mitochondrial. Kwaye inokuphucula uzinzo lwe-chromosome. I-NAD+ ikwaziwa njenge-"miracle molecule" ebuyisela kwaye igcine impilo yeseli. Kwizifundo zezilwanyana, kuye kwaqinisekiswa ukuba inamandla amakhulu okunyanga izifo ezahlukeneyo ezifana nesifo sentliziyo, isifo seswekile, isifo se-Alzheimer, kunye nokutyeba kakhulu.
I-NAD+ ithatha inxaxheba kwiindlela ezahlukeneyo zokusabela kwe-biochemical ngaphakathi kweeseli, ezifana ne-glycolysis, i-fatty acid oxidation, umjikelo we-tricarboxylic acid, umjikelo wokuphefumla, njl. Kwezi nkqubo, i-NAD+ isebenza njengomthumeli we-hydrogen, yamkela ii-electron kunye ne-hydrogen kwi-substrates ize izidlulisele kwezinye iimolekyuli, ezifana ne-NADH kunye ne-FAD, ukugcina ibhalansi ye-redox yangaphakathi kweseli. I-NAD+ idlala indima ebalulekileyo kwimveliso yamandla eseli, ukhuseleko lwe-free radicals, ukulungiswa kwe-DNA, kunye nokubonisa.
Ukongeza, i-NAD+ ikwanxulumene kakhulu nokwaluphala, kwaye amanqanaba ayo ayancipha ngokuhamba kweminyaka. Ke ngoko, ukugcina amanqanaba e-NAD+ kudlala indima ebalulekileyo ekulibaziseni ukuguga, ukuphucula amandla, ukukhuthaza ukulungiswa kweeseli, ukuphucula ukusebenza kwengqondo, kunye nokulawula imetabolism.
Okuphawulekayo kukuba, ukwaluphala kuhamba nokwehla okuqhubekekayo kwamanqanaba e-NAD+ kwizicwili nakwiiseli kwiintlobo ngeentlobo zezinto eziphilayo, kuquka iimpuku kunye nabantu.
Ngoko ke, ukuzalisa umzimba ngexesha elifanelekileyo kunokubangela ukuba uluphale kwaye kuqinisekise impilo. Ukuba ufuna ubudala bube yinombolo nje, yongeza i-NAD+ kwangethuba ukuze ubonakale umncinci ngaphakathi nangaphandle.
Amanqanaba e-NAD+ ayehla ngokukhula kweminyaka, ikakhulu ngenxa yokuba izinga lokuveliswa kwayo alikwazi ukuhambelana nezinga lokusetyenziswa kwayo.
Inani elikhulu lezifundo libonise ukuba ukwehla kwamanqanaba e-NAD+ kunxulumene nezifo ezininzi ezinxulumene nokwaluphala, kubandakanya ukwehla kwengqondo, ukudumba, umhlaza, izifo ze-metabolic, i-sarcopenia, izifo ze-neurodegenerative, njl.njl.
Yiyo loo nto sifuna izongezo ze-NAD+. Njenge-collagen yethu yohlobo lwesithathu, isoloko ilahleka.
I-NAD+ inokumelana nokwaluphala. Yintoni umgaqo osisiseko sayo?
I-NAD+ isebenza kwi-enzyme yokulungisa iijini ze-parp1
Inceda ukulungiswa kwe-DNA Enye yezizathu zokwaluphala kukonakala kwe-DNA. Iinwele zakho ezimhlophe, ukuwohloka kwesibeleko kunye nezinye izitho zomzimba, zonke zinxulumene nokonakala kwe-DNA. Ukuhlala ulele ixesha elide kunye noxinzelelo kuya kwenza umonakalo we-DNA ube mandundu.
Izifundo zifumanise ukuba i-NAD+ inceda ekuvuseleleni i-PARP1 gene (esebenza njengomphenduli wokuqala ukufumanisa umonakalo we-DNA ize ikhuthaze ukukhethwa kweendlela zokulungisa. I-PARP1 ikhokelela ekuncitshisweni kwesakhiwo se-chromatin nge-ADP ribosylation ye-histones, kwaye ibandakanyeka kwiinkalo ezahlukeneyo zokulungisa i-DNA ezisebenzisanayo neziziguqulayo, ngaloo ndlela ziphucula ukusebenza kakuhle kokulungisa), ngaloo ndlela zilungisa umonakalo we-DNA kwaye zikhuthaza ukuqalwa kotshintsho lwe-metabolic.
Ngamafutshane, i-NAD+ inokuchaphazela ngokuthe ngqo nangokungathanga ngqo imisebenzi emininzi ephambili yeseli, kubandakanya iindlela ze-metabolic, ukulungiswa kwe-DNA, ukulungiswa kwe-chromatin, ukukhula kweeseli, ukusebenza kweeseli zomzimba, njl.njl., ngaloo ndlela icothisa inkqubo yokwaluphala komntu.
I-NAD+ sisifinyezo sesiNgesi seNicotinamide adenine dinucleotide. Igama layo elipheleleyo ngesiTshayina yi-nicotinamide adenine dinucleotide, okanye iCoenzyme I ngamafutshane. Njenge-coenzyme edlulisela ii-hydrogen ions, i-NAD+ idlala indima kwiinkalo ezininzi zemetabolism yomntu, kubandakanya i-glycolysis, i-Gluconeogenesis, umjikelo we-tricarboxylic acid, njl. Ezinye izifundo zibonise ukuba ukuncipha kwe-NAD+ kunxulumene nobudala, kwaye iindlela zomzimba ezilawulwa yi-NAD+ zinxulumene nokwaluphala, izifo zemetabolism, i-neuropathy kunye nomhlaza, kubandakanya ukulawula i-homeostasis yeseli, ii-sirtuins ezaziwa ngokuba yi-"longevity genes", ukulungisa i-DNA, iiproteni zosapho lwe-PARP ezinxulumene ne-necroptosis kunye ne-CD38 enceda ekudluliseleni i-calcium.
Ukulwa nokwaluphala
Ukwaluphala kubhekisa kwinkqubo apho iiseli ziyeka ukwahlukana ngokungenakulungiseka. Ukonakala kwe-DNA okungalungiswanga okanye uxinzelelo lweseli lunokubangela ukukhula. Ukwaluphala kuchazwa ngokubanzi njengenkqubo yokuwohloka kancinci kancinci kwemisebenzi yomzimba ngokuhamba kweminyaka; iimpawu zangaphandle ziinguqu zomzimba ezibangelwa kukulahlekelwa yimisipha namathambo, kwaye iimpawu zangaphakathi kukuncipha kwe-basal metabolism kunye nokusebenza komzimba.
Izazinzulu ziye zafunda abantu abaphila ixesha elide, kwaye iziphumo zophando zibonisa ukuba kukho i-gene enxulumene nokuphila ixesha elide kubantu abaphila ixesha elide - i-"Sirtuins gene". Le gene iya kuthatha inxaxheba kwinkqubo yokulungiswa kobonelelo lwamandla emzimbeni kunye nokuphindaphinda kwe-DNA ukugcina ukuthembeka kunye nozinzo lwe-gene, ukususa iiseli ezilupheleyo, ukuphucula inkqubo yomzimba yokuzikhusela ngokusebenzisa iziphumo zokulwa nokuvuvukala kunye ne-antioxidant, kunye nokulibazisa ukuguga kweeseli eziqhelekileyo.
Eyona nto ijolise kuyo kuphela ekusetyenzisweni kwezakhi zofuzo zobomi obude "iiSirtuins" -I-NAD+
I-NAD+ ibalulekile ekugcineni impilo yomzimba kunye nokulinganisela. I-metabolism, i-redox, ukugcinwa kunye nokulungiswa kwe-DNA, uzinzo lwezakhi zofuzo, ukulawulwa kwe-epigenetic, njl. zonke ezi zinto zifuna ukuba i-NAD+ ithathe inxaxheba.
I-NAD+ igcina unxibelelwano lweekhemikhali phakathi kwe-nucleus kunye ne-mitochondria, kwaye unxibelelwano olubuthathaka luyimbangela ebalulekileyo yokwaluphala kweeseli.
I-NAD+ inokususa inani elikhulayo leekhowudi ze-DNA ezingalunganga ngexesha lokusetyenziswa kweeseli, igcine ukubonakaliswa okuqhelekileyo kweejini, igcine ukusebenza okuqhelekileyo kweeseli, kwaye inciphise ukuguga kweeseli zabantu.
Ukulungisa umonakalo we-DNA
I-NAD+ sisixhobo esibalulekileyo kwi-enzyme yokulungisa i-DNA i-PARP, enefuthe elikhulu ekulungisweni kwe-DNA, ukubonakaliswa kwezakhi zofuzo, uphuhliso lweeseli, ukusinda kweeseli, ukwakhiwa kwakhona kwee-chromosome, kunye nokuzinza kwezakhi zofuzo.
Yenza iproteni ehlala ixesha elide isebenze
IiSirtuin zihlala zibizwa ngokuba lusapho lweeproteni zobomi obude kwaye zidlala indima ebalulekileyo ekulawuleni imisebenzi yeeseli, njengokuvuvukala, ukukhula kweeseli, isigqi se-circadian, imetabolism yamandla, umsebenzi we-neuronal, kunye nokumelana noxinzelelo, kwaye i-NAD+ yi-enzyme ebalulekileyo yokwenziwa kweeproteni zobomi obude. Ivuselela zonke iiproteni zobomi obude ezisi-7 emzimbeni womntu, idlala indima ebalulekileyo ekuchaseni uxinzelelo lweeseli, imetabolism yamandla, ukuthintela ukuguqulwa kweeseli, i-apoptosis kunye nokwaluphala.
Nika amandla
Ikhuthaza ukuveliswa kwamandla angaphezu kwama-95% afunekayo kwimisebenzi yobomi. I-Mitochondria kwiiseli zabantu zizityalo zamandla zeeseli. I-NAD+ yi-coenzyme ebalulekileyo kwi-mitochondria ukuvelisa imolekyuli yamandla i-ATP, iguqula izondlo zibe ngamandla afunekayo emzimbeni womntu.
Khuthaza ukuvuselelwa kwemithambo yegazi kwaye ugcine ukuqina kwemithambo yegazi
Imithambo yegazi zizinto ezibalulekileyo kwimisebenzi yobomi. Njengoko sikhula, imithambo yegazi ilahlekelwa bukuguquguquka kwayo kancinci kancinci kwaye iba nzima, ityebe, kwaye inciphe, nto leyo ebangela "i-arteriosclerosis." I-NAD+ inokunyusa umsebenzi we-elastin kwimithambo yegazi, ngaloo ndlela igcina ukuthamba kwemithambo yegazi kunye nokugcina impilo yemithambo yegazi.
Khuthaza imetabolism
I-Metabolism yindibaniselwano yeempendulo ezahlukeneyo zeekhemikhali emzimbeni. Umzimba uya kuqhubeka nokutshintshiselana ngezinto kunye namandla. Xa olu tshintshiselwano luyeka, ubomi bomzimba buya kuphela.
UNjingalwazi uAnthony kunye neqela lakhe lophando kwiYunivesithi yaseCalifornia, eMelika, bafumanise ukuba i-NAD+ inokuphucula ngempumelelo ukucotha kwemetabolism yeeseli enxulumene nokwaluphala, ngaloo ndlela iphucula impilo yabantu kwaye yandise ubomi babo.
Khusela impilo yentliziyo
Intliziyo yeyona nto ibalulekileyo ebantwini, kwaye inqanaba le-NAD+ emzimbeni lidlala indima ebalulekileyo ekugcineni ukusebenza kwentliziyo ngokuqhelekileyo. Ukuncipha kwe-NAD+ kusenokunxulunyaniswa nesifo sentliziyo, kwaye inani elikhulu lezifundo ezisisiseko nalo liqinisekisile isiphumo sokongeza i-NAD+ kwizifo zentliziyo.
Ukuthintela izifo zentliziyo kunye nezifo zemithambo yegazi
Izifundo zibonise ukuba phantse zonke iintlobo ezisixhenxe ze-sirtuins (SIRT1-SIRT7) zinxulumene nokwenzeka kwesifo sentliziyo. Ii-Sirtuins zithathwa njengezona zinto zibalulekileyo zonyango lwezifo zentliziyo, ngakumbi i-SIRT1.
I-NAD+ yeyona nto iphambili kwiSirtuins. Ukongezwa kwe-NAD+ ngexesha elifanelekileyo emzimbeni womntu kunokuvuselela ngokupheleleyo umsebenzi we-Sirtuins nganye, ngaloo ndlela kukhusela impilo yentliziyo kunye nokuthintela izifo zentliziyo.
Khuthaza ukukhula kweenwele
Eyona nto ibangela ukulahleka kweenwele kukulahlekelwa bubomi beeseli zeenwele, kwaye ukulahleka kobomi beeseli zeenwele kungenxa yokuba inqanaba le-NAD+ emzimbeni womntu liyehla. Iiseli zeenwele azina-ATP eyaneleyo yokwenza ukwenziwa kweeproteni zeenwele, ngaloo ndlela zilahlekelwa bubomi bazo kwaye zikhokelele ekulahlekelweni kweenwele. Ke ngoko, ukongeza i-NAD+ kunokuqinisa umjikelo we-asidi kwaye kuvelise i-ATP, ukuze iiseli zeenwele zibe namandla aneleyo okuvelisa iproteni yeenwele, ngaloo ndlela ziphucule ukulahleka kweenwele.
Unyango lwemolekyuli yeseli ye-NAD+
Njengoko iminyaka ikhula, inqanaba le-NAD+ (iCoenzyme I) emzimbeni liya kuwa eweni, nto leyo ekhokelela ngqo ekusebenzeni komzimba nasekugugeni kweeseli! Emva kweminyaka ephakathi, inqanaba le-NAD+ emzimbeni womntu liyehla minyaka le. Kwiminyaka engama-50, inqanaba le-NAD+ emzimbeni liba sisiqingatha nje salo xa uneminyaka engama-20. Xa uneminyaka engama-80, amanqanaba e-NAD+ amalunga ne-1% kuphela yoko wayekuko xa uneminyaka engama-20.
Ngoko ke, umgubo we-NAD+ wahluke njani kwezinye izongezo ezithengiswayo? Makhe sijonge ngokusondeleyo amanye amanqaku abalulekileyo ekufuneka aqwalaselwe:
1. Ukufumaneka kwezinto eziphilayo:
Omnye womahluko ophambili phakathi komgubo we-NAD+ kunye nezinye izongezo kukuba ifumaneka lula emzimbeni. Umgubo we-NAD+ ufunxwa lula ngumzimba kwaye usebenzisa ii-coenzymes ngokufanelekileyo. Ngokwahlukileyo koko, ezinye izongezo zinokuba ne-bioavailability ephantsi, oko kuthetha ukuba umzimba usenokungakwazi ukufunxa nokusebenzisa izithako ezisebenzayo ngokufanelekileyo.
2. Indlela yokusebenza:
Umgubo we-NAD+ usebenza ngokugcwalisa amanqanaba e-NAD+ emzimbeni, ngaloo ndlela uxhasa imisebenzi eyahlukeneyo yeseli. Ezinye izongezo zinokuba neendlela ezahlukeneyo zokusebenza, zijolise kwiindlela ezithile okanye iinkqubo emzimbeni. Ukuqonda iindlela ezithile zokusebenza kwezongezo ezahlukeneyo kunokukunceda ugqibe ukuba zeziphi ezifanelekileyo kwiimfuno zakho.
3. Uphando nobungqina:
Xa ucinga ngayo nayiphi na isongezelelo, kubalulekile ukuphonononga uphando olukhoyo kunye nobungqina obuxhasa ukusebenza kwayo kunye nokhuseleko lwayo. Umgubo we-NAD+ ube ngumxholo wezifundo ezininzi, ugxininisa iingenelo zayo ezinokubakho kwimpilo yeseli kunye nokuphila ixesha elide. Kwelinye icala, ezinye izongezelelo zinokuba nophando olulinganiselweyo lokuxhasa amabango azo. Ukuqonda ubungqina besayensi obungasemva kwesongezelelo kunokukunceda wenze izigqibo ezinolwazi ngakumbi malunga nokusetyenziswa kwaso.
4. Iimfuno zomntu kunye neenjongo zakhe:
Ekugqibeleni, isigqibo sokusebenzisa umgubo we-NAD+ okanye ezinye izongezo kufuneka sisekelwe kwiimfuno zakho zobuqu kunye neenjongo zakho zempilo. Cinga ngokubonisana nengcali yezempilo okanye ingcali yesondlo esifanelekileyo ukuze ubone ukuba zeziphi izongezo ezinokuba luncedo kuwe. Izinto ezinje ngobudala, indlela yokuphila, kunye neemeko zempilo ezikhoyo zonke zinokudlala indima ekumiseleni indlela efanelekileyo yokusetyenziswa kwezongezo.
Izazinzulu beziyifunda iminyaka eli-100. I-NAD+ ayisiyonto intsha kutshanje efunyenweyo, kodwa yinto efundwe iminyaka engaphezu kwe-100.
I-NAD+ yafunyanwa okokuqala ngo-1904 yingcali yebhayoloji yaseBritane uSir Arthur Harden, owathi kamva waphumelela iNobel Prize kwiKhemistri ngo-1929.
Ngo-1920, uHans von Euler-Chelpin wayichola waza wayicoca i-NAD+ okokuqala waza wafumanisa isakhiwo sayo se-dinucleotide, waza emva koko waphumelela iNobel Prize kwiKhemistry ngo-1929.
Ngo-1930, u-Otto Warburg waqala wafumanisa indima ephambili ye-NAD+ njenge-coenzyme kwi-metabolism yezinto kunye namandla, waza kamva waphumelela iNobel Prize kwiMedicine ngo-1931.
Ngo-1980, uGeorge Birkmayer, uprofesa kwiSebe leMichiza yezoNyango kwiYunivesithi yaseGraz e-Austria, waqala ukusebenzisa i-NAD+ encitshisiweyo kunyango lwezifo.
Ngowama-2012, iqela lophando likaLeonard Guarente, iqela lophando lekhemistri edumileyo kwihlabathi uStephen L. Helfand, kunye neqela lophando likaHaim Y. Cohen ngokulandelelana bafumanise ukuba i-NAD+ inokwandisa iintonga ze-Caenorhabditis elegans. Ubomi be-nematodes buphantse bube yi-50%, bunokwandisa ubomi be-fruit fruit fruit fruit fruit floor nge-10%-20%, kwaye bunokwandisa ubomi be-duna mpuku nge-10%.
Uphando nophando lwezazinzulu ngobomi luye lwahlaziywa rhoqo kwaye lwaphindaphindwa. NgoDisemba ka-2013, uDavid Sinclair, uprofesa wezofuzo kwiYunivesithi yaseHarvard, wapapasha incwadi ethi "Supplementing NAD with NAD" kwiphephancwadi lezemfundo eliphambili kwihlabathi i-"Cell". "Emva kweveki enye yokwandisa i-NAD ngearhente, ixesha lokuphila kweempuku landiswa nge-30%." Iziphumo zophando zityhile okokuqala ukuba izongezo ze-NAD+ zinokuguqula kakhulu ukuguga kwaye zandise ixesha lokuphila. Olu phando lwathusa ihlabathi kwaye lwavula indlela eya kudumo lwezongezo ze-NAD njengezinto ezilwa nokuguga. .
Ngolu vumbululo lumangalisayo, i-NAD+ iseke unxibelelwano olungenakwahlulwa phakathi kokulwa nokwaluphala. Kwiminyaka yakutshanje, uphando malunga ne-NAD+ luye lwalawula phantse iijenali zezemfundo eziphezulu ze-SCI ezifana neSayensi, iNdalo, kunye neSeli, lwaba lolona vumbululo lumangalisayo kuluntu lwezonyango. Kuthiwa oku Linyathelo lembali elithatyathwe luluntu kuhambo lokulwa nokwaluphala nokwandisa ixesha lokuphila.
1. Phanda udumo kunye nokungafihlisi kophawu
Xa ucinga ngophawu oluthile lwe-NAD+ powder, kufanelekile ukuphanda udumo kunye nokungafihlisi kwenkampani. Khangela iimpawu ezibeka phambili ukucaca kwiinkqubo zazo zokufumana kunye nokuvelisa. Iimpawu ezidumileyo ziya kubonelela ngolwazi oluneenkcukacha malunga nokufunyanwa kwazo kwe-NAD+ powder, kubandakanya umgangatho wezinto eziluhlaza kunye nemigangatho yokuvelisa abayithobelayo. Ukongeza, khangela uphononongo lwabathengi kunye nobungqina bokuvavanya ulwaneliseko kunye namava abanye abasebenzisi ngeemveliso zephawu.
2. Vavanya ubunyulu bomgubo we-NAD+
Ubunyulu yinto ebalulekileyo xa ukhetha uphawu lwepowder ye-NAD+. Umgubo we-NAD+ osemgangathweni ophezulu kufuneka ungabi nazinto zingcolisayo kunye nezizalisi, ukuqinisekisa ukuba ufumana imveliso ecocekileyo nesebenzayo. Khangela iimpawu ezenza uvavanyo lomntu wesithathu ukuqinisekisa ubunyulu bomgubo wabo we-NAD+. Uvavanyo lomntu wesithathu lubonelela ngesiqinisekiso esongezelelweyo sokuba iimveliso ziyahlangabezana nemigangatho ephezulu yobunyulu kwaye azinazo naziphi na izinto eziyingozi.
3. Cinga ngeenkqubo zokuvelisa kunye nemigangatho yomgangatho
Inkqubo yokuvelisa idlala indima ebalulekileyo kumgangatho we-NAD+ powder. Khetha iimpawu ezilandela amanyathelo angqongqo okulawula umgangatho kwaye zilandela i-Good Manufacturing Practices (GMP). Isiqinisekiso se-GMP siqinisekisa ukuba iimveliso ziveliswa kwindawo ecocekileyo nelawulwayo, sinciphisa umngcipheko wongcoliseko kwaye siqinisekisa umgangatho ohambelanayo. Ukongeza, buza ngokuzibophelela kwe-brand ekuzinzeni nasekufumaneni imveliso ngendlela yokuziphatha, njengoko ezi zinto zinokubonakalisa nomgangatho uwonke wemveliso.
4. Vavanya ukufumaneka kwezinto eziphilayo kunye nokufunxwa komgubo we-NAD+
Ukufumaneka kwezinto eziphilayo kubhekisa kubuchule bomzimba bokufunxa nokusebenzisa izithako ezisebenzayo kwisongezelelo. Xa ukhetha uhlobo lwe-NAD+ powder, cinga ngokufumaneka kwezinto eziphilayo kwimveliso. Khangela iimpawu ezisebenzisa iinkqubo zokuhambisa eziphambili okanye ubuchwepheshe bokunyusa ukufumaneka kwezinto eziphilayo kwi-NAD+. Oku kungabandakanya iimpawu ezifana ne-micronization okanye i-encapsulation, ezinokuphucula ukufunxwa kwe-NAD+ emzimbeni, ekugqibeleni ziphucule ukusebenza kwayo.
5. Funa uphando lwesayensi kunye nophando lweklinikhi
Iimpawu zepowder ze-NAD+ ezidumileyo zihlala zibonelela ngezifundo zesayensi nezeklinikhi ukuxhasa ukusebenza kakuhle kunye nokhuseleko lweemveliso zazo. Khangela iimpawu ezityala imali kuphando nophuhliso, njengoko oku kubonisa ukuzinikela ekuveliseni iimveliso ezisemgangathweni ophezulu nezisekelwe kubungqina. Ukuqinisekiswa kwesayensi kuqinisekisa ukuba ipowder ye-NAD+ iye yavavanywa kwaye yavavanywa ngokuqatha, okuqinisekisa ngakumbi umgangatho kunye nobunyulu bayo.
I-Suzhou Myland Pharm & Nutrition Inc. ibisebenza kwishishini lezongezo zesondlo ukusukela ngo-1992. Yinkampani yokuqala eTshayina ukuphuhlisa nokuthengisa isicatshulwa sembewu yeediliya.
Ngeminyaka engama-30 yamava kwaye iqhutywa bubuchwepheshe obuphezulu kunye nesicwangciso sophando nophuhliso esiphucukileyo, inkampani iphuhlise uluhlu lweemveliso ezikhuphisanayo kwaye yaba yinkampani yeenkonzo zokongeza izinto ezintsha zesayensi yobomi, ukwenziwa kwezinto ngokwezifiso kunye neenkonzo zokuvelisa.
Ukongeza, iSuzhou Myland Pharm & Nutrition Inc. ikwangumvelisi obhalisiweyo kwi-FDA. Izixhobo zeR&D zenkampani, izixhobo zemveliso, kunye nezixhobo zokuhlalutya zizinto zanamhlanje kwaye zisebenza ngeendlela ezininzi kwaye zinokuvelisa iikhemikhali ukusuka kwi-milligrams ukuya kwiitoni ngobukhulu, kwaye ziyahambelana nemigangatho ye-ISO 9001 kunye neenkcukacha zemveliso ze-GMP.
Q: Zisetyenziselwa ntoni izongezo ze-NAD+?
Isongezelelo se-NAD+ sisongezelelo sesondlo esongeza i-coenzyme NAD+ (i-nicotinamide adenine dinucleotide). I-NAD+ idlala indima ebalulekileyo kwi-metabolism yamandla kunye nokulungiswa kweeseli ngaphakathi kweeseli.
Q: Ngaba izongezo ze-NAD+ ziyasebenza ngokwenene?
A: Olunye uphando lubonisa ukuba izongezo ze-NAD+ zinokunceda ukuphucula imetabolism yamandla eseli kunye nokucothisa inkqubo yokwaluphala.
Q: Zeziphi iindlela zokutya ze-NAD+?
A: Imithombo yokutya ye-NAD+ ibandakanya inyama, intlanzi, iimveliso zobisi, iimbotyi, amandongomane kunye nemifuno. Oku kutya kuqulethe i-niacinamide kunye ne-niacin engaphezulu, enokuguqulwa ibe yi-NAD+ emzimbeni.
Q: Ndingayikhetha njani isongezelelo se-NAD+?
A: Xa ukhetha izongezo ze-NAD+, kucetyiswa ukuba uqale ufune ingcebiso kugqirha okanye kwingcali yesondlo ukuze uqonde iimfuno zakho zesondlo kunye nemeko yakho yempilo. Ukongeza, khetha uphawu oluthembekileyo, jonga izithako zemveliso kunye nomlinganiselo, kwaye ulandele isikhokelo somlinganiselo okwiphepha lemveliso.
Isikhanyeli: Eli nqaku lenzelwe ulwazi oluqhelekileyo kuphela kwaye akufuneki lithathwe njengengcebiso yezonyango. Olunye ulwazi lweposi yebhlog luvela kwi-Intanethi kwaye alungobungcali. Le webhusayithi inoxanduva lokuhlela, ukufomatha kunye nokuhlela amanqaku kuphela. Injongo yokudlulisa ulwazi oluthe kratya ayithethi ukuba uyavumelana nezimvo zayo okanye uqinisekisa ubunyani bomxholo wayo. Soloko uqhagamshelana neengcali zezempilo ngaphambi kokusebenzisa naziphi na izongezo okanye ukwenza utshintsho kwindlela yakho yokhathalelo lwempilo.
Ixesha lokuthumela: Agasti-05-2024
