Igama lesayensi le-NAD yi-nicotinamide adenine dinucleotide. I-NAD+ ikhona kwiseli nganye yomzimba wethu. Yi-metabolite ephambili kunye ne-coenzyme kwiindlela ezahlukeneyo ze-metabolic. Ilawula kwaye ithatha inxaxheba kwiinkqubo ezahlukeneyo zebhayoloji. Ii-enzymes ezingaphezu kwama-300 zixhomekeke kwi-NAD+ ukuze isebenze. Nangona kunjalo, inqanaba lomxholo we-NAD+ aliguquki. Njengoko sikhula, umxholo we-NAD+ kwiiseli uya kuncipha. Ingakumbi emva kweminyaka engama-30, inqanaba le-NAD+ liya kwehla kakhulu, okukhokelela ekwehleni kwemisebenzi emininzi kwaye ngaloo ndlela kubonise iimpawu zokwaluphala. I-Nicotinamide riboside chloride luhlobo lwe-vitamin B3. I-Nicotinamide riboside chloride inokuguqulwa ibe yi-NAD+ (nicotinamide adenine dinucleotide). Yenye yezona zinto zifundwa kakhulu ze-NAD+. Ifunxwa lula ngumzimba kwaye isetyenziswe. Izifundo ezininzi zibonise ukuba ukongeza i-NRC kunokunyusa amanqanaba e-NAD+, nto leyo enokuzisa iingenelo kwiinkqubo ze-metabolic, zentliziyo kunye nezemithambo-luvo. Ihlala isetyenziswa njengesongezelelo sokutya ukukhuthaza impilo kunye nokuphila kakuhle.
I-Nicotinamide riboside chloride (NRC) sisithako esiphuma kwi-vitamin B3 nesithako esitsha esisebenzayo kwi-bioactive. Yenziwe yi-ribose yemolekyuli yeswekile kunye ne-vitamin B3 component nicotinamide (ekwaziwa ngokuba yi-nicotinic acid okanye i-vitamin B3). Ingatyiwa ngokutya inyama, intlanzi, iinkozo kunye nokunye ukutya okanye ngezongezo ze-NRC.
I-Nicotinamide ribose chloride ingaguqulwa ibe yi-NAD+ (nicotinamide adenine dinucleotide) kwaye isebenze umsebenzi webhayoloji kwiiseli. I-NAD+ yi-coenzyme ebalulekileyo yangaphakathi kweseli ethatha inxaxheba kwiinkqubo ezahlukeneyo ze-metabolic zeseli, kubandakanya ukuveliswa kwamandla, ukulungiswa kwe-DNA, ukwanda kweeseli, njl. Ngexesha lenkqubo yokwaluphala komzimba womntu, umxholo we-NAD+ uyancipha kancinci kancinci. Ukongezwa kwe-Nicotinamide riboside chloride kunokunyusa umgangatho we-NAD+, okulindeleke ukuba kulibazise ukwenzeka kokwaluphala kweeseli kunye nezifo ezinxulumene noko.
Uphando olwenziwe kwi-nicotinamide riboside chloride lubonise ukuba inemisebenzi emininzi yebhayoloji, efana nale:
Ukuphucula imetabolism yamandla, ukuphucula ukunyamezela kunye nokusebenza kakuhle kokuzivocavoca;
Ukuphucula umsebenzi we-neurological kunye nememori;
Ukuphucula ukusebenza kwenkqubo yomzimba yokuzikhusela.
Lilonke, i-nicotinamide riboside chloride sisithako esithembisayo kakhulu se-nutraceutical esinokusetyenziswa ngokubanzi.
Ukongeza, i-nicotinamide ribose chloride ikwasetyenziswa kakhulu kuphando lwesayensi. Njengento eyandulela i-NAD+, ingasetyenziselwa ukufunda i-biosynthesis kunye neendlela ze-metabolic ze-NAD+ kunye neminye imiba enxulumene nayo. Kwangaxeshanye, i-nicotinamide riboside chloride ikwasetyenziswa njengesithako kwiimveliso zempilo kunye nezinto zokuthambisa ukukhuthaza impilo yeeseli kunye nokunciphisa ukwaluphala kolusu.
Ukwaluphala yinto ehlala ihleli ebantwini. Ngokutsho kophando olwenziwe zizazinzulu, ukwaluphala kweeseli kunxulumene kakhulu nokunciphisa umxholo we-nicotinamide adenine dinucleotide (NAD). I-NAD likhonkco elibalulekileyo kwi-metabolism kunye nokulungiswa kweeseli emzimbeni womntu. Ayinakulibazisa kuphela ukuguga, kodwa ikwagcina amandla eeseli kwaye igcine impilo yomzimba neyengqondo. kodwa. Njengoko sikhula, amanqanaba e-NAD emizimbeni yethu ehla ngokukhawuleza nangokukhawuleza, kwaye anokwehla nangaphezulu kwesiqingatha phakathi kweminyaka engama-40 nama-80.
Kukho i-enzyme ebaluleke kakhulu emzimbeni wethu, eyiyona nto iphambili kwi-metabolism yamandla eseli. Ibaluleke kangakanani? Phantse zonke iinkqubo ezigcina ukusebenza okuqhelekileyo komzimba, ezifana ne-metabolism, ukulungiswa, kunye nokuzikhusela komzimba, zifuna ukuba le enzyme ithathe inxaxheba. Xa amanqanaba ale enzyme ehla, uninzi lweempawu kunye nezifo ezinxulumene nokwaluphala zinokulandela, njengezifo ze-metabolism, ukusebenza okubuthathaka komzimba, ukuwohloka kwengqondo, njl. Le enzyme ibalulekileyo inegama elide: i-nicotinamide adenine dinucleotide, okanye i-NAD+.
Ngamafutshane, ukunciphisa i-NAD+ emzimbeni kuthetha ukwaluphala. Ngoko ke, singayongeza i-NAD+ emzimbeni ukuze kulibazise ukwaluphala? Ukuba uyongeza ngokuthe ngqo i-NAD+, umzimba womntu awuyi kukwazi ukuyifunxa, kwaye iya kuba nemiphumo emibi kakhulu. Ngenxa yoko, abantu bajika ingqalelo yabo kwi-NAD+ engaphambili: i-nicotinamide ribose chloride (NRC).
I-Nicotinamide riboside chloride luhlobo lwe-vitamin B3 kwaye yenye yezona zinto zifundwayo kakhulu ze-NAD+. Ifunxwa kwaye isetyenziswa lula ngumzimba. Izifundo ezininzi zibonise ukuba ukongeza i-NR kunokunyusa amanqanaba e-NAD+, nto leyo enokuzisa iingenelo kwiinkqubo ze-metabolic, zentliziyo kunye nezemithambo-luvo.
Igama elithi “ukulwa nokwaluphala” livakala lingathandeki. Kuvakala ngathi sizama ukuyeka into esele isenzeka, okanye asikwazi ukwamkela iindawo zethu esimele sizithande. Kodwa inyani kukuba utshintsho lwe-metabolic lwenzeka phantsi kolusu ngaphambi kokuba sibone imiphumo yokwaluphala. Ukukhetha ukujongana nempilo yethu ngaphakathi kunokuba yinto esiyidingayo ukuphucula indlela esikhula ngayo.
Enyanisweni, enye yeempawu zokwaluphala yinkqubo eyaziwa ngokuba yi-"mitochondrial dysfunction," igama elibhekisa ekulahlekelweni kwamandla ngokubanzi kunye nokusebenza kakuhle kweeseli zethu ngokuhamba kwexesha. Oku kusenokuba sesinye sezizathu zokuba siluphale. Ukuba i-mitochondria isembindini wokwaluphala kwethu, kufanelekile ukuphanda ngazo zonke iindlela ezinokwenzeka zokuzigcina zisebenza ixesha elide kangangoko kunokwenzeka.
Funda nge-mitochondria.
Phantse ngaphakathi kwiseli nganye kukho ezi organelles zincinci, ezimile ngendlela engaqhelekanga ezibizwa ngokuba yi mitochondria—“indlu yamandla yeseli.” Ezi zitho zincinci zinoxanduva lokuvelisa i-90% yamandla afunekayo emizimbeni yethu. I-Mitochondria yimbangela yokuba siphile namhlanje njengezilwanyana ezintsonkothileyo kunokuba sibe ziibhaktheriya.
Asisoloko siyazi ukuba i-mitochondria ibaluleke kangakanani kwimpilo yethu. Indlela ephambili yokugcina i-mitochondria yakho isempilweni yimolekyuli ebizwa ngokuba yi-NAD+ (nicotinamide adenine dinucleotide). Iiseli zethu ngokwemvelo zivelisa i-NAD+ kwaye siyisebenzisa rhoqo imini yonke.
Siyazi nokuba ukunikezelwa kwethu kwe-NAD+ kuyehla njengoko sikhula. Bakuba abaphandi beqaphele ukuba i-NAD+ inokuba negalelo ekugcineni iiseli zethu ziphilile, bazama ukufumana indlela yokuyisebenzisa ngokupheleleyo.
Abaphandi sele besazi ukuba iivithamini ezimbini ziqala inkqubo yeekhemikhali yokwandisa i-NAD+: i-niacin kunye ne-niacinamide. Ezi zafunyanwa ngeminyaka yoo-1930 ukunyanga i-pellagra, ukungabikho kwe-vitamin B3 okunokubulala.
I-Niacin nayo yayiza kuba lunyango lwe-cholesterol ephezulu ngeminyaka yoo-1950. Nangona kunjalo, kufunyenwe ukuba ukutya iidosi eziphezulu ze-niacin ngamanye amaxesha kunokubangela ukurhawuzelela kolusu okucaphukisayo nokungathandekiyo.
I-Niacinamide ayibangeli ukurhawuzelela kolusu kwaye ngokwethiyori inokubonelela ngeenzuzo ezininzi ezifanayo, kodwa ithintela ukusebenza kweeproteni ezibalulekileyo ezikhuthaza ukulungiswa kweeseli ezibizwa ngokuba yi-sirtuins. I-niacinamide kunye ne-niacin azizange zisebenze njengoko abaphandi babenethemba.
Nangona ezi vithamini zimbini zizinto ezibangela i-NAD+, azisisisombululo esifanelekileyo. Ngenxa yeziphumo ezimbi ze-niacin kunye nokusebenza kakuhle kwe-nicotinamide, abaphandi abanaso isongezelelo esaneleyo seevithamini sokunyusa amanqanaba e-NAD+.
Ukufunyanwa kwe-nicotinamide riboside.
Olunye uhlobo lwevithamini B3 olubizwa ngokuba yi-nicotinamide riboside lwafunyanwa kwimvubelo ngeminyaka yoo-1940. Kodwa kwakungasekuqaleni kweminyaka yoo-2000 apho izazinzulu zaqala ukubona amandla ale vithamini yesithathu, i-B3, kungekuphela nje ukwandisa i-NAD+ kodwa nokuphucula impilo yabantu. Ngowama-2004, iqela lophando leDartmouth College lafumanisa ukuba i-nicotinamide riboside, njengomntakwabo wevithamini B3, sisandulela se-NAD+.
Iqela lophando elikhokelwa nguGqr. Charles Brenner lifumanise ukuba i-nicotinamide riboside yonyusa i-NAD+ kwiimpuku, kwaye iimpuku zifumene iingenelo ezininzi zempilo ngenxa yoko.
Iimpuku zibonise yonke into ukusuka kwiswekile yegazi ephucukileyo kunye namanqanaba e-cholesterol ukuya ekunciphiseni umonakalo wemithambo-luvo kunye nokumelana nokunyuka kobunzima. UGqr. Charles Brenner ufumanise ukuba ezi ziphumo zikhuthaza kakhulu kangangokuba wathabatha inyathelo elilandelayo lokuqonda impembelelo ye-nicotinamide riboside kwimpilo yabantu.
Ngowama-2014, uGqr. Brenner waba ngumntu wokuqala ukuthatha i-nicotinamide riboside njengesongezelelo. Iziphumo ziyakhuthaza ngokulinganayo. Olu hlobo lwevithamini B3 olungaziwayo lwanyusa kakhulu amanqanaba akhe e-NAD+ ngokukhuselekileyo, ngokukhawuleza, kwaye ngaphandle kwemiphumo emibi.
I-Nicotinamide riboside isebenzisa indlela eyahlukileyo yokuvelisa i-NAD+ engasetyenziswa zezinye iivithamini B3.
I-Nicotinamide riboside inokwenza iiproteni ezikhuthaza ukulungiswa kweeseli i-sirtuins zisebenze. Njengoko sikhula, ezi sirtuins zisebenza ixesha elide ukunceda iiseli zihlale zomelele.
Ukuhlala usempilweni njengoko ukhula akusoze kube lula njengevithamini enye, nokuba enye ithembisa njenge-nicotinamide riboside. Kukho izifundo ezingaphezu kwe-100 eziphanda i-nicotinamide riboside, uninzi lwazo lubonisa ukuba amanqanaba aphezulu e-NAD+ anxulunyaniswa nempilo ye-metabolic kunye nemisipha kwiimpuku. Uphando olongezelelweyo luyaqhubeka ukuqonda indima ye-NAD+ ekuxhaseni eminye imingeni yempilo enxulumene nobudala, kubandakanya ukwehla kokusebenza kwesibindi, ukuqina komzimba, amanqanaba e-insulin kunye nokusebenza kwengqondo kwiimpuku.
Yintoni i-NAD?
I-NAD+ yi-coenzyme I, eyi-coenzyme ehambisa iiproton (ngokuchanekileyo, ii-ion ze-hydrogen) kwaye ithatha inxaxheba kwimisebenzi emininzi ye-physiological efana ne-metabolism yezinto zeseli, ukwenziwa kwamandla, kunye nokulungiswa kwe-DNA. I-NAD+ sisondlo esifunekayo kumsebenzi weproteni ye-Sirtuin, ebizwa ngokuba yi-"longevity factor" zizazinzulu. Ngokukodwa, inokugcina ubude bee-telomeres ezibalulekileyo, icothise inkqubo yokwaluphala kwaye yandise ubomi.
I-NAD+ inokukhuthaza ukulungiswa kwezakhi zofuzo kunye nokulibazisa ukuguga kweeseli. I-NAD+ ikhuthaza ukuvuselelwa kweeseli kwaye imelana nezifo zenkqubo yomzimba yokuzikhusela. I-NAD+ iphucula uzinzo lwee-chromosome kwaye inciphisa umngcipheko womhlaza.
Zingabahlobo abakhulu bee-enzymes, zinceda ekukhuthazeni "uomatshini beeseli" odala amandla afunekayo kuyo yonke imisebenzi ebalulekileyo emzimbeni wakho kwinqanaba leseli.
Kutheni i-NAD+ ibalulekile?
Ngenxa yendima yayo ebalulekileyo ekuveliseni amandla eeseli, ukunqongophala kwe-NAD+ emzimbeni wakho kwenza uninzi lwemisebenzi yomzimba ingabi namsebenzi. Ngaphandle kwe-NAD, imiphunga yakho ayizukukwazi ukufunxa ioksijini, intliziyo yakho ayizukukwazi ukupompa igazi, kwaye i-synapses yobuchopho bakho ayizukutsha.
I-NAD+ ikwanceda ekukhuthazeni ukulungiswa kwe-DNA kunye nokulawula umsebenzi weeseli ngokusebenzisana ne-sirtuins kunye ne-poly(ADP-ribose) polymerases (PARPs), ezibaluleke kakhulu ekulawuleni iimpendulo zeeseli kwizithuko ezifana nokutya kakhulu, ukusela utywala, ukuphazamiseka kokulala, kunye neendlela zokuhlala phantsi. Ii-enzymes.
I-NAD+ kunye nokwaluphala
Uphando olwenziwe ngo-2012 liqela elivela kwiSebe leMithi kwiYunivesithi yaseNew South Wales lubonise ukuba imetabolism ye-NAD inxulunyaniswa nobudala. Olu phononongo lubonisa ukuba amanqanaba e-NAD+ kwizicwili zolusu lomntu ehla ukuya kuthi ga kwi-50% phakathi kweminyaka engama-40 nama-60, kwaye ukuncipha kwe-NAD+ kunokudlala indima ebalulekileyo kwinkqubo yokwaluphala.
“Kubonwe ulwalamano olubi oluqinileyo phakathi kwamanqanaba e-NAD+ kunye nobudala kumadoda nabasetyhini,” batsho abaphandi kweli phepha.
Ukongeza, i-NAD ibandakanyeka ekuphefumleni kweeseli, ingakumbi kwi-mitochondria, kwaye inegalelo kwimpilo ye-mitochondria iyonke. Kukho umdla omkhulu wesayensi ekubandakanyekeni kwe-NAD ekungasebenzi kakuhle kwe-mitochondrial, enye yeempawu zokwaluphala.
Kwiminyaka yakutshanje, uphando lugxile ekuqondeni indima ye-NAD ekusombululeni oku kwehla kokusebenza okunxulumene nobudala.
I-Nicotinamide Ribose Chloride yonyusa amanqanaba e-NAD+.
I-NR yintshayelelo ye-NAD, oko kuthetha ukuba "yibhloko yokwakha" apho kwenziwa khona iimolekyuli ze-NAD+. Yafunyanwa ngo-2004 njengentshayelelo yevithamini ye-NAD+, nto leyo eyenza ukuba ibe yenye yeempumelelo zamva nje kuphando lwe-NAD+.
I-NR yivithamini yendalo kwaye iluhlobo olutsha lwevithamini B3, kodwa ukusetyenziswa kwayo njengesongezelelo kuye kwachaphazeleka kakubi ziivithamini "zokwaluphala okunempilo". Isebenza kakhulu ekwandiseni i-NAD, nto leyo eyenza ukuba ibe yenye yezona ndlela zinomdla kakhulu kwizisombululo zokwaluphala okunempilo.
I-NR inokunyusa ngempumelelo amanqanaba e-NAD+. Uvavanyo lweklinikhi olupapashwe kwiScientific Reports lubonise ukuba yonyuse i-NAD+ ukuya kuthi ga kwi-50% emva kweeveki ezimbini zokuyisebenzisa.
Nangona ukongezwa kwe-NR kuye kwangqinwa ngokwezonyango ukuba kunyusa amanqanaba e-NAD+, ukongezwa kwe-NAD+ njengesithako esizimeleyo akusebenzi kangako.
I-NAD+ yimolekyuli enkulu kakhulu kwaye ayinakungena ngqo kwiiseli. Endaweni yoko, umzimba wakho kufuneka uyiqhekeze ibe ziingceba ezincinci ngaphambi kokuba iwele i-membrane yeseli. Ezi nxalenye ziphinda zidityaniswe ngaphakathi kwebhetri.
I-Nicotinamide riboside (NR) kunye i-nicotinamide riboside chloride (NRC) zombini ziintlobo zevithamini B3, ekwaziwa ngokuba yi-niacin. Ivithamini B3 sisondlo esibalulekileyo esidlala indima ebalulekileyo kwimisebenzi eyahlukeneyo yomzimba, kubandakanya ukuveliswa kwamandla, ukulungiswa kwe-DNA, kunye nokuguqulwa kweeseli. Zombini i-NR kunye ne-NRC zizinto eziqala i-nicotinamide adenine dinucleotide (NAD+), i-coenzyme ebandakanyeka kwiinkqubo ezahlukeneyo zebhayoloji, ezinje ngokulawula ukuveliswa kwamandla eseli kunye nokuxhasa ukulungiswa kwe-DNA.
I-Nicotinamide riboside (NR) luhlobo lwevithamini B3 oluye lwafumana ingqalelo ngenxa yeempawu zalo zokulwa nokwaluphala kunye nokunyusa amandla. Yikhompawundi yendalo efumaneka kwizixa ezimbalwa zokutya, kodwa ikwafumaneka njengesongezelelo sokutya. I-NR yaziwa ngokukwazi kwayo ukunyusa amanqanaba e-NAD+ emzimbeni, nto leyo enokuxhasa ukusebenza kwe-mitochondrial, iphucule imveliso yamandla eseli, kwaye inokubonelela ngokhuseleko ekuwohlokeni okunxulumene nobudala.
Kwelinye icala, iNicotinamide riboside chloride (NRC) luhlobo lwetyuwa lwe-NR kwaye isetyenziswa kakhulu kwizongezo zokutya. Ukongeza i-chloride kwi-NR kuvelisa i-NRC, ekukholelwa ukuba inyusa uzinzo lwekhompawundi kunye nokufumaneka kwayo. Oku kuthetha ukuba i-NRC inokuba nokufunxwa okungcono kunye nokusetyenziswa emzimbeni kune-NR yodwa kwaye inokuba nefuthe elibonakalayo kumanqanaba e-NAD+ kunye nomsebenzi weseli.
Omnye wemimahluko ephambili phakathi kwe-NR kunye ne-NRC yindlela ezisebenza ngayo iikhemikhali. I-NR yindlela esisiseko yale khompawundi, ngelixa i-NRC yinguqulelo eguquliweyo ene-chloride eyongeziweyo. Olu tshintsho lwenzelwe ukwandisa ukunyibilika kwekhompawundi kunye nokufumaneka kwayo, okwenza kube lula emzimbeni ukuyifunxa nokuyisebenzisa.
Ngokuphathelele iingenelo zazo zempilo ezinokubakho, i-NR kunye ne-NRC kucingelwa ukuba zineziphumo ezifanayo ngenxa yokukwazi kwazo ukwandisaI-NAD+amanqanaba. Ezi ziphumo zingabandakanya ukuphuculwa komsebenzi we-mitochondrial, ukuphuculwa kwe-metabolism yamandla, kunye nenkxaso enokubakho kwimpilo yeseli iyonke. Nangona kunjalo, ukusebenzisa i-NRC kwisongezelelo kunokuzisa inzuzo eyongezelelweyo yokufunxwa kunye nokusetyenziswa okungcono, okunokubangela iingenelo ezicacileyo xa kuthelekiswa nokusebenzisa i-NR yodwa.
1. Ukuphucula imveliso yamandla eeseli
Enye yezona zibonelelo zibalaseleyo zei-nicotinamide riboside chloride yindima yayo ekuphuculeni imveliso yamandla eseli. I-NR yimanduleli ye-nicotinamide adenine dinucleotide (NAD+), i-coenzyme edlala indima ekuvelisweni kwe-adenosine triphosphate (ATP), imali yamandla ephambili yeseli. indima ebalulekileyo. Njengoko sikhula, amanqanaba e-NAD+ ayancipha, nto leyo ebangela ukwehla kwemveliso yamandla eseli. Ngokudibanisa ne-NR, kukholelwa ukuba amanqanaba e-NAD+ anokuzaliswa kwakhona, ngaloo ndlela exhasa imetabolism yamandla eseli efanelekileyo.
2. Umsebenzi we-Mitochondrial kunye nobomi bayo bonke
I-Mitochondria ziindawo zamandla zeseli, ezinoxanduva lokuvelisa amandla nokulawula iinkqubo zeseli. Uphando lubonisa ukuba i-Nicotinamide Riboside Chloride inokuxhasa umsebenzi we-mitochondrial ngokukhuthaza i-biogenesis ye-mitochondria entsha kunye nokwandisa ukusebenza kwayo kakuhle. Oku kunefuthe kubomi bonke kunye nokwaluphala okunempilo, njengoko i-mitochondria esebenza kakuhle ibalulekile ekugcineni impilo yeseli kunye nokuqina kwayo.
3. Impilo ye-metabolism kunye nolawulo lobunzima
I-NAD+ yi-coenzyme, okanye imolekyuli encedisayo, ebandakanyeka kwiimpendulo ezininzi zebhayoloji. Uphononongo lwakutshanje lufumanise ukuba ukongezwa kwe-nicotinamide ribose kunokukhuthaza ngempumelelo imetabolism ye-NAD+ kubantu abadala abasempilweni nabakhulileyo. Azizange zinyanyezelwe kakuhle kuphela zizithathi-nxaxheba, kodwa zisenokuba zincede ekunciphiseni uxinzelelo lwegazi kunye nokuqina kwemithambo yegazi. Ukunqongophala kwe-NAD+ yimbangela eqhelekileyo yokwaluphala kunye nezifo ezininzi, kwaye uphando lubonisa ukuba ukubuyisela amanqanaba e-NAD+ kunexabiso elikhulu lonyango kunye nesondlo.
Ngokunyusa amanqanaba e-NAD+, i-nicotinamide ribose inceda ukulawulwa kwe-metabolic, ukugcinwa kwamandla, ukwenziwa kwe-DNA, kunye neminye imisebenzi yomzimba.
Ukongeza, izifundo zibonise ukuba ukongezwa kwe-NR kunokuphucula uvakalelo lwe-insulin, kunciphise ukudumba, kwaye kuphucule ukuguquguquka kwe-metabolic. Ezi ziphumo zinokuba luncedo ngakumbi kubantu abafuna ukulawula ubunzima babo kunye nokuxhasa impilo ye-metabolic iyonke.
4. Umsebenzi wokuqonda kunye nempilo yengqondo
Njengesandulela se-NAD+, i-nicotinamide ribose ikhusela iiseli zobuchopho kwi-oxidative stress, enokukhokelela kwizifo zengqondo ezinxulumene nobudala. Ngaphakathi kwiiseli zobuchopho, i-NAD+ inceda ukulawula ukuveliswa kwe-PGC-1-alpha, iproteni ebonakala inceda ukukhusela iiseli kwi-oxidative stress kunye nomsebenzi ongasebenzi kakuhle we-mitochondrial.
Abaphandi bafumanise ukuba kwiimpuku, ukuncipha kwe-NAD+ kudlala indima ebalulekileyo ekuvuvukeni kwemithambo-luvo, ekonakaleni kwe-DNA, nasekuwohlokeni kwemithambo-luvo kwisifo sika-Alzheimer. Kwakhona kwisifundo esenziwe kwityhubhu yovavanyo, i-nicotinamide riboside yonyuse amanqanaba e-NAD+ kwaye iphucule kakhulu umsebenzi we-mitochondrial kwiiseli ze-stem zezigulana zesifo sikaParkinson.
Uphando olusandula ukwenzeka lukwakhomba kwiingenelo zengqondo ezinokubakho ze-nicotinamide riboside chloride. I-NAD+ ibandakanyeka kwiinkqubo ezahlukeneyo ezinxulumene nempilo yengqondo, kubandakanya ukuhanjiswa kwe-neuronal, ukulungiswa kwe-DNA, kunye nokususwa kweeproteni ezonakeleyo. Ngokuxhasa amanqanaba e-NAD+, i-NR inokunceda ukugcina umsebenzi wokuqonda kunye nokuthintela ukwehla kwengqondo okunxulumene nobudala.
5. Ukusebenza kakuhle kwezemidlalo kunye nokuBuyisa
Uphononongo luka-2019 olupapashwe kwi-European Journal of Nutrient Impurities lufumanise ukuba ukusebenzisa izongezo ze-nicotinamide ribose kuphucula izakhono zomzimba kwaye kunciphisa uxinzelelo lwe-oxidative kubantu abadala.
Abaphandi bagqibe kwelokuba ukongezwa kwe-NR kuluncedo kubantu abanengxaki ye-NAD+, bechaza isizathu sokuba kusebenze ngakumbi kubantu abadala kunabantu abancinci.
Abadlali bezemidlalo kunye nabathandi bomzimba banokuba nomdla wokwazi ukuba i-nicotinamide riboside chloride inokuba nefuthe elihle ekusebenzeni kwezemidlalo nasekubuyeleni kwimeko yesiqhelo. I-NAD+ idlala indima ebalulekileyo ekulawuleni iinkqubo zeseli ezibandakanyeka kwimveliso yamandla kunye nokusebenza kwemisipha. Ngokuxhasa amanqanaba e-NAD+, i-NR inokuphucula ukunyamezela, iphucule ukubuyiselwa kwemisipha, kwaye iphucule ukusebenza kwezemidlalo ngokubanzi.
Umgangatho kunye nobunyulu
Xa uthenga i-nicotinamide riboside chloride powder, umgangatho kunye nobunyulu kufuneka kube yeyona nto iphambili kuwe. Khangela iimveliso ezenziwe ziinkampani ezidumileyo kunye nabantu besithathu abavavanyiweyo ukuba bacocekile kwaye banamandla. Okona kulungileyo, iimveliso mazingabi nazinto zingcolisayo kunye nezizalisi ukuqinisekisa ukuba ufumana isongezelelo esisemgangathweni ophezulu esizisa iingenelo ezicwangcisiweyo.
Idosi kunye nokusetyenziswa
Ngaphambi kokuba ufake i-nicotinamide riboside chloride powder kwimisebenzi yakho yemihla ngemihla, kubalulekile ukuqonda idosi efanelekileyo kunye nezikhokelo zokusetyenziswa. Kubalulekile ukuqala ngedosi ephantsi kwaye unyuse kancinci kancinci njengoko kufuneka, njengoko iidosi eziphezulu azilingani neziphumo ezingcono kwaye zinokubangela iziphumo ezibi. Ukongeza, nceda ucinge ngokubonisana neengcali zempilo ukuze ubone ukuba idosi ilungele iinjongo zakho zempilo kunye neemfuno zakho.
Iingenelo ezinokubakho kunye nezinto eziqwalaselwayo
I-Nicotinamide Riboside Chloride Powder idla ngokunconywa ngenxa yeenzuzo zayo ezinokubakho, kubandakanya ukuxhasa amanqanaba amandla, ukusebenza kwe-mitochondrial, kunye nempilo yeeseli iyonke. Uphando lubonisa ukuba inokuba nefuthe ekwaluphaleni nakwizifo ezinxulumene nokuguga.
Ukhuseleko kunye namanyathelo okhuseleko
Njengakwezinye izongezo, kubalulekile ukubeka phambili ukhuseleko kunye nokuqonda amanyathelo okhuseleko anokubakho. Nangona i-nicotinamide riboside chloride idla ngokunyamezelwa kakuhle, abanye abantu banokufumana iziphumo ebezingalindelekanga ezingembi kangako, ezifana nokungonwabi kwesisu. Ukongeza, ukuba uneengxaki zempilo ezifihlakeleyo okanye usela amayeza, qiniseka ukuba ubonisana neengcali zempilo ngaphambi kokuba usebenzise esi songezo ukuqinisekisa ukuba sikhuselekile kwaye sifanelekile kwimeko yakho.
Khetha umthengisi othembekileyo
Xa uthenga iNicotinamide Riboside Chloride Powder, kubalulekile ukukhetha umthengisi othembekileyo obeka phambili umgangatho, ukucaca, kunye nokwaneliseka kwabathengi. Khangela iinkampani ezibonelela ngeenkcukacha malunga neenkqubo zazo zokuvelisa, ukufumana imveliso, kunye novavanyo lomntu wesithathu. Ukongeza, cinga ngokufunda uphononongo lwabathengi kunye nokufuna iingcebiso kwimithombo ethembekileyo ukuqinisekisa ukuba uthenga kumthengisi othembekileyo nothembekileyo.
I-Suzhou Myland Pharm & Nutrition Inc. ibisebenza kwishishini lezongezo zesondlo ukusukela ngo-1992. Yinkampani yokuqala eTshayina ukuphuhlisa nokuthengisa isicatshulwa sembewu yeediliya.
Ngeminyaka engama-30 yamava kwaye iqhutywa bubuchwepheshe obuphezulu kunye nesicwangciso sophando nophuhliso esiphucukileyo, inkampani iphuhlise uluhlu lweemveliso ezikhuphisanayo kwaye yaba yinkampani yeenkonzo zokongeza izinto ezintsha zesayensi yobomi, ukwenziwa kwezinto ngokwezifiso kunye neenkonzo zokuvelisa.
Ukongeza, iSuzhou Myland Pharm & Nutrition Inc. ikwangumvelisi obhalisiweyo kwi-FDA. Izixhobo zeR&D zenkampani, izixhobo zemveliso, kunye nezixhobo zokuhlalutya zizinto zanamhlanje kwaye zisebenza ngeendlela ezininzi kwaye zinokuvelisa iikhemikhali ukusuka kwi-milligrams ukuya kwiitoni ngobukhulu, kwaye ziyahambelana nemigangatho ye-ISO 9001 kunye neenkcukacha zemveliso ze-GMP.
Q: Yintoni i-nicotinamide riboside chloride powder?
A: I-Nicotinamide Riboside Chloride Powder luhlobo lwe-vitamin B3 oluye lwafundwa ngenxa yamandla alo okuxhasa ukuveliswa kwamandla eseli kunye ne-metabolism. Ihlala isetyenziswa njengesongezelelo sokutya ukukhuthaza impilo kunye nokuphila kakuhle iyonke.
Q: Ziziphi iingenelo ezinokubakho ze-nicotinamide riboside chloride powder?
A: Ezinye zeenzuzo ezinokubakho zeNicotinamide Riboside Chloride Powder ziquka ukuxhasa umsebenzi we-mitochondrial, ukukhuthaza ukwaluphala okunempilo, kunye nokuphucula ukunyamezela kunye nokusebenza komzimba. Inokunceda nokuxhasa umsebenzi wokuqonda kunye nempilo yeseli iyonke.
Q: Ndingawuthenga phi umgubo we-nicotinamide riboside chloride?
A: Umgubo weNicotinamide Riboside Chloride uyafumaneka kwiivenkile ezahlukeneyo nakwiivenkile ezikwi-intanethi. Xa uthenga esi songezo, kubalulekile ukukhetha umthombo othembekileyo ukuqinisekisa umgangatho kunye nokhuseleko.
Isikhanyeli: Eli nqaku lenzelwe ulwazi oluqhelekileyo kuphela kwaye akufuneki lithathwe njengengcebiso yezonyango. Olunye ulwazi lweposi yebhlog luvela kwi-Intanethi kwaye alungobungcali. Le webhusayithi inoxanduva lokuhlela, ukufomatha kunye nokuhlela amanqaku kuphela. Injongo yokudlulisa ulwazi oluthe kratya ayithethi ukuba uyavumelana nezimvo zayo okanye uqinisekisa ubunyani bomxholo wayo. Soloko uqhagamshelana neengcali zezempilo ngaphambi kokusebenzisa naziphi na izongezo okanye ukwenza utshintsho kwindlela yakho yokhathalelo lwempilo.
Ixesha lokuthumela: Agasti-14-2024
