Igama lenzululwazi le-NAD yi-nicotinamide adenine dinucleotide. I-NAD + ikhona kuzo zonke iiseli zomzimba wethu. Yimetabolite ephambili kunye ne-coenzyme kwiindlela ezahlukeneyo ze-metabolic. Ilamla kwaye ithathe inxaxheba kwiinkqubo ezahlukeneyo zebhayoloji. Ngaphezulu kwe-300 ye-enzymes ixhomekeke kwi-NAD + Ukusebenza. Nangona kunjalo, umgangatho womxholo we-NAD + awumi. Njengoko sikhula, umxholo we-NAD + kwiiseli uya kuncipha. Ngokukodwa emva kweminyaka engama-30 ubudala, inqanaba le-NAD + liya kuhla kakhulu, likhokelela ekwehleni kwemisebenzi emininzi kwaye ngaloo ndlela ibonakalisa iimpawu zokuguga. INicotinamide riboside chloride luhlobo lwevithamin B3. INicotinamide riboside chloride inokuguqulwa ibe yiNAD+ (nicotinamide adenine dinucleotide). Ngomnye wabafundi abaphambili beNAD +. Ifunxwa lula ngumzimba kwaye isetyenziswe. Izifundo ezininzi zibonise ukuba ukongeza i-NRC kunokunyusa amanqanaba e-NAD +, nto leyo enokuthi izise izibonelelo kwi-metabolic, intliziyo kunye ne-nervous system. Ihlala isetyenziswa njengesongezelelo sokutya ukukhuthaza impilo yonke kunye nokuphila kakuhle.
INicotinamide riboside chloride (NRC) iphuma kwivithamin B3 kunye nento entsha yebioactive. Iqulunqwe yi-ribose ye-sugar molecule kunye ne-vitamin B3 inxalenye ye-nicotinamide (eyaziwa ngokuba yi-nicotinic acid okanye i-vitamin B3). Inokutyiwa ngokutya inyama, intlanzi, iicereals kunye nokunye ukutya okanye ngokusebenzisa izongezo ze-NRC.
INicotinamide ribose chloride inokuguqulwa ibe yiNAD+ (nicotinamide adenine dinucleotide) kwaye yenze umsebenzi webhayoloji ngaphakathi kweeseli. I-NAD + i-coenzyme ebalulekileyo ye-intracellular ethatha inxaxheba kwiinkqubo ezahlukeneyo ze-metabolic zeseli, kubandakanywa ukuveliswa kwamandla, ukulungiswa kwe-DNA, ukwanda kweeseli, njl. Ngexesha lokuguga komzimba womntu, umxholo we-NAD + uyancipha ngokuthe ngcembe. INicotinamide riboside chloride supplementation inokunyusa inqanaba le-NAD +, ekulindeleke ukuba ilibazise ukwenzeka kokuguga kweeseli kunye nezifo ezinxulumene nazo.
Uphando nge-nicotinamide riboside chloride lubonise ukuba inemisebenzi emininzi yebhayoloji, efana nale:
Ukuphucula i-metabolism yamandla, ukuphucula ukunyamezela kunye nokusebenza komzimba;
Ukuphucula umsebenzi we-neurological and memory;
Ukuphucula ukusebenza kwamajoni omzimba.
Lilonke, i-nicotinamide riboside chloride sisithako esithembisayo esinesondlo esinethemba elibanzi losetyenziso.
Ukongeza, i-nicotinamide ribose chloride ikwasetyenziswa ngokubanzi kuphando lwezenzululwazi. Njengento engaphambili ye-NAD+, inokusetyenziselwa ukufunda i-biosynthesis kunye neendlela ze-metabolic ze-NAD+ kunye neminye imiba enxulumeneyo. Kwangelo xesha, i-nicotinamide riboside chloride ikwasetyenziswa njengesithako kwiimveliso zempilo kunye nezithambiso ukukhuthaza impilo yeeseli kunye nokunciphisa ukuguga kolusu.
Ukwaluphala sisihloko esingunaphakade ebantwini. Ngokophando olwenziwa ngoososayensi, ukuguga kweeseli kunxulumene ngokusondeleyo nokwehliswa komxholo we-nicotinamide adenine dinucleotide (NAD). I-NAD likhonkco elibalulekileyo kwi-metabolism kunye nokulungiswa kweeseli emzimbeni womntu. Ayinakulibazisa ukuguga kuphela, kodwa iphinde igcine ubungqabavu beeseli kunye nokugcina impilo yomzimba nengqondo. kodwa. Njengoko sikhula, amanqanaba e-NAD emizimbeni yethu ehla ngokukhawuleza nangokukhawuleza, kwaye anokwehla ngaphezu kwesiqingatha phakathi kweminyaka engama-40 kunye nama-80.
Kukho i-enzyme ebaluleke kakhulu emzimbeni wethu, eyona nxalenye iphambili yemetabolism yamandla eselula. Ibaluleke kangakanani? Phantse zonke iinkqubo ezigcina ukusebenza okuqhelekileyo komzimba, njengemetabolism, ukulungiswa, kunye nokukhuseleka, kufuna ukuthatha inxaxheba kule enzyme. Xa amanqanaba ale enzyme ehla, ezininzi iimpawu kunye nezifo ezinxulumene nokuguga zinokuthi zilandele, njengezifo ze-metabolic, ubuthathaka bomzimba, ukuncipha kwengqondo, njl. Le enzyme ebalulekileyo inegama elide: i-nicotinamide adenine dinucleotide, okanye i-NAD +.
Ngamafutshane, ukuncitshiswa kweNAD + emzimbeni kuthetha ukwaluphala. Ke, ngaba singayongeza i-NAD + emzimbeni ukulibazisa ukwaluphala? Ukuba uyongeza ngokuthe ngqo i-NAD +, umzimba womntu awuzukwazi ukuwufunxa, kwaye uya kuba neziphumo ebezingalindelekanga ezibi. Ke ngoko, abantu bajika ingqalelo yabo kwi-precursor substance ye-NAD +: nicotinamide ribose chloride (NRC).
INicotinamide riboside chloride luhlobo lwevithamin B3 kwaye yenye yezona zinto zifundwayo zeNAD + zangaphambili. Ifunxwa ngokulula kwaye isetyenziswe ngumzimba. Izifundo ezininzi zibonise ukuba ukongeza i-NR kunokonyusa amanqanaba e-NAD +, nto leyo inokuzisa izibonelelo kwinkqubo ye-metabolic, yentliziyo kunye neyemithambo-luvo.
Igama elithi "anti-aging" lifumana i-rap embi. Kuvakala ngathi sizama ukunqanda into esele iqhubeka, okanye asikwazi ukwamkela iinxalenye zethu esimele sizithande. Kodwa inyaniso kukuba utshintsho lwe-metabolic lwenzeka ngaphantsi kwesikhumba ngaphambi kokuba sibone iziphumo zokuguga. Ukukhetha ukusebenzisana nempilo yethu ngaphakathi kusenokuba koko kanye sikufunayo ukuphucula indlela esiguga ngayo.
Ngapha koko, enye yeempawu zokuguga yinkqubo eyaziwa ngokuba "yi-mitochondrial dysfunction," igama elibhekisa ekulahlekelweni jikelele kwamandla kunye nokusebenza kakuhle kweeseli zethu ngokuhamba kwexesha. Oku kusenokuba sesinye sezizathu zokuba siguga. Ukuba i-mitochondria isentliziyweni yethu yokuguga, kufanelekile ukuphanda ngayo yonke indlela enokwenzeka yokuzigcina zisebenza ixesha elide kangangoko kunokwenzeka.
Funda malunga nemitochondria.
Phantse ngaphakathi kwiseli nganye kukho ezi organelles zincinane, ezimile ngendlela engaqhelekanga ezibizwa ngokuba yimitochondria—“umthombo wamandla weseli.” La malungu mancinane anoxanduva lokuvelisa i-90% yamandla afunwa yimizimba yethu. IMitochondria sisizathu sokuba sikhona namhlanje njengezilwanyana ezintsonkothileyo kunebhaktheriya.
Asisoloko sisazi ukuba ibaluleke kangakanani imitochondria kwimpilo yethu. Indlela ephambili yokugcina i-mitochondria yakho isempilweni yimolekyuli ebizwa ngokuba yi-NAD+ (nicotinamide adenine dinucleotide). Iiseli zethu ngokwendalo zivelisa i-NAD + kwaye siyisebenzisa ngokuqhubekayo imini yonke.
Siyazi nokuba ubonelelo lwethu lwe-NAD+ luyehla njengoko sikhula. Nje ukuba abaphandi baqonde ukuba i-NAD+ inokuthi ibambe isitshixo sokugcina iiseli zethu zisempilweni, bangxamele ukufumana indlela yokwenza uninzi lwazo.
Abaphandi sele besazi ukuba iivithamini ezimbini ziqala inkqubo yemichiza yokwandisa i-NAD +: niacin kunye ne-niacinamide. Ezi zafunyanwa ngeminyaka yee-1930s ukunyanga i-pellagra, ukunqongophala kwevithamin B3 enokubulala.
I-Niacin izakuqhubeka nokuba lunyango lwe-cholesterol ephezulu ngeminyaka yoo-1950. Nangona kunjalo, kufunyaniswe ukuba ukusebenzisa iidosi eziphezulu ze-niacin ngamanye amaxesha kunokubangela ukugungxulwa kwesikhumba okucaphukisayo kunye nokungabonakali.
I-Niacinamide ayibangeli ukugungxulwa kwesikhumba kwaye ngokwethiyori inokubonelela ngezibonelelo ezininzi ezifanayo, kodwa ithintela ukusebenza kweeproteni ezibalulekileyo ezikhuthaza ukulungiswa kweeseli ezibizwa ngokuba zii-sirtuins. I-niacinamide okanye i-niacin ayizange isebenze njengoko abaphandi bebenethemba.
Nangona ezi vitamin zimbini zingabanduleli be-NAD +, ayisosisombululo sifanelekileyo. Ngenxa yeziphumo ebezingalindelekanga ezingezizo ze-niacin kunye nokusebenza kakuhle kwe-nicotinamide, abaphandi abakabi naso isongezelelo sevithamini ngokwaneleyo ukunyusa amanqanaba e-NAD+.
Ukufunyanwa kwe-nicotinamide riboside.
Olunye uhlobo lwevithamin B3 ebizwa ngokuba yi-nicotinamide riboside yafunyanwa kwigwele ngeminyaka yoo-1940. Kodwa bekungekho kwasekuqaleni kweminyaka yee-2000 apho izazinzulu zaqala ukubona amandla ale vitamin yesithathu, B3, ukuba inganyusi nje i-NAD + kodwa iphucule impilo yabantu. Ngo-2004, iqela lophando leKholeji yaseDartmouth lafumanisa ukuba i-nicotinamide riboside, njenge-vitamin B3 umzalwana wayo, isandulela se-NAD+.
Iqela lophando elikhokelwa nguGqr Charles Brenner lifumene ukuba i-nicotinamide riboside yonyusa i-NAD + kwiimpuku, kwaye iigundane zafumana i-plethora yeenzuzo zempilo ngenxa yoko.
Iigundane zibonise yonke into ukusuka ekuphuculeni iswekile yegazi kunye namanqanaba e-cholesterol ukunciphisa umonakalo we-nerve kunye nokuchasana nokuzuza ubunzima. Ugqirha uCharles Brenner wafumanisa ezi ziphumo zikhuthaza kangangokuba wathatha inyathelo elilandelayo ukuqonda iimpembelelo ze-nicotinamide riboside kwimpilo yabantu.
Kwi-2014, uDkt Brenner waba ngumntu wokuqala ukuthatha i-nicotinamide riboside njengesongezelelo. Imiphumo ikhuthaza ngokufanayo. Le ndlela ingaziwayo yevithamin B3 yonyuse kakhulu amanqanaba e-NAD+ ngokukhuselekileyo, ngokukhawuleza, kwaye ngaphandle kweziphumo ebezingalindelekanga.
INicotinamide riboside isebenzisa indlela ekhethekileyo yokuvelisa i-NAD + ekungekho enye ivithamin B3 iyisebenzisayo.
INicotinamide riboside inokuphinda ivule iiproteni ezikhuthaza ukulungiswa kweeseli. Njengoko sikhula, ezi sirtuin zisebenza ixesha elongezelelweyo ukunceda iiseli ukuba zihlale zomelele.
Ukuhlala usempilweni njengoko ubudala akunakuze kube lula njengevithamin enye, nokuba enye ithembisa njenge-nicotinamide riboside. Kukho ngaphezulu kwe-100 yezifundo eziphanda i-nicotinamide riboside, uninzi lwazo ezibonisa ukuba amanqanaba aphezulu e-NAD + anxulunyaniswa nempilo ye-metabolic kunye nemisipha kwiimpuku. Uphando olongezelelweyo luyaqhubeka ukuqonda indima ye-NAD + ekuxhaseni eminye imingeni yezempilo enxulumene neminyaka, kubandakanywa ukuncipha kwesibindi, ukufumana ubunzima, amanqanaba e-insulin kunye nokusebenza kwengqondo kwiimpuku.
Yintoni i-NAD?
I-NAD + yi-coenzyme I, eyi-coenzyme ehambisa iiprotons (ngokuchanekileyo ngakumbi, i-hydrogen ion) kwaye ithatha inxaxheba kwimisebenzi emininzi ye-physiological efana ne-cell metabolism, i-energy synthesis, kunye nokulungiswa kwe-DNA. I-NAD + sisondlo esiyimfuneko ekusebenzeni kweprotein ye-Sirtuin, ebizwa ngokuba "yinto yokuphila ixesha elide" zizazinzulu. Ngokukodwa, inokugcina ubude beetelomeres eziphambili, icothise inkqubo yokuguga kunye nokwandisa ubomi.
I-NAD + inokukhuthaza ukulungiswa kofuzo kunye nokulibazisa ukuguga kweeseli. I-NAD + ikhuthaza ukuvuselelwa kweeseli kwaye ixhathise izifo zamajoni omzimba. I-NAD + iphucula uzinzo lwechromosome kwaye inciphisa umngcipheko womhlaza.
Bangabahlobo abasenyongweni bee-enzymes, abancedisa ekufakeni amafutha "oomatshini beselula" abadala amandla afunekayo kuwo wonke umsebenzi ophambili womzimba wakho kwinqanaba leselula.
Kutheni i-NAD+ ibalulekile?
Ngenxa yendima yayo ebalulekileyo kwimveliso yamandla eselula, ukunqongophala kwe-NAD + emzimbeni wakho kwenza uninzi lwemisebenzi yomzimba lungabi namsebenzi. Ngaphandle kwe-NAD, imiphunga yakho ayiyi kukwazi ukuthatha ioksijini, intliziyo yakho ayiyi kukwazi ukumpompa igazi, kwaye i-synapses yakho yobuchopho ayiyi kuvutha.
I-NAD + ikwanceda ukukhuthaza ukulungiswa kwe-DNA kunye nokulawula umsebenzi weseli ngokusebenza kunye ne-sirtuins kunye ne-poly(ADP-ribose) iipolymerases (i-PARPs), ezingundoqo ekulawuleni iimpendulo zeselula kwizithuko ezifana nokutya kakhulu, ukusetyenziswa kotywala, ukuphazamiseka kokulala, kunye neepatheni zokuhlala. Iienzymes.
NAD + kunye nokuguga
Uphando oluqhutywe kwi-2012 liqela elivela kwiSebe le-Pharmacology kwiYunivesithi yaseNew South Wales lubonise ukuba i-NAD metabolism ihambelana nobudala. Uphononongo lubonisa ukuba amanqanaba e-NAD + kwizicubu zesikhumba somntu ehla ukuya kuthi ga kwi-50% phakathi kweminyaka eyi-40 kunye ne-60, kwaye ukuncipha kwe-NAD + kunokudlala indima ebalulekileyo kwinkqubo yokuguga.
"Ulungelelwaniso olomeleleyo olubi lwabonwa phakathi kwamanqanaba e-NAD + kunye nobudala kumadoda nabasetyhini," abaphandi batsho ephepheni.
Ukongeza, i-NAD ibandakanyeka ekuphefumleni kweselula, ngakumbi kwi-mitochondria, kwaye inegalelo kwimpilo yonke ye-mitochondrial. Kukho umdla oqinileyo wesayensi ekubandakanyekeni kwe-NAD kwi-mitochondrial dysfunction, enye yeempawu zokuguga.
Kwiminyaka yakutshanje, uphando lugxile ekuqondeni indima ye-NAD ekujonganeni noku kwehla kokusebenza okunxulumene nobudala.
INicotinamide Ribose Chloride yonyusa amanqanaba e-NAD +.
I-NR isandulela se-NAD, okuthetha ukuba "yibhloko yesakhiwo" apho iimolekyuli zeNAD + zenziwe. Yafunyanwa ngo-2004 njenge-vitamin precursor ye-NAD+, iyenza ibe yenye yeziphumo zamva nje kuphando lwe-NAD+.
I-NR yivithamin eyenzeka ngokwemvelo kunye nohlobo oluthile lwevithamini B3, kodwa ukusetyenziswa kwayo njengesongezelelo kuye kwachatshazelwa kakubi "ukuguga okunempilo". Isebenza kakhulu ekwandiseni i-NAD, iyenza ibe lolona ngenelelo lunomdla kwizisombululo zokwaluphala okunempilo.
I-NR inokunyusa ngokufanelekileyo amanqanaba e-NAD +. Ulingo lwezonyango olupapashwe kwiiNgxelo zeNzululwazi lubonise ukuba lunyuse i-NAD + ukuya kuthi ga kwi-50% emva kweeveki ezimbini zokuyithatha.
Nangona ukuxhaswa kwe-NR kuye kwangqinwa ngokweklinikhi ukuba yonyusa amanqanaba e-NAD+, ukuxhaswa kwe-NAD+ njengesithako esizimeleyo akusebenzi kangako.
I-NAD+ yimolekyuli enkulu kakhulu kwaye ayikwazi ukungena kwiiseli ngokuthe ngqo. Endaweni yoko, umzimba wakho kufuneka uwaphule ube ngamaqhekeza amancinci ngaphambi kokuba uwele inwebu yeseli. La malungu aphinda adityaniswa ngaphakathi ebhetrini.
Nicotinamide riboside (NR) kunye nicotinamide riboside chloride (NRC) zombini ezi ntlobo zevithamin B3, ekwabizwa ngokuba yiniacin. I-Vitamin B3 sisondlo esibalulekileyo esidlala indima ebalulekileyo kwimisebenzi eyahlukeneyo yomzimba, kuquka ukuveliswa kwamandla, ukulungiswa kwe-DNA, kunye ne-cell metabolism. Zombini i-NR kunye ne-NRC zi-precursors ze-nicotinamide adenine dinucleotide (NAD +), i-coenzyme ebandakanyeka kwiinkqubo ezahlukeneyo ze-biological, ezifana nokulawula ukuveliswa kwamandla eselula kunye nokuxhasa ukulungiswa kwe-DNA.
INicotinamide riboside (NR) luhlobo lwevithamin B3 ethe yafumana ingqwalaselo kwizinto zayo ezinokuchasa ukuguga kunye neempawu zokunyusa amandla. Yikhompawundi eyenzeka ngokwemvelo efumaneka kumanani omkhondo kokunye ukutya, kodwa ikwafumaneka njengesongezo sokutya. I-NR yaziwa ngokukwazi ukunyusa amanqanaba e-NAD + emzimbeni, ethi yona ixhase umsebenzi we-mitochondrial, iphucule imveliso yamandla eselula, kwaye inokubonelela ngokhuseleko ekuwohlokeni okunxulumene nobudala.
I-Nicotinamide riboside chloride (NRC), kwelinye icala, yindlela yetyuwa ye-NR kwaye iqhele ukusetyenziswa kwizongezo zokutya. Ukongeza i-chloride kwi-NR ivelisa i-NRC, ekukholelwa ukuba iphucula uzinzo kunye ne-bioavailability yekhompawundi. Oku kuthetha ukuba i-NRC inokuba ne-absorption engcono kunye nokusetyenziswa emzimbeni kune-NR yodwa kwaye inokuba nefuthe elicacileyo kumanqanaba e-NAD + kunye nokusebenza kweselula.
Enye yeeyantlukwano eziphambili phakathi kwe-NR kunye ne-NRC yinkqubo yabo yeekhemikhali. I-NR yindlela yesiseko yale khompawundi, ngelixa i-NRC iyinguqulelo elungisiweyo enekloridi eyongeziweyo. Olu hlengahlengiso lujolise ekonyuseni ukunyibilika kwekhompawundi kunye ne-bioavailability, okwenza kube lula ukuba umzimba ukufunxe kwaye uyisebenzise.
Ngokubhekiselele kwiinzuzo zabo zempilo, i-NR kunye ne-NRC zicingelwa ukuba zineempembelelo ezifanayo ngenxa yokukwazi ukwandisaNAD+amanqanaba. Ezi ziphumo zinokubandakanya ukuphuculwa komsebenzi we-mitochondrial, ukuphuculwa kwamandla e-metabolism, kunye nenkxaso enokubakho kwimpilo yeselula ngokubanzi. Nangona kunjalo, ukusebenzisa i-NRC kwisongezelelo kunokuzisa inzuzo eyongeziweyo yokufunxa ngcono kunye nokusetyenziswa, okunokuthi kubangele izibonelelo ezicacileyo ngakumbi xa kuthelekiswa nokusebenzisa i-NR yodwa.
1. Ukuphucula imveliso yamandla eselula
Enye yeenzuzo eziphawulekayo zenicotinamide riboside chloride yindima yayo ekwandiseni imveliso yamandla eselula. I-NR yi-precursor ye-nicotinamide adenine dinucleotide (NAD+), i-coenzyme edlala indima ekuvelisweni kwe-adenosine triphosphate (ATP), imali yokuqala ye-cell cell. indima ebalulekileyo. Njengoko sikhula, amanqanaba e-NAD+ ayehla, okukhokelela ekunciphiseni ukuveliswa kwamandla eselula. Ngokuncedisa nge-NR, kukholelwa ukuba amanqanaba e-NAD + anokuzaliswa, ngaloo ndlela exhasa i-metabolism yamandla eselula.
2. Umsebenzi weMitochondrial kunye nobomi
I-Mitochondria ziindawo zamandla zeseli, ezinoxanduva lokuvelisa amandla kunye nokulawula iinkqubo zeselula. Uphando lubonisa ukuba iNicotinamide Riboside Chloride inokuxhasa umsebenzi we-mitochondrial ngokukhuthaza i-biogenesis ye-mitochondria entsha kunye nokwandisa ukusebenza kwayo kakuhle. Oku kuneempembelelo kubomi bonke kunye nokuguga okunempilo, njengoko i-mitochondria esebenza kakuhle ibalulekile ekugcineni impilo yeselula kunye nokomelela.
3. Impilo ye-Metabolic kunye nolawulo lobunzima
I-NAD+ yi-coenzyme, okanye i-molecule ye-accessory, ebandakanyeka kwiimpendulo ezininzi zebhayoloji. Uphononongo lwakutsha nje lufumanise ukuba isongezelelo se-nicotinamide ribose sinokuvuselela ngempumelelo imetabolism ye-NAD + kubantu abasempilweni abakwiminyaka ephakathi kunye nabadala. Akunjalo kuphela izongezelelo ze-NR ezinyamezeleke kakuhle ngabathathi-nxaxheba, zinokuthi zincede ukunciphisa uxinzelelo lwegazi kunye nokuqina kwe-arterial. Ukunqongophala kwe-NAD+ yeyona nto iphambili ebangela ukwaluphala kunye nezifo ezininzi, kwaye uphando lubonisa ukuba ukubuyisela amanqanaba e-NAD+ kunexabiso elikhulu lonyango kunye nesondlo.
Ngokunyusa amanqanaba e-NAD +, i-nicotinamide ribose inceda kulawulo lwe-metabolic, oovimba bamandla, i-DNA synthesis, kunye neminye imisebenzi yomzimba.
Ukongeza, izifundo zibonise ukuba ukongezwa kwe-NR kunokuphucula ubuntununtunu kwi-insulin, ukunciphisa ukuvuvukala, kunye nokuphucula ukuguquguquka kwe-metabolic. Ezi ziphumo zinokuba luncedo ngakumbi kubantu abafuna ukulawula ubunzima babo kunye nokuxhasa impilo yonke ye-metabolic.
4. Umsebenzi wokuqonda kunye nempilo yengqondo
Njengesandulela se-NAD +, i-nicotinamide ribose ikhusela iiseli zengqondo kuxinzelelo lwe-oxidative, enokukhokelela kwizifo zengqondo ezinxulumene neminyaka. Ngaphakathi kweeseli zengqondo, i-NAD + inceda ukulawula ukuveliswa kwe-PGC-1-alpha, iprotheni ebonakala inceda ukukhusela iiseli kuxinzelelo lwe-oxidative kunye nokungasebenzi kakuhle kwe-mitochondrial.
Abaphandi bafumanise ukuba kwiimpuku, ukuncipha kwe-NAD + kudlala indima ephambili kwi-neuroinflammation, umonakalo we-DNA, kunye ne-neuronal degeneration kwi-Alzheimer's disease. Kwakhona kuphononongo lwetyhubhu yovavanyo, i-nicotinamide riboside yonyuse amanqanaba e-NAD+ kwaye yaphucula kakhulu ukusebenza kwe-mitochondrial kwiiseli ezisikhondo zezigulana zesifo sikaParkinson.
Uphando olusakhulayo lukwakhomba kwiingenelo ezinokubakho zezengqondo ze-nicotinamide riboside chloride. I-NAD + ibandakanyeka kwiinkqubo ezahlukeneyo ezinxulumene nempilo yobuchopho, kubandakanya ukubonakaliswa kwe-neuronal, ukulungiswa kwe-DNA, kunye nokususwa kweeproteni ezonakeleyo. Ngokuxhasa amanqanaba e-NAD +, i-NR inokunceda ukugcina umsebenzi wokuqonda kunye nokuthintela ukuhla kwengqondo okunxulumene neminyaka.
5. Ukusebenza kwe-Athletic kunye noBuyiselo
Uphononongo luka-2019 olupapashwe kwi-European Journal of Nutrient Impurities lufumanise ukuba ukusebenzisa izongezelelo ze-nicotinamide ribose ziphucule izakhono zomzimba kunye nokunciphisa uxinzelelo lwe-oxidative kubantu abadala.
Abaphandi bagqibe kwelokuba ukuxhaswa kwe-NR kwaba luncedo kubantu abasweleyo be-NAD +, bechaza ukuba kutheni isebenza ngakumbi kubantu abadala kunabantu abancinci.
Iimbaleki kunye nabathanda ukomelela banokuba nomdla wokwazi ukuba i-nicotinamide riboside chloride inokuchaphazela ngokufanelekileyo ukusebenza kwezemidlalo kunye nokuchacha. I-NAD + idlala indima ephambili ekulawuleni iinkqubo zeselula ezibandakanyekayo kwimveliso yamandla kunye nokusebenza kwemisipha. Ngokuxhasa amanqanaba e-NAD+, i-NR inokomeleza unyamezelo, iphucule ukuchacha kwezihlunu, kwaye iphucule ukusebenza kwembaleki ngokubanzi.
Umgangatho kunye nobunyulu
Xa uthenga i-nicotinamide riboside chloride powder, umgangatho kunye nokucoceka kufuneka kube yinto ephambili kuwe. Khangela iimveliso ezenziwe ziinkampani ezithembekileyo kunye nomntu wesithathu ovavanyelwe ubunyulu kunye namandla. Ngokufanelekileyo, iimveliso kufuneka zingabikho kungcoliseko kunye nezihluzi zokuqinisekisa ukuba ufumana isongezelelo esikumgangatho ophezulu esinikezela ngezibonelelo ezicetywayo.
Umthamo kunye nokusetyenziswa
Ngaphambi kokufaka i-nicotinamide riboside chloride powder kwindlela yakho yemihla ngemihla, kubalulekile ukuqonda idosi efanelekileyo kunye nezikhokelo zokusetyenziswa. Kubalulekile ukuqala ngedosi esezantsi kwaye ngokuthe ngcembe unyuke njengoko kufuneka, njengoko iidosi eziphezulu zingalingani neziphumo ezingcono kwaye zinokubangela iziphumo ezibi. Ukongeza, nceda ucinge ngokubonisana nengcali yokhathalelo lwempilo ukumisela idosi eyona ilungileyo kwiinjongo zakho zempilo kunye neemfuno.
Iingenelo ezinokubakho kunye nokuqwalaselwa
I-Nicotinamide Riboside Chloride Powder isoloko iboniswa ngezibonelelo zayo ezinokubakho, kubandakanya ukuxhasa amanqanaba amandla, umsebenzi we-mitochondrial, kunye nempilo yeselula iyonke. Uphando lucebisa ukuba lunokuba nefuthe lokuguga kunye nezifo ezinxulumene neminyaka.
Ukhuseleko kunye nezilumkiso
Njengaso nasiphi na isongezelelo, kubalulekile ukubeka phambili ukhuseleko kwaye uqonde izilumkiso ezinokwenzeka. Nangona i-nicotinamide riboside chloride inyamezeleka kakuhle, abanye abantu banokufumana iziphumo ebezingalindelekanga ezingephi, njengokungakhululeki kwesisu. Ukongezelela, ukuba unayo nayiphi na imeko yezempilo ephantsi okanye uthatha amayeza, qiniseka ukuba udibane nochwepheshe bezempilo ngaphambi kokuba usebenzise le ncediso ukuze uqinisekise ukuba ikhuselekile kwaye ifanelekile kwimeko yakho.
Khetha umthengisi othembekileyo
Xa kuthengwa iNicotinamide Riboside Chloride Powder, kubalulekile ukukhetha umthengisi ohloniphekileyo obeka phambili umgangatho, ukungafihli, kunye nokwaneliseka kwabathengi. Jonga iinkampani ezibonelela ngeenkcukacha malunga neenkqubo zazo zokuvelisa, ukukhangela, kunye novavanyo lomntu wesithathu. Ukongeza, qwalasela ukufunda uphononongo lwabathengi kunye nokufuna iingcebiso kwimithombo ethembekileyo ukuqinisekisa ukuba uthenga kumthengisi othembekileyo nothembekileyo.
I-Suzhou Myland Pharm & Nutrition Inc. ibandakanyeke kwishishini lokongezelela isondlo ukususela ngo-1992. Yinkampani yokuqala e-China ukuphuhlisa nokuthengisa isicatshulwa sembewu yomdiliya.
Iminyaka engama-30 yamava kwaye iqhutywa bubuchwephesha obuphezulu kunye nesicwangciso se-R&D esiphuculwe kakhulu, inkampani iphuhlise uluhlu lweemveliso ezikhuphisanayo kwaye ibe sisongezelelo sesayensi yobomi, ukuhlanganiswa kwesiko kunye nenkampani yeenkonzo zokuvelisa.
Ukongeza, iSuzhou Myland Pharm & Nutrition Inc. ikwangumvelisi obhalisiweyo we-FDA. Izixhobo zeR&D zenkampani, izixhobo zemveliso, kunye nezixhobo zohlalutyo zezanamhlanje kwaye zinemisebenzi emininzi kwaye zinokuvelisa iikhemikhali ukusuka kwimilligram ukuya kwiitoni kwisikali, kwaye zithobela imigangatho ye-ISO 9001 kunye neenkcukacha zemveliso ye-GMP.
Umbuzo: Yintoni i-nicotinamide riboside chloride powder?
A: I-Nicotinamide Riboside Chloride Powder luhlobo lwe-vitamin B3 oluye lwafundelwa amandla ayo okuxhasa ukuveliswa kwamandla eselula kunye ne-metabolism. Ihlala isetyenziswa njengesongezelelo sokutya ukukhuthaza impilo yonke kunye nokuphila kakuhle.
Umbuzo: Ziziphi iingenelo ezinokubakho ze-nicotinamide riboside chloride powder?
A: Ezinye izibonelelo ezinokubakho zeNicotinamide Riboside Chloride Powder ziquka ukuxhasa umsebenzi we-mitochondrial, ukukhuthaza ukuguga okunempilo, kunye nokuphucula ukunyamezela kunye nokusebenza komzimba. Inokunceda kwakhona ukuxhasa umsebenzi wokuqonda kunye nempilo yonke yeselula.
Umbuzo: Ndingayithenga phi i-nicotinamide riboside chloride powder?
A: I-Nicotinamide Riboside Chloride powder ifumaneka kubathengisi abahlukeneyo kunye neevenkile ze-intanethi. Xa kuthengwa le ncediso, kubalulekile ukukhetha umthombo ohloniphekileyo wokuqinisekisa umgangatho kunye nokhuseleko.
Ukuziphendulela: Eli nqaku lelolwazi ngokubanzi kuphela kwaye akufanele lithathwe njengeliphi na icebiso lonyango. Olunye ulwazi lweposti yebhlog luvela kwi-Intanethi kwaye alunamsebenzi. Le webhusayithi inoxanduva kuphela lokuhlela, ukufomatha kunye nokuhlela amanqaku. Injongo yokudlulisa ulwazi olongezelelekileyo ayithethi ukuba uyavumelana neembono zayo okanye uqinisekise ubunyani bomxholo wayo. Soloko udibana nengcali yezempilo ngaphambi kokuba usebenzise naziphi na izongezo okanye wenze utshintsho kwirejimeni yokhathalelo lwempilo.
Ixesha lokuposa: Aug-14-2024
