Kutheni le nto kufuneka uthenge i-Spermidine Powder? IiNzuzo Ezingundoqo Zicacisiwe

I-Spermidine,ekwabizwa ngokuba yi-spermidine, yinto ye-triamine polyamine efumaneka kakhulu kwizityalo ezinjengengqolowa, iimbotyi zesoya, kunye neitapile, ii-microorganisms ezifana ne-lactobacilli kunye ne-bifidobacteria, kunye nezicubu zezilwanyana ezahlukeneyo. I-Spermidine yi-hydrocarbon ene-zigzag-shaped carbon skeleton eyenziwe ngee-athomu ze-carbon ezi-7 kunye namaqela e-amino kuzo zombini iziphelo naphakathi.

Uphando lwangoku lubonise ukuba i-spermidine ibandakanyeka kwiinkqubo zobomi ezibalulekileyo ezifana nokuphindaphinda kwe-DNA yeselula, ukubhalwa kwe-mRNA, kunye nokuguqulelwa kweprotheni, kunye neenkqubo ezininzi ze-pathophysiological ezifana nokukhuselwa koxinzelelo lomzimba kunye ne-metabolism. Inokhuseleko lwe-cardiovascular and neuroprotection, anti-tumor, kunye nokulawulwa kokuvuvukala, njl. Umsebenzi obalulekileyo we-biological.

I-Spermidine ithathwa njenge-activator enamandla ye-autophagy, inkqubo ye-intracellular recycling apho iiseli ezindala zihlaziya kwaye ziphinde zisebenze. I-Spermidine idlala indima ebalulekileyo ekusebenzeni kweeseli kunye nokuphila. Emzimbeni, i-spermidine iveliswa kwi-precursor putrescine, ethi yona isandulela kwenye i-polyamine ebizwa ngokuba yi-spermine, ekwabaluleke kakhulu ekusebenzeni kweeseli.

I-Spermidine kunye ne-purescine ivuselela i-autophagy, inkqubo eqhekeza inkunkuma ye-intracellular kwaye iphinda isebenzise amacandelo eselula kwaye iyindlela yokulawula umgangatho we-mitochondria, i-powerhouses yeseli. I-Autophagy iyaphuka kwaye ilahle i-mitochondria eyonakeleyo okanye enesiphene, kwaye ukuchithwa kwe-mitochondrial yinkqubo elawulwa ngokuqinileyo. Iipolyamines ziyakwazi ukubophelela kwiindidi ezininzi zeeamolekyu, zenze ukuba zisebenziseke. Baxhasa iinkqubo ezifana nokukhula kweeseli, ukuzinza kweDNA, ukwanda kweeseli, kunye ne-apoptosis. Iipolyamines zibonakala zisebenza ngokufanayo kwizinto zokukhula ngexesha lokuhlukana kweeseli, yiyo loo nto i-purescine kunye ne-spermidine zibaluleke kakhulu ekukhuleni nasekusebenzeni kwezicubu eziphilileyo.

Abaphandi bafunde indlela i-spermidine ekhusela ngayo iiseli kuxinzelelo lwe-oxidative, enokonakalisa iiseli kwaye ikhokelele kwizifo ezahlukeneyo. Bafumanisa ukuba i-spermidine yenza i-autophagy. Uphononongo luchonge iijini eziphambili ezichatshazelwa yi-spermidine enciphisa uxinzelelo lwe-oxidative kunye nokukhuthaza i-autophagy kwezi seli. Ukongezelela, bafumanisa ukuba ukuvimba indlela ye-mTOR, edla ngokubandakanyeka ekuvimbeleni i-autophagy, iphucula ngakumbi imiphumo yokukhusela ye-spermidine.

Kukuphi ukutya okuphakamileyo kwi-spermidine?

I-Spermidine i-polyamine ebalulekileyo. Ukongeza ekuvelisweni ngumzimba womntu ngokwawo, imithombo yawo yokutya eninzi kunye ne-intestinal microorganisms nazo ziyiendlela eziphambili zokubonelela. Umthamo we-spermidine ekutyeni okuhlukeneyo uyahluka kakhulu, kunye nentsholongwane yengqolowa ngumthombo owaziwayo wezityalo. Eminye imithombo yokutya ibandakanya i-grapefruit, iimveliso zesoya, iimbotyi, umbona, iinkozo ezipheleleyo, ii-chickert, ii-ertyisi, iipepile eziluhlaza, i-broccoli, iiorenji, iti eluhlaza, ibran yerayisi kunye nepepile entsha eluhlaza. Ukongeza, ukutya okufana namakhowa e-shiitake, imbewu ye-amaranth, ikholifulawa, itshizi evuthiweyo kunye ne-durian nazo zinespermidine.

Kuyafaneleka ukuba uqaphele ukuba ukutya kweMeditera kuqulethe ukutya okuninzi okutyebileyo kwe-spermidine, okunokunceda ukucacisa "indawo eluhlaza okwesibhakabhaka" apho abantu bahlala ixesha elide kwiindawo ezithile. Nangona kunjalo, kubantu abangakwaziyo ukusebenzisa i-spermidine eyaneleyo ngokutya, izongezelelo ze-spermidine ziyindlela esebenzayo. I-spermidine kwezi zongezelelo yi-molecule efanayo ngokwemvelo, iyenza ibe yenye esebenzayo.

Yintoni i-purescine?

Ukuveliswa kwe-purescine kubandakanya iindlela ezimbini, zombini eziqala nge-amino acid arginine. Kwindlela yokuqala, i-arginine iguqulelwa kuqala kwi-agmatine ehlanjululwe yi-arginine decarboxylase. Emva koko, i-agmatine iphinda iguqulwe ibe yi-N-carbamoylputrescine ngesenzo se-agmatine iminohydroxylase. Ekugqibeleni, i-N-carbamoylputrescine iguqulwa ibe yi-purescine, igqibezela inkqubo yokuguqulwa. Indlela yesibini ilula, iguqula ngokuthe ngqo i-arginine ibe yi-ornithine, kwaye emva koko iguqule i-ornithine ibe yi-purescine ngokusebenzisa isenzo se-ornithine decarboxylase. Nangona ezi ndlela zimbini zinamanyathelo ahlukeneyo, bobabini ekugqibeleni bafezekisa ukuguqulwa kwi-arginine ukuya kwi-purescine.

I-Purescine yi-diamine efumaneka kumalungu ahlukeneyo afana ne-pancreas, i-thymus, ulusu, ingqondo, isibeleko kunye nama-ovari. I-Putrescine ikwafumaneka ekutyeni okufana nentsholongwane yengqolowa, ipepile eluhlaza, iimbotyi zesoya, iipistachios, neeorenji. Uphononongo lwakutsha nje lubonise ukuba i-purescine yinto ebalulekileyo yokulawula i-metabolic enokuthi isebenze kunye ne-biological macromolecules ezifana ne-DNA ehlawuliswa kakubi, i-RNA, i-ligands eyahlukeneyo (njenge-β1 kunye ne-β2 i-adrenergic receptors), kunye neeprotheni ze-membrane. , ekhokelela kuluhlu lweenguqu zomzimba okanye ze-pathological emzimbeni.

Impembelelo yeSpermidine

Umsebenzi we-Antioxidant: I-Spermidine inomsebenzi onamandla we-antioxidant kwaye inokusabela kunye ne-radicals yamahhala ukunciphisa umonakalo owenziwe nge-oxidative kwiiseli ezibangelwa yi-radicals yamahhala. Emzimbeni, i-spermidine inokukhuthaza ukubonakaliswa kwe-antioxidant enzymes kunye nokuphucula amandla e-antioxidant.

Ukulawulwa kwe-metabolism yamandla: I-Spermidine ibandakanyeka ekulawuleni amandla e-metabolism yezinto eziphilayo, inokukhuthaza ukuxutywa kunye nokusetyenziswa kwe-glucose emva kokutya, kwaye ichaphazela umlinganiselo we-aerobic metabolism kunye ne-anaerobic metabolism ngokulawula ukusebenza kokuveliswa kwamandla emitochondrial.

i-anti-inflammatory effect

I-Spermidine ineempembelelo ezichasayo kwaye inokulawula ukubonakaliswa kwezinto ezivuthayo kunye nokunciphisa ukuvela kokuvuvukala okungapheliyo. Ikakhulu inxulumene ne-nuclear factor-κB (NF-κB) indlela.

Ukukhula, uphuhliso kunye nokulawulwa kwe-immune: I-Spermidine nayo idlala indima ebalulekileyo ekukhuleni, ekuphuhliseni nasekulawuleni i-immune. Inokukhuthaza ukukhuselwa kwehomoni yokukhula emzimbeni womntu kwaye incede ukuphucula uphuhliso lwezicubu ezahlukeneyo kunye namalungu omzimba. Ngelo xesha, ekulawuleni i-immune, i-spermidine iphakamisa ukuxhathisa umzimba kwiintsholongwane kunye nezifo ngokulawula ukuveliswa kweeseli ezimhlophe zegazi kunye nokukhuthaza ukususwa kweentlobo ze-oksijini ezisebenzayo.

Ukulibaziseka ukuguga: I-Spermidine inokukhuthaza i-autophagy, inkqubo yokucoca ngaphakathi kweeseli ezinceda ukususa i-organelles eyonakalisiweyo kunye neeprotheni, ngaloo ndlela ilibazise ukuguga.

Ukulawulwa kweeseli ze-glial: I-Spermidine idlala indima ebalulekileyo yokulawula kwiiseli ze-glial. Inokuthatha inxaxheba kwiinkqubo zokubonisa iiseli kunye nokudibanisa okusebenzayo phakathi kweeseli ze-nerve, kwaye idlala indima ebalulekileyo yokulawula ekuphuhlisweni kwe-neuron, ukuhanjiswa kwe-synaptic, kunye nokuchasana neuropathy.

Ukukhuselwa kwentliziyo: Kwintsimi ye-cardiovascular, i-spermidine inokunciphisa i-lipid accumulation kwi-atherosclerotic plaques, ukunciphisa i-hypertrophy ye-cardiac, kunye nokuphucula umsebenzi we-diastolic, ngaloo ndlela ifezekisa ukukhuselwa kwentliziyo. Ukongezelela, ukutya okudliwayo kwe-spermidine kuphucula uxinzelelo lwegazi kunye nokunciphisa ukugula kwe-cardiovascular and morbidity.

Kwi-2016, uphando olupapashwe kwi-Atherosclerosis luqinisekisile ukuba i-spermidine inokunciphisa i-lipid accumulation kwi-atherosclerotic plaques. Ngaloo nyaka, uphando olupapashwe kwi-Nature Medicine luqinisekisile ukuba i-spermidine inokunciphisa i-hypertrophy ye-cardiac kunye nokuphucula umsebenzi we-diastolic, ngaloo ndlela ikhusela intliziyo kunye nokwandisa ubomi beegundane.

Ukuphucula isifo sika-Alzheimer

I-Spermidine intake inenzuzo kumsebenzi wememori yomntu. Iqela likaNjingalwazi uReinhart wase-Australia wafumanisa ukuba unyango lwe-spermidine lunokuphucula umsebenzi wokuqonda kwabantu abadala. Uphononongo lwamkele uyilo olunamaziko amaninzi oluyimfama kwaye lwabhalisa abantu abadala abangama-85 kumakhaya abantu abalupheleyo abangama-6, abahlulwe ngokungacwangciswanga baba ngamaqela amabini kwaye basebenzise iidosi ezahlukeneyo ze-spermidine. Umsebenzi wabo wokuqonda wavavanywa ngovavanyo lwenkumbulo kwaye wahlulahlulwe yangamaqela amane: akukho dementia, ukuncipha kwengqondo, ukuncipha kwengqondo okuphakathi kunye nokuphazamiseka okukhulu kwengqondo. Iisampulu zegazi zaqokelelwa ukuvavanya ukuxinana kwe-spermidine egazini labo. Iziphumo zibonise ukuba ugxininiso lwe-spermidine lwalunxulumene kakhulu nomsebenzi wokuqonda kwiqela elingenayo i-dementia, kunye nenqanaba lokuqonda kwabantu abadala abane-dementia epholileyo ukuya kwimodareyitha yaphucula kakhulu emva kokungena kwiidosi eziphezulu ze-spermidine.

I-Autophagy

I-Spermidine inokukhuthaza i-autophagy, njenge-mTOR (ithagethi ye-rapamycin) inhibitory pathway. Ngokukhuthaza i-autophagy, inceda ukususa i-organelles ezonakalisiweyo kunye neeprotheni kwiiseli kunye nokugcina impilo yeseli.

I-Spermidine hydrochloride isetyenziswa kwiinkalo ezahlukeneyo

Kwintsimi yamachiza, i-spermidine hydrochloride isetyenziswe njengeyeza le-hepatoprotective elinokuphucula ukusebenza kwesibindi kunye nokunciphisa umonakalo wesibindi. Ukongezelela, i-spermidine hydrochloride ingasetyenziselwa ukunyanga iimeko ezifana ne-cholesterol ephezulu, i-hypertriglyceridemia, kunye nesifo senhliziyo.

I-Spermidine hydrochloride isebenza ngokunciphisa amanqanaba e-plasma homocysteine ​​​​(Hcy), ngaloo ndlela inciphisa umngcipheko wesifo senhliziyo. Ucwaningo luye lwabonisa ukuba i-spermidine hydrochloride inokukhuthaza i-metabolism ye-Hcy kunye nokunciphisa umngcipheko wesifo senhliziyo ngokunciphisa amanqanaba e-plasma Hcy.

Uphononongo malunga nemiphumo ye-spermidine hydrochloride kwingozi yesifo senhliziyo ibonise ukuba i-spermidine hydrochloride inokunciphisa amanqanaba e-plasma e-Hcy, ngaloo ndlela inciphisa ingozi yesifo senhliziyo. Kuphononongo, abaphandi bahlula abathathi-nxaxheba bangamaqela amabini, elinye lifumana i-spermidine hydrochloride supplementation kwaye elinye lifumana indawo ye-placebo.

Iziphumo zophando zibonise ukuba abathathi-nxaxheba abafumene i-spermidine hydrochloride supplementation babenamanqanaba aphantsi kakhulu e-plasma ye-Hcy kunye nokunciphisa okuhambelanayo kwingozi yesifo senhliziyo. Ukongezelela, kukho ezinye izifundo ezixhasa indima ye-spermidine hydrochloride ekunciphiseni umngcipheko wesifo senhliziyo.

Kwintsimi yokutya, i-spermidine hydrochloride isetyenziswa njenge-flavour enhancer kunye ne-humectant ukuphucula incasa yokutya kunye nokugcina ukufuma kokutya. Ukongeza, i-spermidine hydrochloride inokusetyenziswa njengesongezo sokutya ukuphucula izinga lokukhula kunye nomgangatho wezihlunu zezilwanyana.

Kwizinto zokuthambisa, i-spermidine hydrochloride isetyenziswa njenge-humectant kunye ne-antioxidant ukugcina umswakama wesikhumba kunye nokunciphisa umonakalo omkhulu wamahhala. Ukongezelela, i-spermidine hydrochloride ingasetyenziselwa kwi-sunscreens ukunciphisa umonakalo wemitha ye-ultraviolet kwesikhumba.

Kwintsimi yezolimo, i-spermidine hydrochloride isetyenziswa njengomlawuli wokukhula kwezityalo ukukhuthaza ukukhula kwezityalo kunye nokwandisa isivuno.