Kutheni i-Alpha Ketoglutarate Magnesium ibalulekile kwimpilo yakho

I-Calcium Alpha ketoglutarate (AKG) yi-metabolite ephakathi yomjikelo we-tricarboxylic acid kwaye ithatha inxaxheba ekuhlanganisweni kwee-amino acids, iivithamini kunye nee-organic acids kunye ne-metabolism yamandla. Ingasetyenziswa njengesongezelelo sokutya kwaye inamathuba amaninzi okusetyenziswa. Ukongeza kwimisebenzi yayo yebhayoloji emzimbeni womntu, i-calcium alpha-ketoglutarate ikwasetyenziswa kakhulu kwicandelo lamayeza kwaye ibe yinxalenye ebalulekileyo yeemveliso ezininzi zempilo kunye nezisombululo zonyango.

Yintoni i-alpha-ketoglutarate?

I-AKG yi-metabolite eyenzeka ngokwendalo eyinxalenye yomjikelo weKrebs, oko kuthetha ukuba imizimba yethu iyayivelisa. Ishishini lezongezo likwavelisa uhlobo lokwenziwa olufana ngokweekhemikhali ne-AKG eveliswe ngokwendalo.

Yintoni eyenziwa yi-AKG?

I-AKG yimolekyuli ebandakanyeka kwiindlela ezininzi ze-metabolic kunye neeseli. Isebenza njengomnikeli wamandla, isandulela semveliso ye-amino acid kunye nemolekyuli yokubonisa iiseli, kwaye ilawula iinkqubo ze-epigenetic. Yimolekyuli ebalulekileyo kumjikelo weKrebs, elawula isantya somjikelo we-citric acid wezinto eziphilayo. Isebenza kwiindlela ezahlukeneyo emzimbeni ukunceda ukwakha izihlunu kunye nokunceda ekuphilisweni kwamanxeba, enye yezizathu zokuba ithandwe kwihlabathi lokwakha umzimba.

I-AKG ikwasebenza njengomxumi we-nitrogen, ithintela ukugcwala kwe-nitrogen kwaye ithintela ukuqokelelana kwe-ammonia egqithisileyo. Ikwangumthombo omkhulu we-glutamate kunye ne-glutamine, ezikhuthaza ukwenziwa kweeproteni kwimisipha kwaye zithintele ukuwohloka kweeproteni.

Ukongeza, ilawula i-enzyme ye-10-11 translocation (TET) ebandakanyeka kwi-DNA demethylation kunye ne-Jumonji C domain-containing lysine demethylase, eyi-histone demethylase ephambili. Ngale ndlela, ingumdlali obalulekileyo ekulawuleni nasekubonakaliseni ii-gene.

Ngaba i-AKG ingalibazisa ukuguga?

Kukho ubungqina bokuba i-AKG inokuba nefuthe ekwaluphaleni, kwaye izifundo ezininzi zibonisa ukuba kunjalo. Uphononongo luka-2014 lubonise ukuba i-AKG yongeza ubomi be-C. elegans yabantu abadala malunga ne-50% ngokuthintela i-ATP synthase kunye nethagethi ye-rapamycin (TOR).

Kolu phononongo, sifumanise ukuba i-AKG ayigcini nje ngokwandisa ubomi kodwa ikwalibazisa ezinye iimpawu ezinxulumene nobudala, ezifana nokulahlekelwa ziintshukumo zomzimba ezihambelanayo ngokukhawuleza eziqhelekileyo kwi-C. elegans ezindala. Ukuze siqonde indlela i-AKG echaphazela ngayo ukwaluphala, siza kuchaza iindlela i-AKG ethintela ngazo i-ATP synthase kunye ne-TOR ukwandisa ubomi kwi-C. elegans kunye nezinye iintlobo.

Indlela esebenza ngayo i-calcium alpha-ketoglutarate

Okokuqala, i-calcium alpha-ketoglutarate idlala indima ebalulekileyo kwi-metabolism yamandla. Njengemveliso ephakathi yomjikelo we-tricarboxylic acid (umjikelo we-TCA), i-calcium α-ketoglutarate ithatha inxaxheba kwinkqubo yokuvelisa amandla angaphakathi kweseli. Ngomjikelo we-TCA, izondlo ezifana nee-carbohydrate, amafutha, kunye neeproteni ziyanyibilikiswa kwaye ziboliswe ukuze kuveliswe i-ATP (adenosine triphosphate) ukubonelela ngamandla kwiiseli. Njengenxalenye ebalulekileyo yomjikelo we-TCA, i-calcium α-ketoglutarate inokukhuthaza imetabolism yamandla eseli, yonyuse amanqanaba amandla omzimba, incede ekuphuculeni amandla omzimba kunye nokunyamezela, kwaye iphucule ukudinwa komzimba.

Okwesibini, i-calcium α-ketoglutarate idlala indima ebalulekileyo kwi-metabolism ye-amino acid. Ii-amino acids ziiyunithi ezisisiseko zeproteni, kwaye i-calcium α-ketoglutarate ibandakanyeka ekuguqulweni nasekusetyenzisweni kwe-amino acids. Kwinkqubo yokuguqula ii-amino acids zibe zezinye ii-metabolites, i-calcium α-ketoglutarate i-transaminates kunye nee-amino acids ukuvelisa ii-amino acids ezintsha okanye ii-α-keto acids, ngaloo ndlela ilawula ibhalansi kunye nokusetyenziswa kwee-amino acids. Ukongeza, i-calcium α-ketoglutarate ingasebenza njenge-substrate ye-oxidation yee-amino acids, ithathe inxaxheba kwi-metabolism ye-oxidative yee-amino acids, kwaye ivelise amandla kunye ne-carbon dioxide. Ke ngoko, i-calcium α-ketoglutarate ibaluleke kakhulu ekugcineni i-homeostasis yee-amino acids kunye ne-metabolism yeproteni emzimbeni.

Ukongeza, i-calcium alpha-ketoglutarate isebenza njenge-antioxidant esusa ii-free radicals kwaye ikhusela iiseli ekonakaleni kwe-oxidative. Kwangaxeshanye, i-calcium α-ketoglutarate inokulawula ukusebenza kwenkqubo yomzimba yokuzikhusela, ikhuthaze ukusebenza kunye nokwanda kweeseli zomzimba, kwaye iphucule ukumelana komzimba nezifo kunye nosulelo. Ke ngoko, i-calcium α-ketoglutarate ibaluleke kakhulu ekugcineni ibhalansi yomzimba yokuzikhusela kunye nokuxhathisa izifo.

Uphando malunga nemiphumo ye-calcium α-ketoglutarate ekwaluphaleni

Ukwaluphala kusichaphazela sonke kwaye kuyimbangela yezifo ezininzi, kwaye ngokwezibalo zoluntu lweMedicare, amathuba okugula ayanda njengoko iminyaka ikhula.

I-calcium alpha-ketoglutarate yi-metabolite ebalulekileyo emzimbeni wethu, eyaziwa ngendima yeseli kumjikelo weKrebs, umjikelo obalulekileyo ekufakweni kwe-oxidation ye-fatty acids kunye ne-amino acids, okuvumela i-mitochondria ukuba ivelise i-ATP (i-ATP ngumthombo wamandla weeseli).

Oku kuquka ukulayishwa kwenkqubo ye-calcium alpha-ketoglutarate, ngoko ke i-calcium alpha-ketoglutarate inokuguqulwa ibe yi-glutamate ize emva koko ibe yi-glutamine, enokunceda ekuvuseleleni ukwenziwa kweproteni kunye ne-collagen (i-collagen yiproteni ye-A fibrous eyenza i-1/3 yazo zonke iiproteni emzimbeni kwaye inceda ukuxhasa impilo yamathambo, ulusu kunye nemisipha).

I-calcium α-ketoglutarate, njengesongezelelo sesondlo esisebenzayo, inamathuba amaninzi okusetyenziswa kwiimveliso zokhathalelo lwempilo. Imisebenzi yayo eyahlukeneyo yebhayoloji efana ne-antioxidant, i-anti-aging, i-immune regulation kunye ne-amino acid metabolism yenza ukuba ibe sisixhobo esinamandla sokuphucula impilo yabantu. Ngokwanda kolwazi ngenkathalo yempilo kunye nobunzulu bophando lwesayensi, kukholelwa ukuba ukusetyenziswa kwe-calcium ye-α-ketoglutarate kwicandelo leemveliso zokhathalelo lwempilo kuya kufumana ingqwalasela kunye nophuhliso olungakumbi.