Kutheni iAlpha Ketoglutarate Magnesium ibalulekile kwiMpilo yakho

Icalcium Alpha ketoglutarate (AKG) yi-metabolite ephakathi yomjikelo we-tricarboxylic acid kwaye ithatha inxaxheba kwi-synthesis ye-amino acids, iivithamini kunye ne-organic acids kunye ne-metabolism yamandla. Ingasetyenziswa njengesongezelelo sokutya kwaye inethuba elibanzi lokusebenzisa. Ukongeza kwimisebenzi yayo yezinto eziphilayo emzimbeni womntu, i-calcium alpha-ketoglutarate isetyenziswa ngokubanzi kwintsimi yamachiza kwaye ibe yinto ebalulekileyo kwiimveliso ezininzi zempilo kunye nezisombululo zonyango.

Yintoni ialpha-ketoglutarate?

I-AKG yimetabolite engaphakathi eyenzeka ngokwemvelo eyinxalenye yomjikelo we-Krebs, oku kuthetha ukuba imizimba yethu iyayivelisa. Ishishini lokuncedisa livelisa inguqulelo eyenziweyo efana nekhemikhali kwi-AKG eveliswe ngokwemvelo.

I-AKG yenza ntoni?

I-AKG yimolekyuli ebandakanyeka kwiindlela ezininzi ze-metabolic kunye neselula. Isebenza njengomnikeli wamandla, i-precursor yemveliso ye-amino acid kunye ne-cell signing molecule, kwaye i-modulator yeenkqubo ze-epigenetic. Yimolekyuli ephambili kumjikelo weKrebs, olawula isantya esipheleleyo somjikelo we-citric acid. Isebenza ngeendlela ezahlukeneyo emzimbeni ukunceda ukwakha izihlunu kunye nokunceda ukuphilisa amanxeba, esinye sezizathu zokuba idume kwihlabathi lokwakha umzimba.

I-AKG ikwasebenza njenge-nitrogen scavenger, ikhusela ukugcwala kwenitrogen kunye nokuthintela ukwakheka kweammonia engaphezulu. Kwakhona ngumthombo omkhulu we-glutamate kunye ne-glutamine, evuselela i-protein synthesis kwimisipha kwaye inqanda ukuthotywa kweprotheni.

Ukongeza, ilawula i-10-11 translocation (TET) enzyme ebandakanyekayo kwi-DNA demethylation kunye ne-Jumonji C domain-containing lysine demethylase, eyona nto iphambili ye-histone demethylase. Ngale ndlela, ngumdlali obalulekileyo kulawulo lwemfuza kunye nokubonakalisa.

Ngaba i-AKG inokulibazisa ukwaluphala?

Kukho ubungqina bokuba i-AKG inokuchaphazela ukwaluphala, kwaye izifundo ezininzi zibonisa ukuba oku kunjalo. Uphononongo lwe-2014 lubonise ukuba i-AKG yandisa ixesha lokuphila kwabantu abadala be-C. elegans malunga ne-50% ngokuthintela i-ATP synthase kunye nethagethi ye-rapamycin (TOR).

Kolu phononongo, sifumene ukuba i-AKG ayandisi nje kuphela ubude bokuphila kodwa iphinde ilibazise i-phenotypes ethile enxulumene nobudala, njengokulahleka kweentshukumo ezikhawulezayo ezilungelelanisiweyo zomzimba eziqhelekileyo kwi-C. elegans endala. Ukuqonda indlela i-AKG echaphazela ngayo ukuguga, siya kuchaza iindlela apho i-AKG inqanda i-ATP synthase kunye ne-TOR ukwandisa ixesha lokuphila kwi-C. elegans kwaye mhlawumbi nezinye iintlobo.

Isebenza njani i-calcium alpha-ketoglutarate

Okokuqala, i-calcium alpha-ketoglutarate idlala indima ebalulekileyo kwi-metabolism yamandla. Njengemveliso ephakathi yomjikelezo we-tricarboxylic acid (umjikelezo we-TCA), i-calcium α-ketoglutarate ithatha inxaxheba kwinkqubo yokuvelisa amandla e-intracellular. Ngomjikelezo we-TCA, izondlo ezifana ne-carbohydrates, amafutha, kunye neeprotheni zixutywe kwaye zichithwa ukuze zenze i-ATP (i-adenosine triphosphate) ukunika amandla kwiiseli. Njengomda obalulekileyo ophakathi kumjikelezo we-TCA, i-calcium α-ketoglutarate inokukhuthaza i-cell metabolism yamandla, ikhulise inqanaba lamandla omzimba, incede ukuphucula amandla omzimba kunye nokunyamezela, kunye nokuphucula ukukhathala komzimba.

Okwesibini, i-calcium α-ketoglutarate idlala indima ebalulekileyo kwi-amino acid metabolism. I-amino acids ziinyunithi ezisisiseko zeprotheni, kunye ne-calcium α-ketoglutarate ibandakanyeka ekuguquleni kunye ne-metabolism ye-amino acids. Kwinkqubo yokuguqula i-amino acids kwezinye i-metabolites, i-calcium α-ketoglutarate idlulisa nge-amino acids ukuvelisa ama-amino acids amatsha okanye i-α-keto acids, ngaloo ndlela ilawula ukulingana kunye nokusetyenziswa kwe-amino acids. Ukongezelela, i-calcium α-ketoglutarate inokuphinda isebenze njenge-oxidation substrate ye-amino acids, ithathe inxaxheba kwi-metabolism ye-oxidative ye-amino acids, kwaye ivelise amandla kunye ne-carbon dioxide. Ke ngoko, i-calcium α-ketoglutarate ibaluleke kakhulu ekugcineni i-homeostasis yee-amino acids kunye neprotein metabolism emzimbeni.

Ukongeza, i-calcium alpha-ketoglutarate isebenza njenge-antioxidant etyhala i-radicals yasimahla kwaye ikhusela iiseli kumonakalo owenziwe nge-oxidative. Ngelo xesha, i-calcium α-ketoglutarate inokulawula umsebenzi we-immune system, ikhuthaze ukusebenza kunye nokwanda kweeseli ze-immune, kunye nokuphucula ukuxhathisa komzimba kwizifo kunye nokusuleleka. Ke ngoko, i-calcium α-ketoglutarate ibaluleke kakhulu ekugcineni ibhalansi yokhuselo lomzimba kunye nokumelana nezifo.

Uphando malunga nemiphumo ye-calcium α-ketoglutarate ekugugeni

Ukwaluphala kusichaphazela sonke kwaye kungumngcipheko wezifo ezininzi, kwaye ngokutsho kweshishini le-Medicare, amathuba okugula ayanda ngokukhula.

I-calcium alpha-ketoglutarate yi-metabolite ebalulekileyo emzimbeni wethu, eyaziwayo ngendima yeseli kumjikelezo we-Krebs, umjikelo oyimfuneko kwi-oxidation ye-fatty acids kunye ne-amino acids, evumela i-mitochondria ukuba ivelise i-ATP (i-ATP ngumthombo wamandla weeseli).

Okubandakanya ukulayishwa kwenkqubo ye-calcium alpha-ketoglutarate, ngoko ke i-calcium alpha-ketoglutarate inokuguqulwa ibe yi-glutamate emva koko ibe yi-glutamine, enokunceda ukuvuselela ukuhlanganiswa kweprotheyini kunye ne-collagen (i-collagen yi-protein ene-fibrous eyenza i-1/3 yazo zonke iiprotheyini ezisemzimbeni kwaye inceda ukuxhasa impilo yamathambo, ulusu kunye nezihlunu).

I-Calcium α-ketoglutarate, njengesongezelelo sesondlo esisebenza ngeendlela ezininzi, inethuba elibanzi lesicelo kwiimveliso zokhathalelo lwempilo. Imisebenzi yayo eyahlukeneyo yezinto eziphilayo ezifana ne-antioxidant, i-anti-aging, i-immune regulation kunye ne-amino acid metabolism yenza kube sisixhobo esinamandla sokuphucula impilo yabantu. Ngokunyuka kolwazi lwezempilo kunye nokujula kophando lwezenzululwazi, kukholelwa ukuba ukusetyenziswa kwe-α-ketoglutarate calcium kwintsimi yeemveliso zokhathalelo lwempilo kuya kufumana ingqalelo kunye nophuhliso.