Yintoni i-N-Boc-O-Benzyl-D-Serine kwaye Kutheni ibalulekile?

Kwimizi-mveliso yeekhemikhali kunye namayeza, i-N-Boc-O-benzyl-D-serine yinto ebalulekileyo ye-amino acid derivative ngenxa yokusetyenziswa kwayo kwi-synthesis yama-molecule e-bioactive kunye neziyobisi. Itsale ingqalelo enkulu kwisicelo sayo esibanzi kuphuhliso."N-Boc" ibhekisa kwiqela elikhuselayo le-tert-butoxycarbonyl (Boc), elisoloko lisetyenziselwa ukukhusela iqela le-amino lee-amino acid kwi-peptide synthesis. "I-O-Benzyl" ithetha ukuba iqela le-benzyl lidityaniswe kwiqela le-hydroxyl ye-serine, ngaloo ndlela iphucula uzinzo kunye nokunyibilika kwayo.

Intshayelelo ye-N-Boc-O-benzyl-D-serine

I-N-Boc-O-benzyl-D-serine (CAS: 47173-80-8), ibonakala njengomgubo omhlophe ukuya kumhlophe, i-N- Boc-O-Benzyl-D-serine iphuma kwi-amino acid D-serine. Ngenxa yezakhiwo zayo ezikhethekileyo, idlala indima ebalulekileyo kwi-chemical synthesis kunye ne-peptide chemistry. Oku kulandelayo yinkcazo ecacileyo yamacandelo ayo: apho i-N-Boc ibhekisela kwiqela elikhuselayo le-tert-butoxycarbonyl (Boc).

Amaqela akhuselayo asetyenziswa kwi-organic synthesis ukukhusela okwethutyana amaqela asebenzayo, evumela ukusabela okukhethiweyo ngaphandle kokuphazamiseka kwezinye iisayithi zokusabela. I-O-benzyl ibonisa ukuba iqela le-benzyl lifakwe kwi-oksijini yeqela le-hydroxyl ye-serine. I-Benzyl yinto eqhelekileyo enevumba elimnandi elinokuchaphazela ukunyibilika kunye nokusebenza kwakhona kweekhompawundi. I-D-serine yenye yeeenantiomers ezimbini ze-serine kwaye yeyentsapho ye-methionine. I-Serine ibalulekile i-amino acid kwi-biosynthesis, imveliso yamandla kunye nokuveliswa kwe-agent ye-intracellular. Ezi nkqubo zibalulekile ekukhuleni nasekukhuleni kweeseli zomhlaza.

Intshayelelo yoMsebenzi we-N-Boc-O-benzyl-D-serine

1. I-D-serine inokunciphisa iimpawu zokuncipha kwengqondo.

Ukubonakaliswa kwe-Glutaminergic kuyaziwa ngokunyusa ukubunjwa kwememori ngenxa yokuba ukusebenza kwe-NMDA receptors kubangela ukungena kwe-calcium kunye nokuhlanganiswa kwe-calodulin-dependent kinase (CaMK) kunye ne-CREB-binding proteins, eyenza ukuba ibangele amandla exesha elide (LTP), eyenza isiseko indlela eyaziwa ngokuba yimemori, kwaye iphumela ekunyukeni komqondiso we-NMDA (ingakumbi nge-subunit ye-NR2B) ebangela ukwanda kwememori kunye ne-LTP. Oku kukwayindlela yokuphucula imemori ebonwe nge-magnesium L-threonate. Ngenxa yokuba i-D-serine inokuphucula ukubonakaliswa ngokusebenzisa i-NMDA receptors, idityaniswe nomsebenzi we-D-serine kule nkqubo kunye novakalelo olwaziwayo lweeseli ze-hippocampal kwi-D-serine stimulation, kukholelwa ukuba ukuncedisa i-D-serine kunokukhuthaza imemori nokufunda.

2.Uphando lufumene ukuba ukulahlekelwa kweprotheni ye-Menin kwi-hypothalamus yinto ebalulekileyo ekhokelela ekugugeni, kwaye ukuncedisa i-D-serine kunokuphucula ukuphazamiseka kwengqondo kwiigundane ezikhulileyo.

Uphononongo lufumene ukuba i-hypothalamus nayo idlala indima ephambili ekuphazamisekeni kwengqondo okubangelwa kukwaluphala. Ngexesha lenkqubo yokuguga, iprotheni yeMenin kwi-hypothalamus (emva koku kuthiwa yiMenin) iya kuncipha ngokuthe ngcembe kunye nenkqubo yokuguga, echaphazela ukuhlanganiswa kwe-D-serine, ngakumbi ukukhawuleza inkqubo yokuguga kunye nokungasebenzi kwengqondo. Ukongeza, ukuxhaswa kwe-D-serine kunokuphucula kakhulu i-phenotype yokuguga kunye nokunciphisa ukuphazamiseka kwengqondo kwiigundane ezikhulileyo.

Iziphumo zophononongo zibonise ukuba emva kokuncedisa i-D-serine, amanqanaba e-D-serine kwi-hypothalamus kunye ne-hippocampus yamaqela amathathu eempuku anyuswe kakhulu xa kuthelekiswa nohlobo olufanayo lweegundane ezingazange zongezwa nge-D-serine (p. <0.01), kwaye imeko yabo yokuqonda iphuculwe. Ukuphuculwa okuphawulekayo (p<0.05), ebonisa ukuba i-D-serine supplementation ingaba yindlela yokonyango yokuphucula ukuphazamiseka kwengqondo okuguga.

I-N-Boc-O-Benzyl-D-Serine vs. Ezinye ii-Amino Acids: Yintoni Umahluko?

1. Ukwahluka kwesakhiwo

Umahluko ocacileyo phakathi kwe-N-Boc-O-benzyl-D-serine kunye nezinye i-amino acids yisakhiwo sayo. Nangona i-amino acids eqhelekileyo inomqolo olula oquka amaqela e-amino, amaqela e-carboxyl kunye namatyathanga asecaleni, i-N-Boc-O-benzyl-D-serine inamaqela asebenzayo awongezelelweyo aguqula iimpawu zayo.

Umzekelo, iqela le-Boc libonelela ngokhuseleko ngexesha le-peptide synthesis, livumela ukuphendula okuntsokothileyo ukuba kwenziwe ngaphandle kokuphendula okungafunwayo. Amaqela eBenzyl aphucula ukusebenzisana kwe-hydrophobic, ngaloo ndlela echaphazela ukusongwa kunye nokuzinza kweepeptides kunye neeproteni.

2. Iimpawu zokusebenza

I-N-Boc-O-Benzyl-D-Serine ibonisa iipropati ezisebenzayo ezizodwa xa kuthelekiswa nezinye i-amino acids. Ukucwangciswa kwayo kwe-D kuvumela ukuba isebenzisane ngokungafaniyo kunye neenkqubo zebhayoloji xa kuthelekiswa noqwalaselo oluqhelekileyo lwe-L olufumaneka kwiiprotheni ezininzi. Oku kunokukhokelela kutshintsho kwimisebenzi yebhayoloji, kuyenza ibe sisixhobo esixabisekileyo kuyilo nophuhliso lwamachiza.

Ngokwahlukileyo, kulula, i-amino acids eqhelekileyo efana ne-glycine okanye i-alanine ayinayo inqanaba elifanayo lobunzima okanye ukuchaneka ekusebenzisaneni kwabo. Oku kwenza i-N-Boc-O-Benzyl-D-Serine ibe luncedo ngakumbi kwizifundo ze-neuropharmacology kunye nokusebenzisana kwe-receptor.

3. Izicelo kuphando kunye namayeza

I-N-Boc-O-Benzyl-D-Serine iye yatsala ingqalelo kwiinkalo ezahlukeneyo, ngakumbi kwiinkalo zekhemikhali yamayeza kunye ne-neurobiology. Ukukwazi kwayo ukumodareyitha umsebenzi we-NMDA ye-receptor yenza ukuba ibe lichiza lomviwa lokufunda ukuphazamiseka kwemithambo-luvo njenge-schizophrenia kunye nesifo sika-Alzheimer. Abaphandi baphonononga amandla ayo njengearhente yonyango yokuphucula ukusebenza kwengqondo okanye ukunciphisa iinkqubo ze-neurodeergenerative.

Ngokwahlukileyo, i-amino acids eziqhelekileyo ezifana ne-leucine okanye i-valine ziye zafundwa rhoqo ngendima yazo kwi-metabolism ye-muscle kunye ne-protein synthesis. Nangona ziyimfuneko kwimpilo yonke kunye nokuphila kakuhle, izicelo zabo ezijoliswe kuzo kwi-neuropharmacology zihluke kwi-N-Boc-O-Benzyl-D-Serine.

4. Ukudibanisa kunye nokuzinza

I-synthesis ye-N-Boc-O-benzyl-D-serine ibandakanya ukuphendulwa kweekhemikhali eziyinkimbinkimbi kune-amino acids eziqhelekileyo. Ukuqaliswa kwamaqela akhuselayo kunye nesidingo seemeko ezithile zokusabela kunokwenza ukuba ukuhlanganiswa kwawo kube nzima ngakumbi. Nangona kunjalo, olu hlengahlengiso lukwakhulisa uzinzo lwayo, luyenza ilungele iimeko ezahlukeneyo zovavanyo.

Ngokwahlukileyo, i-amino acids eqhelekileyo ifumaneka ngokulula kwaye kulula ukuyidibanisa, kodwa ayinakubonelela ngezinga elifanayo lokuzinza okanye ukucaciswa okufunekayo kwizicelo zophando oluphambili.

Izicelo ze-D-Real-Life ze-N-Boc-O-Benzyl-D-Serine

I-Serine idlala imisebenzi ebalulekileyo ye-physiological kumzimba womntu, ngakumbi ukulawulwa kunye nokukhuselwa kwenkqubo ye-nervous. I-N-Boc-O-benzyl-D-serine njenge-serine derivative yiklasi ebalulekileyo yeemolekyuli ze-bioactive ezisetyenziswa rhoqo kwi-peptide synthesis kunye nezinye izicelo ze-organic chemistry, ngakumbi ekuphuhliseni iziyobisi kunye ne-bioactive compounds. Iqela elikhuselayo linokususwa phantsi kweemeko ezithile ukufumana i-amino acids yamahhala okanye ezinye izinto eziphuma kuzo zophando oluqhubekayo okanye isicelo. Isetyenziswa kakhulu kuphando lwezonyango kunye nebhayoloji.

1. Ukwenziwa kweekhemikhali kunye ne-peptide chemistry

I-N-Boc-O-benzyl-D-serine isetyenziswe njengebhloko yokwakha kwi-chemical synthesis ye-compounds eyahlukeneyo kwaye iyinxalenye ephambili kwi-peptide chemistry. Ukusetyenziswa kwayo kule ntsimi kubangelwa ukukwazi ukufakwa kwizakhiwo ezinkulu ze-molecular, ezincedisa ukuphuhliswa kwamachiza amatsha kunye neemolekyuli ze-bioactive.

2. Ishishini lamachiza

I-N-Boc-O-benzyl-D-serine yayisetyenziswa njenge-precursor yokulungiswa kwe-naphthodiazolidinones efakwe endaweni. Ezi khompawundi zisebenza njenge-protein tyrosine phosphatase degraders kwaye zinezicelo zonyango ezinokubakho kunyango lomhlaza kunye nezifo ze-metabolic. Ukuthotywa kwezi phosphatases kunceda ukulawula iindlela zokubonisa iiseli, ngaloo ndlela ukubonelela ngendlela yonyango yokulwa nezi zifo.

3. Uphando kunye nophuhliso

Kuphando kunye nophuhliso, i-N-Boc-O-benzyl-D-serine isetyenziselwa ukudibanisa iimolekyuli ezintsha ezinomsebenzi webhayoloji. Ubume bayo obukhethekileyo buvumela izazinzulu ukuba zihlolisise iimpawu zayo kunye nezicelo zokudala iziyobisi ezintsha kunye nonyango kwiimeko zonyango ezahlukeneyo.

Indawo yokuthenga i-N-Boc-O-benzyl-D-serine?

Njengomvelisi we-N-Boc-O-benzyl-D-serine powder, i-Suzhou Myland iphumelele ukuthembela kwabathengi abaninzi kunye neemveliso zayo ezicocekileyo kunye nokulawula umgangatho ongqongqo. Inkampani izibophelele ekuboneleleni abathengi ngemathiriyeli ekrwada ekumgangatho ophezulu kwaye ibancede baphumelele kumashishini abo.

1. Umgangatho wemveliso othembekileyo

I-N-Boc-O-benzyl-D-serine powder yaseSuzhou Myland ifumana iimvavanyo ezininzi ukuqinisekisa ukucoceka kwayo kunye nomgangatho ohambelana nemigangatho yoshishino. Inkampani ineqela lokuhlola umgangatho oqeqeshiweyo oqhuba uhlolo olungenamkhethe lweemveliso rhoqo ukuqinisekisa umgangatho ozinzileyo webhetshi nganye yeemveliso.

2. Ukubonelela ngezakhono eziguquguqukayo

Ingaba ibhetshi encinci okanye iodolo enkulu, i-Suzhou Mailun Biotechnology inokuphendula ngokuguquguqukayo ukuqinisekisa ukuba iimfuno zabathengi ziyafezekiswa. Inkampani iseke inkqubo epheleleyo yolungiselelo lokuhambisa ngokukhawuleza iimveliso kubathengi.

3. Inkxaso yobuchwephesha yobugcisa

Iqela leR&D laseSuzhou Myland liqulunqwe liqela leengcaphephe zeshishini kwaye linokubonelela abathengi ngothethwano lobuchwephesha kunye nenkxaso ukunceda abathengi baqonde ngcono kwaye basebenzise i-N-Boc-O-benzyl-D-serine.

4. Ixabiso lokukhuphisana

Kwisiseko sokuqinisekisa umgangatho wemveliso, iSuzhou Myland ibonelela ngamaxabiso akhuphisanayo ukunceda abathengi banciphise iindleko zokuthenga kunye nokuphucula ukukhuphisana kwemarike.

Ukukhetha umboneleli we-N-Boc-O-benzyl-D-serine ofanelekileyo ngundoqo ekuqinisekiseni umgangatho wemveliso kunye nokhuseleko. I-Suzhou Myland iye yaba lukhetho oluthembekileyo kwishishini kunye neemveliso zayo ezicocekileyo, ulawulo olungqongqo lwekhwalithi kunye neenkonzo zobungcali. Ingaba uyinkampani yamachiza okanye iziko lophando lwezenzululwazi, iSuzhou Myland inokukunika umgangatho ophezulu we-N-Boc-O-benzyl-D-serine powder ukuncedisa uphando lwakho nophuhliso. Ukufumana iinkcukacha ezithe vetshe, nceda undwendwele iwebhusayithi ye-Suzhou Myland esemthethweni.