Oko kufuneka ukwazi malunga nokwaluphala kunye neendlela onokuzithatha ukuze unciphise isantya sakho

Njengoko abantu bekhula, abaninzi bafuna iindlela zokucothisa inkqubo nokugcina inkangeleko yobutsha kunye namandla. Kukho iindlela ezahlukeneyo zobuchule ezingasetyenziswa ukunceda ukucothisa inkqubo yokwaluphala nokukhuthaza impilo-ntle iyonke.

Uphando lwamva nje lubonisa ukuba ukwaluphala akwenzeki kancinci kancinci, kodwa kukwaqala nakwixesha elithile phakathi kweminyaka engama-44 ukuya kwengama-60.

Ukususela kwiminyaka yakho yokuqala yama-40, i-lipid kunye ne-alcohol metabolism yakho iyatshintsha, ngelixa ukusebenza kwezintso zakho, i-carbohydrate metabolism, kunye nokulawulwa komzimba kuqala ukwehla xa uneminyaka engama-60 ubudala. Abaphandi bakwaqaphele utshintsho olukhulu kumngcipheko wesikhumba, izihlunu kunye nesifo sentliziyo phakathi kweminyaka engama-40 ukuya kuma-60 ubudala.

Olu phononongo luquke kuphela abemi baseCalifornia abali-108 abaneminyaka ephakathi kwama-25 nama-75, kwaye kufuneka uphando oluthe kratya ukuqinisekisa iziphumo. Nangona kunjalo, ezi ziphumo zinokukhokelela kwiimvavanyo ezintsha zokuxilonga kunye namaqhinga okuthintela izifo ezinxulumene nokwaluphala.

Ubomi obude abuthethi ukuba umntu omdala usempilweni okanye ukhuthele. Ngokutsho kombhali ophezulu wolu phando uGqr. Michael Snyder, umlawuli weZiko leGenomics kunye neMedicine eSt. Stanford University, kubantu abaninzi, ixesha labo eliqhelekileyo "lempilo" - ixesha abalichitha besempilweni entle - lide kunexesha labo lobomi elifutshane leminyaka eli-11-15.

Ubudala obuphakathi bubalulekile ekwaluphaleni okunempilo

Uphando lwangaphambili lubonise ukuba impilo yakho phakathi kobomi (ngesiqhelo phakathi kweminyaka engama-40 nama-65) idlala indima ebalulekileyo kwimpilo yakho kamva ebomini. Uphononongo luka-2018 kwijenali iNutrition ludibanise izinto ezithile zendlela yokuphila phakathi kobomi, ezinje ngobunzima obusempilweni, ukusebenza ngokomzimba, ukutya ukutya okunempilo kunye nokungatshayi, kunye nokuphucula impilo ngexesha lokwaluphala. 2

Ingxelo epapashwe kwijenali ka-2020 ikwabonise ukuba ixesha lokukhula kobomi lixesha elibalulekileyo lokutshintsha impilo yengqondo. Ukulawula uxinzelelo lwegazi nokuhlala usebenza ngokwasentlalweni, ngokwengqondo nangokomzimba ngeli nqanaba lobomi kunokunceda ukunciphisa umngcipheko we-dementia kamva ebomini, itsho ingxelo.

Olu phononongo lutsha longeza kwicandelo lophando lwe-healthspan kwaye lugxininisa ukubaluleka kokuphuhlisa imikhwa ethile yokuphila kwasebuntwaneni.

“Indlela ophila ngayo xa uneminyaka engama-60, engama-70 okanye engama-80 ixhomekeke kwinto oyenzileyo kwiminyaka engamashumi angaphambi kwakho,” utshilo uKenneth Boockvar, MD, umlawuli weZiko loPhando oluDibeneyo ngoKuguga kwiYunivesithi yaseAlabama eBirmingham.” kodwa wayengabandakanyekanga kolu phando.

Wongeze ngelithi bekusekutsha kakhulu ukwenza izindululo ezithile ngokusekelwe kuphando olutsha, kodwa abantu abafuna ukuhlala besempilweni xa bekwiminyaka engama-60 kufuneka baqale ukuqaphela ukutya kwabo nendlela abaphila ngayo xa bekwiminyaka engama-40 kunye nama-50.

Ukwaluphala akunakuphepheka, kodwa utshintsho kwindlela yokuphila lunokwandisa ubomi obusempilweni

Uphando olutsha lufumanisa ukuba iimolekyuli kunye neentsholongwane ezinxulumene nokwaluphala ziyancipha ngexesha lamanqanaba athile omjikelo wobomi, kodwa uphando oluzayo luyafuneka ukuze kuchongwe ukuba utshintsho olufanayo lweemolekyuli luyenzeka na kumaqela ahlukeneyo.

“Sifuna ukuhlalutya abantu abaninzi kulo lonke ilizwe ukuze sibone ukuba izinto esizibonileyo ziyasebenza na kuye wonke umntu — kungekuphela nje kubantu abakwiBay Area,” utshilo uSnyder. “Sifuna ukuhlalutya umahluko phakathi kwamadoda nabafazi. Abafazi baphila ixesha elide kwaye sifuna ukuqonda ukuba kutheni.”

Ukwaluphala akunakuphepheka, kodwa utshintsho oluthile kwindlela yokuphila lunokunceda ekunciphiseni umngcipheko wezifo ezinxulumene nokwaluphala. Nangona kunjalo, ezinye izinto ezininzi ezifana nokusingqongileyo, uzinzo lwezemali, ukhathalelo lwempilo kunye namathuba emfundo nazo zinefuthe kwiziphumo zokwaluphala ezisempilweni kwaye kunzima ukuba abantu bazilawule.

Abantu banokwenza utshintsho oluncinci kwindlela yokuphila efana nokuhlala bemanzi ukuze balondoloze impilo yezintso, ukwakha ubunzima bemisipha ngoqeqesho lobunzima kunye nokuthatha amayeza e-cholesterol ukuba i-LDL cholesterol iphakanyisiwe, utshilo uSnyder.

Wongeze wathi: "Oku kusenokungayekisi ukwaluphala, kodwa kuya kunciphisa iingxaki esizibonayo kwaye kuncede ukwandisa ubomi babantu obusempilweni."

Yintoni enokwenziwa ukuze kuthintelwe ukuguga?

Enye yezona zinto zibalulekileyo ekucothiseni ukuguga kukugcina indlela yokuphila enempilo. Oku kuquka ukutya ukutya okunesondlo okutyebileyo kwiziqhamo, imifuno, iinkozo ezipheleleyo kunye neproteni engenamafutha. Ukuphepha ukutya okucutshungulwayo, iswekile egqithisileyo, kunye namafutha angenampilo kunokunceda ukunciphisa ukudumba emzimbeni kunye nokuxhasa impilo iyonke. Ukuhlala unamanzi ngokusela amanzi amaninzi kubalulekile ekugcineni ulusu kunye namalungu omzimba esempilweni.

Ukuzilolonga rhoqo yenye into ebalulekileyo kwindlela yokuphila enempilo kwaye kunokunceda ukucothisa inkqubo yokwaluphala. Ukuzilolonga kunceda ukuphucula impilo yentliziyo, ukugcina ubunzima bemisipha, kunye nokuxhasa ukuhambahamba kunye nokuguquguquka. Ukuthatha inxaxheba kwimisebenzi efana nokuhamba, ukudada, i-yoga okanye uqeqesho lwamandla kunokunceda umzimba wakho ubonakale umncinci kwaye unamandla ngakumbi.

Ukongeza kwindlela yokutya nokuzilolonga, ukulawula uxinzelelo kubalulekile ekunciphiseni ukuguga. Uxinzelelo olungapheliyo lunokuba nemiphumo emibi emzimbeni, nto leyo ekhokelela ekuvuvukeni okukhulu kunye nobuthathaka benkqubo yomzimba yokuzikhusela. Ukuziqhelanisa neendlela zokunciphisa uxinzelelo ezifana nokucamngca, ukuphefumla nzulu, okanye ukuqaphela kunokunceda ukukhuthaza ukuphumla kunye nokuphila kakuhle.

Enye into ebalulekileyo yokucothisa ukuguga kukufumana ubuthongo obaneleyo. Ukulala kubalulekile ekulungiseni nasekuvuseleleni umzimba, kwaye ukungabikho kokulala okusemgangathweni kunokubangela ukwaluphala kwangethuba. Ukumisela ishedyuli yokulala rhoqo kunye nokwenza ixesha lokulala eliphumlayo kunokunceda ukuphucula umgangatho wokulala kunye nokuxhasa impilo iyonke.

Ukongeza kwizinto zendlela yokuphila, kukho iindlela ezahlukeneyo zonyango ezinokunceda ekunciphiseni ukuguga. Ezi zinokubandakanya iindlela zokunyamekela ulusu, iinkqubo zobuhle, kunye nokungenelela kwezonyango. Ukusebenzisa i-sunscreen kunye nokufumisa ulusu lwakho kunokunceda ukuthintela umonakalo welanga kunye nokugcina inkangeleko yobutsha. Iindlela zobuhle ezifana neBotox, izizalisi, kunye nonyango lwe-laser zinokunceda ekunciphiseni ukubonakala kwemibimbi kunye nemigca emincinci.

Ukongeza, kukho ezinye izongezo zokulwa nokwaluphala ezikhoyo ezinokuxhasa impilo iyonke kunye namandla. Phakathi kwezo zongezo ezinobungqina besayensi obuxhasa indima yazo ekuphuculeni impilo ye-mitochondrial kunye nokucothisa ukuguga kukho ii-precursors ze-NAD+ kunye ne-urolithin A.

Izongezo ze-NAD+

Apho kukho i-mitochondria, kukho i-NAD+ (nicotinamide adenine dinucleotide), imolekyuli efunekayo ekuphuhliseni imveliso yamandla. I-NAD+ iyancipha ngokwendalo xa ikhula, nto leyo ebonakala ihambelana nokuncipha kokusebenza kwe-mitochondrial okunxulumene nobudala.

Uphando lubonisa ukuba ngokunyusa i-NAD+, unokuphucula imveliso yamandla e-mitochondrial kwaye uthintele uxinzelelo olunxulumene nobudala. Izongezo zangaphambili ze-NAD+ zinokuphucula ukusebenza kwezihlunu, impilo yengqondo, kunye ne-metabolism ngelixa zinokulwa nezifo ze-neurodegenerative. Ukongeza, zinciphisa ukutyeba, ziphucula ukuvalelwa kwe-insulin, kwaye zilungelelanise amanqanaba e-lipid, njengokunciphisa i-LDL cholesterol.

I-Coenzyme Q10

Njenge-NAD+, i-coenzyme Q10 (CoQ10) idlala indima ethe ngqo nebalulekileyo kwimveliso yamandla e-mitochondrial. Njenge-astaxanthin, i-CoQ10 inciphisa uxinzelelo lwe-oxidative, imveliso yemveliso yamandla e-mitochondrial eba mandundu xa i-mitochondria ingekho mpilweni. Ukongeza i-CoQ10 kunciphisa umngcipheko wokuhlaselwa sisifo sentliziyo, isifo sohlangothi kunye nokufa. Xa ucinga ukuba i-CoQ10 iyehla ngokukhula, ukongeza i-CoQ10 kunokubonelela ngezibonelelo zobomi obude kubantu abadala.

I-Urolithin A

I-Urolithin A (UA) iveliswa yibhaktiriya yethu yamathumbu emva kokutya iipolyphenols ezifumaneka ekutyeni okufana neepomegranate, amastrawberry, kunye neewalnuts. Ukongezwa kwe-UA kwiimpuku ezikwiminyaka ephakathi kuvuselela ii-sirtuins kwaye kwandisa amanqanaba e-NAD+ kunye namandla eeseli. Okubalulekileyo kukuba, i-UA ibonakalisiwe ukuba isusa i-mitochondria eyonakeleyo kwimisipha yomntu, ngaloo ndlela iphucula amandla, ukumelana nokudinwa, kunye nokusebenza kwezemidlalo. Ke ngoko, ukongezwa kwe-UA kunokwandisa ubomi ngokulwa nokwaluphala kwemisipha.

I-Spermidine

Njenge-NAD+ kunye ne-CoQ10, i-spermidine yimolekyuli yendalo eyanciphayo xa ukhula. Ngokufanayo ne-UA, i-spermidine iveliswa yintsholongwane yethu yamathumbu kwaye ibangela i-mitophagy - ukususwa kwe-mitochondria engonakaliyo neyonakeleyo. Izifundo zeempuku zibonisa ukuba ukongezwa kwe-spermidine kunokukhusela kwizifo zentliziyo kunye nokwaluphala kokuzala kwabasetyhini. Ukongeza, i-spermidine yokutya (efumaneka kwiintlobo ngeentlobo zokutya kuquka i-soy kunye neenkozo) iphucule inkumbulo kwiimpuku. Kufuneka uphando olungakumbi ukuze kuqinisekiswe ukuba ezi ziphumo zinokuphindaphindwa na ebantwini.

I-Suzhou Myland Pharm & Nutrition Inc. ngumvelisi obhalisiweyo kwi-FDA obonelela ngomgubo we-urolithin A osemgangathweni ophezulu nococekileyo.

Apha eSuzhou Myland Pharm sizibophelele ekuboneleleni ngeemveliso ezikumgangatho ophezulu ngamaxabiso angcono. Umgubo wethu we-Urolithin A uvavanywa ngokungqongqo ubumsulwa kunye namandla, ukuqinisekisa ukuba ufumana isongezelelo esisemgangathweni onokusithemba. Nokuba ufuna ukuxhasa impilo yeseli, ukukhulisa amajoni akho omzimba okanye ukuphucula impilo iyonke, umgubo wethu we-Urolithin A lukhetho olufanelekileyo.

Ngamava angama-30 eminyaka kwaye eqhutywa bubuchwepheshe obuphezulu kunye namaqhinga ophando nophuhliso aphucukileyo, iSuzhou Myland Pharm iphuhlise uluhlu lweemveliso ezikhuphisanayo kwaye yaba yinkampani yeenkonzo zokongeza izinto ezintsha zesayensi yobomi, ukwenziwa kwezinto ngokwezifiso kunye neenkonzo zokuvelisa.

Ukongeza, iSuzhou Myland Pharm ikwangumvelisi obhalisiweyo yi-FDA. Izixhobo zeR&D zenkampani, izixhobo zemveliso, kunye nezixhobo zokuhlalutya zizinto zanamhlanje kwaye zisebenza ngeendlela ezininzi, kwaye zinokuvelisa iikhemikhali ukusuka kwi-milligrams ukuya kwiitoni ngobukhulu, kwaye zihambelana nemigangatho ye-ISO 9001 kunye neenkcukacha zemveliso ze-GMP.