Yintoni i-telomerase activator-cycloastraganol efunyenweyo ngoku?

Ngo-1985, uGreider nabanye baqala ukufumana i-telomerase, kwaye le enzyme isandul’ ukufunyanwa inokongeza ukuphindaphinda kwe-DNA kwiziphelo zee-chromosomes ukugcina ubude be-telomere. I-Telomerase yi-ribonucleoprotein complex ene-catalytic core equka i-TERT kunye ne-TERC, apho i-TERT ingundoqo ekulawuleni umsebenzi we-telomerase. Ubude be-Telomere buyaqhubeka bufutshane njengoko iiseli zahlukana. Xa ifikelela kwixabiso elibalulekileyo, ibangela imiqondiso yomonakalo we-DNA, ekhokelela kumjikelo weseli omfutshane kunye nothotho lwezifo zokungaphumeleli kwezicubu ezibonakaliswa zii-telomeres ezimfutshane.

Ngowama-2010, inkampani yaseMelika iGeron yasebenzisana neYunivesithi yeSayensi neTekhnoloji yaseHong Kong kwiprojekthi yophando yokuvavanya ii-activators ze-telomerase. Kwafunyaniswa ukubai-cycloastraganolingenza umsebenzi we-telomerase usebenze kwaye ibangele ulwandiso lwe-telomere. Olu fumaniso lukhuthaze ngokukhutheleyo uphuhliso lwe-telomerase activators. Inkqubela phambili yophando kunye nophuhliso lwemveliso enxulumeneyo ye-astragalus alcohol. I-Cycloastragenol (CAG) okwangoku yeyona kuphela i-telomerase activator exeliweyo phakathi kweemveliso zendalo. Ingalwa ngempumelelo nokunciphisa i-telomere kwaye ine-anti-aging, anti-apoptosis, anti-fibrosis, regulation immune, promotion of cell splicing and cold medication, etc. Iziphumo ze-pharmacological, ngaloo ndlela ineziphumo zonyango ezinokubakho kwizifo ezinxulumene nokungasebenzi kakuhle kwe-telomere.

I-Cycloastragenol kunye nokwaluphala

iitelomere
IiTelomeres zizakhiwo ezikhethekileyo ezisekupheleni kweechromosomes ezikhusela iichromosomes kwaye zifutshane ngokuphindaphinda kweechromosomes kunye nokwahlukana kweeseli. Iiseli nazo ziyaguga njengoko iitelomeres zimfutshane.

i-telomerase
I-Telomerase inokudibanisa ii-telomere ukuze izinzise ubude kunye nolwakhiwo lwee-telomere, ngaloo ndlela ikhusela ii-chromosomes kwaye ilibazise ukuguga kweeseli.

I-Anti-aging: I-telomerase activator, edlala isiphumo sokulwa nokwaluphala ngokwandisa i-telomerase ngaloo ndlela ilibazisa ukufinyela kwee-telomeres.

IiTelomeres zizigqubuthelo ezikwiziphelo zeechromosomes zeseli ezizikhusela ekonakaleni ngexesha lokwahlukana kweeseli. Njengoko iiseli ziqhubeka zahlukana, iitelomeres ziyaqhubeka zifutshane, zifikelela kwinqanaba elibalulekileyo apho iiseli ziya kwaluphala okanye zife. ITelomerase inokwandisa ubude beetelomeres, kwaye ubomi beeseli buya kwanda ngokwemvelo ngokufanelekileyo.

Ukwaluphala yinxalenye yobomi engenakuphepheka; nangona kunjalo, abaphandi bafunda iindlela ezahlukeneyo zonyango ukuzama ukuphepha ezinye zeziphumo zokwaluphala, kuquka nokufunda nge-senolytics. Ii-Senolytics ziikhompawundi ezisusa iiseli ezisandul’ ukuguga kwaye zibonakalisiwe ukuba ziyanciphisa iziphumo zokwaluphala. Uphononongo olutsha lubonisa ukuba i-cycloastraganol ineziphumo zokulwa nokwaluphala.

Olu phononongo, oluvela eTshayina kwaye lwapapashwa kwi-International Journal of Molecular Sciences, lugxile kwiiseli zabantu ezikhulileyo kunye neempuku ezine-radiation-induced senescence. I-Cycloastragenol iyanciphisa iiseli ezikhulileyo ngaphandle kokuchaphazela iiseli ezingezizo ezikhulileyo. Unyango lwe-Cycloastragenol lukwanciphisa iiproteni kwiiseli ezikhulileyo ezifunekayo ekukhuleni nasekuphileni kweeseli. Ukongeza, luthintela iintshukumo zeeseli ezinxulumene neeseli kunye neenkqubo zokudumba ezinxulumene nobudala. Iimpuku ezindala ezinyangwe nge-cycloastraganol zifunyenwe zine-sensescent cells ezimbalwa kunye nokuphucula ukungasebenzi kakuhle komzimba okunxulumene nobudala.

I-Cycloastragenol inciphisa iiseli ezisandul’ ukufikisa

Ukuguga luphawu olwaziwayo lokwaluphala, kodwa abaphandi bafumanise ukuba ukususa iiseli ezisandul’ ukuvela kunye neemolekyuli zazo ezibonisa ukudumba kunokunceda ekuthinteleni izifo ezinxulumene nokuguga kwaye ziphinde zibuyisele umva kwezinye iimeko. Apha, abaphandi banyanga iiseli zabantu nge-cycloastraganol kwaye bafumanisa ukuba iyazisusa ngempumelelo iiseli ezisandul’ ukuvela ngaphandle kokuchaphazela iiseli ezingezizo ezisandul’ ukuvela. Ukongeza, iimpawu zeeseli zeeseli ezisandul’ ukuvela zancitshiswa kakhulu emva konyango lwe-cycloastraganol.

Uphando lwangaphambili lubonise ukuba indlela ye-PI3K/AKT/mTOR—indlela yokubonisa ebandakanyeka ekukhuleni nasekusindeni kweeseli—ibandakanyeka kwiinkqubo zokudumba eziqalwa ziiseli ezisandul’ ukufikisa, zinceda ekukhuthazeni ukukhula kweeseli ezijikelezileyo. Abaphandi bafumanise ukuba i-cycloastragenol incede ekunciphiseni iiproteni kule ndlela, nto leyo ebonisa ukuba le khemikhali ingasebenza ngokuvala indlela ye-PI3K/AKT/mTOR ukunceda ekuthinteleni ukwaluphala. Ngaphezu koko, i-cycloastragenol ibonakalisiwe ukuba inciphisa amandla eeseli ezisandul’ ukufikisa okukhuthaza ukukhula ngokukhupha iimolekyuli ezivuthayo, izinto zokukhula, kunye ne-immunomodulators, ngokuhambelana neengcebiso zokuba ukunciphisa i-PI3K, i-AKT, kunye ne-mTOR signaling kunokunciphisa iziphumo ezikhuthaza ukukhula kweeseli ezijikelezileyo.

I-Cycloastragenol yeye-triterpene saponins kwaye ifumaneka kakhulu kwi-hydrolysis ye-astragaloside IV. Inobunzima obuncinci be-molecular kunye ne-lipophilicity enamandla, eluncedo ekungeneni kwe-biofilm kunye nokufunxwa kwesisu ukuze kufezekiswe ukufumaneka ngcono kwe-bioavailability. Ukusebenza kakuhle kwe-cycloastragalinol
1. Unyango lomonakalo wobuchopho
2. Ukuphucula i-fibrosis yesibindi
3. Unyango lwe-osteoporosis
4. Isiphumo sokulwa nokwaluphala
5. Ukulibazisa ukuguga kweeseli

Kutheni kuyimfuneko ukwenza i-cycloastraganol?

① I-Cycloastraganol ineziphumo ezahlukeneyo ze-pharmacological ezifana nokuthintela i-apoptosis yeeseli zobuchopho kunye nokudumba kwe-neuroinflammation ngexesha le-cerebral ischemia kunye nokugcina umqobo wegazi-ingqondo.
② I-Cycloastragenol yeyona molekyuli incinci kuphela equlethe i-terpenoid compound enomsebenzi we-telomerase ofunyenweyo ukuza kuthi ga ngoku kwaye inokunyanga izifo ze-neurodegenerative.
③ Inefuthe lokuthintela i-myocardial fibrosis kunye nokuphucula ukhuseleko lomzimba oluchasene nethumba. Yimolekyuli edumileyo kuphando kunye nophuhliso lwamayeza okulwa nokwaluphala.

Iingxaki ezikhoyo

Umxholo we-cycloastraganol kwi-Astragalus membranaceus uphantsi kakhulu kwaye kunzima ukuyifumana ngokuthe ngqo. Icebo lokuvelisa i-cycloastraganol elikhoyo lixhomekeke ekukhutshweni kwamayeza emveli aseTshayina, afunyanwa kakhulu ngokuguqula i-astragaloside IV kwi-Astragalus membranaceus. Oko kukuthi, i-astragaloside IV ifunyanwa ngokusebenzisa iteknoloji yokutyala i-astragalus kunye nokukhulisa izicubu, kwaye emva koko i-astragaloside IV iguqulwa ibe yi-cycloastragaloside kusetyenziswa i-acidolysis, i-Smith degradation, i-enzyme kunye ne-microbial hydrolysis. Nangona kunjalo, ezi ndlela zokulungiselela zibiza kakhulu, kulula ukubangela ungcoliseko lokusingqongileyo, kunzima ukuhlulahlula nokuhlambulula, kwaye azilungele ukusetyenziswa kunye nokukhuthaza. Ke ngoko, abantu bajike ingqalelo yabo ekuqulunqweni kwe-cycloastraganol yokwenziwa.

Uyisebenzisa njani ibhayoloji yokwenziwa ukuze udibanise? ---Ibhayoloji yokwenziwa

I-Synthetic Biology ibhekisa kuyilo olujoliswe kulo, utshintsho, kwanokudala "ubomi bokwenziwa" ngemisebenzi engeyoyamvelo phantsi kwesikhokelo seengcinga zobunjineli, oko kukuthi, ubunjineli bebhayoloji. Ngokubanzi, iveliswa kusetyenziswa iindlela zebhayoloji.