Yintoni efunyenwe ngoku i-telomerase activator-cycloastraganol?

Ngowe-1985, Greider et al. I-telomerase yokuqala yafunyanwa, kwaye le enzyme esanda kufunyanwa inokongeza ukuphindaphinda kwe-DNA ukuya eziphelweni zeechromosomes ukugcina ubude be-telomere. I-Telomerase yi-ribonucleoprotein complex engundoqo we-catalytic uquka i-TERT kunye ne-TERC, apho i-TERT isitshixo sokulawula umsebenzi we-telomerase. Ubude beTelomere buqhubeka bufutshane njengoko iiseli zihlukana. Xa ifikelela kwixabiso elibalulekileyo, ibangela izibonakaliso zomonakalo we-DNA, ekhokelela kumjikelezo weseli omfutshane kunye noluhlu lwezifo ezingapheliyo ezibonakaliswa yi-telomeres emfutshane.

Kwi-2010, inkampani yaseMelika iGeron ibambisene neYunivesithi yaseHong Kong yeSayensi kunye neTeknoloji kwiprojekthi yophando yokuhlola i-activators ye-telomerase. Kwafunyaniswa ukubacycloastraganolinokuvula umsebenzi we-telomerase kwaye ikhuthaze ukwandiswa kwe-telomere. Oku kufunyanisiweyo kukhuthaze uphuhliso lwee-activators ze-telomerase. Inkqubela phambili yophando kunye nokuphuhliswa kwemveliso ehambelanayo ye-astragalus alcohol. I-Cycloastragenol (CAG) ngoku kuphela kwe-telomerase activator exeliweyo phakathi kweemveliso zendalo. Iyakwazi ukulwa ngokuphumelelayo nokunciphisa i-telomere kwaye ine-anti-aging, i-anti-apoptosis, i-anti-fibrosis, i-immune regulation, ukukhuthaza ukwanda kweeseli kunye nokuphulukiswa kwesilonda, njl.

Cycloastragenol kunye nokuguga

iitelomeres
I-Telomeres zizakhiwo ezikhethekileyo ekupheleni kweechromosomes ezikhusela i-chromosomes kwaye zifutshane ngokuphindaphinda kwechromosome kunye nokwahlukana kweeseli. Iiseli nazo ziyaguga njengoko i-telomeres imfutshane.

itelomerase
I-telomerase inokudibanisa ii-telomeres ukuzinzisa ubude kunye nesakhiwo se-telomeres, ngaloo ndlela ikhusela iichromosomes kunye nokulibazisa ukuguga kweselula.

Ukuchasana nokuguga: I-activator ye-telomerase, edlala impembelelo yokuchasana nokuguga ngokwandisa i-telomerase kwaye ngaloo ndlela ilibazisa ukucuthwa kwe-telomeres.

I-Telomeres yiminqwazi ebekwe ekupheleni kweechromosomes zeeseli ezikhusela emonakalweni ngexesha lokwahlukana kweeseli. Njengoko iiseli ziqhubeka nokwahlula, i-telomeres iyaqhubeka ifinyeza, ifikelele kwindawo ebalulekileyo apho iiseli ziza kuguga okanye zife. I-Telomerase inokwandisa ubude be-telomeres, kwaye ubomi beeseli buya kunyuka ngokwendalo ngokufanelekileyo.

Ukwaluphala yinxalenye engenakuphepheka yobomi; nangona kunjalo, abaphandi bafunda iindlela ezahlukeneyo zonyango ukuzama ukuphepha ezinye iziphumo zokwaluphala, kubandakanya nokufunda i-senolytics. I-Senolytics zikhompawundi eziphelisa i-senescent (ukuguga) iiseli kwaye zibonakaliswe ukunciphisa imiphumo yokuguga. Uphononongo olutsha lubonisa ukuba i-cycloastraganol ineempembelelo zokuchasa ukuguga.

Uphononongo, oluvela e-China kwaye lupapashwe kwiJenali yeHlabathi yeSayensi yeMolekyuli, igxile kwiiseli zomntu oselula kunye neempuku ezine-radiation-induced senescence. I-Cycloastragenol inciphisa iiseli ze-senescent ngaphandle kokuchaphazela iiseli ezingenayo i-senescent. Unyango lwe-Cycloastragenol lukwanciphisa iiproteni kwiiseli ze-senescent ezifunekayo ekukhuleni kweeseli kunye nokuphila. Ukongezelela, inqanda ukunyakaza kweeseli ezinxulumene neeseli ezivuthayo ezinxulumene neminyaka kunye neenkqubo. Iimpuku ezindala eziphathwe nge-cycloastraganol zifunyenwe zineeseli ze-senescent ezimbalwa kunye nokuphucula ukungasebenzi komzimba okunxulumene nobudala.

I-Cycloastragenol inciphisa iiseli ze-senescent

I-Senescence luphawu olwaziwayo lokuguga, kodwa abaphandi baye bafumanisa ukuba ukuphelisa iiseli ze-senescent kunye neemolekyuli zabo ezibonisa ukudumba kunokunceda ukuthintela izifo ezinxulumene neminyaka kunye nokuzibuyisela umva kwezinye iimeko. Apha, abaphandi baphatha iiseli zomntu nge-cycloastraganol kwaye bafumanisa ukuba iphelisa ngokufanelekileyo iiseli ze-senescent ngaphandle kokuchaphazela iiseli ezingenayo i-senescent. Ukongeza, iimpawu zeselula zeeseli ze-senescent zancitshiswa kakhulu emva konyango lwe-cycloastraganol.

Uphando lwangaphambili luye lwabonisa ukuba indlela ye-PI3K / AKT / mTOR-indlela yokubonakalisa impawu ebandakanyekayo ekukhuleni kweeseli kunye nokuphila-ibandakanyeka kwiinkqubo ezivuthayo eziqalwa ngamaseli e-senescent, ekuncedeni ukukhuthaza i-senescence kwiiseli ezijikelezayo. Abaphandi bafumanisa ukuba i-cycloastragenol yanceda ukunciphisa iiprotheyini kule ndlela, iphakamisa ukuba i-compound inokusebenza ngokuthintela i-PI3K/AKT/mTOR indlela yokunceda ukukhusela ukuguga. Ngapha koko, i-cycloastragenol ibonakaliswe ukunciphisa amandla eeseli ze-senescent ukukhuthaza i-senescence ngokukhululwa kweemolekyuli ezivuthayo, izinto zokukhula, kunye ne-immunomodulators, ngokuhambelana neziphakamiso zokunciphisa i-PI3K, i-AKT, kunye nokusayinwa kwe-mTOR kunokunciphisa imiphumo yokukhuthaza i-senescence phakathi kweeseli ezijikelezileyo. .

I-Cycloastragenol yeye-triterpene saponins kwaye ifumaneka ikakhulu kwi-hydrolysis ye-astragaloside IV. Inobunzima obuncinci bemolekyuli kunye ne-lipophilicity eyomeleleyo, eluncedo ekungeneni kwe-biofilm kunye nokufunxa kwesisu ukufezekisa ukufumaneka kwe-bioavailability engcono. Ukusebenza kwe-cycloastragalinol
1. Unyango lokulimala kwengqondo
2. Ukuphucula i-fibrosis yesibindi
3. Unyango lwe-osteoporosis
4. Impembelelo yokuguga
5. Libazise ukuguga kweeseli

Kutheni kuyimfuneko ukwenza i-cycloastraganol?

① I-Cycloastraganol ineempembelelo ezahlukeneyo ze-pharmacological ezifana nokuthintela i-apoptosis yeseli yobuchopho kunye ne-neuroinflammation ngexesha le-cerebral ischemia kunye nokugcina umqobo wegazi-ubuchopho.
② I-Cycloastragenol kuphela kwemolekyuli encinci ye-terpenoid ikhompawundi kunye nomsebenzi we-telomerase ofunyenweyo ukuza kuthi ga ngoku kwaye inokunyanga izifo ze-neurodeergenerative.
③ Ineempembelelo zokuthintela i-myocardial fibrosis kunye nokuphucula i-anti-tumor immunity. I-molecule ethandwayo kuphando kunye nophuhliso lwamachiza achasene nokuguga.

Iingxaki ezikhoyo

Umxholo we-cycloastraganol e-Astragalus membranaceus uphantsi kakhulu kwaye kunzima ukuwufumana ngokuthe ngqo. Isicwangciso esikhoyo sokuvelisa i-cycloastraganol sixhomekeke ekutsalweni kwamayeza emveli aseTshayina, afunyanwa ikakhulu ngokuguqula i-astragaloside IV kwi-Astragalus membranaceus. Oko kukuthi, i-astragaloside IV ifunyanwa ngokutyala i-astragalus kunye neteknoloji yenkcubeko ye-tissue, kwaye ke i-astragaloside IV iguqulwa ibe yi-cycloastragaloside isebenzisa i-acidolysis, i-Smith degradation, i-enzyme kunye ne-microbial hydrolysis. Nangona kunjalo, ezi ndlela zokulungiselela zibiza kakhulu, kulula ukubangela ukungcoliseka kwendalo, kunzima ukwahlula kunye nokuhlanjululwa, kwaye azihambisani nesicelo kunye nokukhuthazwa. Ke ngoko, abantu baye bajika ingqalelo yabo kwi-artificial synthesis ye-cycloastraganol.

Uyisebenzisa njani ibhayoloji yokwenziwa ukudibanisa? ---Synthetic Biology

I-Synthetic Biology ibhekisa kuyilo ekujoliswe kulo, inguqu, kunye nokudala "ubomi obungeyonyani" obunemisebenzi engeyoyamvelo phantsi kwesikhokelo seengcinga zobunjineli, oko kukuthi, ubunjineli bebhayoloji. Ngokuqhelekileyo, iveliswa kusetyenziswa iindlela zebhayoloji.