Yintoni iSqualene kwaye kutheni kufuneka ukhathalele?

Njengoko abantu bexhalabela ngakumbi impilo yabo, iSqualene ifumana udumo ngenxa yeempawu zayo ezintle zokuthambisa kunye ne-antioxidant. Njengekhompawundi yendalo, iSqualene isetyenziswa kakhulu kwiimveliso zokhathalelo lolusu, izinto zokuthambisa kunye nezongezo zokutya. Njengoko imfuno yabathengi yezithako zendalo iqhubeka isanda, imfuno yomgubo weSqualene okumgangatho ophezulu kwimarike iyanda.

I-Squalene (CAS: 111-02-4) lulwelo olunamafutha olungenambala. Luyi-compound ye-trans triterpene enesakhiwo se-isoprene kwaye luyinxalenye ebalulekileyo kwindlela ye-metabolism ye-cholesterol yomntu. I-intermediate ephambili, i-terpenoids ifumaneka rhoqo kwi-nutraceuticals nakwi-cosmetics. I-Squalene ikholelwa ukuba ineenzuzo ezininzi emzimbeni womntu, kubandakanya ukwehlisa amafutha egazini, i-antioxidant, i-anti-inflammatory kunye ne-immune-enhancing effects. I-Squalene inokuthatha inxaxheba kwi-metabolism njengomphambili wokwenziwa kwe-steroid, kwaye idlala indima ebalulekileyo kwiindlela zokwenziwa kwe-β-carotene, i-coenzyme Q10, i-vitamin D, i-vitamin E kunye ne-vitamin K1.

I-Squalene ifumaneka kakhulu kwizilwanyana, izityalo kunye neentsholongwane. Yenziwa kwi-endoplasmic reticulum kwaye igcinwe kwi-vesicles okanye idluliselwe kwi-membrane yeseli nge-vesicles. Ngenxa yomsebenzi wayo onamandla webhayoloji, isetyenziswa kakhulu ekutyeni nakwizinto zokuthambisa. Iindawo zoshishino. I-Squalene ifumaneka kukutya okuninzi, phakathi kwayo i-oyile yesibindi se-shark iqulethe amanqanaba aphezulu, kwaye iioyile ezimbalwa zemifuno ezifana neoyile yomnquma kunye neoyile yerayisi zikwanawo amanqanaba aphezulu e-squalene.

I-Squalene ineziphumo ezininzi ezisebenzayo kwi-bioactive, kuquka ukuphucula ukunyamezela i-hypoxia, ukuthintela ukukhula kweentsholongwane, ukulwa neentsholongwane kunye nokudumba, kunye nokulawula imetabolism ye-cholesterol. Ukongeza, inamandla okucima i-singlet oxygen, ikhusela ngempumelelo ulusu kwi-lipid peroxidation kwaye ikhusela iiseli ekonakaleni kwe-oxidative kwi-DNA. Le nto ikwabonisa imisebenzi eyahlukeneyo ebalulekileyo ye-physiological efana nokuthintela izifo zentliziyo kunye nokuphucula amasosha omzimba womntu.

Intshayelelo kwimisebenzi ye-squalene

1. Umsebenzi we-Antioxidant

I-squalene inokuthintela ngempumelelo ukusabela kwee-free radicals emzimbeni womntu kwaye idlale indima ye-antioxidant. Imolekyuli ye-squalene yenziwe ngee-6 non-conjugated unsaturated double bonds kwaye ineempawu ezinamandla ze-antioxidant.

2. Imiphumo yokulwa neentsholongwane kunye nokudumba

I-Squalene inefuthe lokulwa neentsholongwane, ukudumba kunye nokubulala iintsholongwane kwaye ingasetyenziselwa usulelo lwendlela yokuphefumla ephezulu kunye nezifo zesikhumba ezibangelwa ziintsholongwane, kunye nokutsha, izilonda zesikhumba kunye nezifo ze-aphthous. Uphando lubonisa ukuba i-squalene inokukhawulezisa inkqubo yokuphiliswa kwamanxeba kunye nokusikeka. Iimpawu zayo zokulwa nokuvuvukala kunye ne-antioxidant zinceda ekupholeni ngokukhawuleza, okwenza ukuba ibe yongezo oluxabisekileyo kuyo nayiphi na ikhithi yoncedo lokuqala.

3. Isixhobo sokucoca iiradical zasimahla, ukuphucula amasosha omzimba

I-Squalene inamandla amakhulu okuhlutha ii-free radicals kwaye idlala indima ebalulekileyo ekukhuthazeni imetabolism yomntu. Ngokuvuselela imetabolism, i-squalene inceda ukuphucula ukufunxwa komzimba kunye nokusebenza kakuhle kwezondlo, ngaloo ndlela ikhuthaza ukugcinwa kwempilo. Njengesongezelelo sokutya esisebenzayo, i-squalene isetyenziswa kwiimveliso ezahlukeneyo zempilo, ezifana nezongezo zesondlo, ukutya okunempilo, kunye neziselo ezisebenzayo. Uphando kunye nokusetyenziswa kwe-squalene nako kuyanda rhoqo, kunika abantu amathuba amaninzi okufumana izibonelelo zempilo ngokutya.

4. Ukufumisa kunye nokulwa neentsholongwane

I-Squalene ineengenelo ezininzi zempilo yolusu, kuquka ukukhuselwa kwimitha ye-UV kunye ne-antioxidant. Iphucula ulusu, inciphisa iimbobo kunye nemibimbi, kwaye ifumisa ulusu ngaphandle kokubangela ukurhawuzelelwa. Uvavanyo olwenziwe kubasetyhini abangaphezu kweminyaka engama-50 lubonise ukuba ukutya i-squalene kunokunciphisa kakhulu imibimbi yobuso kwaye kuphucule ukurhawuzelelwa kobuso kunye nombala. Ukongeza, i-squalene inokunyusa umsebenzi we-enzyme ye-antioxidant yolusu, kwaye isiphumo singcono kakhulu kune-vitamin E. Ngenxa yemiphumo yayo emihle yokuthambisa, ezinye iimpawu zobuhle ezaziwayo ziye zayisebenzisa kwiimveliso zokhathalelo lolusu kunye neenwele ezifana ne-serums ezimanzi kunye neeoyile zokhathalelo lolusu.

3. Ukusetyenziswa kweshishini le-Squalene

1). I-Squalene kunye neemveliso zayo ezine-hydrogen zithandwa ngenxa yeendlela ezahlukeneyo zokusetyenziswa kwazo kwizithambiso. I-Squalene ineenzuzo ezininzi zempilo yolusu, kubandakanya ukukhuselwa kwimitha ye-UV kunye ne-antioxidant. Iphucula ubume bolusu, inciphisa iimbobo kunye nemibimbi, kwaye ifumisa ulusu ngaphandle kokubangela ukurhawuzelelwa.

2). Njengeoyile yendalo, i-squalene isetyenziswa kakhulu njengomthwali weziyobisi ohambelana nebhayoloji ukuze kukhutshwe amayeza rhoqo. Amayeza e-emulsion aqulethe i-squalene anokwandisa isiqingatha sobomi beziyobisi.

3). I-Squalene ibonakalise amandla amaninzi okusetyenziswa kuphando lwezonyango: kwiiseli ze-HepG2, ihlola indlela yokunciphisa i-cholesterol ngokuthintela ukwanda kweeseli kunye nokwandisa ukubonakaliswa kwe-LDLR; okwesibini, izifundo zokufaka iimolekyuli zibonisa ukuba i-squalene inokuba nendima kunyango lomhlaza wesikhumba ukuze idlale indima; ekugqibeleni, ngokufakwa kwi-PLGA NPs, ukusebenza kakuhle kokuthathwa kweeseli kwioyile yomnquma kuyaphucuka, kwaye inamandla okugcina impilo yeeseli kunye nokumelana noxinzelelo lwe-oxidative.

4). Njengesongezelelo sokutya esisebenzayo, i-squalene itsale ingqalelo enkulu kwaye ifundwe ngokubanzi ngendima yayo ekuthinteleni izifo zentliziyo, umhlaza kunye nezinye izifo.

Ungayithenga phi iSqualene?

Izinto ezibalulekileyo ekukhetheni umthengisi weSqualene

1. Umgangatho wemveliso

Xa ukhetha umthengisi, into yokuqala ekufuneka uyiqwalasele ngumgangatho wemveliso. Umgubo we-squalene ococekileyo kakhulu uqinisekisa ukusebenza kwawo ngokwebhayoloji kunye nokusebenza kwawo kakuhle. Umgubo we-squalene obonelelwa yiSuzhou Myland uvavanywe ngokungqongqo umgangatho ukuqinisekisa ukuba iqela ngalinye leemveliso lihlangabezana nemigangatho yamazwe ngamazwe kwaye linomgangatho oqinisekisiweyo.

2. Umthamo wemveliso

Umthamo wemveliso yomenzi uchaphazela ngokuthe ngqo ixesha kunye nokuzinza kobonelelo. I-Suzhou Myland inezixhobo zokuvelisa eziphambili kunye netekhnoloji enokwanelisa iimfuno zemveliso enkulu, iqinisekisa ukuba abathengi banokufumana iimveliso abazifunayo ngexesha elifanelekileyo xa bezifuna.

3. Amandla oR&D

Umthengisi obalaseleyo uhlala eneqela elinamandla le-R&D elinokuphucula iimveliso rhoqo kwaye liphuhlise iimveliso ezintsha. I-Suzhou Myland ifumene amava amaninzi kuphando kunye nokusetyenziswa kwe-Squalene kwaye iyakwazi ukubonelela abathengi ngenkxaso yobuchwephesha kunye nezisombululo.

4. Inkonzo yabathengi

Inkonzo elungileyo kubathengi yinto engenakuyityeshelwa xa ukhetha umthengisi. I-Suzhou Myland igxile kunxibelelwano nabathengi kwaye iyakwazi ukubonelela ngeenkonzo ezenzelwe wena ngokweemfuno zabathengi ukuqinisekisa ukuba abathengi bafumana amava angcono ngexesha lenkqubo yokuthenga.

5. Isiqinisekiso kunye nokuthobela imithetho

Ukuqinisekisa ukuba ababoneleli baneziqinisekiso ezifanelekileyo kunye nokuthobela imithetho zizinto ezibalulekileyo ekukhetheni. I-Suzhou Myland inesiqinisekiso se-ISO kwaye ihambelana nemigangatho ye-GMP (Good Manufacturing Practice), iqinisekisa ukuba iimveliso zayo zilandela inkqubo yolawulo lomgangatho engqongqo ngexesha lenkqubo yemveliso.

Ukuququmbela

Ukukhetha umthengisi weSqualene ofanelekileyo kubalulekile ekuqinisekiseni umgangatho kunye nokhuseleko lwemveliso. ISuzhou Myland iye yaba lukhetho oluthembekileyo kushishino ngenxa yeemveliso zayo ezicocekileyo kakhulu, ulawulo oluqinileyo lomgangatho kunye neenkonzo zobungcali. Nokuba ungumenzi wemveliso yokhathalelo lolusu, inkampani yezithambiso okanye omnye umntu ofuna imveliso, iSuzhou Myland inokukunika umgubo weSqualene okumgangatho ophezulu ukunceda impilo yakho kunye nophuhliso lomsebenzi. Ukuze ufumane iinkcukacha ezithe vetshe, nceda undwendwele iwebhusayithi esemthethweni yeSuzhou Mailun Biology.